Infection最新文献

{"title":"Correction: Interleukin-6 as a critical inflammatory marker for early diagnosis of surgical site infection after spine surgery.","authors":"Paul Jonathan Roch, Carolin Ecker, Katharina Jäckle, Marc-Pascal Meier, Maximilian Reinhold, Friederike Sophie Klockner, Wolfgang Lehmann, Lukas Weiser","doi":"10.1007/s15010-024-02319-5","DOIUrl":"10.1007/s15010-024-02319-5","url":null,"abstract":"","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":"2561"},"PeriodicalIF":5.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11621178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141310590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of clinical outcomes in hospitalized patients with COVID-19 or non-COVID-19 community-acquired pneumonia in a prospective observational cohort study.","authors":"Hans-Jakob Meyer, Lukas Mödl, Olesya Unruh, Weiwei Xiang, Sarah Berger, Moritz Müller-Plathe, Gernot Rohde, Mathias W Pletz, Jan Rupp, Norbert Suttorp, Martin Witzenrath, Thomas Zoller, Mirja Mittermaier, Fridolin Steinbeis","doi":"10.1007/s15010-024-02292-z","DOIUrl":"10.1007/s15010-024-02292-z","url":null,"abstract":"<p><strong>Purpose: </strong>Coronavirus disease 2019 (COVID-19) and non-COVID-19 community-acquired pneumonia (NC-CAP) often result in hospitalization with considerable risks of mortality, ICU treatment, and long-term morbidity. A comparative analysis of clinical outcomes in COVID-19 CAP (C-CAP) and NC-CAP may improve clinical management.</p><p><strong>Methods: </strong>Using prospectively collected CAPNETZ study data (January 2017 to June 2021, 35 study centers), we conducted a comprehensive analysis of clinical outcomes including in-hospital death, ICU treatment, length of hospital stay (LOHS), 180-day survival, and post-discharge re-hospitalization rate. Logistic regression models were used to examine group differences between C-CAP and NC-CAP patients and associations with patient demography, recruitment period, comorbidity, and treatment.</p><p><strong>Results: </strong>Among 1368 patients (C-CAP: n = 344; NC-CAP: n = 1024), C-CAP showed elevated adjusted probabilities for in-hospital death (aOR 4.48 [95% CI 2.38-8.53]) and ICU treatment (aOR 8.08 [95% CI 5.31-12.52]) compared to NC-CAP. C-CAP patients were at increased risk of LOHS over seven days (aOR 1.88 [95% CI 1.47-2.42]). Although ICU patients had similar in-hospital mortality risk, C-CAP was associated with length of ICU stay over seven days (aOR 3.59 [95% CI 1.65-8.38]). Recruitment period influenced outcomes in C-CAP but not in NC-CAP. During follow-up, C-CAP was linked to a reduced risk of re-hospitalization and mortality post-discharge (aOR 0.43 [95% CI 0.27-0.70]).</p><p><strong>Conclusion: </strong>Distinct clinical trajectories of C-CAP and NC-CAP underscore the need for adapted management to avoid acute and long-term morbidity and mortality amid the evolving landscape of CAP pathogens.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":"2359-2370"},"PeriodicalIF":5.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11621138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140954851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenotypic and molecular characterization of extended spectrum- and metallo- beta lactamase producing Pseudomonas aeruginosa clinical isolates from Egypt.","authors":"Eva A Edward, Marwa R El Shehawy, Alaa Abouelfetouh, Elsayed Aboulmagd","doi":"10.1007/s15010-024-02297-8","DOIUrl":"10.1007/s15010-024-02297-8","url":null,"abstract":"<p><strong>Background: </strong>Antimicrobial resistance among Pseudomonas aeruginosa (P. aeruginosa), a leading cause of nosocomial infections worldwide, is escalating. This study investigated the prevalence of extended-spectrum β-lactamases (ESBLs) and metallo-β-lactamases (MBLs) among 104 P. aeruginosa clinical isolates from Alexandria Main University Hospital, Alexandria, Egypt.</p><p><strong>Methods: </strong>Antimicrobial susceptibility testing was performed using agar dilution technique, or broth microdilution method in case of colistin. ESBL and MBL prevalence was assessed phenotypically and genotypically using polymerase chain reaction (PCR). The role of plasmids in mediating resistance to extended-spectrum β-lactams was studied via transformation technique using plasmids isolated from ceftazidime-resistant isolates.