Infection最新文献

{"title":"Correction: Unmasking the mimic: vertebral alveolar echinococcosis diagnosed by metagenomic next‑generation sequencing.","authors":"Tassilo Kruis, Marion Wassermann, Barbara Graf, Katharina Lührig, Peter Menzel, Rolf Schwarzer, Johannes Ziegler, Caroline Isner","doi":"10.1007/s15010-026-02771-5","DOIUrl":"https://doi.org/10.1007/s15010-026-02771-5","url":null,"abstract":"","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147638874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Publisher Correction: A review on antibiotic and non-antibiotic decolonization strategies of multidrug-resistant bacteria in the gastrointestinal tract.","authors":"Tobias Weirauch, Dafna Yahav, Itay Zahavi, Silvia Würstle, Maria J G T Vehreschild","doi":"10.1007/s15010-026-02777-z","DOIUrl":"https://doi.org/10.1007/s15010-026-02777-z","url":null,"abstract":"","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147638823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Efficacy and safety of colistin-doxycycline combination therapy in multi-drug resistance Gram-negative infections: a double-blind randomized controlled trial.","authors":"Shaghayegh Abaft, Zeynab Yassin, Mahdi Ahmadinia, Azadeh Eshraghi, Behnaz Gholizadeh Niari, Sara Minaeian, Maryam Farasatinasab","doi":"10.1007/s15010-026-02756-4","DOIUrl":"https://doi.org/10.1007/s15010-026-02756-4","url":null,"abstract":"","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147638795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delayed hyperergic reaction ensuing puncture drainage of an echinococcal cyst in the left hepatic lobe of a six-year-old boy.","authors":"Amelie Fell, Luise Martin, Florian Nima Fleckenstein, Dominik Geisel, Robert Oellinger, Ute Aurbach, Joachim Richter, Horst von Bernuth","doi":"10.1007/s15010-026-02791-1","DOIUrl":"https://doi.org/10.1007/s15010-026-02791-1","url":null,"abstract":"<p><strong>Background: </strong>The WHO expert group for echinococcosis recommends percutaneous treatment for the treatment of unilocular echinococcal cysts. In the rare case a hyperergic reaction occurs, it occurs as a type I immediate allergic reaction immediately after the cyst wall puncture.</p><p><strong>Case presentation: </strong>A 6-year-old boy with a unilocular echinococcal cyst in the left hepatic lobe, was treated with cyst puncture / drainage via the right hepatic lobe and falciform ligament under coverage with praziquantel and albendazole. No allergic reaction occurred during the procedure, but three hours later an acute severe hyperergic reaction occurred.</p><p><strong>Conclusion: </strong>Patients who have undergone an invasive therapy or suffered an acute leakage of an echinococcal cyst must be closely surveilled with the possibility of intensive care for at least 24 h after intervention.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147633241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chikungunya virus: global epidemiology, transmission dynamics, and emerging challenges for public health.","authors":"Dinglei Rao, Daoyuan Lu, Zijun Yuan, Xin Li, Xu Wu, Mingxing Li, Fukuan Du, Yueshui Zhao, Jing Shen, Chi Hin Cho, Wenxian Yin, Xi He, Zhangang Xiao","doi":"10.1007/s15010-026-02780-4","DOIUrl":"https://doi.org/10.1007/s15010-026-02780-4","url":null,"abstract":"<p><p>During the last twenty years, Chikungunya virus (CHIKV), an arthropod-borne alphavirus, has resurged globally and emerged as an important public health concern. Driven by viral adaptive mutations, rapid urbanization, climate change, and the global expansion of Aedes mosquito habitats, CHIKV has continuously expanded its geographic distribution and triggered recurrent outbreaks across multiple continents. In this review, we comprehensively synthesize recent progress in virology, epidemiology, vector biology, diagnostic innovations, and vaccine research, emphasizing the integrated mechanisms that support its continued worldwide spread. Available data suggest that variation in vector competence, viral evolutionary adaptations (e.g., the E1-A226V mutation), and climatic-ecological shifts are key determinants of CHIKV transmission dynamics. Despite the approval of two vaccines, questions persist concerning their long-term safety profile, sustained immunogenicity, economic viability, and fair access in low-resource regions. Furthermore, substantial clinical overlap with dengue and Zika virus infections poses challenges to accurate diagnosis and epidemiological surveillance. It is essential to reinforce genomic and comprehensive vector surveillance and to develop cross-disciplinary risk prediction platforms within a \"One Health\" framework to improve global preparedness and response capacity. The establishment of data-informed, cooperative prevention strategies remains crucial for reducing the worldwide burden of CHIKV and other comparable arboviral diseases.