Infection最新文献

{"title":"Efficacy and safety of praziquantel combined with artemisinin derivatives versus praziquantel monotherapy for schistosomiasis: a meta-analysis of randomized controlled trials.","authors":"Yao Yang, Jiahao Meng, Chunhui Li, Pan Liu, Yumei Wu, Xuanyu Wang, Zhuoyang Xia, Shuguang Gao","doi":"10.1007/s15010-026-02807-w","DOIUrl":"https://doi.org/10.1007/s15010-026-02807-w","url":null,"abstract":"<p><strong>Background: </strong>Praziquantel (PZQ) is the mainstay treatment for schistosomiasis, but its efficacy against juvenile schistosomes is limited, which can lead to treatment failure and reinfection. Artemisinin derivatives (ARTs) exhibit potent activity against juvenile worms, offering a complementary mechanism. However, the potential risk of accelerating artemisinin resistance, particularly in schistosomiasis-malaria co-endemic regions, warrants consideration when evaluating ART-based regimens. To find a more optimal regimen for the treatment of schistosomiasis, this meta-analysis evaluated the effectiveness of ARTs and PZQ in combination or as a single agent for the treatment of schistosomiasis.</p><p><strong>Purpose: </strong>To evaluate the efficacy and safety of PZQ combined with ARTs compared with praziquantel alone for the treatment of schistosomiasis through a meta-analysis of randomized controlled trials.</p><p><strong>Methods: </strong>Randomized controlled trials (RCTs) of artemisinin derivatives in combination with praziquantel in the treatment of schistosomiasis were selected from computerized searches of PubMed, Embase, Cochrane Library, and Web of Science, up to November 2025. The inclusion criteria were randomized controlled trials involving participants diagnosed with Schistosoma mansoni, S. haematobium, or S. japonicum, who were treated with PZQ combined with ARTs or PZQ alone, and reporting on efficacy and safety outcomes. The primary outcome indicator was cure rate (CR), and secondary outcome indicators were egg count reduction rate and number of adverse events. The meta-analysis was performed using a random-effects model. Subgroup analyses were conducted to explore the impact of different types of schistosomes.</p><p><strong>Results: </strong>A total of eight studies, involving 1595 patients with schistosomiasis, explored the cure rate of PZQ combined with ARTs and PZQ alone. The pooled result showed that PZQ combined with ARTs had a significantly higher cure rate than PZQ alone (RR 1.12; 95% CI 1.01-1.24; P = 0.02). The corresponding subgroup analysis results showed that the CR of patients with S. mansoni treated with PZQ combined with ARTs was still higher than that of patients treated with PZQ alone (RR 1.16; 95% CI 1.01-1.34; P = 0.03). However, there was no statistically significant difference between PZQ combined with ARTs and PZQ for S. haematobium (RR 1.11; 95% CI 0.99-1.23; P = 0.06) or S. japonicum (RR 1.02; 95% CI 0.95-1.09; P = 0.60) in subgroup analyses. In addition, our study also found that there was no significant difference in egg count reduction between the PZQ-ARTs and PZQ-alone groups, either for S. mansoni (MD - 4.54, 95% CI - 17.67 to 8.58; P = 0.50) or for S. haematobium (MD - 13.74; 95% CI - 55.64 to 28.15; P = 0.52). Furthermore, the combination therapy was associated with a higher incidence of adverse events compared with PZQ alone (RR 1.41; 95% CI 1.01 to 1.96; P = 0.04).</p><p><strong>Co","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147837351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Syphilis mimicking a metastatic tumour: a case report and review of the literature.","authors":"Tobias R Dashi, Sebastian Boeltz, Kristina Schilling, Olaf Conrad, Shahed Shafaei, Eva L Balbach, Franziska Schmid, Barbara Nuebel, Abbas Agaimy, Jochen Wacker, Giuseppe Valenza, Georg Schett, Thomas Harrer","doi":"10.1007/s15010-026-02803-0","DOIUrl":"https://doi.org/10.1007/s15010-026-02803-0","url":null,"abstract":"<p><strong>Purpose: </strong>Syphilis is an infectious disease with a wide range of clinical manifestations. Diagnosis is often challenging as the symptoms of syphilis can mimic malignant or autoimmune diseases. Here, we report on a patient with tertiary syphilis mimicking a metastatic testicular tumour.