</p><p><strong>Results: </strong>Antimicrobial susceptibility testing revealed alarming resistance rates to carbapenems, cephalosporins, and fluoroquinolones. Using PCR as the gold standard, phenotypic methods underestimated ESBL production while overestimating MBL production. Eighty-five isolates (81.7%) possessed only ESBL encoding genes, among which 69 isolates harbored a single ESBL gene [bla_OXA-10 (n = 67) and bla_PER (n = 2)]. Four ESBL-genotype combinations were detected: bla_PER + bla_OXA-10 (n = 8), bla_VEB-1 + bla_OXA-10 (n = 6), bla_PSE + bla_OXA-10 (n = 1), and bla_PER + bla_VEB-1 + bla_OXA-10 (n = 1). Three isolates (2.9%) possessed only the MBL encoding gene bla_VIM. Three ESBL + MBL- genotype combinations: bla_OXA-10 + bla_AIM, bla_OXA-10 + bla_VIM, and bla_PER + bla_OXA-10 + bla_AIM were detected in 2, 1 and 1 isolate(s), respectively. Five plasmid preparations harboring bla_VEB-1 and bla_OXA-10 were successfully transformed into chemically competent Escherichia coli DH5α with transformation efficiencies ranging between 6.8 × 10 3 and 3.7 × 10 4    CFU/μg DNA plasmid. Selected tested transformants were ceftazidime-resistant and harbored plasmids carrying bla_OXA-10.</p><p><strong>Conclusions: </strong>The study highlights the importance of the expeditious characterization of ESBLs and MBLs using genotypic methods among P. aeruginosa clinical isolates to hinder the development and dissemination of multidrug resistant strains.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":"2399-2414"},"PeriodicalIF":5.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11621155/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141186229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infection episodes and islet autoantibodies in children at increased risk for type 1 diabetes before and during the COVID-19 pandemic.","authors":"Ivo Zeller, Andreas Weiss, Stefanie Arnolds, Katharina Schütte-Borkovec, Sari Arabi, Thekla von dem Berge, Kristina Casteels, Angela Hommel, Olga Kordonouri, Helena Elding Larsson, Markus Lundgren, Anne Rochtus, Matthew D Snape, Agnieszka Szypowka, Manu Vatish, Christiane Winkler, Ezio Bonifacio, Anette-Gabriele Ziegler","doi":"10.1007/s15010-024-02312-y","DOIUrl":"10.1007/s15010-024-02312-y","url":null,"abstract":"<p><strong>Objectives: </strong>To determine the impact of the COVID-19 pandemic on the incidence rates of infection and islet autoimmunity in children at risk for type 1 diabetes.</p><p><strong>Methods: </strong>1050 children aged 4 to 7 months with an elevated genetic risk for type 1 diabetes were recruited from Germany, Poland, Sweden, Belgium and the UK. Reported infection episodes and islet autoantibody development were monitored until age 40 months from February 2018 to February 2023.</p><p><strong>Results: </strong>The overall infection rate was 311 (95% Confidence Interval [CI], 304-318) per 100 person years. Infection rates differed by age, country, family history of type 1 diabetes, and period relative to the pandemic. Total infection rates were 321 per 100 person-years (95% CI 304-338) in the pre-pandemic period (until February 2020), 160 (95% CI 148-173) per 100 person-years in the first pandemic year (March 2020-February 2021; P < 0.001) and 337 (95% CI 315-363) per 100 person-years in subsequent years. Similar trends were observed for respiratory and gastrointestinal infections. Islet autoantibody incidence rates were 1.6 (95% CI 1.0-2.4) per 100 person-years in the pre-pandemic period, 1.2 (95% CI 0.8-1.9) per 100 person-years in the first pandemic year (P = 0.46), and 3.4 (95% CI 2.3-4.8) per 100 person-years in subsequent years (P = 0.005 vs. pre-pandemic year; P < 0.001 vs. first pandemic year).</p><p><strong>Conclusions: </strong>The COVID-19 pandemic was associated with significantly altered infection patterns. Islet autoantibody incidence rates increased two-fold when infection rates returned to pre-pandemic levels.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":"2465-2473"},"PeriodicalIF":5.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11621198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141317028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Presentation, management, and outcomes of older compared to younger adults with hospital-acquired bloodstream infections in the intensive care unit: a multicenter cohort study.","authors":"Ili Margalit, Dafna Yahav, Tomer Hoffman, Alexis Tabah, Stéphane Ruckly, François Barbier, Pierre Singer, Jean-François Timsit, Virginie Prendki, Niccolò Buetti","doi":"10.1007/s15010-024-02377-9","DOIUrl":"10.1007/s15010-024-02377-9","url":null,"abstract":"","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":"2565-2566"},"PeriodicalIF":5.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11621161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142055446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Compassionate use of cefiderocol in a complex case of extensively drug-resistant Acinetobacter baumannii fracture-related infection: a comprehensive approach and multidisciplinary management.","authors":"Flavia Petrucci, Beatrice Perciballi, Marco Rivano Capparuccia, Giancarlo Iaiani, Federico Lo Torto, Diego Ribuffo, Stefano Gumina, Daniele De Meo","doi":"10.1007/s15010-024-02306-w","DOIUrl":"10.1007/s15010-024-02306-w","url":null,"abstract":"","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":"2559"},"PeriodicalIF":5.