Infection最新文献

{"title":"Pulmonary fungus ball due to Scedosporium apiospermum mimicking aspergilloma: a case report.","authors":"Koji Ohyama, Yasuhiro Hida, Yuka Kondo, Akira Watanabe","doi":"10.1007/s15010-025-02609-6","DOIUrl":"https://doi.org/10.1007/s15010-025-02609-6","url":null,"abstract":"","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rehospitalizations for ambulatory care sensitive conditions in sepsis survivors- a nationwide cohort study using health claims data 2016-2019.","authors":"Lisa Wedekind, Norman Rose, Antje Freytag, Aurelia Kimmig, Peter Schlattmann, Mathias W Pletz, Thomas Ruhnke, Patrik Dröge, Carolin Fleischmann-Struzek","doi":"10.1007/s15010-025-02606-9","DOIUrl":"https://doi.org/10.1007/s15010-025-02606-9","url":null,"abstract":"<p><strong>Purpose: </strong>Sepsis survivors suffer from frequent rehospitalizations, of which a certain proportion is considered preventable by timely and adequate management in the outpatient setting (= ambulatory care sensitive conditions, ACSC). We aimed to assess the frequency of and risk factors for ACSC and infection-associated ACSC rehospitalization among sepsis survivors.</p><p><strong>Methods: </strong>Population-based, retrospective cohort study among using nationwide health claims data of the \"AOK- die Gesundheitskasse\". Sepsis patients with inpatient treatment in 2016-2019 were identified using ICD-codes. Among sepsis hospital survivors, ACSC and infection-related ACSC were identified. Patient-related risk factors for ACSC were assessed by a multiple logistic regression analysis.</p><p><strong>Results: </strong>We included 347,826 sepsis patients and 234,874 sepsis hospital survivors. A total of 53.2% and 21.3% of sepsis survivors had at least one ACSC and infection-related ACSC rehospitalizations in the 12-months post-discharge, respectively. ACSC rehospitalizations often occurred closely after discharge and more frequently affected older, male, care dependent patients as well as those living in rural areas.</p><p><strong>Conclusion: </strong>ACSC are common among sepsis survivors. This underlines to need for structured aftercare programs and interventions in these patients, particularly for ACSC risk groups which comprise older, male, care dependent patients in rural areas.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Head-to-head: meropenem/vaborbactam versus ceftazidime/avibactam in ICUs patients with KPC-producing K. pneumoniae infections- results from a retrospective multicentre study.","authors":"Andrea Marino, Alberto Enrico Maraolo, Maria Mazzitelli, Alessandra Oliva, Nicholas Geremia, Andrea De Vito, Chiara Gullotta, Vincenzo Scaglione, Eleonora Vania, Sara Lo Menzo, Paolo Navalesi, Lorenzo Volpicelli, Andrea Fiori, Pamela Prestifilippo, Annamaria Cattelan, Claudio Maria Mastroianni, Giordano Madeddu, Bruno Cacopardo, Giuseppe Nunnari","doi":"10.1007/s15010-025-02608-7","DOIUrl":"https://doi.org/10.1007/s15010-025-02608-7","url":null,"abstract":"","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diverse clinical manifestations of Parvovirus B19 infections during the 2024 outbreak in Germany.","authors":"A Holzem, J Stemler, S Böhm, H Gruell, A Zeuzem, E Schalk, T Schober, C Deppe, J Hübner, M von Bergwelt-Baildon, K Spiekermann","doi":"10.1007/s15010-025-02598-6","DOIUrl":"https://doi.org/10.1007/s15010-025-02598-6","url":null,"abstract":"<p><strong>Purpose: </strong>In 2024, human parvovirus B19 (PB19V) infections have increased in Germany and globally. It is an infection associated with a broad spectrum of clinical manifestations. To raise awareness, we present representative cases and virological data from different specialties across three German university hospitals.</p><p><strong>Methods: </strong>Following a nationwide survey by the AGIHO in March 2024 indicating increased PB19V infections, we conducted a retrospective, multi-center descriptive study across Munich, Cologne, and Magdeburg. Anonymized clinical and virological data from 2022 to 2024 were collected, including patient demographics, underlying diseases, and diagnostic findings. Acute PB19V infection was defined by real-time quantitative PCR-based detection of PB19V DNA in any specimen.</p><p><strong>Results: </strong>Clinical manifestations of acute PB19V infections can range from severe anemia and pancytopenia in hematologic patients, to fetal hydrops in pregnant women, and systemic inflammatory symptoms in patients with chronic conditions. In 2024, the Max von Pettenkofer Institute in Munich conducted 936 PB19V PCR tests. A marked increase in positive cases was observed in early 2024, with positivity rates of 16% in Q1 and 18.2% in Q2, compared to an annual positivity rate of 2.3% in 2023. Similar trends were seen at the University Hospitals Cologne and Magdeburg. Most infections were acute with high viral loads. Most cases originated from pediatric, gynecologic, and hematologic departments, highlighting particularly vulnerable patient populations.