Intensive Care Medicine最新文献

{"title":"Persistent signs of poisoning after massive drug ingestion: move the ultrasound probe to the stomach","authors":"N. Lautrou-cabasson, H. Pirollet, C. Lombois, Guillaume Dumas","doi":"10.1007/s00134-025-07925-x","DOIUrl":"https://doi.org/10.1007/s00134-025-07925-x","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"28 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143979456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reconsidering methodological choices and future research avenues in awake prone positioning studies. Author's reply","authors":"Mariano Esperatti, Nora Fuentes, Matias Olmos","doi":"10.1007/s00134-025-07941-x","DOIUrl":"https://doi.org/10.1007/s00134-025-07941-x","url":null,"abstract":"No Abstract","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"21 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143979670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Providing support to children during the loss of an important adult in the ICU","authors":"Ruth Kleinpell, Bénédicte Gaillard-Le Roux, Jozef Kesecioglu","doi":"10.1007/s00134-025-07915-z","DOIUrl":"https://doi.org/10.1007/s00134-025-07915-z","url":null,"abstract":"Managing critically ill patients in the intensive care unit (ICU) setting is challenging for critical care clinicians, who often have to balance the demands of treating acutely ill patients, while also providing support to family members. Family-centered care practice and bereavement needs of the family are closely related as a supportive, inclusive, and communicative approach in the ICU can significantly influence the grieving process, and the impact on family symptoms [1]. In ICU settings that typically care for adult patients, caring for a bereaved child in the ICU can be especially stressful. While family-centered care practice in the ICU is globally well supported [2], addressing the unique bereavement needs of children can lead to uncertainty among ICU clinicians as to how to best provide support. Although guidelines exist to support clinicians to improve quality of dying and death, minimize the adverse effects of the experience on families, and serve as a resource for hospital administrators and healthcare policymakers [3], uncertainty exists as to how to best provide child-centered bereavement support in an adult ICU. This shows the necessity of prioritizing research on the bereaved children, caregivers, and health care providers in the ICU, to build up evidence and develop targeted interventions [4].","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"230 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143939975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of targeting high mean arterial pressure for older patients with septic shock (OPTPRESS): a multicentre, pragmatic, open-label, randomised controlled trial","authors":"Akira Endo, Kazuma Yamakawa, Takashi Tagami, Yutaka Umemura, Takeshi Wada, Ryo Yamamoto, Hiroki Nagasawa, Wataru Takayama, Masayuki Yagi, Kyosuke Takahashi, Mitsuaki Kojima, Chihiro Narita, Satoshi Kazuma, Jiro Takahashi, Atsushi Shiraishi, Masaki Todani, Masaki Nakane, Toshihiko Nagata, Shohei Tanaka, Yuta Yokokawa, Kunihiko Takahashi, Haruka Ishikita, Ryo Hisamune, Junichi Sasaki, Ken-ichi Muramatsu, Hiroyuki Sonobe, Kazunobu Minami, Hiromasa Hoshi, Yasuhiro Otomo","doi":"10.1007/s00134-025-07910-4","DOIUrl":"https://doi.org/10.1007/s00134-025-07910-4","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>We examined the effect of a high-target mean arterial pressure (MAP) on septic shock in a previously underrepresented region.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>A multicentre, pragmatic, open-label, randomised controlled trial was conducted in 29 hospitals in Japan, where the prevalence of chronic hypertension among older individuals is 66.9%. Patients who were diagnosed with septic shock, aged ≥ 65 years, and admitted to an intensive care unit were randomised 1:1 to the high (target MAP = 80–85 mmHg) or control (target MAP = 65–70 mmHg) groups from 1 July 2021 to 12 December 2023. The target MAP was maintained for 72 h or until vasopressors were no longer required. The primary outcome was the 90-day all-cause mortality. Secondary outcomes included organ support-free days and adverse events.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>The trial was terminated early on the basis of the interim analysis results, suggesting the harm of the high-target strategy. Of the 518 patients, 258 were in the high-target group, and 260 were in the control group. By 90 days after randomisation, 101 patients (39.3%) in the high-target group and 74 (28.6%) in the control group had died from any cause (risk difference = 10.7; 95% confidence interval, 2.6–18.9). Renal replacement therapy-free days at 28 days were shorter in the high-target group. No clinical benefits for any outcome were observed in any subpopulation, including those with known chronic hypertension.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Among older patients with septic shock, high-target MAP significantly increased mortality compared with standard care.</p><h3 data-test=\"abstract-sub-heading\">Trial registration</h3><p>UMIN Clinical Trials Registry; UMIN000041775; 13 September 2020.