Infection最新文献

{"title":"Antigen-specific chemokine CCL3 as a biomarker for distinguishing between recent and remote tuberculosis infection.","authors":"Chunyan Chang, Zichun Ma, Weicong Ren, Wei Wang, Haohan Liu, Rujie Zhong, Shanshan Li, Mengqiu Gao, Yu Pang","doi":"10.1007/s15010-025-02571-3","DOIUrl":"https://doi.org/10.1007/s15010-025-02571-3","url":null,"abstract":"<p><strong>Background: </strong>Identifying recent tuberculosis (TB) infection individuals and administering TB preventive therapy (TPT) are critical strategies for controlling TB. However, current diagnostics fail to identify these individuals at high risk for developing active TB. Herein, we aimed to explore the candidate biomarkers to distinguish recent TB infection from remote TB infection individuals.</p><p><strong>Methods: </strong>Close contacts of TB patients were continuously recruited. A total of 121 participants meeting study inclusion criteria were assigned to screening and validation cohorts, consisting of 45 participants assigned to screening cohort, and 76 participants assigned to validation cohort. The inflammation-related protein biomarkers in Mtb antigen-stimulated blood plasma were measured in the screening cohort using the Olink targeted proteomics. The candidate biomarkers were verified in validation cohort with the customized Luminex-based multiplex microbead array.</p><p><strong>Results: </strong>Quantitative proteomics analysis reveals that significant differences in Mycobacterium tuberculosis (Mtb) antigen-stimulated blood plasma levels of CCL3, CCL20, CCL23 and TNF-α between remote and recent TB infection group. The different response profiles of memory immune cells to Mtb antigens could stem from activation of the NF-κB signaling pathway. The levels of CCL3, CCL20 and TNF-α were predictive of recent TB infection group, of which CCL3 exhibited the best performance with an AUC value of 0.859, yielding a sensitivity and specificity of 86.4% and 75%, respectively.</p><p><strong>Conclusions: </strong>The Mtb antigen-specific assay utilizing CCL3 exhibits superior diagnostic performance and could potentially enhance diagnostic accuracy for identifying recent TB infection patients among LTBI individuals.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of mortality of enterococcal bacteraemia and the role of source control interventions; a retrospective cohort study.","authors":"Virgile Zimmermann, Nicolas Fourré, Laurence Senn, Benoit Guery, Matthaios Papadimitriou-Olivgeris","doi":"10.1007/s15010-025-02561-5","DOIUrl":"https://doi.org/10.1007/s15010-025-02561-5","url":null,"abstract":"<p><strong>Purpose: </strong>To identify predictors of mortality among patients with enterococcal bacteraemia.</p><p><strong>Methods: </strong>This retrospective study was conducted at the Lausanne University Hospital, Switzerland and included adult patients with enterococcal bacteraemia from 2014 to 2023.</p><p><strong>Results: </strong>During the study period, 768 enterococcal bacteraemia episodes were included. The predominant species was Enterococcus faecalis (427 episodes; 56%). Sepsis or septic shock were present in 351 (46%) episodes. The overall 30-day mortality rate was 19% (148 episodes). The Cox multivariable regression model showed that age > 60 years (aHR: 1.75, 95% CI: 1.05-2.90), nosocomial infection (1.78, 1.19-2.65), sepsis or septic shock (3.67, 2.48-5.45), and not performing source control interventions within 48 h, in patients on or discussing of transitioning to limitations of care (5.91, 3.13-11.14) were associated with 30-day mortality. Conversely, infectious diseases (ID) consultation within 48 h (0.40, 0.28-0.57), appropriate antimicrobial therapy within 48 h (0.54, 0.34-0.86), and source control interventions performed within 48 h (0.22, 0.14-0.36) or not warranted (0.54; 0.34-0.86) were associated with survival. Among the 737 episodes without limitation of care, the Cox multivariable regression model showed that nosocomial infection (1.78, 1.19-2.67), sepsis or septic shock (3.76, 2.42-5.82), were associated with 30-day mortality. Conversely, ID consultation within 48 h (0.44, 0.30-0.65), appropriate antimicrobial therapy within 48 h (0.51, 0.30-0.86), and source control interventions performed within 48 h (0.25, 0.16-0.40) or not warranted (0.40; 0.26-0.61) were associated with survival.</p><p><strong>Conclusions: </strong>Our findings underscore the pivotal role of early management of enterococcal bacteraemia, including ID consultation, appropriate antimicrobial treatment initiation and performance of source control interventions.