Inorganica Chimica Acta最新文献

{"title":"Scrutinizing the DNA interactions and antimicrobial potential of mixed ligand metal complexes incorporating salicylaldehyde-isoniazid Schiff base ligand and quercetin","authors":"Lakshmanan Ramgeetha ,&nbsp;Selvaraj Freeda Selva Sheela ,&nbsp;Michael Samuel ,&nbsp;Natarajan Raman ,&nbsp;Karuppiah Arunsunai Kumar","doi":"10.1016/j.ica.2025.122816","DOIUrl":"10.1016/j.ica.2025.122816","url":null,"abstract":"<div><div>In this work, four mixed ligand transition metal complexes were synthesized to achieve the maximum level of biological efficiency. These complexes were designed by employing a Schiff base incorporating salicylaldehyde and isoniazid (primary ligand), along with quercetin as the co-ligand. Notably, the quercetin meaning a phenolic compound with a greater number of hydroxyl groups, is being used to assess its impact on biological activity. Elemental analysis and various spectroscopic techniques confirm the formation of the complexes. Physico-chemical analyses indicate that all the synthesized metal(II) complexes exhibit an octahedral geometry. The antimicrobial properties of both the ligand and metal(II) complexes were assessed against different bacterial and fungal strains. Additionally, the SWISS ADME online tool was employed to assess their drug-like properties and pharmacokinetic profiles. Further investigations into the DNA binding activity of these metal complexes were conducted using UV absorption studies and viscosity titrations, which supported an intercalative binding mechanism. Notably, molecular docking studies were performed to evaluate interactions with the 1BNA. The outcome of this work suggests that the synthesized complexes exhibit higher biological efficiency when related to the isoniazid incorporated Schiff base ligand due to chelation effect.</div></div>","PeriodicalId":13599,"journal":{"name":"Inorganica Chimica Acta","volume":"587 ","pages":"Article 122816"},"PeriodicalIF":2.7,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A room temperature ionic liquid-based molecular chameleon for selective and sensitive detection of sarin analog","authors":"Jyoti Chourasia ,&nbsp;Akash Deep Jaiswal ,&nbsp;Sabbir Ahamed ,&nbsp;Shubham Lama ,&nbsp;Najmin Tohora ,&nbsp;Manas Mahato ,&nbsp;Ziaur Rahman ,&nbsp;Upika Darnal ,&nbsp;Susanta Ghanta ,&nbsp;Sudhir Kumar Das","doi":"10.1016/j.ica.2025.122814","DOIUrl":"10.1016/j.ica.2025.122814","url":null,"abstract":"<div><div>To ensure the safety of our globe from the deadly nerve gases used by anti-nationalists, the identification and quantification of these lethal substances require more attention from the scientific community. The present report introduces an anionic ionic liquids (ILs)-based chromogenic probe <strong>CsIL</strong>, which is prepared based on an ion exchange reaction between sodium salt of 4-amino-1-naphthalenesulfonic acid and the ionic liquid trihexyltetradecylphosphonium chloride (TTP⁺Cl⁻) and the resultant, followed by simple condensation with <em>N</em>, <em>N</em>-dimethyl cinnamaldehyde, which instantly detects the deadly nerve agent sarin gas mimic diethylchlorophosphate (DCP) in both liquid and gas phases. This ILs-based model probe <strong>CsIL</strong> exhibits remarkable sensitivity and selectivity towards DCP with detection and quantification limits of 11.3 nM and 37.6 nM, respectively, as well as a binding affinity constant of 14,847.9 M⁻¹, thus surpassing many existing chemosensors and being found to be more advantageous than non-ILs-based ones. The probe <strong>CsIL</strong> instantly identifies DCP specifically and selectively by showing a visual colorimetric