Intensive Care Medicine最新文献

{"title":"Early mobilization for mechanical ventilation for sepsis or acute respiratory failure (EVER): a multicenter randomized controlled trial with 12-month outcomes.","authors":"Chi Ryang Chung, Suk-Kyung Hong, Danbee Kang, Ryoung-Eun Ko, Juhee Cho, Won Kim, Jong Geol Do, Myung-Jun Shin, Yong Beom Shin, So Young Ahn, Yu Hui Won, Song I Lee, Hak-Jae Lee, Heung-Bum Lee, Myunghun Jang, Jiyeon Kang, Gee Young Suh","doi":"10.1007/s00134-026-08598-w","DOIUrl":"https://doi.org/10.1007/s00134-026-08598-w","url":null,"abstract":"<p><strong>Purpose: </strong>Early mobilization is recommended for adults on mechanical ventilation, but the timing, the dose, and the real-world effectiveness, particularly in Asian ICUs, remain unclear. We assessed whether a structured six-step early mobilization programme enhances functional status at ICU discharge and longer-term recovery.</p><p><strong>Methods: </strong>A multicenter, randomized, open-label study was conducted across five tertiary hospitals in South Korea (September 2020 to July 2024). Adult patients with sepsis or respiratory failure anticipated to require invasive ventilation for ≥ 48 h were randomly assigned (1:1) to the intervention or usual care. The primary outcome was the FSS-ICU at ICU discharge. Secondary outcomes included in-hospital mortality, muscle strength, physical performance, and patient-reported outcomes evaluated at 1, 3, 6, and 12 months. Analyses followed the intention-to-treat principle.</p><p><strong>Results: </strong>We enrolled 169 participants (93 intervention; 76 usual care). At ICU discharge, the FSS-ICU did not differ between groups (mean 23.6 [SD 11.8] vs. 22.2 [SD 10.8]; P = 0.44). The intervention group began mobilization earlier (median 30.0 vs. 45.9 h), underwent more sessions (median 11 vs. 4), and accumulated more mobilization time (median 330 vs. 120 min). Patients achieving mobilization Step ≥ 4 (sit to stand or higher) had higher FSS-ICU at ICU discharge compared with matched usual care (mean 30.6 vs. 23.3; P < 0.01). Long-term outcomes (EQ-5D, SF-36 PCS/MCS, IES-R-K, MoCA-BLIND, and PICS) improved similarly in both groups over 12 months without significant differences.</p><p><strong>Conclusions: </strong>In this multicenter randomized controlled trial of mechanically ventilated patients with sepsis or acute respiratory failure, a protocolized early mobilization program did not improve functional status at ICU discharge or at 12 months compared with usual care.</p><p><strong>Trial registration: </strong>NCT04582760, registered 12 October 2020.</p>","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":""},"PeriodicalIF":22.0,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148828033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of a strategy using multiplex PCR on targeted antibiotic therapy for patients with suspected ventilator-associated pneumonia or hospital-acquired pneumonia requiring mechanical ventilation: a randomized, single-blind trial","authors":"Guillaume Millot, Anahita Rouze, Frédéric Wallet, Caroline Loiez, Sébastien Preau, Côme Bureau, Nicolas Dognon, Alexandre Gaudet, Maxime Granier, Inès Gueguen, Julien Labreuche, Léa Mortain, Saad Nseir","doi":"10.1007/s00134-026-08591-3","DOIUrl":"https://doi.org/10.1007/s00134-026-08591-3","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"7 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148768955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Respiratory mechanics modifies the impact of ventilator settings on clinical outcome in patients with acute brain injury","authors":"Domenico Luca Grieco, Alessandro Stronati, Chiara Robba, Tommaso Rosà, Ida G. Iavarone, Emanuele Rezoagli, Filippo Bongiovanni, Antonio M. Dell’Anna, Alessandro Cardu, Francesca Graziano, Stefania Galimberti, Anselmo Caricato, Nicolò Patroniti, Fabio Silvio Taccone, Giuseppe Citerio, Massimo Antonelli","doi":"10.1007/s00134-026-08562-8","DOIUrl":"https://doi.org/10.1007/s00134-026-08562-8","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"35 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148768956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular adrenoceptors physiology in patients with shock","authors":"Mathieu Jozwiak, Mervyn Singer, Djillali Annane","doi":"10.1007/s00134-026-08589-x","DOIUrl":"https://doi.org/10.1007/s00134-026-08589-x","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"34 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148768958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early red blood cell transfusion strategy in septic shock among patients with cancer: the TRANSPORT randomized controlled trial","authors":"Frédéric Pène, Clara Vigneron, Antoine Lafarge, Djamel Mokart, Yoann Zerbib, Emmanuel Canet, Toufik Kamel, Anne-Sophie Moreau, Cyril Cadoz, Maxens Decavèle, Armand Mekontso Dessap, Nathan Ebstein, Guillaume Lacave, Jonathan Chelly, Danielle Reuter, Laurent Argaud, Hafid Ait-Oufella, Naïke Bigé, Mélanie Levrard, Julien Charpentier, Magali Bisbal, Julien Maizel, Soraya Benguerfi, François Barbier, Côme Bureau, Noémie Bigot, Matthieu Resche-Rigon, Jérôme Lambert, Elie Azoulay","doi":"10.1007/s00134-026-08582-4","DOIUrl":"https://doi.org/10.1007/s00134-026-08582-4","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"13 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148768957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning for prediction in secondary hemophagocytic lymphohistiocytosis: real progress, real limits, and the potential of synthetic data","authors":"Louis Delamarre, Jan-Inge Henter","doi":"10.1007/s00134-026-08568-2","DOIUrl":"https://doi.org/10.1007/s00134-026-08568-2","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"60 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148768959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ARDS management beyond the guidelines: a practical physiology-based approach to individualized care","authors":"Nattapat Wongtirawit, Luca Salvatore Menga, Roberto Brito, Mattia Docci, Glauco M. Plens, Glasiele Alcala, Ben Cantan, Karen J. Bosma, Matthew Ko, Georgiana Roman-Sarita, Trinity Purcell, Davide Raimondi Cominesi, Richard A. Greendyk, Laurent Brochard","doi":"10.1007/s00134-026-08563-7","DOIUrl":"https://doi.org/10.1007/s00134-026-08563-7","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"34 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148768960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prehospital non-invasive ventilation: from efficacy to implementation.","authors":"Rosario Losiggio, Filippo D'Amico, Katia Donadello","doi":"10.1007/s00134-026-08585-1","DOIUrl":"https://doi.org/10.1007/s00134-026-08585-1","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":""},"PeriodicalIF":22.0,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148706356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpreting the HISTAP trial: the roles of AKI criteria and cumulative exposure to hypotension.","authors":"Cedric Cirenei, Eric Kipnis, Benoit Tavernier","doi":"10.1007/s00134-026-08584-2","DOIUrl":"https://doi.org/10.1007/s00134-026-08584-2","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":""},"PeriodicalIF":22.0,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148678345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging the gap: pragmatic neuromonitoring and management of traumatic brain injury in resource-limited settings.","authors":"Andres M Rubiano, Laura M Loaiza-Cardona, Walter Videtta","doi":"10.1007/s00134-026-08455-w","DOIUrl":"10.1007/s00134-026-08455-w","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":"1769-1773"},"PeriodicalIF":22.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147814604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}