Intensive Care Medicine最新文献

{"title":"Correction: Effect of the 1-h bundle on mortality in patients with suspected sepsis in the emergency department: a stepped wedge cluster randomized clinical trial.","authors":"Yonathan Freund, Marta Cancella de Abreu, Soufiane Lebal, Alexandra Rousseau, Thomas Lafon, Youri Yordanov, Richard Macrez, Fabien Coisy, Pierrick Le Borgne, Florent Femy, Delphine Douillet, Neus Robert Boter, Xavier Eyer, Jean-Baptiste Bouillon-Minois, Carl Ogereau, Donia Bouzid, Hélène Goulet, Mélanie Roussel, Geoffroy Rousseau, Jeremy Guénézan, Celine Occelli, Tahar Chouihed, Gina Osorio Quispe, Marine Clea Renard, Judith Gorlicki, Ben Bloom, Tabassome Simon, Camille Gerlier","doi":"10.1007/s00134-024-07600-7","DOIUrl":"10.1007/s00134-024-07600-7","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":"1728"},"PeriodicalIF":27.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of environmental, economic and professional impacts of levetiracetam according to its administration route in intensive care unit.","authors":"Solen Santander, Loic Le Guennec, Inès de Maisoncelle, Amélie Liou, Clémence Marois","doi":"10.1007/s00134-024-07575-5","DOIUrl":"10.1007/s00134-024-07575-5","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":"1708-1710"},"PeriodicalIF":27.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142107043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Terlipressin use in HRS-AKI and respiratory failure.","authors":"Romain Arrestier, Pierre-Antoine Billiet, Thomas Frapard, Armand Mekontso Dessap","doi":"10.1007/s00134-024-07556-8","DOIUrl":"10.1007/s00134-024-07556-8","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":"1711-1712"},"PeriodicalIF":27.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selective digestive tract decontamination implementation.","authors":"Jeroen Schouten, Margo van Mol, Jan J De Waele","doi":"10.1007/s00134-024-07500-w","DOIUrl":"10.1007/s00134-024-07500-w","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":"1688-1691"},"PeriodicalIF":27.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141456566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of sensory stimulations on thirst in critically ill mechanically ventilated patients.","authors":"Côme Bureau, Jérémie Mallet, Thomas Similowski, Alexandre Demoule","doi":"10.1007/s00134-024-07606-1","DOIUrl":"10.1007/s00134-024-07606-1","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":"1705-1707"},"PeriodicalIF":27.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142055503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges in optimizing the treatment of Pneumocystis pneumonia in the intensive care unit.","authors":"Florian Reizine, Nahema Issa, Romain Lécuyer, Benoit Tessoulin, Benjamin Gaborit","doi":"10.1007/s00134-024-07568-4","DOIUrl":"10.1007/s00134-024-07568-4","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":"1719-1720"},"PeriodicalIF":27.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141889100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term outcomes in nutrition trials: after all, this is what our patients are looking for!!","authors":"Leandro Utino Taniguchi, Yaseen M Arabi","doi":"10.1007/s00134-024-07608-z","DOIUrl":"10.1007/s00134-024-07608-z","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":"1681-1684"},"PeriodicalIF":27.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142004127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of withholding early parenteral nutrition on 2-year mortality and functional outcome in critically ill adults.","authors":"Michael P Casaer, Hendrik Stragier, Greet Hermans, Alexandra Hendrickx, Pieter J Wouters, Jasperina Dubois, Fabian Guiza, Greet Van den Berghe, Jan Gunst","doi":"10.1007/s00134-024-07546-w","DOIUrl":"10.1007/s00134-024-07546-w","url":null,"abstract":"<p><strong>Purpose: </strong>In critically ill adults, withholding parenteral nutrition until 1 week after intensive care admission (Late-PN) facilitated recovery as compared with early supplementation of insufficient enteral nutrition with parenteral nutrition (Early-PN). However, the impact on long-term mortality and functional outcome, in relation to the estimated nutritional risk, remains unclear.</p><p><strong>Methods: </strong>In this prospective follow-up study of the multicenter EPaNIC randomized controlled trial, we investigated the impact of Late-PN on 2-year mortality (N = 4640) and physical functioning, assessed by the 36-Item Short Form Health Survey (SF-36; in 3292 survivors, responding 819 [738-1058] days post-randomization). To account for missing data, we repeated the analyses in two imputed models. To identify potential heterogeneity of treatment effects, we investigated the impact of Late-PN in different nutritional risk subgroups as defined by Nutritional Risk Screening-2002-score, modified NUTrition Risk in the Critically Ill-score, and age (above/below 70 years), and we evaluated whether there was statistically significant interaction between classification to a nutritional risk subgroup and the effect of the randomized intervention. Secondary outcomes were SF-36-derived physical and mental component scores (PCS & MCS).