change from yellow to pink, which is reversed in the presence of triethylamine (TEA). Also, to ensure a real-time handy application, a paper-strip based test kit experiment is been performed for the convenient and reliable detection aid to detect DCP. To explore more about the probe, a smartphone-based experiment is also performed, which provides an outstanding route for the on-site visual detection and quantification of DCP in the presence of different analytes. Furthermore, real sample analysis is also performed by collecting and testing different types of soil to prove the applicability of our probe <strong>CsIL</strong> in real applications. Therefore, our model <strong>CsIL</strong> may prove to be a reliable and effective candidate for the detection of DCP, ensuring the ability to detect sarin gas in real threat scenarios.</div></div>","PeriodicalId":13599,"journal":{"name":"Inorganica Chimica Acta","volume":"587 ","pages":"Article 122814"},"PeriodicalIF":2.7,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144281004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic hybrid of polypyrrole microtubes and magnesium silicates for efficient organic pollutant removal","authors":"Meijun Ji,&nbsp;Xingyu Chi,&nbsp;Mintong Guo,&nbsp;Min Zhang","doi":"10.1016/j.ica.2025.122800","DOIUrl":"10.1016/j.ica.2025.122800","url":null,"abstract":"<div><div>Wastewater contaminated with dyes has garnered significant attention due to its detrimental effects on the environment and public health. Adsorption, being a non-toxic, cost-effective, and highly efficient method, is widely employed for dye removal. Tubular structured materials stand out as attractive adsorbents because of their high specific surface areas and rapid mass transfer capabilities. In this study, we present, for the first time, the synthesis of tubular structured PPy@MgSiO₃ nanocomposites through an innovative approach combining polymerization, the Stöber method, and subsequent hydrothermal treatment. These nanocomposites, featuring hierarchical MgSiO₃ nanosheets (NSs), PPy interlayers, and a tubular structure with an exceptional specific surface area, demonstrate remarkable adsorption capabilities. Specifically, they effectively remove methylene blue (MB) from water within 180 min at room temperature. The adsorption process primarily adheres to Lagergren pseudo-first-order kinetics, while the Langmuir isotherm model provides an excellent fit, indicating a very high monolayer adsorption capacity of 224.57 mg/g at ambient temperature. Moreover, this protecting layer assisted Stöber method can be extended to synthesize tubular FeOOH@CuSiO₃ composites, which was also proved to be an excellent dye adsorbent. This work pioneers a straightforward strategy for crafting different kinds of hierarchical tubular metal silicate composites for dye removal.</div></div>","PeriodicalId":13599,"journal":{"name":"Inorganica Chimica Acta","volume":"587 ","pages":"Article 122800"},"PeriodicalIF":2.7,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144281000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel Zirconocene derived from substituted as-indacene: Synthesis, characterization, and DFT insights into its electronic structure and stability","authors":"Yuvaraja Dibdalli ,&nbsp;Cesar Morales-Verdejo ,&nbsp;Daniela E. Ortega ,&nbsp;Andy Mella ,&nbsp;Elies Molins ,&nbsp;Sateesha M. Kannakatte ,&nbsp;Mahesha ,&nbsp;Mungalimane K. Amshumali","doi":"10.1016/j.ica.2025.122801","DOIUrl":"10.1016/j.ica.2025.122801","url":null,"abstract":"<div><div>We focus on the synthesis, characterization, and theoretical analysis of a novel zirconocene complex derived