</p>","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"74 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143939948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The brain: an overloaded but overlooked organ","authors":"Juliana Caldas, Fernanda Alves, Sergio Brasil, Carla Rynkowisk","doi":"10.1007/s00134-025-07918-w","DOIUrl":"https://doi.org/10.1007/s00134-025-07918-w","url":null,"abstract":"No Abstract","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"44 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143939949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ESICM-ESPNIC international expert consensus on quantitative lung ultrasound in intensive care.","authors":"Silvia Mongodi,Andrea Cortegiani,Almudena Alonso-Ojembarrena,Daniele Guerino Biasucci,Lieuwe D J Bos,Belaid Bouhemad,Massimo Cantinotti,Ioana Ciuca,Francesco Corradi,Martin Girard,Rebeca Gregorio-Hernandez,Maria Rosaria Gualano,Francesco Mojoli,George Ntoumenopoulos,Luigi Pisani,Francesco Raimondi,Javier Rodriguez-Fanjul,Marilena Savoia,Marry R Smit,Pieter R Tuinman,Laurent Zieleskiewicz,Daniele De Luca","doi":"10.1007/s00134-025-07932-y","DOIUrl":"https://doi.org/10.1007/s00134-025-07932-y","url":null,"abstract":"PURPOSETo provide an international expert consensus on technical aspects and clinical applications of quantitative lung ultrasound in adult, paediatric and neonatal intensive care.METHODSThe European Society of Intensive Care (ESICM) and the European Society of Paediatric and Neonatal Intensive Care (ESPNIC) endorsed the project. We selected an international panel of 20 adult, paediatric and neonatal intensive care experts with clinical and research expertise in quantitative lung ultrasound, plus two non-voting methodologists. Fourteen clinical questions were proposed by the chairs to the panel, who voted for their priority (1-9 Likert-type scale) and proposed modifications/supplementing (two-round vote). All the questions achieved the predefined threshold (mean score > 5) and 14 groups of 3 mixed adult/paediatric experts were identified to develop the statements for each clinical question; predefined groups of experts in the fields of adult and paediatric/neonatal intensive care voted statements specific for these subgroups. An iterative approach was used to obtain the final consensus statements (two-round vote, 1-9 Likert-type scale); statements were classified as with agreement (range 7-9), uncertainty (4-6), disagreement (1-3) when the median score and ≥ 75% of votes laid within a specific range.RESULTSA total of 46 statements were produced (4 adults-only, 4 paediatric/neonatal-only, 38 interdisciplinary); all obtained agreement. This result was also achieved by acknowledging in the statements the current limitations of quantitative lung ultrasound.CONCLUSIONThis consensus guides the use of quantitative lung ultrasound in adult, paediatric and neonatal intensive care and helps identify the fields where further research will be needed in the future.","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"111 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemoadsorption in septic shock – CON","authors":"Girardis Massimo, Tosi Martina, David Sascha","doi":"10.1007/s00134-025-07911-3","DOIUrl":"https://doi.org/10.1007/s00134-025-07911-3","url":null,"abstract":"Sepsis is a life-threatening condition caused by a dysregulated host response to infection that leads to systemic inflammation, organ dysfunction, and high mortality. Although, there is a lack of precise criteria for recognising a dysregulated immune response, septic patients have worse clinical outcomes when bacterial burden, endotoxin levels, and pro- and anti-inflammatory cytokine/chemokine levels are elevated in tissues and blood [1].","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"36 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143909713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: The Doppler combined assessment of splanchnic perfusion and congestion in cardiogenic shock: a physiological approach","authors":"Francesco Corradi, Guido Tavazzi","doi":"10.1007/s00134-025-07929-7","DOIUrl":"https://doi.org/10.1007/s00134-025-07929-7","url":null,"abstract":"<b>Correction: Intensive Care Med</b> <b>https://doi.org/10.1007/s00134-025-07855-8</b>","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"8 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143909715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correspondence about the VENTIBRAIN study. Authors’ reply","authors":"Giuseppe Citerio, Daniele Giardiello, Paola Rebora, Fabio S. Taccone, Chiara Robba","doi":"10.1007/s00134-025-07914-0","DOIUrl":"https://doi.org/10.1007/s00134-025-07914-0","url":null,"abstract":"No Abstract","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"110 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143910204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reevaluating the safety of shortened antibiotic treatment: a critical evaluation of the EUROBACT-2 study. Authors’ reply","authors":"Lena Gajdos, Niccolo Buetti, Alexis Tabah, Jean-François Timsit","doi":"10.1007/s00134-025-07927-9","DOIUrl":"https://doi.org/10.1007/s00134-025-07927-9","url":null,"abstract":"No Abstract","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"10 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143909712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}