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor regarding: \"Ceftazidime-avibactam versus polymyxins in treating patients with carbapenem‑resistant Enterobacteriaceae infections: a systematic review and meta‑analysis\".","authors":"Tanya Babich, Leonard Leibovici, Vered Daitch","doi":"10.1007/s15010-025-02563-3","DOIUrl":"https://doi.org/10.1007/s15010-025-02563-3","url":null,"abstract":"","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meropenem plasma concentrations in critically ill patients treated with the novel multi organ replacement therapy ADVOS.","authors":"David Totschnig, Theresa Mader, Thomas Stimpfl, Klaus Breinbauer, Cristina Groza, David Stücklschwaiger, Stephanie Neuhold, Emanuela Friese, Johannes Holbik, Martina Delivuk, Tom Ripplinger, Marcell Leber, Clemens Ott, Wolfgang Hoepler, Aritz Perez Ruiz de Garibay, Christoph Wenisch, Otto Frey, Alexander Zoufaly, Marianna Traugott","doi":"10.1007/s15010-025-02554-4","DOIUrl":"https://doi.org/10.1007/s15010-025-02554-4","url":null,"abstract":"<p><strong>Background: </strong>Optimal dosing of antibiotics in critically ill patients treated with the novel multi organ replacement therapy ADVOS (ADVanced Organ Support) based on albumin dialysis is unclear. This study aims to provide real life data on meropenem plasma concentrations after prolonged infusion in patients treated with ADVOS and a critically ill control group with and without continuous veno-venous hemodiafiltration (CVVHDF).</p><p><strong>Methods: </strong>We retrospectively analyzed plasma concentrations of meropenem obtained as part of our standard of care therapeutic drug monitoring in the intensive care unit. Meropenem was administered as a prolonged infusion over 3 h. We measured peak and trough levels, pre-and post-filter levels of meropenem using high performance liquid chromatography. We calculated the meropenem clearance and compared the measured clearance with predicted clearance based on creatinine, calculated by the MeroEasy tool.</p><p><strong>Results: </strong>In total, 159 measurements across 16 patients were analyzed. Meropenem trough concentrations were highest in the CVVHDF group with a median of 23.5 mg/L, followed by the ADVOS (median 9.3 mg/L) and control group (median 7.6 mg/L). No trough levels were below the lower limit of 2 mg/L in the CVVHDF and ADVOS groups. Meropenem machine clearance by CVVHDF was calculated to be 1.8 (± 0.5) L/h and 3.5 (± 1) L/h for ADVOS.</p><p><strong>Conclusion: </strong>Our results suggest that ADVOS treatment in critically ill patients receiving a high dose meropenem regimen (2 g IV q8h) does not lead to underdosing. Some trough values were even within potentially toxic levels, especially in the CVVHDF group, highlighting the importance of therapeutic drug monitoring.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suspected Buruli ulcer cases in Tonkolili District, Sierra Leone- a prospective cohort study.","authors":"Jonathan Vas Nunes, Lars Wassill, Giulia Mönnink, Abdul-Mac Falama, Hanna Mathéron, Amara Conteh, Maxwell Sesay, Aminata Sesay, Håkon Bolkan, Martin P Grobusch, Frieder Schaumburg","doi":"10.1007/s15010-025-02548-2","DOIUrl":"https://doi.org/10.1007/s15010-025-02548-2","url":null,"abstract":"<p><strong>Purpose: </strong>There is a high burden of chronic ulcers in Sierra Leone. However, (early) diagnosis and treatment are challenging. Data on endemicity of Mycobacterium ulcerans is limited to WHO reports from 2008 to 2011.</p><p><strong>Methods: </strong>Patients presenting with wounds at Masanga Teaching Hospital were included in a prospective cohort study and scored following the WHO clinical list for Buruli ulcer (BU). Wounds were screened for M. ulcerans by selective culture on solid and liquid media and loop-mediated isothermal amplification (LAMP) of the M. ulcerans specific IS2404.</p><p><strong>Results: </strong>Between July 2019 and November 2020, 159 patients were included. The median age was 41 years (range: 2-92), 34% (54/159) were female and 56% (89/159) were literate. The median duration of a wound before admission was 12 months (range: 0-720 months), 87% (137/159) of lesions were below the knee. Wounds of 37% (58/159) of the patients were clinically scored as '(very) likely to be Buruli ulcer'. Seven out of 72 patients tested by LAMP were positive for IS2404, two showed specific melting curves. None of the wound swabs yielded a positive culture for M. ulcerans. Ninety-eight (62%) patients had a wound-related surgery during this study, 101 (63%) of patients were improving or healed at the time of discharge.</p><p><strong>Conclusions: </strong>The prevalence of BU based on the WHO scoring system is high in Sierra Leone. National and international awareness, training of healthcare workers, development of in-country bacteriology as well as the furthering of robust molecular and immunological assays could reduce the burden of this neglected tropical disease.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A large outbreak of multiple Salmonella serovars linked to alfalfa sprouts in Norway, October to December 2024.","authors":"Arthur Rakover, Liz E Ødeskaug, Hilde Lund, Heidi Lange, Karina Kaupang, Taran O Skjerdal, Laila Jensvoll, Bjarne Bergsjø, Polina Katsiouleri, Lamprini Veneti, Umaer Naseer, Lin T Brandal","doi":"10.1007/s15010-025-02556-2","DOIUrl":"https://doi.org/10.1007/s15010-025-02556-2","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigates a nationwide Salmonella outbreak in Norway during October-December 2024 involving four different serovars-S. Newport, S. Typhimurium, S. Kisarawe, and S. Kinondoni. The investigation aimed to assess the outbreak's scope, identify the source, and implement control measures.