from substituted 2,7-diethyl-1,8-dihydro-<em>as</em>-indacene (<em>as</em>-Ic'H₂).This complex [(Cp*ZrCl₂)₂-<em>as</em>-Ic´], was synthesized from the dilithiated salt of <em>as</em>-indacene [<em>as</em>-Ic´][Li]₂ with two equivalents of [(Cp*ZrCl₃)]. Comprehensive characterization was performed using ¹H and ¹³C NMR spectroscopy, elemental analysis, and X-ray diffraction. Density Functional Theory (DFT) calculations revealed that the dicationic pathway for ethylene polymerization exhibits enhanced thermodynamic stability and favorable orbital interactions, offering a more efficient initiation process than the cationic pathway. However, higher activation barriers were identified in the dicationic pathway, suggesting that targeted steric modifications could further optimize catalytic performance. These findings provide strategic insights for designing more effective bimetallic zirconocene catalysts.</div></div>","PeriodicalId":13599,"journal":{"name":"Inorganica Chimica Acta","volume":"587 ","pages":"Article 122801"},"PeriodicalIF":2.7,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144270997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of potent water-soluble Ag(I) coordination polymers based on bridging phthalate linker: X-ray structure, anticancer, and antimicrobial evaluation","authors":"Mostafa A. El-Naggar ,&nbsp;Morsy A.M. Abu-Youssef ,&nbsp;Matti Haukka ,&nbsp;Assem Barakat ,&nbsp;Ayman El-Faham ,&nbsp;Saied M. Soliman ,&nbsp;Amal Yousri","doi":"10.1016/j.ica.2025.122810","DOIUrl":"10.1016/j.ica.2025.122810","url":null,"abstract":"<div><div>Two novel polymeric Ag(I)-phthalate complexes with pyrazinamide (<strong>PZA</strong>) or 3-cyanopyridine (<strong>3CNPy</strong>) were constructed using self-assembly technique. The complexes' structure was analyzed by single crystal X-ray diffraction (SCX-RD), FTIR, and NMR spectra, in addition to elemental analysis. <strong>[Ag(PZA)(HPhth)]</strong>_{<strong>n</strong>}; <strong>1</strong> (where <strong>HPhth</strong> is hydrogen phthalate group) exhibits two-dimensional polymeric structure <em>via</em> phthalate and <strong>PZA</strong> bridges. The metal center in <strong>[Ag(3CNPy)</strong>_{<strong>2</strong>}<strong>(HPhth)]</strong>_{<strong>n</strong>}; <strong>2</strong> is surrounded by two monodentate <strong>3CNPy</strong> molecules and two bridging phthalate groups giving rise to a 1D coordination polymer. Both complexes have τ₄ value of 0.6 indicating a tetra-coordinated Ag(I) with a highly distorted tetrahedral coordination geometry. Using Hirshfeld surface analysis, the polymeric character of <strong>1</strong> and <strong>2</strong> was demonstrated by the red patches in their d_norm maps corresponding to Ag<img>O bonds with percentages of 8.1 and 2.4%, respectively. Complexes <strong>1</strong> and <strong>2</strong> display promising cytotoxicity against lung (IC₅₀ = 4.87 ± 0.48 and 6.48 ± 0.64 μM, respectively) and breast (IC₅₀ = 2.98 ± 0.30 and 5.47 ± 0.48 μM, respectively) carcinoma. This remarkable anticancer activity is better than the anticancer drug <em>cis</em>-platin (IC₅₀ = 24.91 ± 2.29 and 15.24 ± 1.76 μM for A-549 and MCF-7, respectively). With SI up to 6.0, both complexes are considered as safe anticancer treatments. In addition, <strong>1</strong> and <strong>2</strong> show wide-spectrum antimicrobial activities where <strong>2</strong> shows potent antibacterial action against <em>B. subtilis</em> with MIC = 9.7 μg/mL.