Geographic origins, transmission hotspots, and drug resistance mutations of HIV-1 CRF08_BC in Zhejiang Province, China.

IF 5.4 2区医学 Q1 INFECTIOUS DISEASES

Infection Pub Date : 2025-04-08 DOI:10.1007/s15010-025-02530-y

Hehe Zhao, Jun Jiang, Chengliang Chai, Xiaohong Pan, Fan Lyu, Hui Xing, Yi Feng, Wei Cheng, Guixia Li, Jianhua Mei, Ping Zhong, Zhihong Guo, Xin Zhou, Qin Fan, Jiafeng Zhang

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引用次数: 0

Abstract

Purpose: To understand the geographic origins, transmission hotspots, and drug resistance mutations (DRMs) of HIV-1 CRF08_BC in Zhejiang Province, China.

Methods: This study analyzed HIV-1 CRF08_BC pol sequences collected between 2020 and 2023. Bayesian inference was employed to investigate temporal epidemic trends, while HIV-TRACE and MCODE were used to identify transmission clusters (TCs), key hotspots and super-spreaders. DRMs associated with CRF08_BC were also characterized. Additionally, demographic data were integrated with these findings, allowing for a description of the transmission dynamics.

Results: This study revealed that CRF08_BC strains in Zhejiang likely originated from Guangxi, with significant transmission among individuals aged 50 and older, particularly those with low educational levels. Molecular transmission analysis showed that 58.9% of CRF08_BC sequences were in TCs, with geographic concentrations in Taizhou (TZ) and Lishui (LS). 14 large clusters maintained effective reproductive numbers (Re) above 1, representing considerable epidemic growth. Hangzhou (HZ) emerged as a key transmission hub, with 10 TCs showing active transmission. LS established strong epidemiological links with HZ, Ningbo (NB), Taizhou (TZ), and Wenzhou (WZ), creating a pattern of viral spread radiating from LS to surrounding areas. DRMs were identified in 76 cases (6.0%), with NNRTI and NRTI mutations exhibiting distinct geographic clustering.

Conclusions: The CRF08_BC strains in Zhejiang likely originated from Guangxi and are mainly found in individuals aged 50 and older with low education. The current epidemic hotspots are in TZ and LS, where NNRTI and NRTI mutations are clustered, significantly impacting treatment efficacy.

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目的：了解中国浙江省HIV-1 CRF08_BC的地理起源、传播热点和耐药性变异（DRMs）：本研究分析了 2020 年至 2023 年间收集的 HIV-1 CRF08_BC pol 序列。研究采用贝叶斯推断法调查疫情的时间趋势，同时利用HIV-TRACE和MCODE识别传播集群（TC）、关键热点和超级传播者。还对与 CRF08_BC 相关的 DRM 进行了特征描述。此外，还将人口统计学数据与这些发现结合起来，以描述传播动态：研究结果表明，浙江的CRF08_BC菌株可能来自广西，在50岁及以上人群中传播显著，尤其是低学历人群。分子传播分析表明，58.9%的CRF08_BC序列在TC中，地域集中在台州和丽水。14个大集群的有效繁殖数（Re）保持在1以上，表明疫情有相当大的增长。杭州（HZ）成为主要的传播中心，有 10 个 TC 出现活跃的传播。LS与杭州（HZ）、宁波（NB）、台州（TZ）和温州（WZ）建立了紧密的流行病学联系，形成了从LS向周边地区辐射的病毒传播模式。在76个病例（6.0%）中发现了DRMs，其中NNRTI和NRTI变异表现出明显的地域聚集性：结论：浙江的 CRF08_BC 株系可能来自广西，主要存在于 50 岁及以上的低学历人群中。目前的流行热点在浙江省和江苏省，NNRTI和NRTI突变在这两个地区聚集，严重影响了治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Infection 医学-传染病学

CiteScore

12.50

自引率

1.30%

发文量

224

审稿时长

6-12 weeks

期刊介绍： Infection is a journal dedicated to serving as a global forum for the presentation and discussion of clinically relevant information on infectious diseases. Its primary goal is to engage readers and contributors from various regions around the world in the exchange of knowledge about the etiology, pathogenesis, diagnosis, and treatment of infectious diseases, both in outpatient and inpatient settings. The journal covers a wide range of topics, including: Etiology: The study of the causes of infectious diseases. Pathogenesis: The process by which an infectious agent causes disease. Diagnosis: The methods and techniques used to identify infectious diseases. Treatment: The medical interventions and strategies employed to treat infectious diseases. Public Health: Issues of local, regional, or international significance related to infectious diseases, including prevention, control, and management strategies. Hospital Epidemiology: The study of the spread of infectious diseases within healthcare settings and the measures to prevent nosocomial infections. In addition to these, Infection also includes a specialized "Images" section, which focuses on high-quality visual content, such as images, photographs, and microscopic slides, accompanied by brief abstracts. This section is designed to highlight the clinical and diagnostic value of visual aids in the field of infectious diseases, as many conditions present with characteristic clinical signs that can be diagnosed through inspection, and imaging and microscopy are crucial for accurate diagnosis. The journal's comprehensive approach ensures that it remains a valuable resource for healthcare professionals and researchers in the field of infectious diseases.