Infection最新文献

{"title":"Towards shortening the duration of antibiotic therapy for Lyme borreliosis: a systematic review and meta-analysis.","authors":"Alice Raffetin, Anna J Henningsson, Katharina Ornstein, Pauline Arias, Volker Fingerle, Solene Patrat-Delon, Daniel Bremell, Per Eric Lindgren, Tobias A Rupprecht, Benoît Jaulhac, Klaus-Peter Hunfeld, Céline Cazorla, Mateusz Markowicz, Reto Lienhard, Alje P van Dam, Elisabeth Baux, Sally Mavin, Joppe W Hovius, M E Baarsma, Kristine Karlsrud Berg, Randi Eikeland, Ram B Dessau","doi":"10.1007/s15010-025-02501-3","DOIUrl":"10.1007/s15010-025-02501-3","url":null,"abstract":"<p><strong>Objectives: </strong>Systematic review and meta-analysis on shortening antibiotic therapy for Lyme borreliosis (LB) patients.</p><p><strong>Methods: </strong>Data sources: Medline, Google, and Google Scholar (queried from January 2022-February 2024), following the PRISMA method and the Cochrane Handbook.</p><p><strong>Eligibility criteria: </strong>Randomized clinical trials, comparative studies; clear definitions of LB, duration of antibiotics and outcome; follow-up ≥ 6-12 months. Meta-analysis included studies that examined three outcomes: treatment failure; residual symptoms; adverse events.</p><p><strong>Intervention: </strong>Short vs. extended antibiotic therapy for erythema migrans (≤ 10 days vs. > 10 days) and disseminated LB (≤ 21 days vs. > 21 days). Assessment of risk of bias. Independently, using the Cochrane Tools.</p><p><strong>Methods: </strong>of data synthesis. Estimation of treatment effects based on a fixed-effect model (Mantel-Haenszel or Peto method), with odds ratio (OR) and 95% confidence intervals (CI).</p><p><strong>Results: </strong>Thirty-eight full-text articles were examined (850 patients): 29 were included in the qualitative analysis; six in the meta-analysis. Heterogeneity was low (I² = 0%). At 12 months, short-term treatment did not differ from long-term treatment in terms of failures (OR1.50, 95%CI[0.43-5.22]) and residual symptoms (OR0.95, 95%CI[0.66-1.37]), albeit with small samples.</p><p><strong>Conclusion: </strong>This meta-analysis was underpowered to prove non-inferiority of shorter treatment, but suggests its safety for EM. Studies focusing on antibiotics duration, with sufficient sample sizes and clear outcomes, are warranted.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":"809-830"},"PeriodicalIF":5.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful therapy of a newborn with Stenotrophomonas maltophilia nosocomial pneumonia with cefiderocol.","authors":"Janina Trauth, Rahel Schuler, Markus Waitz, Harald Ehrhardt, Moritz Fritzenwanker, Susanne Herold","doi":"10.1007/s15010-024-02404-9","DOIUrl":"10.1007/s15010-024-02404-9","url":null,"abstract":"<p><p>Cefiderocol is a new siderophore-beta-lactam antibiotic used for the treatment of severe multidrug-resistant infections like sepsis, hospital-acquired and ventilator-associated pneumonia in adults, but there are only single reports on its use in the neonatal population. We describe the successful cefiderocol treatment of a newborn with pneumogenic sepsis due to Stenotrophomonas maltophilia.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":"1227-1231"},"PeriodicalIF":5.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12137400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142380761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discrepancy between antibiotic pack sizes and guideline recommendations: a real-world analysis based on claims data.","authors":"Sabrina M Stollberg, Sereina M Graber, Andreas Kronenberg, Oliver Senn, Stefan Neuner-Jehle, Catherine Pluess-Suard, Carola A Huber, Andreas Plate","doi":"10.1007/s15010-024-02420-9","DOIUrl":"10.1007/s15010-024-02420-9","url":null,"abstract":"<p><strong>Purpose: </strong>Antibiotics are often only available in predefined pack sizes, which may not align with guideline recommendations. This can result in leftover pills, leading to inappropriate self-medication or waste disposal, which can both foster the development of antibiotic resistance. The magnitude of inappropriate pack sizes is largely unknown. The objective of this study was to evaluate the potential non-conformity of prescribed antibiotic pack sizes.