</div></div>","PeriodicalId":13599,"journal":{"name":"Inorganica Chimica Acta","volume":"587 ","pages":"Article 122810"},"PeriodicalIF":2.7,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144271000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probing the effect of isomeric -OH group in heteroleptic Copper(I)-triphenylphosphine appended dithiocarbamates on their electrocatalytic properties for homogeneous hydrogen evolution reactions","authors":"Daniel Omoding ,&nbsp;Aparna Kushwaha ,&nbsp;Shreya Srivastava ,&nbsp;Mohd. Muddassir ,&nbsp;Gabriele Kociok-Köhn ,&nbsp;Abhinav Kumar","doi":"10.1016/j.ica.2025.122802","DOIUrl":"10.1016/j.ica.2025.122802","url":null,"abstract":"<div><div>Due to increasing interest in alternative cost-effective electrocatalysts containing transition metals, three new heteroleptic triphenylphenylphosphine appended copper(I) dithiocarbamate complexes [Cu(S₂CN(CH₂C₆H₅)(CH₂C₆H₄-<em>o</em>-OH))(PPh₃)₂] (<strong>Cu-<em>o</em>-OH</strong>), [Cu(S₂CN(CH₂C₆H₅)(CH₂C₆H₄-<em>m</em>-OH))(PPh₃)₂] (<strong>Cu-<em>m</em>-OH</strong>) and [Cu(S₂CN(CH₂C₆H₅)(CH₂C₆H₄-<em>p</em>-OH))(PPh₃)₂] (<strong>Cu-<em>p</em>-OH</strong>), have been synthesized, characterized spectroscopically and by single crystal X-ray diffraction. The single crystal X-ray studies suggest that for <strong>Cu-<em>o</em>-OH</strong> and <strong>Cu-<em>m</em>-OH,</strong> copper(I) possess a distorted P₂S₂ coordinate tetrahedral geometry. The solid-state framework of <strong>Cu-<em>o</em>-OH</strong> has been found to be majorly stabilized by O-H···S intermolecular interactions, while that of <strong>Cu-<em>m</em>-OH</strong> is sustained by C-H···C and O-H···S interactions, whose nature has been assessed by Hirshfeld surface analysis. The homogeneous electrocatalytic properties of the complexes for proton reduction reveal that the <em>i</em>_cat/<em>i</em>_Pc values of complexes are greater than 28, while utilizing trifluoroacetic acid (TFA) as a proton source. In all complexes, the ratio <em>i</em>_c/<em>i</em>_wc have been found to be greater than 1, indicating that these complexes can effectively catalyze proton reduction to hydrogen in acetonitrile. Amongst all the three complexes, <strong>Cu-<em>p</em>-OH</strong> has been found to be the best electrocatalyst with low overpotential (<em>η</em>) of 0.876 V and a highest turnover frequency (TOF) of 539.60 s⁻¹ on adding 70 mM TFA. The best catalytic activity of <strong>Cu-<em>p</em>-OH</strong> has been attributed to its larger HOMO-LUMO energy gap and a more positive charge on copper(I) compared to other isomeric complexes that assists the complex to attract more electron density that could have readily enhanced its electrocatalytic performance.</div></div>","PeriodicalId":13599,"journal":{"name":"Inorganica Chimica Acta","volume":"587 ","pages":"Article 122802"},"PeriodicalIF":2.7,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anion influence on the structure and cytotoxicity of Copper(II) complexes based on 2,2’-bipyridine/1,10-phenanthroline and benzimidazole derivative","authors":"Yu.A. Golubeva ,&nbsp;E.A. Ermakova ,&nbsp;K.S. Smirnova ,&nbsp;L.S. Klyushova ,&nbsp;N.P. Zaytsev ,&nbsp;N.A. Osik ,&nbsp;A.S. Berezin ,&nbsp;A.S. Potapov ,&nbsp;E.V. Lider","doi":"10.1016/j.ica.2025.122803","DOIUrl":"10.1016/j.ica.2025.122803","url":null,"abstract":"<div><div>Eight new copper(II) coordination compounds have been synthesized by the reactions of Cu(X)₂ salts (X = Cl⁻, Br⁻, NO₃⁻ or ClO₄⁻), 2,2′-bipyridine / 1,10-phenanthroline and 1-(1H-benzimidazol-1-ylmethyl)-1H-1,2,3-benzotriazole (L): [Cu(bipy/phen)LCl₂]·H₂O <strong>(1)/(5)</strong>, [Cu(bipy/phen)LBr₂]·H₂O <strong>(2)/(6)</strong>, Cu(bipy)L₂(NO₃)₂(H₂O) (<strong>3</strong>), [Cu(bipy)L₂(ClO₄)₂]·0.4C₂H₅OH (<strong>4</strong>), {[Cu(phen)L₂(NO₃)]NO₃·0.5H₂O·0.8C₂H₅OH}_n (<strong>7</strong>), [Cu(phen)L₂(MeCN)ClO₄]ClO₄ (<strong>8</strong>). The complexes were characterized by CHN, thermogravimetric and high-resolution electrospray mass spectrometric analysis, IR spectroscopy, powder and single-crystal X-ray diffraction. A crystallographic study revealed that Cu:bipy/phen:L ratio, the geometry of the complexes and their nuclearity differ depending on the selected anions. Stability of the complexes in ethanol and phosphate-buffered saline was studied by UV–Vis and EPR spectroscopy. <em>In vitro</em> cytotoxic activity was determined against three tumor cell lines (A549, Hep2, HepG2) and non-tumor lung fibroblasts MRC5. All complexes exhibit dose-dependent cytotoxicity on tumor cells with phenanthroline-based compounds <strong>5–8</strong> being 3–10 times more cytotoxic than medical drug cisplatin.</div></div>","PeriodicalId":13599,"journal":{"name":"Inorganica Chimica Acta","volume":"587 ","pages":"Article 122803"},"PeriodicalIF":2.7,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144255001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, structure and chemical reactivity of pyridine-2-thione/pyrimidine-2-thione derivatives of mercury (II) and silver(I)","authors":"Yachika Teji ,&nbsp;Kashima Soni ,&nbsp;Tarlok S. Lobana ,&nbsp;Ray J. Butcher","doi":"10.1016/j.ica.2025.122798","DOIUrl":"10.1016/j.ica.2025.122798","url":null,"abstract":"<div><div>A reaction of mercury (II) iodide with pyridine-2-thione (pytH) in 1: 2 (M: L) molar ratio in a CH₃CN-MeOH mixture yielded a light brown compound, [HgI₂(κ¹S-pytH)₂] <strong>1.</strong> A similar reaction with pyrimidine-2-thione (pymtH) also formed pale yellow crystals of [HgI₂(κ¹S-pymtH)₂] <strong>2.</strong> Further, mercury(II) bromide with pytH in CH₃CN in presence of DMF yielded a de-brominated compound [Hg(κ¹S-pyt)₂] <strong>3</strong>. Compounds <strong>1</strong> and <strong>2</strong> have distorted tetrahedral geometry, while compound <strong>3</strong> has linear geometry. In case of silver, the reaction of AgBr with pytH in the presence of excess PPh₃, designed for the preparation of a mononuclear compound, [AgBr(pytH)(PPh₃)₂], rather yielded a dinuclear compound, [Ag₂Br₂(μ-S-pytH)₂(PPh₃)₂] <strong>4.</strong> Finally, AgNO₃ with pymtH and PPh₃ in a 1: 1: 2 M ratio has formed the ionic complex, [Ag(κ¹S-pymtH)(PPh₃)₂](NO₃) <strong>5,</strong> with a distorted trigonal planar cation. The presence of DMF solvent under hot experimental conditions favoured de-halogenation of mercury halides (Br, Cl), and in case of silver, the size of the anions affected the nature of the silver products.</div></div>","PeriodicalId":13599,"journal":{"name":"Inorganica Chimica Acta","volume":"587 ","pages":"Article 122798"},"PeriodicalIF":2.7,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A mini review: Chalcogenated triazole schiff base ligands utilized for Hg2+ metal ion detection","authors":"Arjumand Sumayya,&nbsp;Umme Salma,&nbsp;Salman A. Khan","doi":"10.1016/j.ica.2025.122789","DOIUrl":"10.1016/j.ica.2025.122789","url":null,"abstract":"<div><div>It is a scientifically demanding task to use triazole schiff bases as fluorogenic cation sensors and fluorescent chemosensors. Triazole schiff base derivatives have recently drawn increased interest due to their structural diversity. Because of intramolecular charge transfer (ICT), donor and acceptor group joined with a delocalized π-orbital exhibit superior fluorescence effect. A slight alteration in photophysical characteristics and the usual sensing behaviour of a hypochromic/hyperchromic or hypsochromic/bathochromic shift are the results of triazole schiff bases coordinating with the metal ions. In this review, we looked into the design, synthesis, ON/OFF &amp; OFF/ON Hg²⁺ metal ion sensing mechanism, and practical application of the probes in an effort to merge the previously published triazole schiff baes-derived sensors. This review centres on the development of triazole schiff base as a fluorescent chemosensor for the study of Hg²⁺ metal ions over the course of decades. In order to further explore the topic of triazole schiff base-based sensors for metal ion detection, we hope that this review will offer a basic framework.