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11621175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141283657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological and clinical characterization of community, healthcare-associated and nosocomial colonization and infection due to carbapenemase-producing Klebsiella pneumoniae and Escherichia coli in Spain.","authors":"Elena Salamanca-Rivera, Zaira R Palacios-Baena, Javier E Cañada, Zaira Moure, María Pérez-Vázquez, Jorge Calvo-Montes, Luis Martínez-Martínez, Rafael Cantón, Guillermo Ruiz Carrascoso, Cristina Pitart, Ferran Navarro, Germán Bou, Xavier Mulet, Juan José González-López, Fran Sivianes, Mercedes Delgado-Valverde, Álvaro Pascual, Jesús Oteo-Iglesias, Jesús Rodríguez-Baño","doi":"10.1007/s15010-024-02267-0","DOIUrl":"10.1007/s15010-024-02267-0","url":null,"abstract":"<p><strong>Background: </strong>Community-acquired (CA) and healthcare-associated (HCA) infections caused by carbapenemase-producing Enterobacterales (CPE) are not well characterized. The objective was to provide detailed information about the clinical and molecular epidemiological features of nosocomial, HCA and CA infections caused by carbapenemase-producing Klebsiella pneumoniae (CP-Kp) and Escherichia coli (CP-Ec).</p><p><strong>Methods: </strong>A prospective cohort study was performed in 59 Spanish hospitals from February to March 2019, including the first 10 consecutive patients from whom CP-Kp or CP-Ec were isolated. Patients were stratified according to acquisition type. A multivariate analysis was performed to identify the impact of acquisition type in 30-day mortality.</p><p><strong>Results: </strong>Overall, 386 patients were included (363 [94%] with CP-Kp and 23 [6%] CP-Ec); in 296 patients (76.3%), the CPE was causing an infection. Acquisition was CA in 31 (8.0%) patients, HCA in 183 (47.4%) and nosocomial in 172 (48.3%). Among patients with a HCA acquisition, 100 (54.6%) had been previously admitted to hospital and 71 (38.8%) were nursing home residents. Urinary tract infections accounted for 19/23 (82.6%), 89/130 (68.5%) and 42/143 (29.4%) of CA, HCA and nosocomial infections, respectively. Overall, 68 infections (23%) were bacteremia (8.7%, 17.7% and 30.1% of CA, HCA and nosocomial, respectively). Mortality in infections was 28% (13%, 14.6% and 42.7% of CA, HCA and nosocomial, respectively). Nosocomial bloodstream infections were associated with increased odds for mortality (adjusted OR, 4.00; 95%CI 1.21-13.19).</p><p><strong>Conclusions: </strong>HCA and CA infections caused by CPE are frequent and clinically significant. This information may be useful for a better understanding of the epidemiology of CPE.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":"2231-2240"},"PeriodicalIF":5.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11621176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140850426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of post-COVID-19 symptoms in patients infected with the SARS-CoV-2 variants delta and omicron-results of the Cross-Sectoral Platform of the German National Pandemic Cohort Network (NAPKON-SUEP).","authors":"Sina M Hopff, Katharina S Appel, Olga Miljukov, Johannes Schneider, Marylyn M Addo, Robert Bals, Sven Bercker, Sabine Blaschke, Isabel Bröhl, Nikolaus Büchner, Hiwa Dashti, Johanna Erber, Anette Friedrichs, Ramsia Geisler, Siri Göpel, Marina Hagen, Frank Hanses, Björn-Erik Ole Jensen, Maria Keul, Adalbert Krawczyk, Bettina Lorenz-Depiereux, Patrick Meybohm, Milena Milovanovic, Lazar Mitrov, Carolin Nürnberger, Wilfried Obst, Christoph Römmele, Christian Schäfer, Christian Scheer, Margarete Scherer, Julia Schmidt, Kristina Seibel, Shimita Sikdar, Johannes Josef Tebbe, Phil-Robin Tepasse, Philipp Thelen, Maria J G T Vehreschild, Christina Weismantel, J Janne Vehreschild","doi":"10.1007/s15010-024-02270-5","DOIUrl":"10.1007/s15010-024-02270-5","url":null,"abstract":"<p><strong>Purpose: </strong>The influence of new SARS-CoV-2 variants on the post-COVID-19 condition (PCC) remains unanswered. Therefore, we examined the prevalence and predictors of PCC-related symptoms in patients infected with the SARS-CoV-2 variants delta or omicron.</p><p><strong>Methods: </strong>We compared prevalences and risk factors of acute and PCC-related symptoms three months after primary infection (3MFU) between delta- and omicron-infected patients from the Cross-Sectoral Platform of the German National Pandemic Cohort Network. Health-related quality of life (HrQoL) was determined by the EQ-5D-5L index score and trend groups were calculated to describe changes of HrQoL between different time points.