</p><p><strong>Methods: </strong>Syphilis was diagnosed by serological testing and immunohistochemistry of tissue biopsies using specific antibodies. Additionally, a comprehensive literature review was conducted using a PubMed database search to identify previously reported cases and relevant studies.</p><p><strong>Results: </strong>A 57-year-old male patient developed fever, night sweats and weight loss for three months after he had been treated with glucocorticoids for lumbar disc herniation. At first presentation, physical examination was unremarkable except for cervical lymphadenopathy. FDG-PET revealed hepatic and testicular lesions suspicious for malignancy. Biopsy of the hepatic lesion was inconclusive and showed features of pseudotumourous inflammation. The orchiectomy specimen demonstrated a large inflammatory pseudotumour composed of mixed lymphoplasmacytic and granulocytic infiltrates, with no evidence of neoplasia. Serological testing yielded elevated titers of Treponema pallidum antibodies and immunohistochemistry detected high numbers of spirochaetes in the biopsies. Antibiotic treatment with ceftriaxone and benzylpenicillin led to relief of symptoms and a decline of antibody titers. Literature review identified several cases of syphilis masquerading as malignant disease, whereas a potential reactivation of syphilis under immunosuppressive therapy remains rare.</p><p><strong>Conclusion: </strong>This case highlights tertiary syphilis as a rare but important differential diagnosis of pseudotumorous lesions mimicking metastatic malignancy, particularly in the presence of atypical histopathology. Immunosuppression may have contributed to clinical manifestation.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147837403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of cancer and immunosuppression in pneumocystis pneumonia: a large comprehensive population-based study.","authors":"Fabian Reichel, Falko Tesch, Saskia Berger, Martin Seifert, Dirk Koschel, Jochen Schmitt, Martin Kolditz","doi":"10.1007/s15010-026-02802-1","DOIUrl":"https://doi.org/10.1007/s15010-026-02802-1","url":null,"abstract":"<p><p>Although pneumocystis jirovecii pneumonia (PJP) in non-HIV patients is increasingly recognized, comprehensive data on immunosuppressive drivers remain limited. We conducted a population-based cohort study using a German health insurance's claims data (2015-2023). PJP, comorbidities, immunocompromising conditions and therapies were identified by means of ICD-10-GM-, ATC- and OPS-coded records. 922,200 individuals were assessed for PJP occurrence, hospitalization and 30-day all-cause mortality. An Andersen-Gill model adjusted for key covariates. We identified 171 PJP episodes, with hospitalization in 88.3% and mortality in 24.5%. Frequent immunocompromising causes were hematologic cancers (42.6%), immunosuppressants (28.7%) and steroids (28.7%). Immunosuppression rather than typical CAP risk factors strongly predicted all outcomes (HR 49.9 [31.5-78.9]). Robust associations with PJP occurred for HIV (HR 67.5 [19.4-235]), systemic steroids (> 20 mg prednisone daily equivalent (HR 26.2 [13.2-52.1])) and hematologic cancers (HR 8.5 [4.5-16.3]). Mortality was driven by hematologic cancers (HR 13.9 [4.8-40.2]) and high-dose steroids (HR 8.6 [1.6-47.1]). Malignancy-related immunosuppression and steroids critically affect PJP risk and prognosis.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147837401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular manifestations and outcomes in patients with leptospirosis admitted to a tertiary care center in the Coastal Karnataka region in India.","authors":"M Sudhakar Rao, Jyothi Samanth, Vidya Nayak, R Padmakumar, Asmitha G Nayak, P K Sanjana Nambiar, Shephali Rajesh Rao, Pratheeksha Rao","doi":"10.1007/s15010-026-02806-x","DOIUrl":"https://doi.org/10.1007/s15010-026-02806-x","url":null,"abstract":"<p><strong>Introduction: </strong>Leptospirosis is a globally prevalent zoonotic infection caused by Leptospira species. Cardiac involvement is increasingly recognized, yet large-scale studies comprehensively evaluating electrocardiographic and echocardiographic manifestations, including myocarditis, remain limited.