柠檬醛的抗炎作用是否能改变肥胖小鼠的下丘脑炎症?

Proceedings of MOL2NET'21, Conference on Molecular, Biomedical & Computational Sciences and Engineering, 7th ed. Pub Date : 2021-11-15 DOI:10.3390/mol2net-07-11806

Priscila Raimundo, V. Rodrigues, M. Emílio-Silva, V. Gomes, Gabriela Bueno, Lúcia Regina Machado da Rocha, C. Hiruma-Lima

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引用次数: 1

摘要

摘要肥胖与身体不同组织的炎症过程有关，包括对能量稳态至关重要的下丘脑区域。柠檬醛，是一种具有抗炎、抗氧化等活性的单萜。本研究旨在评价柠檬醛对雄性瑞士小鼠肥胖引起的下丘脑炎症的影响，并确定柠檬醛对组织中促炎介质浓度的影响。肥胖雄性瑞士小鼠连续7、14和21天口服柠檬醛(25、100和300 mg/kg)。下丘脑样本用于测定细胞因子

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Is citral´s anti-inflammatory action capable of changing the hypothalamic inflammation in obese mice?

Abstract. Obesity is linked to an inflammatory process in the different tissues of the body, including hypothalamic regions that are crucial for energy homeostasis. Citral, is a monoterpene with anti-inflammatory, antioxidant and other activities. The aim of the present study was to evaluate the effect of citral on hypothalamic inflammation triggered by obesity in male Swiss mice, and to determine the effect of citral on the concentration of pro-inflammatory mediators in the tissue. Obese male Swiss mice were treated orally with citral (25, 100 and 300 mg/kg) for seven, 14 and 21 consecutive days. Hypothalamus samples were used to determine cytokines

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Proceedings of MOL2NET'21, Conference on Molecular, Biomedical & Computational Sciences and Engineering, 7th ed.

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