</p><p><strong>Results: </strong>We considered 758 patients for our analysis (delta: n = 341; omicron: n = 417). Compared with omicron patients, delta patients had a similar prevalence of PCC at the 3MFU (p = 0.354), whereby fatigue occurred most frequently (n = 256, 34%). HrQoL was comparable between the groups with the lowest EQ-5D-5L index score (0.75, 95% CI 0.73-0.78) at disease onset. While most patients (69%, n = 348) never showed a declined HrQoL, it deteriorated substantially in 37 patients (7%) from the acute phase to the 3MFU of which 27 were infected with omicron.</p><p><strong>Conclusion: </strong>With quality-controlled data from a multicenter cohort, we showed that PCC is an equally common challenge for patients infected with the SARS-CoV-2 variants delta and omicron at least for the German population. Developing the EQ-5D-5L index score trend groups showed that over two thirds of patients did not experience any restrictions in their HrQoL due to or after the SARS-CoV-2 infection at the 3MFU.</p><p><strong>Clinical trail registration: </strong>The cohort is registered at ClinicalTrials.gov since February 24, 2021 (Identifier: NCT04768998).</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":"2253-2267"},"PeriodicalIF":5.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11621170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140864469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Results of a monocentric field study: value of histology compared to sonication method and conventional tissue culture in the diagnosis of periprosthetic joint infection (PJI).","authors":"Alexander Röhrl, Frank Klawonn, Bernd Füchtmeier, Christian Wulbrand, Andre Gessner, Jozef Zustin, Andreas Ambrosch","doi":"10.1007/s15010-024-02399-3","DOIUrl":"10.1007/s15010-024-02399-3","url":null,"abstract":"","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":"2567-2570"},"PeriodicalIF":5.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142464323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ceftazidime-avibactam versus other antimicrobial agents for treatment of Multidrug-resistant Pseudomonas aeruginosa: a systematic review and meta-analysis.","authors":"Chhavi Gupta, Susan Shin-Jung Lee, Monalisa Sahu, Sudipta Mukherjee, Kuan-Sheng Wu","doi":"10.1007/s15010-024-02371-1","DOIUrl":"10.1007/s15010-024-02371-1","url":null,"abstract":"<p><strong>Objectives: </strong>Multidrug-resistant Pseudomonas aeruginosa (MDR-PA) is a life-threatening infection with limited treatment options. This is the first meta-analysis of recently published data to compare the clinical outcomes of ceftazidime-avibactam (CAZ-AVI) with other antimicrobial agents in treating MDR-PA infections.</p><p><strong>Design: </strong>Systematic review and meta-analysis.</p><p><strong>Data sources: </strong>PubMed, Embase and the Cochrane Library have been systematically reviewed, for publications in the English language, from database inception to July 2023.</p><p><strong>Eligibility criteria for selecting studies: </strong>Studies comparing CAZ-AVI outcomes with other antimicrobial agents were included. In-hospital mortality & 30-day mortality were assessed as the main outcomes.</p><p><strong>Data extraction and synthesis: </strong>Literature screening, data extraction, and the quality evaluation of studies were conducted by two researchers independently, with disagreements resolved by another researcher. The Newcastle-Ottawa Scale was used to assess the bias risk for the included studies. Review Manager V.5.4 was employed for the meta-analysis.</p><p><strong>Results: </strong>The meta-analysis included four retrospective studies, enrolling 1934 patients. The CAZ-AVI group demonstrated significantly lower in-hospital mortality (risk ratio (RR) = 0.60, 95% CI:0.37-0.97, I2 = 74%, p = 0.04) in three studies with 1444 patients and lower 30-day mortality, in 438 patients from three studies (RR = 0.54, 95% CI:0.28-1.05, I2 = 67%, p = 0.07). No significant difference in clinical success, microbiological success, length of hospital, and ICU stay was observed.</p><p><strong>Conclusions: </strong>This meta-analysis demonstrated that CAZ-AVI treatment significantly lowered in-hospital mortality compared with other antimicrobial agents in MDR-PA infections. However, the analysis only included a few observational studies and high-quality, randomized controlled trials are needed to investigate further the scope of CAZ-AVI in MDR-PA  infections.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":"2183-2193"},"PeriodicalIF":5.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142046596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}