Outbreak of Monkeypox Virus Disease: An Update on Epidemiology, Pathophysiology and Available Treatment Options.

Q3 Pharmacology, Toxicology and Pharmaceutics
Akash Kumar, Neeti Angaria, Gurvinder Singh, Rajesh Kumar
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引用次数: 0

Abstract

The monkeypox virus is a zoonotic illness with a tropical distribution in Africa, and around the world. The disease is spread through contact with infected animals or humans, and can also be spread from person to person through close contact with respiratory or bodily fluids. Fever, swollen lymph nodes, blisters, and crusted rashes characterize the disease. The incubation period is five to twenty-one days. It is difficult to distinguish the rash caused by infection from varicella and smallpox. Laboratory investigations are essential aspects of illness diagnosis and surveillance, and novel tests are required for more accurate and faster diagnosis. Antiviral drugs are being used to treat monkeypox. Scarring as well as other comorbidities, are prevalent in survivors, with the case mortality rate varying from 1 to 11%. The virus was found in monkeys at a Danish research facility in 1958, from which the term 'monkeypox' is derived. The primary human case was found in a child in the Democratic Republic of the Congo (DRC) in 1970. The World Health Organisation (WHO) has recently declared monkeypox a public health emergency of international concern. This manuscript attempts to review the various aspects of monkeypox disease and its allopathic as well as alternative treatment options available and serves as a valuable resource for healthcare professionals, researchers, and the general public.

猴痘病毒疾病爆发:流行病学、病理生理学和现有治疗方案的最新进展。
猴痘病毒是一种人畜共患病,分布在非洲和世界各地的热带地区。该病通过与受感染的动物或人类接触传播,也可通过呼吸道或体液的密切接触在人与人之间传播。发热、淋巴结肿大、水疱和结痂皮疹是该病的特征。潜伏期为五到二十一天。很难将感染引起的皮疹与水痘和天花区分开来。实验室检查是疾病诊断和监测的重要环节,需要新的检测方法来提高诊断的准确性和速度。目前正在使用抗病毒药物治疗猴痘。疤痕和其他并发症在幸存者中很普遍,病例死亡率从1%到11%不等。1958 年,丹麦一家研究机构在猴子身上发现了猴痘病毒,"猴痘 "一词由此而来。最初的人类病例是 1970 年在刚果民主共和国的一名儿童身上发现的。世界卫生组织(WHO)最近宣布猴痘为国际关注的突发公共卫生事件。本手稿试图回顾猴痘疾病的各个方面,以及现有的对抗疗法和替代疗法,为医疗保健专业人员、研究人员和公众提供宝贵的资料。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Infectious disorders drug targets
Infectious disorders drug targets Pharmacology, Toxicology and Pharmaceutics-Pharmacology
CiteScore
3.10
自引率
0.00%
发文量
123
期刊介绍: Infectious Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in infectious disorders e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics on drug targets involved in infectious disorders. As the discovery, identification, characterization and validation of novel human drug targets for anti-infective drug discovery continues to grow, this journal will be essential reading for all pharmaceutical scientists involved in drug discovery and development.
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