驱动压力作为肺保护策略的目标：从ARDS危重患者到手术室-来自IMPROVE-2试验的经验教训

IF 21.2 1区医学 Q1 CRITICAL CARE MEDICINE

Intensive Care Medicine Pub Date : 2025-09-18 DOI:10.1007/s00134-025-08120-8

Louis Delamarre, John J. Marini, Claude Guerin

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引用次数: 0

摘要

保护肺部免受机械通气造成的损伤仍然是围手术期和重症监护医学的基石。然而，如何最好地实现这一目标，以及这一策略是否能改善无急性呼吸窘迫综合征（ARDS）患者的预后，仍引发争论。Futier等人最近发表的一项改进-2试验为这一讨论增加了重要内容，该试验研究了在手术室中针对驱动压（DP）个体化呼气末正压（PEEP）是否可以预防有术后呼吸衰竭风险的患者的术后肺部并发症。

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Driving pressure as a target for lung protective strategies: from ARDS critically-ill patients to the operating room—Lessons from the IMPROVE-2 Trial

Protecting the lung from injurious strain imposed by mechanical ventilation remains a cornerstone in perioperative and critical care medicine. Yet, how best to achieve this goal and whether this strategy translates into improved outcomes in patients without established acute respiratory distress syndrome (ARDS) continues to spark debate. The recently published IMPROVE-2 trial by Futier et al. [1] adds an important piece to this discussion, examining whether targeting driving pressure (DP) to individualize positive end expiratory pressure (PEEP) in the operating room can prevent postoperative pulmonary complications in patients at risk of postoperative respiratory failure.

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来源期刊

Intensive Care Medicine 医学-危重病医学

CiteScore

51.50

自引率

2.80%

发文量

326

审稿时长

1 months

期刊介绍： Intensive Care Medicine is the premier publication platform fostering the communication and exchange of cutting-edge research and ideas within the field of intensive care medicine on a comprehensive scale. Catering to professionals involved in intensive medical care, including intensivists, medical specialists, nurses, and other healthcare professionals, ICM stands as the official journal of The European Society of Intensive Care Medicine. ICM is dedicated to advancing the understanding and practice of intensive care medicine among professionals in Europe and beyond. The journal provides a robust platform for disseminating current research findings and innovative ideas in intensive care medicine. Content published in Intensive Care Medicine encompasses a wide range, including review articles, original research papers, letters, reviews, debates, and more.