A fatal pediatric case of meningitis and streptococcal toxic shock syndrome caused by emm12 Streptococcus pyogenes strain in Jiangsu, China, 2024.

IF 3.6 2区医学 Q1 INFECTIOUS DISEASES

Infection Pub Date : 2025-09-05 DOI:10.1007/s15010-025-02638-1

Lili Huang, Zhenhua Liu, Zhenjiang Bai, Mi Zhou, Panpan Lv, Yue Jiang, Mingliang Chen

引用次数: 0

Abstract

A 23-month-old boy was admitted to our hospital with onset of fever and paroxysmal cough but progressed to death on Day 9. Streptococcus pyogenes was positive in cerebrospinal fluid and blood by next-generation sequencing, and was cultured from sputum. The isolate was resistant to erythromycin, clindamycin, and tetracycline. By genomic analysis, the isolate was identified to be emm12 of global Clade II and harbor mobile genetic elements of ICE-emm12 and ΦHKU.vir, carrying resistance genes ermB and tetM. We report a fatal case of meningitis case complicated with streptococcal toxic shock syndrome caused by emm12 S. pyogenes in China, which is rare in this country.

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2024年江苏省emm12型化脓性链球菌致小儿脑膜炎链球菌中毒性休克综合征1例死亡

一名23个月大的男婴因发热和阵发性咳嗽入院，但在第9天进展至死亡。脑脊液和血液经新一代测序检测为化脓性链球菌阳性，痰培养为化脓性链球菌。该分离株对红霉素、克林霉素和四环素耐药。通过基因组分析，该分离物被鉴定为全球Clade II的emm12，并含有ICE-emm12和ΦHKU的移动遗传元件。vir，携带抗性基因ermB和tetM。我们报告一例由emm12化脓性链球菌引起的脑膜炎合并链球菌中毒性休克综合征致死病例，这在中国是罕见的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Infection 医学-传染病学

CiteScore

12.50

自引率

1.30%

发文量

224

审稿时长

6-12 weeks

期刊介绍： Infection is a journal dedicated to serving as a global forum for the presentation and discussion of clinically relevant information on infectious diseases. Its primary goal is to engage readers and contributors from various regions around the world in the exchange of knowledge about the etiology, pathogenesis, diagnosis, and treatment of infectious diseases, both in outpatient and inpatient settings. The journal covers a wide range of topics, including: Etiology: The study of the causes of infectious diseases. Pathogenesis: The process by which an infectious agent causes disease. Diagnosis: The methods and techniques used to identify infectious diseases. Treatment: The medical interventions and strategies employed to treat infectious diseases. Public Health: Issues of local, regional, or international significance related to infectious diseases, including prevention, control, and management strategies. Hospital Epidemiology: The study of the spread of infectious diseases within healthcare settings and the measures to prevent nosocomial infections. In addition to these, Infection also includes a specialized "Images" section, which focuses on high-quality visual content, such as images, photographs, and microscopic slides, accompanied by brief abstracts. This section is designed to highlight the clinical and diagnostic value of visual aids in the field of infectious diseases, as many conditions present with characteristic clinical signs that can be diagnosed through inspection, and imaging and microscopy are crucial for accurate diagnosis. The journal's comprehensive approach ensures that it remains a valuable resource for healthcare professionals and researchers in the field of infectious diseases.