</p><p><strong>Methods: </strong>Epidemiological analyses included trawling and targeted questionnaires, a matched case-control study, and grocery receipt analysis. Whole-genome sequencing (WGS) determined genetic links between Salmonella isolates from human cases, food, and environmental samples. Traceback investigations identified potential contamination sources.</p><p><strong>Results: </strong>A total of 230 cases (69% female, median age: 48 years) were identified, with 33% requiring hospitalization. Sprout consumption was reported by 69% of cases interviewed through trawling or targeted questionnaires. Grocery receipts were collected from some of the cases, and half of these had purchased sprouts. A matched case-control study found cases to be associated with consumption of sprouts (penalized adjusted odds ratio of 3.13). WGS established genetic links between clinical, food, and environmental isolates, identifying alfalfa sprouts as the outbreak source. Traceback investigations identified potential risk associated with seeds from an Italian supplier, previously associated with two Salmonella outbreaks in Norway in 2024 and multiple outbreaks across the European Union. The Italian supplier reported negative findings for Salmonella in their self-monitoring checks on seeds sent to Norway. Control measures included product withdrawal, seed batch quarantine, and public health advisories.</p><p><strong>Conclusion: </strong>This multi-serovar outbreak highlights the public health risks associated with consumption of raw sprouts and emphasizes the need for improved detection methods and stricter regulations to prevent future outbreaks.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cellulosimicrobium cellulans endocarditis: a challenge for detection and treatment in interdisciplinary teams.","authors":"Tonina T Mueller, Julius Steffen, Clemens Scherer, Matthias Wa Angstwurm","doi":"10.1007/s15010-025-02551-7","DOIUrl":"https://doi.org/10.1007/s15010-025-02551-7","url":null,"abstract":"<p><p>We present a case of subacute endocarditis with the detection of Cellulosimicrobium cellulans after tricuspid valve replacement and pacemaker extraction without detection in blood cultures before pacemaker extraction despite multiple testing. This atypical pathogen has rarely been reported in cases of subacute endocarditis, particularly in non-immunocompromised patients. Treatment was initiated using fosfomycin and flucloxacillin and switched to vancomycin upon pathogen detection after pacemaker lead removal and tricuspid valve replacement. Interdisciplinary cooperation between cardiologists, cardiothoracic surgeons, and the infectious disease team enabled an accurate diagnosis and optimized antibiotic therapy before surgical intervention.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fusarium oxysporum infection: a rare case of fusarium oxysporum resistance to amphotericin b following traumatic intracranial injury in an 18-month-old boy.","authors":"Matthias Krause, Arwin Rezai, Matthias Schaffert, Konstanze Pfeiffer, Christoph J Griessenauer, Johann Gradl, Cornelia Lass-Flörl, Jan Marco Kern","doi":"10.1007/s15010-025-02560-6","DOIUrl":"https://doi.org/10.1007/s15010-025-02560-6","url":null,"abstract":"","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A very rare case of osseous involvement of the dens axis in a 52-year-old HIV positive patient as part of secondary syphilis.","authors":"K Lange, C Helbig, N Eckardt, M Baier, J Guse, S Hagel, A Stallmach, B T Schleenvoigt","doi":"10.1007/s15010-025-02552-6","DOIUrl":"https://doi.org/10.1007/s15010-025-02552-6","url":null,"abstract":"","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vibrio fluvialis cholangitis with bacteremia and refractory septic shock: a case report and review of the literature.","authors":"Roberto Lazzari, María Borja Cano, Alba Rivera Martínez, Marc Rubio Bueno, Marta Castella Rovira, Mireia Puig Campmany","doi":"10.1007/s15010-025-02535-7","DOIUrl":"https://doi.org/10.1007/s15010-025-02535-7","url":null,"abstract":"<p><p>Vibrio fluvialis is an emerging pathogen primarily associated with gastroenteritis, though an increasing number of extraintestinal infections have been reported. We present the first documented case in Europe of V. fluvialis cholangitis with liver abscess and bacteremia. An 85-year-old man with diabetes mellitus and chronic steroid use was admitted with severe epigastric pain but no fever or gastrointestinal symptoms. Initial laboratory tests were unremarkable, yet imaging revealed a hepatic abscess. Despite early antibiotic therapy, the patient rapidly developed refractory septic shock and died within 12 h. Blood cultures confirmed V. fluvialis. This case highlights the potential for severe V. fluvialis infections even in the absence of known seafood or seawater exposure. Given the global rise in raw seafood consumption, physicians should consider V. fluvialis as a potential pathogen in diabetic or immunocompromised patients presenting with hepatobiliary infections and sepsis.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}