</p><p><strong>Methods: </strong>This retrospective observational study was based on claims data from a large Swiss health insurance company. The study analysed the prescriptions of eleven different antibiotic substances recommended for the five most common indications for antibiotics in Switzerland. All prescriptions for adult outpatients issued by general practitioners in 2022 were included and extrapolated to the entire Swiss population. Potential non-conformity was defined as a mismatch between the total dosage in a pack and the total dosage recommended.</p><p><strong>Results: </strong>A total of n = 947,439 extrapolated prescriptions were analysed. In 10 of 23 of all analysed substance/indication combinations none of the prescribed packs aligned with the respective guideline recommendation. Considering pack sizes in which the total prescribed dosage of a substance did not correspond to any of the total dosages recommended in at least one of the guidelines, 31.6% of prescriptions were potentially non-conform and an estimated number of 2.7 million tablets were overprescribed.</p><p><strong>Conclusions: </strong>We found a large discrepancy between prescribed pack sizes and guideline recommendations. Since inadequately prepacked antibiotics may lead to antibiotic resistance and unnecessary waste, efforts are needed to implement alternatives like exact pill dispensing.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":"1029-1039"},"PeriodicalIF":5.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12137524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Tryptophan-Kynurenine pathway in people living with HIV: a systematic review.","authors":"Tshiamo Will Sebigi, Levanco K Asia, Grant G January, Esmé Jansen van Vuren, Monray Edward Williams","doi":"10.1007/s15010-025-02557-1","DOIUrl":"https://doi.org/10.1007/s15010-025-02557-1","url":null,"abstract":"<p><strong>Purpose: </strong>HIV-1 disrupts the metabolic profile of people living with HIV (PLWH), including the Tryptophan-Kynurenine (Trp-Kyn) pathway, linked to disease outcomes and comorbidities. Despite numerous studies, consensus on key dysregulated metabolites in antiretroviral therapy (ART)-treated PLWH is lacking. This systematic review compiles data to identify and highlight the most noteworthy Trp-Kyn metabolites.</p><p><strong>Methods: </strong>PubMed, Scopus, and Web of Science databases were searched using a search protocol specifically designed for this study. Studies that investigated the levels of metabolites in the Trp-Kyn pathway in the peripheral blood of PLWH on ART, as well as in healthy control groups were included.</p><p><strong>Results: </strong>Thirteen metabolomic studies that investigated this pathway met our inclusion criteria. The findings revealed that Trp, Kyn, and the Kyn/Trp ratio (indicative of indoleamine 2,3-dioxygenase IDO activity) were the most investigated metabolites in this metabolic pathway. Evidence consistently demonstrated that Trp levels were lower in PLWH, while predicted IDO activity was consistently higher. Despite the widespread investigation of Kyn, there was no clear consensus on its levels in PLWH, with some studies reporting higher levels and others finding no significant differences compared to HIV-negative controls.</p><p><strong>Conclusion: </strong>In the modern ART era, Trp metabolism and IDO activity may play key regulatory roles in HIV-1 pathogenesis, as evidenced by the consistent patterns observed across various studies. These metabolites and related pathways warrant further investigation as potential targets for improved diagnostics, prognostics, and therapeutics in the context of HIV-1.