Proceedings of MOL2NET'21, Conference on Molecular, Biomedical & Computational Sciences and Engineering, 7th ed.最新文献

{"title":"Pharmacobotanical study of aerial vegetative organs of Senna splendida (Leguminosae): a species of ethnomedicinal interest","authors":"F. Souto, E. Santos, Ana Kelly Lima e Silva, M. F. Agra","doi":"10.3390/mol2net-07-11813","DOIUrl":"https://doi.org/10.3390/mol2net-07-11813","url":null,"abstract":". Senna splendida (Vogel) H.S.Irwin & Barneby (Leguminosae) is a ethnomedicinal species native to Brazil, popularly known in the country as “fedegoso-grande and “feijão-brabo”, it is used against kidney diseases, bronchitis, rheumatism, anemia and inflammations. A pharmacobotanical study of the aerial vegetative organs of S. splendida was carried out, looking for morphoanatomical data that can contribute to the taxonomy and quality control of its ethno-drugs. Paradermic sections of both epidermal surfaces and cross sections of the leaf and stem were made freehand. Histochemical tests were also performed to indicate the types of plant metabolites. Senna splendida is a sub-shrubby to shrubby, with cylindrical stems, leaves with 4-leaflets, sub-cylindrical petiole","PeriodicalId":136053,"journal":{"name":"Proceedings of MOL2NET'21, Conference on Molecular, Biomedical & Computational Sciences and Engineering, 7th ed.","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123741379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maxi-K channels: structure, characteristics, biological process and principal blockers and activators. A general overview.","authors":"Brenda de la Caridad Fundora Ortiz","doi":"10.3390/mol2net-07-11822","DOIUrl":"https://doi.org/10.3390/mol2net-07-11822","url":null,"abstract":"Maxi-K also known as BK channels, Slo1 or KCa1.1 channels, are one type of calcium-activated potassium channels that have large single channel conductance of 100–300 pS . Their most important physiological property is dual regulation through membrane voltage and intracellular Ca 2+ . 1 The complexity of this channel function mirrors the complexity of its protein structure. The amino acid sequence includes the integral membrane pore shared by all K + channels, the integral membrane voltage sensor domains present in voltage-dependent channels, and a cytoplasmic domain (CTD) consisting of approximately 800 amino acids per subunit, which accounts for the C-terminal two thirds of the entire channel. The CTD structure confers upon the BK channel its ability to respond to changes in intracellular Ca 2+ . 2-5 It is also the source of functional heterogeneity through alternate splicing, polymorphisms, phosphorylation, and protein interactions, which modulate BK channel activity. 5-8 These channels modulate several physiological events, like blood pressure, smooth muscle relaxation or electrical tuning of hair cells in the cochlea and have a leading role in many pathophysiological conditions such as epilepsy, ischemic stroke, cognitive disorders, and the behavioral response to alcohol, to give only a few examples. 9, 10 Studies involving activation and inactivation with pharmacological and genetic tools, including global, and tissue-specific knockouts, have implicated Maxi-K channels in cardiac function, neuroprotection, and cardio-protection from ischemia-reperfusion (IR) injury, in addition to IR-induced inflammation and mucosal barrier disruption in the small intestine. 11 It is also known that Maxi-K channels function as neuronal calcium sensors and contribute to the control of cellular excitability and the regulation of neurotransmitter release. 9 Numerous Maxi-K channel blockers and activators are used to identify these channels and study their functions. Some of the most common","PeriodicalId":136053,"journal":{"name":"Proceedings of MOL2NET'21, Conference on Molecular, Biomedical & Computational Sciences and Engineering, 7th ed.","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128266323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective infection prevention clothing and transparent equipment capable of inactivating SARS-CoV-2 and multidrug-resistant bacteria","authors":"Ã. Serrano-Aroca, Alberto Tuñón-Molina, Alba Cano-Vicent, Irene Jimeno-Catalán, Andrea Martínez-Agut, M. Martí, Kazuo Takayama","doi":"10.3390/mol2net-07-11816","DOIUrl":"https://doi.org/10.3390/mol2net-07-11816","url":null,"abstract":"","PeriodicalId":136053,"journal":{"name":"Proceedings of MOL2NET'21, Conference on Molecular, Biomedical & Computational Sciences and Engineering, 7th ed.","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114734480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of biomarkers in the prediction of septic diseases produced by microorganisms by IA.","authors":"Maxim Belii","doi":"10.3390/mol2net-07-11815","DOIUrl":"https://doi.org/10.3390/mol2net-07-11815","url":null,"abstract":"","PeriodicalId":136053,"journal":{"name":"Proceedings of MOL2NET'21, Conference on Molecular, Biomedical & Computational Sciences and Engineering, 7th ed.","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130934024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Baccharis trimera Less (DC) essential oil in obese mice on a high-fat diet, part 1. adipose tissues evaluation.","authors":"Gabriela Bueno, Vinícius Peixoto Rodrigues, Rie Ohara, Maycon Tavares Emílio Silva, Renata Assunção, V. Gomes, Felipe Lima Dario, Priscila Raimundo Romano, Ana Fioretto, Lúcia Regina Machado da Rocha, C. Hiruma-Lima","doi":"10.3390/mol2net-07-11804","DOIUrl":"https://doi.org/10.3390/mol2net-07-11804","url":null,"abstract":"Graphical Abstract Abstract. Obesity is a metabolic disorder characterized by the accumulation of fat in the body that poses a risk to the individual's health. In