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147627712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric malaria in a non-endemic European setting: clinical patterns, laboratory markers, and the ambiguous role of immunity.","authors":"Roberta Caiazzo, Benedetta Panero, Marta Carello, Crescenzo Coppola, Raffaella Di Tonno, Anna Hermine Markowich, Marta Stracuzzi, Maria Sole Valentino, Silvia Grosso, Anna Gigantiello, Vania Giacomet","doi":"10.1007/s15010-026-02783-1","DOIUrl":"https://doi.org/10.1007/s15010-026-02783-1","url":null,"abstract":"<p><strong>Purpose: </strong>Pediatric malaria in non-endemic regions poses diagnostic and management challenges, particularly in the context of migration and international travel. This study aimed to characterize clinical, laboratory, and epidemiological features of pediatric malaria in a European non-endemic setting and to evaluate whether presumed immune status influences disease severity.</p><p><strong>Methods: </strong>We conducted a retrospective study of children diagnosed with malaria at a tertiary center in Milan, Italy (2004-2024). Patients were stratified by presumed immune status into Non-Immune (NI) (Italian-born) and Presumed-Immune (PI) (foreign-born or frequent travelers to endemic areas). Differences between groups were analyzed using the Mann-Whitney U and Fisher's exact tests. Associations between laboratory markers (serum sodium, C-reactive protein [CRP], and platelet count) and clinical outcomes (length of hospital stay and fever duration) were evaluated using Spearman's rank correlation (ρ).</p><p><strong>Results: </strong>Seventy-four cases were included (59% male; median age 9.0 years). Patients were stratified into Non-Immune (NI, 47.3%) and Presumed-Immune (PI, 52.7%) groups; the PI group was significantly older (p < 0.001). P. falciparum (62.2%) and P. vivax (27%) were the main species. Severe malaria (WHO 2015 criteria) occurred in 23% of patients, with no significant difference between NI and PI groups (p = 0.783). Spearman's analysis showed that serum sodium levels were inversely associated with length of hospital stay (ρ = - 0.284, p = 0.020), while CRP levels correlated positively with fever duration (ρ = 0.256, p = 0.033) and strongly negatively with platelet counts (ρ = - 0.585, p < 0.001). A significant therapeutic shift occurred post-2015, with intravenous artesunate replacing quinine as the gold standard treatment for severe malaria.</p><p><strong>Conclusion: </strong>Pediatric malaria severity and biochemical profiles appeared largely independent of presumed immune status in non-endemic settings. Clinical outcomes were more closely associated with admission laboratory markers-particularly hyponatremia and elevated CRP levels-than with geographic proxies of immunity. The adoption of intravenous artesunate as first-line therapy after 2015 was associated with improved clinical management. These findings highlight the need for careful monitoring of all pediatric malaria cases, regardless of prior exposure, as traditional classifications based on presumed immunity may not reliably predict disease severity.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147618677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of Gepotidacin for urogenital infections: a systematic review and meta-analysis of randomized controlled trials.","authors":"Ashesh Das, Umama Alam, Akif Shahid Khan, Debvarsha Mandal, Sailesh I S Kumar, Kommu Hrishikesh, Aparna Malireddi, Hanisha Reddy Kukunoor, Venkata Dileep Kumar Veldi, Ali Naseem, Asim Ali Syed","doi":"10.1007/s15010-026-02726-w","DOIUrl":"https://doi.org/10.1007/s15010-026-02726-w","url":null,"abstract":"<p><strong>Background: </strong>Gepotidacin is a novel triazaacenaphthylene antibiotic that has been proven to be an effective therapeutic option for several urogenital infections, including Neisseria gonorrhoeae (NG). Amidst the rising antimicrobial resistance, this offers a promising alternative to traditional antibiotics. This systematic review and meta-analysis evaluate its efficacy and safety in treating urogenital infections.</p><p><strong>Methods: </strong>A systematic search of PubMed, Embase and Scopus identified Randomized Controlled Trials (RCTs) comparing Gepotidacin with standard antibiotics for urogenital infections from inception up to May 24th, 2025. Data were analyzed using RevMan 5.4.1. Pooled risk ratios (RRs) with 95% CIs were calculated using Mantel-Haenszel methods. Fixed- or random-effects models were used based on heterogeneity (I²). Statistical significance was p < 0.05. Risk of bias was assessed via RoB 2.0.