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical features, course, and risk factors of infection-associated secondary hemophagocytic lymphohistiocytosis.","authors":"Michael Ruzicka, Thomas Wimmer, Hans-Joachim Stemmler, Stephanie-Susanne Stecher, Hendrik Schulze-Koops, Fabian Hauck, Marion Subklewe, Michael von Bergwelt-Baildon, Karsten Spiekermann","doi":"10.1007/s15010-025-02559-z","DOIUrl":"https://doi.org/10.1007/s15010-025-02559-z","url":null,"abstract":"<p><p>Hemophagocytic lymphohistiocytosis (HLH) is an orphan disease characterized by excessive inflammation and poor outcome. We sought to further characterize clinical features, courses, and risk factors of secondary HLH (sHLH) triggered by infection (iHLH). 28 (43.1%) of 65 adult sHLH cases treated at our hospital from 2012-2024 were infection-associated. iHLH patients were mostly male (71.4%). Infectious agents most frequently detected were EBV (57.1%) and leishmania (14.3%). The median time to diagnosis was 13 [6.0;24.8] days. iHLH patients had a mortality rate of 39.3% (median follow-up time: 735 [336;1140] days), worse survival than patients with autoimmune-triggered (hazard ratio: 3.33 (1.01-11.10), p = 0.049), and better survival than patients with paraneoplastic HLH (hazard ratio: 0.19 (0.10-0.84), p = 0.002). Elevated levels of soluble interleukin-2 receptor (sIL2R; > 6,000 I/U), low thrombocyte counts (< 40 G/l), and a history of malignant disease were associated with adverse outcomes. Protracted time to diagnosis was associated with severe disease courses and with leishmaniosis. Further, sIL2R levels correlated positively with prolonged aPTT and thrombocytopenia, and hypertriglyceridemia with elevated INRs. Patients with an elevated sIL2R:ferritin ratio were more likely to have a history of malignant comorbidities. Taken together, sIL2R, thrombocytopenia, and a history of malignant disease are important prognostic factors of iHLH. Patients with high sIL2R levels or hypertriglyceridemia may be at higher risk of bleeding, and patients with elevated sIL2R:ferritin ratios should be assessed for possible malignant comorbidities. Lastly, increased awareness of the disease and newly emerging pathogens (i.e. leishmania) may shorten the time to diagnosis, and thus reduce severe courses of iHLH.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144158483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging oral and systemic health: exploring pathogenesis, biomarkers, and diagnostic innovations in periodontal disease.","authors":"Max Foroughi, Mahmoud Torabinejad, Nikola Angelov, David M Ojcius, Keykavous Parang, Marcus Ravnan, Jerika Lam","doi":"10.1007/s15010-025-02568-y","DOIUrl":"https://doi.org/10.1007/s15010-025-02568-y","url":null,"abstract":"<p><strong>Purpose: </strong>This narrative review explores the multifaceted links between periodontal diseases (gingivitis and periodontitis) and systemic health conditions, including cardiovascular disease, diabetes, adverse pregnancy outcomes, Alzheimer's disease, cancers, rheumatoid arthritis, and respiratory infections. It aims to synthesize evidence on how local oral infections exert systemic effects and evaluate the potential of diagnostic technologies to monitor these interactions.</p><p><strong>Methods: </strong>This narrative review synthesizes current scientific literature on periodontal disease pathogenesis, focusing on key pathogens (e.g., Porphyromonas gingivalis, Fusobacterium nucleatum) and their roles in driving local and systemic inflammation via virulence factors and microbial dysbiosis. It examines biomarker-based diagnostic approaches (e.g., IL-1β, TNF-α, microbial DNA) in saliva, blood, and gingival crevicular fluid (GCF) and evaluates current and emerging diagnostic tools (e.g., ELISA, PCR, lateral flow assays, biosensors, microfluidics).</p><p><strong>Results: </strong>The review highlights that periodontal pathogens contribute to systemic disease through complex mechanisms including persistent inflammation (driven by cytokines like IL-1β, TNF-α), endotoxemia (via LPS, noting pathogen-specific structural variations impacting immune response), molecular mimicry, and immune modulation. Current diagnostic methods provide valuable information but often face limitations in speed, portability, and multiplexing capability needed for comprehensive point-of-care assessment. Emerging technologies, particularly multiplex platforms integrating biosensors or microfluidics, demonstrate significant potential for rapid, user-friendly analysis of multiple biomarkers, facilitating earlier detection and personalized risk stratification, especially in high-risk populations.