</p><p><strong>Conclusions: </strong>This resurgence in symptomatic PB19V infections, likely driven by pandemic-related shifts in immunity and exposure, underscores the need for heightened clinical awareness, early testing in high-risk populations, and sustained surveillance to anticipate future outbreaks.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rising rates of sepsis in England: an ecological study.","authors":"Victoria B Allen, Katie Bechman, Mark D Russell, Maryam A Adas, Anna L Goodman, Mark J McPhail, Sam Norton, James B Galloway","doi":"10.1007/s15010-025-02601-0","DOIUrl":"https://doi.org/10.1007/s15010-025-02601-0","url":null,"abstract":"<p><strong>Purpose: </strong>Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. It is a major cause of morbidity and mortality. A contemporary overview of sepsis epidemiology in England is long overdue. This study provides an update on the incidence of sepsis-coded hospital admissions and mortality following the COVID-19 pandemic, focusing on the relative contribution of different bacterial pathogens to sepsis-coded admissions.</p><p><strong>Methods: </strong>We undertook a descriptive study of all hospital admissions from April 1998 to March 2024 using routinely collected health data. Information on sepsis admission episodes, causative pathogens, age, sex, length-of-stay and mortality were collected.</p><p><strong>Results: </strong>Sepsis-coded hospital admissions increased from 27.9 admissions per 100,000 in 1998 to 210.4 in 2023, a 7.5-fold increase. The incidence of sepsis-coded admissions due to most pre-specified pathogens of interest increased. The largest increases were seen for sepsis due to Enterococci, Streptococcus pyogenes, gram-negative bacteria, Streptococcus agalactiae, Staphylococcus aureus and Listeria spp. Sepsis due to meningococcus decreased. The percentage of patients aged ≥ 75 years admitted with sepsis increased from 32.4 to 52.5% of sepsis cases. Median length-of-stay was 6.1 days. Sepsis-coded admissions and mortality decreased during the COVID-19 pandemic. These have now returned to pre-pandemic levels.</p><p><strong>Conclusion: </strong>The recorded incidence of sepsis-coded hospital admissions has risen. This may have been impacted by coding changes and improved disease recognition. The decrease in meningococcal sepsis may reflect the success of vaccination campaigns. Further research is needed to explore concurrent trends in sepsis severity, predict who is at greatest risk and improve prevention efforts.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Untreated baseline imbalances distort piperacillin/tazobactam versus carbapenem non-inferiority evaluation.","authors":"Taiga Yaginuma, Mizuki Seki, Atsushi Shiraishi","doi":"10.1007/s15010-025-02594-w","DOIUrl":"https://doi.org/10.1007/s15010-025-02594-w","url":null,"abstract":"","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Bacteremic nosocomial pneumonia caused by Gram-negative bacilli: results from the nationwide ALARICO study in Italy.","authors":"Giusy Tiseo, Valentina Galfo, Sergio Carbonara, Andrea Marino, Giovanni Di Caprio, Anna Carretta, Alessandra Mularoni, Michele Fabiano Mariani, Alberto Enrico Maraolo, Riccardo Scotto, Lidia Dalfino, Lorenzo Corbo, Margherita Macera, Alice Annalisa Medaglia, Maria Luca d'Errico, Claudia Gioè, Christian Sgroi, Rosa Fontana Del Vecchio, Giancarlo Ceccarelli, Antonio Albanese, Calogero Buscemi, Simona Talamanca, Giuseppe Foti, Giulio De Stefano, Antonina Franco, Carmelo Iacobello, Salvatore Corrao, Domenico Morana, Filippo Pieralli, Ivan Gentile, Teresa Santantonio, Antonio Cascio, Nicola Coppola, Bruno Cacopardo, Mario Venditti, Francesco Menichetti, Marco Falcone","doi":"10.1007/s15010-025-02528-6","DOIUrl":"https://doi.org/10.1007/s15010-025-02528-6","url":null,"abstract":"","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum copper, zinc and selenium and their ratios as predictors of pneumonia death risk in men: the Kuopio Ischaemic Heart Disease Risk Factor Study.","authors":"Jaakko T Laine, Tomi-Pekka Tuomainen, Jukka T Salonen, Jyrki K Virtanen","doi":"10.1007/s15010-025-02596-8","DOIUrl":"https://doi.org/10.1007/s15010-025-02596-8","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to assess the associations between serum concentrations of copper, zinc and selenium, and pneumonia death risk.</p><p><strong>Methods: </strong>Study included 2088 men from the Kuopio Ischaemic Heart Disease Risk Factor Study aged 42-60 years. Pneumonia deaths were collected by computer linkage to the national Causes of Death Register. Cox proportional hazards regression models, adjusted for multiple variables, were used for analysis.</p><p><strong>Results: </strong>During a mean follow-up of 21.7 years (SD 7.5 years), 139 pneumonia deaths occurred. The multivariable-adjusted hazard ratio for pneumonia death in the highest serum copper-to-zinc-ratio and copper concentration tertiles were 1.75 (95% CI: 1.13-2.71) and 1.64 (95% CI: 1.08-2.50), respectively. Serum zinc concentration showed a statistically significant association with pneumonia death, with the lowest risk observed in the second tertile and no further decrease in risk in the highest tertile. Serum copper-to-selenium ratio nor selenium concentrations were associated with pneumonia death risk.