第一个6-羟黄酮和7-羟黄酮修饰的单螺环三磷腈化合物：合成、表征和生物活性研究

IF 2.7 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Inorganica Chimica Acta Pub Date : 2025-06-16 DOI:10.1016/j.ica.2025.122812

İbrahim Kitmür , Seda Mesci , Ebru Batı Ay , Tuba Yıldırım , Gönül Yenilmez Çiftçi

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引用次数: 0

摘要

与癌症的斗争需要一种多功能和更有效的癌症治疗方法，将新药设计、靶向治疗和对肿瘤微环境的更深入了解结合起来。对羟基黄酮和环三磷腈的研究强调了它们在癌症研究中的重要性，展示了它们从抗癌特性到潜在应用的多种药理活性。本研究首次合成了6-和7-羟基黄酮修饰的单螺旋环三磷杂烯，并通过元素分析、MALDI-TOF MS、1H、13C、31P NMR和FT-IR光谱对其进行了分析。此外，通过DPPH自由基清除试验、总酚含量和总黄酮含量分析来评价化合物的抗氧化活性。此外，使用WST-8细胞活力测定法在MCF-7（乳腺腺癌）和MCF-12A（非致瘤性乳腺上皮）细胞系中评估了化合物的细胞毒性作用。羟基黄酮衍生的环三磷腈化合物具有选择性抗氧化活性（DPPH: %93.48，总酚：91.74，总黄酮：87.20）。WST-8法测定化合物对MCF-7（人乳腺癌）细胞的细胞毒活性为54.13 (IC50:27.10)，为抗癌研究提供了有意义和有效的数据。这些发现共同强调了羟黄酮修饰的环三磷烯在推进癌症治疗策略中的重要作用。

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The first 6-hydroxyflavone and 7-hydroxyflavone decorated monospiro cyclotriphosphazene compounds: Synthesis, characterization and biological activity studies

The fight against cancer requires a versatile and more effective approach to cancer treatments that combines the design of new drugs, targeted therapies, and a deeper understanding of the tumour microenvironment. Research on hydroxyflavones and cyclotriphosphazene underscores their importance in cancer research, showcasing their diverse pharmacological activities ranging from anti-cancer properties to potential applications. In our study, the first 6- and 7-hydroxyflavone decorated monospiro cyclotriphosphazenes were synthesized and analysed by elemental analysis, MALDI-TOF MS, ¹H, ¹³C, ³¹P NMR and FT-IR spectroscopy. Furthermore, the antioxidant activities of the compounds were evaluated using DPPH radical scavenging assay, total phenolic content, and total flavonoid content analyses. Additionally, the cytotoxic effects of the compounds were assessed in MCF-7 (breast adenocarcinoma) and MCF-12A (non-tumorigenic mammary epithelial) cell lines using the WST-8 cell viability assay. Hydroxyflavone-derived cyclotriphosphazene compounds showed selective antioxidant (DPPH: %93.48, total phenolic: 91.74, and total flavonoid: 87.20) activities. The cytotoxicity results of the compounds in MCF-7 (human breast cancer) cells using the WST-8 method showed a viability% activity of 54.13 (IC₅₀:27.10), providing meaningful and effective data for anticancer studies. These findings collectively emphasize the significant role of hydroxyflavone decorated cyclotriphosphazenes in advancing cancer treatment strategies.

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来源期刊

Inorganica Chimica Acta 化学-无机化学与核化学

CiteScore

6.00

自引率

3.60%

发文量

440

审稿时长

35 days

期刊介绍： Inorganica Chimica Acta is an established international forum for all aspects of advanced Inorganic Chemistry. Original papers of high scientific level and interest are published in the form of Articles and Reviews. Topics covered include: • chemistry of the main group elements and the d- and f-block metals, including the synthesis, characterization and reactivity of coordination, organometallic, biomimetic, supramolecular coordination compounds, including associated computational studies; • synthesis, physico-chemical properties, applications of molecule-based nano-scaled clusters and nanomaterials designed using the principles of coordination chemistry, as well as coordination polymers (CPs), metal-organic frameworks (MOFs), metal-organic polyhedra (MPOs); • reaction mechanisms and physico-chemical investigations computational studies of metalloenzymes and their models; • applications of inorganic compounds, metallodrugs and molecule-based materials. Papers composed primarily of structural reports will typically not be considered for publication.