Antipyretic effect of myrcene (MCN) as a potential therapeutic alternative for the treatment of systemic inflammation response (SI) in euthermic rats model

Abstract. The new coronavirus pneumonia (COVID-19) is characterized by hemodynamic changes with a large release of inflammatory mediators, that inducing a systemic inflammation response (SI). Thus, SI can be induced by peripheral injection of lipopolysaccharide (LPS) in rodents, which promote the increase of systemic inflammatory mediators that induced an essential survival effector response, such as fever. Myrcene (MCN) is a monoterpene with anti-inflammatory, antioxidant, and analgesic actions are described. Our aim was to evaluate the MCN effect in euthermic rats against SI induced by low-dose LPS. Male Wistar rats were used to assess body temperature (Tb) by dataloggers. The animals were orally treated with Tween 80-1% (Tw; 10 mL/kg) or MCN (7.5 mg/kg) 30 min before the i.p. administration of induction with LPS (100 µg/kg) or Saline (1 mL/kg). After 360 min, the rats were sacrificed to evaluate the inflammatory mediators’ levels through Multiplex assay. Rats in the Tw+LPS group present a significant increase in Tb when compared