</p><p><strong>Conclusions: </strong>Our findings suggest that a higher serum copper-to-zinc-ratio and higher serum copper concentration are associated with increased risk of pneumonia death, while a higher serum zinc concentration is linked to a decreased risk of pneumonia death in middle-aged and older men.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to identify respiratory pathogens in primary health care - a review on the benefits, prospects and pitfalls in using point of care tests.","authors":"Manfred Nairz, Guenter Weiss","doi":"10.1007/s15010-025-02600-1","DOIUrl":"https://doi.org/10.1007/s15010-025-02600-1","url":null,"abstract":"<p><strong>Purpose: </strong>Respiratory tract infections are among the most common reasons for consultations in primary health care (PHC) settings. In this review, we aim to provide an overview of diagnostic tests for selected respiratory pathogens useful in PHC.</p><p><strong>Methods: </strong>We performed a PubMed search on diagnostic tests for influenza virus, respiratory syncytial virus (RSV), Severe Acute Respiratory Syndrome Coronavirus type 2 (SARS-CoV-2), Streptococcus pneumoniae, Legionella pneumophila, Mycoplasma pneumoniae and Bordetella pertussis. We then selected and summarized clinical trials, meta-analyses and systematic reviews published between May 1994 and April 2025 relevant to PHC.</p><p><strong>Results: </strong>Diagnostic tests are useful if the test result will guide subsequent clinical management. Polymerase chain reaction (PCR) tests have high diagnostic accuracy but are not always available in PHC. Accurate rapid antigen detections tests (RADTs) are required to have a sensitivity of at least 80% and a specificity of at least 97% and are available for influenza virus, RSV and SARS-CoV-2 as are urinary antigen tests for Streptococcus pneumoniae and Legionella pneumophila. In contrast, due to the lack of appropriate RADTs, infections with Mycoplasma pneumoniae or Bordetella pertussis typically require PCR tests.</p><p><strong>Conclusion: </strong>From a clinical perspective, the differentiation between viral and bacterial infections and the accurate identification of the specific causative agent may guide medical interventions including antimicrobial therapy. From a diagnostic perspective, adequate microbiologic sampling and careful interpretation of laboratory test results in a clinical context are central requirements.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting antimicrobial restriction: outcomes of pharmacist-led stewardship interventions at the university hospital Salzburg.","authors":"Eva Past, Laura Hartmann, Robert Zimmermann, Georg Zimmermann, Markus Wallner, Lisa Walter, Ulrike Porsche, Jan Marco Kern","doi":"10.1007/s15010-025-02604-x","DOIUrl":"https://doi.org/10.1007/s15010-025-02604-x","url":null,"abstract":"<p><strong>Purpose: </strong>Antimicrobial overuse and misuse remain critical challenges. This study examined pharmacist-led post-prescription interventions targeting restricted antimicrobials in a university hospital, identifying underlying drug-related problems (DRPs), their clinical relevance, economic impact and characteristic patterns of inappropriate use.</p><p><strong>Methods: </strong>A retrospective observational analysis (January- December 2022) was conducted at the Salzburg State Hospitals using routine data of pharmacist-led interventions on restricted antimicrobials. DRPs and intervention types were categorized using validated criteria. Clinical relevance was independently assessed through an external survey, and interrater reliability was determined to ensure consistency in classification and evaluation. Potential cost savings and acceptance rates of the pharmaceutical interventions were assessed.</p><p><strong>Results: </strong>A total of 3897 restricted antimicrobial prescriptions were analyzed, with 11.7% (456) showing at least one DRP in 366 patients. The majority of DRPs (80.2%) exhibited marked clinical relevance, mainly due to non-conformance with guidelines (27.4%), unclear indication (27.2%), and the need for patient or drug monitoring (12.5%). Broad-spectrum agents linezolid (25.0%), meropenem (24.1%), ciprofloxacin (15.8%), and piperacillin-tazobactam (8.8%) accounted for nearly 74% of all DRPs. DRP-related interventions aimed at optimizing PK/PD parameters (30.6%), treatment discontinuation (28.1%), and de-escalation (17.9%). The acceptance rate of interventions was high (82.7%). A cost reduction potential was identified in 89.7% of interventions, saving €180,420 in avoided drug expenses.</p><p><strong>Conclusion: </strong>Pharmacist-led post-prescription interventions within an established AMS program effectively identified clinically relevant misuse of restricted antimicrobials. Targeted actions on key agents enable high-impact optimization, supported by strong acceptance and cost-saving potential - thereby enhancing stewardship efforts, guiding improvements in diagnostics, and prescribing behavior.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}