Preliminary study on ex vivo efficacy of curcumin‑silver nanoparticles as a treatment of human pterygium-derived keratinocytes

IF 2.7 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Inorganica Chimica Acta Pub Date : 2025-06-23 DOI:10.1016/j.ica.2025.122826

Francesco Rossi , Gianmarco Stati , Thithawat Trakoolwilaiwan , Nguyen Thi Kim Thanh , Silvia Sancilio , Roberta Di Pietro

引用次数: 0

Abstract

Pterygium is a progressive disease of the human eye in which an invasive growth arises from the sub-conjunctival tissue and extends onto the cornea, eventually reaching the pupil and compromising visual function. This disease is commonly diffused in human population living in the tropical region with an average incidence of 7 % of cases in India, Singapore and China and peaks of 30 % in Japan. The available surgical or pharmacological treatments are only partially successful in stopping the disease and imply a great risk of aggressive relapse. The proposed inorganic nanoparticles conjugated with curcumin have demonstrably been able to reduce of 30 % ± 0.2 % the vitality of pterygium keratinocytes extracted by affected patients, thus offering an alternative therapeutic option for the containment of this human disease.

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姜黄素-银纳米颗粒治疗人翼状胬肉源性角化细胞体外疗效的初步研究

翼状胬肉是人眼的一种进行性疾病，其侵袭性生长起源于结膜下组织并延伸到角膜，最终到达瞳孔并损害视觉功能。该病通常在生活在热带地区的人群中传播，印度、新加坡和中国的平均发病率为7%，日本的峰值为30%。现有的手术或药物治疗只能部分成功地阻止疾病，并且有很大的复发风险。拟议的与姜黄素结合的无机纳米颗粒已被证明能够使受影响患者提取的翼状胬肉角质形成细胞的活力降低30%±0.2%，从而为遏制这种人类疾病提供了另一种治疗选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Inorganica Chimica Acta 化学-无机化学与核化学

CiteScore

6.00

自引率

3.60%

发文量

440

审稿时长

35 days

期刊介绍： Inorganica Chimica Acta is an established international forum for all aspects of advanced Inorganic Chemistry. Original papers of high scientific level and interest are published in the form of Articles and Reviews. Topics covered include: • chemistry of the main group elements and the d- and f-block metals, including the synthesis, characterization and reactivity of coordination, organometallic, biomimetic, supramolecular coordination compounds, including associated computational studies; • synthesis, physico-chemical properties, applications of molecule-based nano-scaled clusters and nanomaterials designed using the principles of coordination chemistry, as well as coordination polymers (CPs), metal-organic frameworks (MOFs), metal-organic polyhedra (MPOs); • reaction mechanisms and physico-chemical investigations computational studies of metalloenzymes and their models; • applications of inorganic compounds, metallodrugs and molecule-based materials. Papers composed primarily of structural reports will typically not be considered for publication.