Intensive Care Medicine最新文献

{"title":"Oxygenation indexes for classification of severity of ARDS. Authors' reply.","authors":"Giulia Catozzi, Tommaso Pozzi, Domenico Nocera, Luigi Camporota","doi":"10.1007/s00134-025-07850-z","DOIUrl":"10.1007/s00134-025-07850-z","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":"817-819"},"PeriodicalIF":27.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond perfection: why imperfect routinely collected intensive care data still hold value.","authors":"Niklas Rodemund, Bernhard Wernly, Ottokar Stundner, Patrick Rockenschaub, Andreas Koköfer","doi":"10.1007/s00134-025-07844-x","DOIUrl":"10.1007/s00134-025-07844-x","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":"829-830"},"PeriodicalIF":27.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supporting the bereaved child in the adult ICU: let's take the first step! Author's reply.","authors":"Annelies Rowland, Carole Boulanger, Louise Dalton","doi":"10.1007/s00134-025-07886-1","DOIUrl":"10.1007/s00134-025-07886-1","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":"826"},"PeriodicalIF":27.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analyzing PaO₂/FiO₂? Mind the interaction with PEEP! Authors' reply.","authors":"Giulia Catozzi, Luigi Camporota","doi":"10.1007/s00134-025-07836-x","DOIUrl":"10.1007/s00134-025-07836-x","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":"800-801"},"PeriodicalIF":27.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing ICU antifungal therapy: overcoming pharmacokinetic limitations with combination strategies.","authors":"Rongqiang Liao, Xiaoyuan Zheng","doi":"10.1007/s00134-025-07846-9","DOIUrl":"10.1007/s00134-025-07846-9","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":"811-812"},"PeriodicalIF":27.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuous infusion of beta-lactam antibiotics in critically ill patients with sepsis: insights from daily clinical practice.","authors":"Isabel Spriet, Matthias Gijsen, Marijke Peetermans, Yves Debaveye, Charlotte Quintens","doi":"10.1007/s00134-025-07819-y","DOIUrl":"10.1007/s00134-025-07819-y","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":"827-828"},"PeriodicalIF":27.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sedatives in neurocritical care: the old, the new, the future.","authors":"Veerle De Sloovere, Katarzyna Kotfis, Geert Meyfroidt","doi":"10.1007/s00134-025-07823-2","DOIUrl":"10.1007/s00134-025-07823-2","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":"776-778"},"PeriodicalIF":27.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-risk pulmonary embolism: the significance and perspectives of pulmonary reperfusion","authors":"Oliver Hunsicker, Xavier Monnet, Martin W. Dünser","doi":"10.1007/s00134-025-07874-5","DOIUrl":"https://doi.org/10.1007/s00134-025-07874-5","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"72 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143737148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A consensus of European experts on the definition of ventilator-associated pneumonia recurrences obtained by the Delphi method: the RECUVAP study","authors":"Antoine Gaillet, Charles-Edouard Luyt, Jean-Francois Timsit, Karim Asehnoune, Francois Barbier, Matteo Bassetti, Lila Bouadma, Adrien Bouglé, Jean Chastre, Andrew Conway Morris, Jan J. De Waele, François Dépret, George Dimopoulos, Stephan Ehrmann, Santiago Ewig, Muriel Fartoukh, Arnaud Foucrier, José Garnacho-Montero, Sami Hraiech, Marc Leone, Demosthenes Makris, Ignacio Martin-Loeches, Dimitrios Matthaiou, Antoine Monsel, Philippe Montravers, Saad Nseir, José-Artur Paiva, Laurent Papazian, Garyfallia Poulakou, Pedro Póvoa, Jérôme Pugin, Alejandro H. Rodriguez, Antoine Roquilly, Damien Roux, Anahita Rouzé, Fabio Silvio Taccone, Antoni Torres, Jean-Ralph Zahar, Emmanuel Weiss, Keyvan Razazi","doi":"10.1007/s00134-025-07856-7","DOIUrl":"https://doi.org/10.1007/s00134-025-07856-7","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background</h3><p>There are recognized diagnostic criteria for a first ventilator-associated pneumonia (VAP) episode, but not for recurrences. Many randomized clinical trials (RCTs) have used the recurrence of VAP as a criterion for efficacy evaluation. Still, the different definitions used in RCTs make it difficult to compare studies. We aimed to develop a consensual definition of VAP recurrences and of the various types of VAP recurrences.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Thirty-six European experts constituting a multidisciplinary group of physicians (critical care, infectious diseases, microbiology) with special interest in the management of VAP were polled using the Delphi methodology.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>After the completion of four iterations of the DELPHI method, 94% of experts agreed that the diagnostic criteria for a first VAP episode could also be used for recurrences, except for the radiological criterion, which not all the experts considered to be mandatory. Consensus was also reached regarding the definition of four distinct entities: relapse, persistent VAP, superinfection, and new-pathogen VAP. For relapse and persistent VAP, bacteriological findings were identical for different VAP episodes, whereas they differed for superinfection and new-pathogen VAP. The distinction between relapse and persistent VAP, and between superinfection and new-pathogen VAP depended on the timing of antibiotic treatment (before or after 48–72 h after the end of antibiotic therapy) and the clinical course. Microbiological criteria were proposed to facilitate the diagnosis of persistent VAP.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>This consensus by European experts proposes four different VAP recurrence entities which should facilitate the harmonization of recurrence criteria for clinical practice and future studies.</p>","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"18 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143737147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sepsis subphenotypes, theragnostics and personalized sepsis care","authors":"David B. Antcliffe, Aidan Burrell, Andrew J. Boyle, Anthony C. Gordon, Daniel F. McAuley, Jon Silversides","doi":"10.1007/s00134-025-07873-6","DOIUrl":"https://doi.org/10.1007/s00134-025-07873-6","url":null,"abstract":"<p>Heterogeneity between critically ill patients with sepsis is a major barrier to the discovery of effective therapies. The use of machine learning techniques, coupled with improved understanding of sepsis biology, has led to the identification of patient subphenotypes. This exciting development may help overcome the problem of patient heterogeneity and lead to the identification of patient subgroups with treatable traits. Re-analyses of completed clinical trials have demonstrated that patients with different subphenotypes may respond differently to treatments. This suggests that future clinical trials that take a precision medicine approach will have a higher likelihood of identifying effective therapeutics for patients based on their subphenotype. In this review, we describe the emerging subphenotypes identified in the critically ill and outline the promising immune modulation therapies which could have a beneficial treatment effect within some of these subphenotypes. Furthermore, we will also highlight how bringing subphenotype identification to the bedside could enable a new generation of precision-medicine clinical trials.</p>","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"58 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143737097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}