</p><p><strong>Results: </strong>Two-year mortality (20.5% in Late-PN, 19.8% in Early-PN; P = 0.54) and physical functioning (70 [40-90] in both study-arms; P = 0.99) were similar in both groups, also after imputation of missing physical functioning data. Likewise, Late-PN had no impact on 2-year mortality and physical functioning in any nutritional risk subgroup. PCS and MCS were similar in both groups.</p><p><strong>Conclusion: </strong>Late-PN did not alter 2-year survival and physical functioning in adult critically ill patients, independent of anticipated nutritional risk.</p>","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":"1593-1602"},"PeriodicalIF":27.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141626724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tracheal intubation in critically ill adults with a physiologically difficult airway. An international Delphi study.","authors":"Kunal Karamchandani, Prashant Nasa, Mary Jarzebowski, David J Brewster, Audrey De Jong, Philippe R Bauer, Lauren Berkow, Calvin A Brown, Luca Cabrini, Jonathan Casey, Tim Cook, Jigeeshu Vasishtha Divatia, Laura V Duggan, Louise Ellard, Begum Ergan, Malin Jonsson Fagerlund, Jonathan Gatward, Robert Greif, Andy Higgs, Samir Jaber, David Janz, Aaron M Joffe, Boris Jung, George Kovacs, Arthur Kwizera, John G Laffey, Jean-Baptiste Lascarrou, J Adam Law, Stuart Marshall, Brendan A McGrath, Jarrod M Mosier, Daniel Perin, Oriol Roca, Amélie Rollé, Vincenzo Russotto, John C Sakles, Gentle S Shrestha, Nathan J Smischney, Massimiliano Sorbello, Avery Tung, Craig S Jabaley, Sheila Nainan Myatra","doi":"10.1007/s00134-024-07578-2","DOIUrl":"10.1007/s00134-024-07578-2","url":null,"abstract":"<p><strong>Purpose: </strong>Our study aimed to provide consensus and expert clinical practice statements related to airway management in critically ill adults with a physiologically difficult airway (PDA).</p><p><strong>Methods: </strong>An international Steering Committee involving seven intensivists and one Delphi methodology expert was convened by the Society of Critical Care Anaesthesiologists (SOCCA) Physiologically Difficult Airway Task Force. The committee selected an international panel of 35 expert clinician-researchers with expertise in airway management in critically ill adults. A Delphi process based on an iterative approach was used to obtain the final consensus statements.</p><p><strong>Results: </strong>The Delphi process included seven survey rounds. A stable consensus was achieved for 53 (87%) out of 61 statements. The experts agreed that in addition to pathophysiological conditions, physiological alterations associated with pregnancy and obesity also constitute a physiologically difficult airway. They suggested having an intubation team consisting of at least three healthcare providers including two airway operators, implementing an appropriately designed checklist, and optimizing hemodynamics prior to tracheal intubation. Similarly, the experts agreed on the head elevated laryngoscopic position, routine use of videolaryngoscopy during the first attempt, preoxygenation with non-invasive ventilation, careful mask ventilation during the apneic phase, and attention to cardiorespiratory status for post-intubation care.</p><p><strong>Conclusion: </strong>Using a Delphi method, agreement among a panel of international experts was reached for 53 statements providing guidance to clinicians worldwide on safe tracheal intubation practices in patients with a physiologically difficult airway to help improve patient outcomes. Well-designed studies are needed to assess the effects of these practice statements and address the remaining uncertainties.</p>","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":"1563-1579"},"PeriodicalIF":27.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142004129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding, assessing and treating immune, endothelial and haemostasis dysfunctions in bacterial sepsis.","authors":"Massimo Girardis, Sascha David, Ricard Ferrer, Julie Helms, Nicole P Juffermans, Ignacio Martin-Loeches, Pedro Povoa, Lene Russell, Manu Shankar-Hari, Toshiaki Iba, Irene Coloretti, Nicholas Parchim, Nathan D Nielsen","doi":"10.1007/s00134-024-07586-2","DOIUrl":"10.1007/s00134-024-07586-2","url":null,"abstract":"<p><p>The interplay between the immune system, coagulation, and endothelium is critical in regulating the host response to infection. However, in sepsis and other critical illnesses, a dysregulated immune response can lead to excessive alterations in these mechanisms, resulting in coagulopathy, endothelial dysfunction, and multi-organ dysfunction. This review aims to provide a comprehensive analysis of the pathophysiological mechanisms that govern the complex interplay between immune dysfunction, endothelial dysfunction, and coagulation in sepsis. It emphasises clinical significance, evaluation methods, and potential therapeutic interventions. Understanding these mechanisms is essential for developing effective treatments that can modulate the immune response, mitigate thrombosis, restore endothelial function, and ultimately improve patient survival.</p>","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":"1580-1592"},"PeriodicalIF":27.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142107050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}