</p><p><strong>Methods: </strong>This retrospective study included adult patients with clinically suspected leptospirosis and positive IgM ELISA admitted to a tertiary care hospital in South India between January 2016 and September 2020. Clinical features, electrocardiographic (ECG) findings, two-dimensional echocardiographic parameters, and in-hospital outcomes were analyzed. Binomial logistic regression was performed to identify independent predictors of all-cause mortality and myocarditis.</p><p><strong>Results: </strong>A total of 510 patients were analyzed (mean age 48.4 ± 13.7 years; 66.5% male). The mean hospital stay was 10.1 ± 6.1 days, with 40% requiring hospitalization beyond 10 days. Diabetes mellitus and hypertension were present in 16.7% and 16.9% of patients, respectively. Acute respiratory distress syndrome occurred in 10.6%, and 28% developed multiorgan dysfunction syndrome; 17.8% required hemodialysis. The most common ECG abnormalities were corrected QT interval prolongation (21.0%) and sinus tachycardia (20.8%). Echocardiographic evidence of myocarditis was observed in 10.4% of patients, including isolated left ventricular dysfunction (4.1%), isolated right ventricular dysfunction (3.9%), and biventricular dysfunction (2.4%). The overall in-hospital mortality rate was 8%. Increasing age, sinus tachycardia, QTc prolongation, hypertension, hemodialysis requirement, and myocarditis were independent predictors of mortality.</p><p><strong>Conclusions: </strong>Myocarditis represents a significant cardiac complication in leptospirosis and is associated with increased mortality. Routine cardiac evaluation may facilitate early detection and risk stratification.</p><p><strong>Clinical trial registration: </strong>Not applicable, as this study was retrospective in nature.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147814667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Budget impact analysis of aztreonam-avibactam for metallo-β-lactamase carbapenem-resistant enterobacterales infections in China.","authors":"Junling Weng, Kemiao Zhang, Qiang Liu, Dunming Xiao, Zichun Zhou, Yi Yang, Xin Li, Yingyao Chen","doi":"10.1007/s15010-026-02801-2","DOIUrl":"https://doi.org/10.1007/s15010-026-02801-2","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the budget impact on the China's basic medical insurance fund (BMIF) following the inclusion of aztreonam-avibactam (ATM-AVI) for metallo-β-lactamase carbapenem-resistant enterobacterales (MBL-CRE) infections in the National Reimbursement Drug List (NRDL).</p><p><strong>Methods: </strong>A budget impact model was developed with a 2-year time horizon (2026-2027) from the perspective of China's basic medical insurance. The analysis included drug acquisition costs and other direct medical costs. Relevant data were collected from published literature, and supplemented through expert consultation. The study compared costs under two scenarios with and without ATM-AVI reimbursement to estimate its impact on BMIF. One way sensitivity analyses were conducted to identify key parameters influencing the results.</p><p><strong>Results: </strong>After the inclusion of ATM-AVI in the NRDL, the BMIF was projected to save 152,156,598 Chinese yuan (21,310,448 United States dollar) and 210,914,875 Chinese yuan (29,539,898 United States dollar) in 2026 and 2027, respectively. Following reimbursement, ATM-AVI was expected to yield 291 and 342 additional cured patients, 804 and 888 fewer deaths, 11,256 and 13,031 fewer intensive care unit days, and 11,336 and 13,071 fewer total hospitalization days in 2026 and 2027, respectively. Across all parameter variations, ATM-AVI remained cost-saving to BMIF.</p><p><strong>Conclusion: </strong>In China, timely reimbursement of innovative antibiotics can simultaneously improve patient outcomes and reduce medical insurance fund expenditure, underscoring the value of value-based reimbursement policies in promoting access to effective therapies while supporting the sustainability of the health insurance system.