Is citral´s anti-inflammatory action capable of changing the hypothalamic inflammation in obese mice?

Abstract

Abstract. Obesity is linked to an inflammatory process in the different tissues of the body, including hypothalamic regions that are crucial for energy homeostasis. Citral, is a monoterpene with anti-inflammatory, antioxidant and other activities. The aim of the present study was to evaluate the effect of citral on hypothalamic inflammation triggered by obesity in male Swiss mice, and to determine the effect of citral on the concentration of pro-inflammatory mediators in the tissue. Obese male Swiss mice were treated orally with citral (25, 100 and 300 mg/kg) for seven, 14 and 21 consecutive days. Hypothalamus samples were used to determine cytokines