Effect of Baccharis trimera Less (DC) essential oil in obese mice on a high-fat diet, part 1. adipose tissues evaluation.

Graphical Abstract Abstract. Obesity is a metabolic disorder characterized by the accumulation of fat in the body that poses a risk to the individual's health. In adipose tissue, changes occur in the profile of immune cell. The relationship between obesity and metabolic diseases makes the inflammatory pathways an important therapeutic target for study. Baccharis trimera Less (DC) is used by the population for weight loss and some studies point to a possible anti-obesogenic effect. The aim was to evaluate the effect of Baccharis trimera essential oil (EOBT) in obese mice of the C57BL/6J lineage that consumed a high-fat diet. Male C57BL/J6 mice were subjected to obesity induction through the ingestion of a high-fat diet FOR 12 weeks and were orally treated with EOBT at doses of 1, 10 or 100 mg/kg for 14 days. As a result, it was observed that after 12 weeks with the high-fat diet, the mice showed changes in body mass, adiposity index, dyslipidemia, insulin resistance and changes in anti-inflammatory mediators, when compared to animals treated with the standard diet. The results indicate that the C57BL/6J mouse