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147814620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognosis and aetiology of hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) in patients with active lung or lower head and neck cancer (PEPP-C): a retrospective, matched multicentre cohort study in Germany and Spain.","authors":"Sina M Pütz, Marie Engelhard, Sebastian M Wingen-Heimann, David F Brilz, Brune Akrich, Heike Kohl, Annika Y Classen, Carlota Gudiol, Enric Sastre-Escola, Franziska C Trudzinski, Arturo Olivares Rivera, Eva Lücke, Tadeusz Marczewski, Ayham Daher, Stephan Eisenmann, Jacqueline Schmitz, Anke Reinacher-Schick, Julia von Tresckow, Rebekka Mispelbaum, Tessa Hattenhauer, J Janne Vehreschild","doi":"10.1007/s15010-026-02805-y","DOIUrl":"https://doi.org/10.1007/s15010-026-02805-y","url":null,"abstract":"<p><strong>Purpose: </strong>Patients with active lung or lower head and neck cancer (HNC) are at increased risk of infection, particularly hospital-acquired pneumonia (HAP), ventilated HAP (vHAP) and ventilator-associated pneumonia (VAP), due to immunosuppression and treatment-related side effects. These infections are associated with increased mortality, prolonged hospital stays and interruptions in cancer therapy. Despite their clinical relevance, data on epidemiology, risk factors, treatment, and outcomes in this population remain limited.</p><p><strong>Methods: </strong>We conducted a retrospective, observational, multicentre matched cohort study at eight tertiary care centres in Germany and Spain. Patients with lung or lower HNC who received anti-cancer treatment between January 2018 and May 2022 and were hospitalised for at least 48 h were included. Patients with HAP/vHAP/VAP (case group) were matched 1:1 to those without pneumonia (control group) and followed for 90 days.</p><p><strong>Results: </strong>A total of 256 patients were included, with median ages of 65 (cases) and 64 years (controls). Most patients had lung cancer (94%, n = 240), predominantly in stages III-IV (81%, n = 207). In the case group, patients had mostly HAP (88%, n = 113), diagnosed in median 7 days after hospital admission. Common antibiotics given included penicillin derivatives with β-lactamase inhibitors, cephalosporins and carbapenems. Patients with HAP/vHAP/VAP had significantly higher mortality and longer hospital stays (p < 0.001). Cox regression identified HAP/vHAP/VAP and dysphagia as independent predictors of mortality.</p><p><strong>Conclusion: </strong>HAP/vHAP/VAP imposes a significant clinical burden in patients with lung or lower HNC. Early prevention, timely diagnosis, and close monitoring of high-risk patients are essential to improve outcomes.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147814653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric meningoencephalitis in the molecular diagnostic era: epidemiological insights from 1198 suspected cases in Germany between 2016 and 2024.","authors":"Yannik Vollmuth, Benjamin Soric, Jana Beer, Uta Behrends, Marco Paolini, Astrid Blaschek, Melanie Meyer-Bühn, Christoph Klein, Johannes Hübner, Gerhard Dobler, Tilmann Schober","doi":"10.1007/s15010-026-02811-0","DOIUrl":"https://doi.org/10.1007/s15010-026-02811-0","url":null,"abstract":"<p><strong>Purpose: </strong>The epidemiology of suspected pediatric meningoencephalitis has changed in the era of conjugate vaccines and multiplex PCR. Updated epidemiologic data are needed to adapt diagnostic and therapeutic algorithms to current practice.</p><p><strong>Methods: </strong>This retrospective single-center study included children < 18 years who underwent lumbar puncture with cerebrospinal fluid multiplex PCR for suspected central nervous system infection at a tertiary pediatric hospital in Germany between 2016 and 2024. Clinical, laboratory, and outcome data were extracted from electronic medical records. Cerebrospinal fluid was analyzed using the BioFire^® FilmArray^® Meningitis/Encephalitis Panel. Statistical analyses included descriptive statistics, nonparametric comparisons, and receiver operating characteristic analyses.</p><p><strong>Results: </strong>Among 1,198 children, definite bacterial meningitis was diagnosed in 13 (1.1%), definite viral meningitis in 80 (6.7%), aseptic meningitis of unknown etiology in 131 (11.0%), confirmed/probable encephalitis in 53 (4.4%), and possible encephalitis in 34 (2.8%). Bacterial meningitis represented 5.8% of meningitis cases. A causative pathogen was identified in all bacterial cases, most commonly Streptococcus pneumoniae (n = 7). Enterovirus (n = 52) and parechovirus (n = 9) predominated in viral meningitis, while an infectious etiology was identified in only 13/53 confirmed/probable encephalitis cases. The Bacterial Meningitis Score showed 80.0% sensitivity and 57.6% specificity. The recently published UK-ChiMES pre- and post-lumbar puncture scores demonstrated sensitivities of 84.6% and 76.9% and specificities of 86.3% and 92.7%, respectively.