Cryptosporidiosis in Yellow Nail Syndrome - A Rare Case Report.

Q3 Pharmacology, Toxicology and Pharmaceutics

Infectious disorders drug targets Pub Date : 2023-01-01 DOI:10.2174/1871526522666220920142423

Aditya Kundu, Saumya Srivastava, Vibhor Tak, Jagdish Prasad Goyal

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引用次数: 0

Abstract

Background: Cryptosporidium species infection causes malabsorption and severe diarrhea in immunocompromised hosts. Association of Yellow Nail Syndrome (YNS) and Cryptosporidiosis is rare and has not been reported till date. Immunity can also be affected in this case of YNS is associated with autoimmune disorders.

Case presentation: Here, we describe a case of persistent diarrhea in an 8 month old YNS patient. Modified Ziehl-Neelsen staining and Saffranine-Methylene blue revealed oocyts of Cryptosporidium species. Following appropriate treatment, the patient's symptoms improved and the patient was discharged in a hemodynamically stable condition.

Discussion: Cryptosporidiosis is a significant cause of morbidity and mortality in immunocompromised patients. YNS per se as well as treatment including steroids leads to immunosuppression in individuals making them susceptible host for opportunistic infections like Cryptosporidiosis.

Conclusion: Clinicians should be aware of the condition and screen for Cryptosporidiosis in any immunocompromised patients with diarrheal symptoms, as parasitic infection like this are opportunistic in them.

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黄指甲综合征隐孢子虫病1例报道。

背景:隐孢子虫感染导致免疫功能低下的宿主吸收不良和严重腹泻。黄指甲综合征(YNS)与隐孢子虫病的关联是罕见的，迄今尚未报道。在这种情况下，免疫也会受到影响，YNS与自身免疫性疾病有关。病例介绍:在这里，我们描述了一个8个月大的YNS患者持续腹泻的病例。改良Ziehl-Neelsen染色和藏红花-亚甲基蓝显示隐孢子虫种的卵母细胞。经过适当治疗，患者症状改善，出院时血流动力学稳定。讨论:隐孢子虫病是免疫功能低下患者发病和死亡的重要原因。YNS本身以及包括类固醇在内的治疗导致个体免疫抑制，使其成为隐孢子虫病等机会性感染的易感宿主。结论:临床医生应了解任何有腹泻症状的免疫功能低下患者的病情并筛查隐孢子虫病，因为这种寄生虫感染在他们身上是机会性的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Infectious disorders drug targets Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

3.10

自引率

0.00%

发文量

123

期刊介绍： Infectious Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in infectious disorders e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics on drug targets involved in infectious disorders. As the discovery, identification, characterization and validation of novel human drug targets for anti-infective drug discovery continues to grow, this journal will be essential reading for all pharmaceutical scientists involved in drug discovery and development.