</div></div>","PeriodicalId":13599,"journal":{"name":"Inorganica Chimica Acta","volume":"587 ","pages":"Article 122789"},"PeriodicalIF":2.7,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144335749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amendment of the biocidal linkers in the metal-organic framework (MIL-68-NH2) through post-synthetic modification to increase biological activity","authors":"F.M. Aldosari ,&nbsp;Roba M.S. Attar ,&nbsp;Mohammed A. Imam ,&nbsp;Rami Pashameah ,&nbsp;Awatif R.Z. Almotairy ,&nbsp;Aisha Hossan ,&nbsp;Ameena M. Al-Bonayan ,&nbsp;Nashwa M. El-Metwaly","doi":"10.1016/j.ica.2025.122799","DOIUrl":"10.1016/j.ica.2025.122799","url":null,"abstract":"<div><div>Conventional antibiotics are ineffective against the growing number of multidrug-resistant bacteria that are posing a high risk to public health. Although traditional nanoparticles like metal and metal oxides have potent antibacterial properties, their excessive release of metal ions into human tissues as well as bacteria might have detrimental health effects. As a result, looking for alternative material becomes essential. Metal-organic frameworks (MOFs) are gaining interest, due to they combine two distinct areas—an organic part that exhibits intense and rapid bacterial activity and an inorganic part that contains broad-spectrum antibacterial agents. Additionally, MOFs' appropriate size enables them to either break through the bacterial membrane and degrade it or enter biofilm walls and start acting as an antibacterial agent. The ions for metal release, biocidal linkers, or even biocidal compounds enclosed in MOFs may be the source of MOFs' biological activity. MOFs are attractive prospects for biological and pharmaceutical applications because of these characteristics. Organic linkers of MOFs can be altered through solid-liquid reactions without compromising the characteristics of MOFs, the post-synthetic modification (PSM) technique is suited for bio active MOF synthesis because biocidal linkers are difficult to synthesis and can damaged before MOF formation. Here, 3-(2-hydroxyphenyl)-3-oxopropanal, methyl vinyl ketone, glyoxylic acid, and phthalaldehyde were used to synthesis and post-synthetically modify the metal organic framework based on indium ions (MIL-68-NH₂), yielding MIL-68-HP, MIL-68-VK, MIL-68-GA, and MIL-68-PA in 40, 80, 87, and 92 %, respectively. The comprehensive study, involving synthesis, characterization, and detailed biological activity testing of the modified MOFs was investigated. The findings suggest that the PSM MOFs exhibit greater biological activity than commercial antibiotics against several tested microbial species. The obtained results showed the importance of MOFs used as an alternative to conventional antibiotics, and the PSM approach to tailor their properties was a valid strategy.</div></div>","PeriodicalId":13599,"journal":{"name":"Inorganica Chimica Acta","volume":"586 ","pages":"Article 122799"},"PeriodicalIF":2.7,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144205244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}