Intensive Care Medicine最新文献

{"title":"ICP‑AId: International expert survey assessing the potential clinical impact of intracranial pressure predictions at the bedside","authors":"Brenda Pörteners, Giorgia Carra, Marcel Aries, Fabian Guïza, Geert Meyfroidt","doi":"10.1007/s00134-025-08092-9","DOIUrl":"https://doi.org/10.1007/s00134-025-08092-9","url":null,"abstract":"No Abstract","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"21 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144923954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revisiting the timing of intervention in necrotising pancreatitis","authors":"M. Gatt, G. Piton, D. Poole","doi":"10.1007/s00134-025-08078-7","DOIUrl":"https://doi.org/10.1007/s00134-025-08078-7","url":null,"abstract":"Acute pancreatitis is a leading cause of emergency hospitalisation, with its incidence and aetiology varying geographically [1]. While most patients pursue a mild course, approximately 20% develop acute necrotising pancreatitis (ANP), with some progressing to secondary infected necrotising pancreatitis (INP), often associated with organ failure, and consequent high morbidity and mortality [2, 3]. Persistent organ failure (POF) for 48 h or more, which defines severe acute pancreatitis as per the revised Atlanta classification [3], remains a major clinical challenge, frequently requiring intensive care support with a commensurate strain on healthcare resources. Much effort has been expended into trying to modify disease progression in patients with INP with the ultimate aspiration of improving outcome.","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"30 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144923980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personalized driving pressure-guided positive end-expiratory pressure in patients at risk of postoperative respiratory failure (IMPROVE-2): a multicenter, pragmatic, randomized clinical trial","authors":"Emmanuel Futier, Audrey De Jong, Cédric Cirenei, Thomas Godet, Matthieu Jabaudon, Jean-Michel Constantin, Nicolas Grillot, Pierre Bouzat, Lois Henry, Dimitri Margetis, Gilles Lebuffe, Marc Garnier, Céline Lambert, Bruno Pereira, Samir Jaber","doi":"10.1007/s00134-025-08082-x","DOIUrl":"https://doi.org/10.1007/s00134-025-08082-x","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>Airway driving pressure has garnered considerable attention for lung-protective ventilation. We evaluated the clinical effectiveness of airway driving pressure as a target to individualize positive-end-expiratory pressure (PEEP) setting in mechanically ventilated patients at risk for postoperative respiratory failure.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>We conducted a multicenter, pragmatic, assessor-masked, randomized trial among adult patients undergoing emergency abdominal surgery in 22 hospitals in France. Patients were assigned 1:1 to receive individually adjusted highest PEEP targeting a driving pressure &lt; 13 cmH₂O after an initial recruitment maneuver (intervention group) or to a fixed PEEP level of 5 cmH₂O (control group). The primary outcome was a composite of postoperative respiratory failure (failure to wean from the ventilator or the composite of reintubation or curative non-invasive ventilation) or all-cause mortality at 30 days. Secondary outcomes included components of the composite primary outcome.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>The primary outcome occurred in 87 out of 338 (25.7%) intervention patients and in 69 out of 341 (20.2%) control patients (difference, 5.5%; 95% confidence interval [CI] − 0.8 to 11.8; relative risk, 1.27; 95%CI 0.96–1.68; <i>p</i> = 0.08). The difference was primarily due to an increased incidence of reintubation or need for curative non-invasive ventilation among intervention patients (difference, 7.1%; 95% CI 2.5–11.9; relative risk, 1.97; 95% CI 1.24–3.11; <i>p</i> = 0.004). Other secondary outcomes did not differ.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Among patients at risk for postoperative respiratory failure after emergency abdominal surgery, a strategy of individually adjusted highest PEEP in targeting driving pressure lower than 13 cmH₂O did not reduce postoperative respiratory failure or death.</p><h3 data-test=\"abstract-sub-heading\">Trial registration</h3><p>ClinicalTrials.gov Identifier: NCT03987789.</p>","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"26 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144923953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges in assessing HRQoL after ICU sepsis: Author's reply.","authors":"Peter Halvorsen, Michael Marks-Hultström, Ewa Wallin, Björn Ahlström, Miklós Lipcsey","doi":"10.1007/s00134-025-08083-w","DOIUrl":"10.1007/s00134-025-08083-w","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":""},"PeriodicalIF":21.2,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2D- and 3D-EIT are different, but which one is correct? Author's reply.","authors":"Siyi Yuan, Yelin Gao, Ke Zhang, Huaiwu He","doi":"10.1007/s00134-025-08090-x","DOIUrl":"10.1007/s00134-025-08090-x","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":""},"PeriodicalIF":21.2,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delirium Related to Sedation: Prevention Strategies and Patient Perspectives.","authors":"Gerald Chanques, John P Kress","doi":"10.1007/s00134-025-08062-1","DOIUrl":"10.1007/s00134-025-08062-1","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":""},"PeriodicalIF":21.2,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Shortening antibiotic therapy duration for hospital-acquired bloodstream infections in critically ill patients: a causal inference model from the international EUROBACT-2 database.","authors":"Lena Gajdos, Niccolo Buetti, Alexis Tabah, Stephane Ruckly, Murat Akova, Frederik Sjöval, Kostoula Arvaniti, Jan de Waele, Hendrik Bracht, Francois Barbier, Jean-François Timsit","doi":"10.1007/s00134-025-08071-0","DOIUrl":"10.1007/s00134-025-08071-0","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":""},"PeriodicalIF":21.2,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why interventions to prevent acute kidney injury are needed now and why preventing long-term outcomes will only come later.","authors":"John A Kellum, Alexander Zarbock","doi":"10.1007/s00134-025-08080-z","DOIUrl":"10.1007/s00134-025-08080-z","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":""},"PeriodicalIF":21.2,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sodium bicarbonate in critical illness: targeted or too broad?","authors":"Qiuyun Chen, Qingliu Zheng","doi":"10.1007/s00134-025-08085-8","DOIUrl":"10.1007/s00134-025-08085-8","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":""},"PeriodicalIF":21.2,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sodium bicarbonate in critical illness: targeted or too broad? Author's reply.","authors":"Ruth Miriam Blank, Sebastiaan Paul Blank, Kevin B Laupland, Kyle C White, Mahesh Ramanan","doi":"10.1007/s00134-025-08091-w","DOIUrl":"10.1007/s00134-025-08091-w","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":""},"PeriodicalIF":21.2,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}