</p><p><strong>Conclusion: </strong>Periodontal diseases significantly impact systemic health via intricate microbial and inflammatory pathways. The complexity of these interactions necessitates moving beyond conventional diagnostics towards integrated, advanced technologies. Implementing rapid, multiplex biomarker detection platforms within a multidisciplinary healthcare framework holds the potential to revolutionize early detection of linked conditions, improve personalized management strategies, and ultimately reduce the systemic burden of periodontal disease.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Micro- and nanoplastics reduce the phagocytosis and intracellular killing of E. coli by THP1-Blue™ NFκB monocytes.","authors":"Florian Edbauer, Hans-Christoph Ludwig, Marie Julia Moritz, Roland Nau, Jana Seele","doi":"10.1007/s15010-025-02565-1","DOIUrl":"https://doi.org/10.1007/s15010-025-02565-1","url":null,"abstract":"<p><strong>Purpose: </strong>Micro- and nanoplastic particles occur ubiquitously in the environment and have been detected in various organs in animals and humans. We studied, how micro- and nanoplastic influence phagocytosis and intracellular killing of live bacteria in human monocytes.</p><p><strong>Methods: </strong>Cells of the human reporter cell line THP1-Blue™ NFκB were pre-treated with different concentrations of micro- and nanoplastic (diameter 1 μm and 100 nm) and then incubated with Escherichia coli DH5α. Phagocytosis and intracellular killing was studied using an antibiotic protection assay. The activation of the NFκB promoter was quantified by measuring the production of alkaline phosphatase. Cytokines were measured by enzyme immunoassay. Cell viability was determined by trypan blue staining and lactate dehydrogenase measurement. Electron microscopic images were taken to localize micro- and nanoplastic.</p><p><strong>Results: </strong>Micro- and nanoplastic particles were rapidly internalized by monocytes. They reduced phagocytosis of E. coli in a concentration- and time-dependent manner. Exposure to micro- and nanoplastic also reduced the intracellular killing of bacteria in a concentration-dependent manner. Plain plastic particles did not induce NFκB synthesis and IL1β and IL6 release. At concentrations inhibiting phagocytosis, micro- and nanoplastic was not cytotoxic. Endotoxin stimulated phagocytosis of bacteria. High concentrations of plastic particles reduced the stimulatory effect of endotoxin on phagocytosis of bacteria, but not the effect on NFκB synthesis.</p><p><strong>Conclusion: </strong>Exposure to micro- and nanoplastic reduced the ability of phagocytes to internalize and kill bacteria. High plastic concentrations decreased the endotoxin-stimulated phagocytosis of bacteria. Hence, exposure to plastic particles may reduce the host`s immune defence against bacterial pathogens.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antigen-specific chemokine CCL3 as a biomarker for distinguishing between recent and remote tuberculosis infection.","authors":"Chunyan Chang, Zichun Ma, Weicong Ren, Wei Wang, Haohan Liu, Rujie Zhong, Shanshan Li, Mengqiu Gao, Yu Pang","doi":"10.1007/s15010-025-02571-3","DOIUrl":"https://doi.org/10.1007/s15010-025-02571-3","url":null,"abstract":"<p><strong>Background: </strong>Identifying recent tuberculosis (TB) infection individuals and administering TB preventive therapy (TPT) are critical strategies for controlling TB. However, current diagnostics fail to identify these individuals at high risk for developing active TB. Herein, we aimed to explore the candidate biomarkers to distinguish recent TB infection from remote TB infection individuals.