</p><p><strong>Findings: </strong>Three RCTs (N = 3756) were included. Gepotidacin achieved similar microbiological cure rates for urogenital NG vs. controls (RR 1.10; 95% CI 0.96-1.27; p = 0.17; I² = 85%). Microbiological failure rates were lower in the gepotidacin group but did not reach statistical significance (RR 0.83; 95% CI 0.69-1.00; p = 0.06; I² = 49%). Extragenital site cure rates also showed no statistically significant difference (RR 1.04; 95% CI 0.88-1.22; p = 0.64; I² = not reported). Clinical cure rates were comparable (RR 1.02; 95% CI 0.97-1.07; p = 0.36; I² = 0%). However, Gepotidacin was linked to a higher rate of treatment-emergent adverse events (AEs) (RR 1.71; 95% CI 1.31-2.24; p < 0.0001; I² = 88%), notably gastrointestinal AEs like diarrhea (RR 4.72; 95% CI 3.59-6.20; p < 0.00001; I² = 33%) and nausea (RR 3.40; 95% CI 1.67-6.91; p = 0.0007; I² = 84%). AST elevations were also more frequent (RR 1.93; 95% CI 1.08-3.44; p = 0.03; I² = 0%).</p><p><strong>Interpretation: </strong>Gepotidacin demonstrates comparable efficacy to standard antibiotic treatment options for Neisseria gonorrhoeae and other urogenital infections. However, it is associated with a significantly higher incidence of gastrointestinal adverse events and elevated liver enzymes, which may impact patient tolerability and compliance.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ecthyma gangrenosum in a neutropenic patient.","authors":"Andrea Misin, Stefano Di Bella","doi":"10.1007/s15010-026-02788-w","DOIUrl":"https://doi.org/10.1007/s15010-026-02788-w","url":null,"abstract":"","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of an oral bedaquiline regimen for treating multidrug-resistant TB in China: a randomized trial.","authors":"Jingtao Gao, Zhongfeng Huang, Fei Ren, Yuqing Wu, Hua Wang, Guihui Wu, Juan Du, Xiaofeng Yan, Yi Pei, Long Jin, Yu Xiong, Lian Shi, Junwei Cui, Xiaohong Chen, Xiujie Li, Wei Sha, Huiru An, Katleen Callewaert, Nacer Lounis, Nyasha Bakare, Yanxin Jiang, Ruiqi Zhang, Lu Wang, Mengqiu Gao, Liang Li","doi":"10.1007/s15010-026-02734-w","DOIUrl":"https://doi.org/10.1007/s15010-026-02734-w","url":null,"abstract":"<p><strong>Introduction: </strong>Bedaquiline (BDQ) is recommended in China as component of oral short-course regimens (SCR) for MDR-TB patients. However, the efficacy and safety of BDQ containing oral SCRs remain insufficiently validated in large-scale, well-designed clinical trials involving the Chinese population.</p><p><strong>Methods: </strong>A randomized, non-inferiority, open-label trial was conducted at 17 hospital clinics in China, enrolling adult patients with MDR-TB. Participants were assigned in a 1:1 ratio to receive either a 40-week oral BDQ-containing SCR or a 40-week oral non BDQ-containing SCR. The primary endpoint was the proportion of participants achieving favorable outcome at the end of treatment. The non-inferiority margin of the difference in proportion between the BDQ and control groups in the modified intent-to-treat (mITT) population was set at -15%.</p><p><strong>Results: </strong>A total of 217 participants were randomized. Among 182 patients in the mITT population, the BDQ-containing SCR group achieved an 80.0% favorable outcome compared to 59.8% in the non-BDQ group, with an adjusted difference of 22.27% (95% CI 9.41-35.13%). BDQ-containing SCR was also associated with higher proportions of modified favorable outcomes and cure rates. Additionally, BDQ-containing SCR resulted in a higher culture conversion rate at the end of treatment and a shorter time to culture conversion. Serious adverse events occurred in 16 of 110 participants (14.5%) in the BDQ-containing SCR group and 25 of 107 participants (23.4%) in the non-BDQ-containing SCR group.</p><p><strong>Conclusion: </strong>40-week BDQ-SCR proved non-inferior and superior, safe, and well tolerated in Chinese patients with MDR-TB. Further investigation into the long-term safety and efficacy of the BDQ-containing regimen is still needed in China.</p><p><strong>Clinicaltrials: </strong>gov NCT05306223. Prospectively registered on 16 March 2022.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147591889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary fungus ball due to Scedosporium apiospermum mimicking aspergilloma: a case report.","authors":"Koji Ohyama, Yasuhiro Hida, Yuka Kondo, Akira Watanabe","doi":"10.1007/s15010-025-02609-6","DOIUrl":"10.1007/s15010-025-02609-6","url":null,"abstract":"","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":"1021-1025"},"PeriodicalIF":3.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}