adipose tissue, changes occur in the profile of immune cell. The relationship between obesity and metabolic diseases makes the inflammatory pathways an important therapeutic target for study. Baccharis trimera Less (DC) is used by the population for weight loss and some studies point to a possible anti-obesogenic effect. The aim was to evaluate the effect of Baccharis trimera essential oil (EOBT) in obese mice of the C57BL/6J lineage that consumed a high-fat diet. Male C57BL/J6 mice were subjected to obesity induction through the ingestion of a high-fat diet FOR 12 weeks and were orally treated with EOBT at doses of 1, 10 or 100 mg/kg for 14 days. As a result, it was observed that after 12 weeks with the high-fat diet, the mice showed changes in body mass, adiposity index, dyslipidemia, insulin resistance and changes in anti-inflammatory mediators, when compared to animals treated with the standard diet. The results indicate that the C57BL/6J mouse","PeriodicalId":136053,"journal":{"name":"Proceedings of MOL2NET'21, Conference on Molecular, Biomedical & Computational Sciences and Engineering, 7th ed.","volume":"216 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124267698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antipyretic effect of myrcene (MCN) as a potential therapeutic alternative for the treatment of systemic inflammation response (SI) in euthermic rats model","authors":"M. Emílio-Silva, M. Zarricueta, V. Rodrigues, Priscila Raimundo, L. D. da Rocha, C. Hiruma-Lima","doi":"10.3390/mol2net-07-11807","DOIUrl":"https://doi.org/10.3390/mol2net-07-11807","url":null,"abstract":"Abstract. The new coronavirus pneumonia (COVID-19) is characterized by hemodynamic changes with a large release of inflammatory mediators, that inducing a systemic inflammation response (SI). Thus, SI can be induced by peripheral injection of lipopolysaccharide (LPS) in rodents, which promote the increase of systemic inflammatory mediators that induced an essential survival effector response, such as fever. Myrcene (MCN) is a monoterpene with anti-inflammatory, antioxidant, and analgesic actions are described. Our aim was to evaluate the MCN effect in euthermic rats against SI induced by low-dose LPS. Male Wistar rats were used to assess body temperature (Tb) by dataloggers. The animals were orally treated with Tween 80-1% (Tw; 10 mL/kg) or MCN (7.5 mg/kg) 30 min before the i.p. administration of induction with LPS (100 µg/kg) or Saline (1 mL/kg). After 360 min, the rats were sacrificed to evaluate the inflammatory mediators’ levels through Multiplex assay. Rats in the Tw+LPS group present a significant increase in Tb when compared","PeriodicalId":136053,"journal":{"name":"Proceedings of MOL2NET'21, Conference on Molecular, Biomedical & Computational Sciences and Engineering, 7th ed.","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126859112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction in infection of Helicobacter Pylori with machine learning","authors":"Maxim Belii","doi":"10.3390/mol2net-07-11810","DOIUrl":"https://doi.org/10.3390/mol2net-07-11810","url":null,"abstract":"","PeriodicalId":136053,"journal":{"name":"Proceedings of MOL2NET'21, Conference on Molecular, Biomedical & Computational Sciences and Engineering, 7th ed.","volume":"238 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130640615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Citral, a valuable aid against metabolic inflammation?","authors":"Vinícius Peixoto Rodrigues, M. Emílio-Silva, Rie Ohara, Gabriela Bueno, Priscila Romano Raimundo, V. Gomes, Lúcia Regina Machado da Rocha, Clélia Akiko Hiruma-Lima","doi":"10.3390/mol2net-07-11805","DOIUrl":"https://doi.org/10.3390/mol2net-07-11805","url":null,"abstract":"","PeriodicalId":136053,"journal":{"name":"Proceedings of MOL2NET'21, Conference on Molecular, Biomedical & Computational Sciences and Engineering, 7th ed.","volume":"36 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133390338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is citral´s anti-inflammatory action capable of changing the hypothalamic inflammation in obese mice?","authors":"Priscila Raimundo, V. Rodrigues, M. Emílio-Silva, V. Gomes, Gabriela Bueno, Lúcia Regina Machado da Rocha, C. Hiruma-Lima","doi":"10.3390/mol2net-07-11806","DOIUrl":"https://doi.org/10.3390/mol2net-07-11806","url":null,"abstract":"Abstract. Obesity is linked to an inflammatory process in the different tissues of the body, including hypothalamic regions that are crucial for energy homeostasis. Citral, is a monoterpene with anti-inflammatory, antioxidant and other activities. The aim of the present study was to evaluate the effect of citral on hypothalamic inflammation triggered by obesity in male Swiss mice, and to determine the effect of citral on the concentration of pro-inflammatory mediators in the tissue. Obese male Swiss mice were treated orally with citral (25, 100 and 300 mg/kg) for seven, 14 and 21 consecutive days. Hypothalamus samples were used to determine cytokines","PeriodicalId":136053,"journal":{"name":"Proceedings of MOL2NET'21, Conference on Molecular, Biomedical & Computational Sciences and Engineering, 7th ed.","volume":"64 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114014794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of machine learning and rare diseases","authors":"Maxim Belii","doi":"10.3390/mol2net-07-11811","DOIUrl":"https://doi.org/10.3390/mol2net-07-11811","url":null,"abstract":"","PeriodicalId":136053,"journal":{"name":"Proceedings of MOL2NET'21, Conference on Molecular, Biomedical & Computational Sciences and Engineering, 7th ed.","volume":"8 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131752190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}