</p><p><strong>Methods: </strong>Close contacts of TB patients were continuously recruited. A total of 121 participants meeting study inclusion criteria were assigned to screening and validation cohorts, consisting of 45 participants assigned to screening cohort, and 76 participants assigned to validation cohort. The inflammation-related protein biomarkers in Mtb antigen-stimulated blood plasma were measured in the screening cohort using the Olink targeted proteomics. The candidate biomarkers were verified in validation cohort with the customized Luminex-based multiplex microbead array.</p><p><strong>Results: </strong>Quantitative proteomics analysis reveals that significant differences in Mycobacterium tuberculosis (Mtb) antigen-stimulated blood plasma levels of CCL3, CCL20, CCL23 and TNF-α between remote and recent TB infection group. The different response profiles of memory immune cells to Mtb antigens could stem from activation of the NF-κB signaling pathway. The levels of CCL3, CCL20 and TNF-α were predictive of recent TB infection group, of which CCL3 exhibited the best performance with an AUC value of 0.859, yielding a sensitivity and specificity of 86.4% and 75%, respectively.</p><p><strong>Conclusions: </strong>The Mtb antigen-specific assay utilizing CCL3 exhibits superior diagnostic performance and could potentially enhance diagnostic accuracy for identifying recent TB infection patients among LTBI individuals.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of mortality of enterococcal bacteraemia and the role of source control interventions; a retrospective cohort study.","authors":"Virgile Zimmermann, Nicolas Fourré, Laurence Senn, Benoit Guery, Matthaios Papadimitriou-Olivgeris","doi":"10.1007/s15010-025-02561-5","DOIUrl":"https://doi.org/10.1007/s15010-025-02561-5","url":null,"abstract":"<p><strong>Purpose: </strong>To identify predictors of mortality among patients with enterococcal bacteraemia.</p><p><strong>Methods: </strong>This retrospective study was conducted at the Lausanne University Hospital, Switzerland and included adult patients with enterococcal bacteraemia from 2014 to 2023.</p><p><strong>Results: </strong>During the study period, 768 enterococcal bacteraemia episodes were included. The predominant species was Enterococcus faecalis (427 episodes; 56%). Sepsis or septic shock were present in 351 (46%) episodes. The overall 30-day mortality rate was 19% (148 episodes). The Cox multivariable regression model showed that age > 60 years (aHR: 1.75, 95% CI: 1.05-2.90), nosocomial infection (1.78, 1.19-2.65), sepsis or septic shock (3.67, 2.48-5.45), and not performing source control interventions within 48 h, in patients on or discussing of transitioning to limitations of care (5.91, 3.13-11.14) were associated with 30-day mortality. Conversely, infectious diseases (ID) consultation within 48 h (0.40, 0.28-0.57), appropriate antimicrobial therapy within 48 h (0.54, 0.34-0.86), and source control interventions performed within 48 h (0.22, 0.14-0.36) or not warranted (0.54; 0.34-0.86) were associated with survival. Among the 737 episodes without limitation of care, the Cox multivariable regression model showed that nosocomial infection (1.78, 1.19-2.67), sepsis or septic shock (3.76, 2.42-5.82), were associated with 30-day mortality. Conversely, ID consultation within 48 h (0.44, 0.30-0.65), appropriate antimicrobial therapy within 48 h (0.51, 0.30-0.86), and source control interventions performed within 48 h (0.25, 0.16-0.40) or not warranted (0.40; 0.26-0.61) were associated with survival.</p><p><strong>Conclusions: </strong>Our findings underscore the pivotal role of early management of enterococcal bacteraemia, including ID consultation, appropriate antimicrobial treatment initiation and performance of source control interventions.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor regarding: \"Ceftazidime-avibactam versus polymyxins in treating patients with carbapenem‑resistant Enterobacteriaceae infections: a systematic review and meta‑analysis\".","authors":"Tanya Babich, Leonard Leibovici, Vered Daitch","doi":"10.1007/s15010-025-02563-3","DOIUrl":"https://doi.org/10.1007/s15010-025-02563-3","url":null,"abstract":"","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}