</p><p><strong>Conclusion: </strong>Bacterial meningitis was rare, whereas viral and etiologically unresolved infections predominated despite routine multiplex PCR. Clinical prediction scores supported risk stratification, with the UK-ChiMES pre-lumbar puncture score showing the most favorable sensitivity-specificity balance.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147814665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Defining dissemination in spinal tuberculosis: insights and limitations of whole-body PET/CT.","authors":"Teruhiko Imamura","doi":"10.1007/s15010-026-02809-8","DOIUrl":"https://doi.org/10.1007/s15010-026-02809-8","url":null,"abstract":"","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147770537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemic cycles and post-epidemic decline of Mycoplasma pneumoniae in Italian children: implications for empirical macrolide prescribing.","authors":"Marco Bianchi, Alice Rubeo, Lorenza Romani, Laura Cursi, Stefania Bernardi, Velia Chiara Di Maio, Carlo Federico Perno, Alberto Villani, Mara Pisani","doi":"10.1007/s15010-026-02800-3","DOIUrl":"https://doi.org/10.1007/s15010-026-02800-3","url":null,"abstract":"<p><p>Mycoplasma pneumoniae (MP) circulation has recently re-emerged worldwide, raising concerns about empirical macrolide use in pediatric respiratory infections. We analyzed long-term trends of MP circulation in a tertiary-care pediatric center in Italy between 2017 and 2025. Among 20,539 respiratory molecular tests performed, 648 were positive for MP, with the highest burden observed in children aged 5-12 years. Two epidemic peaks were identified, occurring in 2019 and 2024, followed by a marked and sustained decline in positivity from the last quarter of 2025 onward. Hospitalization was frequent, particularly among patients with underlying comorbidities. Compared with the previous epidemic cycle, the 2024 peak was characterized by higher overall positivity but a lower proportion of hospitalized cases. The sharp post-epidemic reduction in MP circulation underscores the importance of continuous epidemiological surveillance to inform clinical decision-making. These findings support reconsideration of empirical macrolide prescribing during periods of low MP circulation and highlight the role of real-time surveillance data in strengthening antimicrobial stewardship strategies in pediatric care.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147814615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological and molecular analysis of the Chikungunya virus outbreak in the state of Rondônia.","authors":"Karolaine Santos Teixeira, Tárcio Peixoto Roca, Ana Maisa Passos-Silva, Edilene Pereira Pimentel, Jackson Alves da Silva Queiroz, Lourdes Maria Pinheiro Borzacov, Jansen Fernandes Medeiros, Juan Miguel Villalobos Salcedo, Deusilene Vieira","doi":"10.1007/s15010-026-02773-3","DOIUrl":"https://doi.org/10.1007/s15010-026-02773-3","url":null,"abstract":"<p><strong>Purpose: </strong>The Chikungunya virus (CHIKV) is an arbovirus transmitted by hematophagous arthropods, widely distributed in tropical and subtropical regionsAQ1. In Brazil, its introduction in 2014 marked the beginning of a significant expansion, becoming a major public health problem.</p><p><strong>Methods: </strong>This work consists of a cross-sectional study conducted from October 2024 to July 2025, in which 830 samples from patients with acute febrile illness and negative diagnosis for malaria were evaluatedAQ2. The samples were tested for dengue, Zika, and chikungunya and subjected to duplex RT-qPCR to detect Mayaro and Oropouche.</p><p><strong>Results: </strong>Of the samples analyzed, 5,18% (43/830) tested positive for some arbovirus investigated in this cohort, of which 53,49% (23/43) were detectable for CHIKV. The phylogenetic analysis showed that all samples belonged to the East/Central/South African (ECSA) genotype, demonstrating its circulation in the region.</p><p><strong>Conclusions: </strong>The findings reinforce the need for continuous molecular surveillance to monitor the circulation of medically important arboviruses in the Amazon region.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147770551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}