Inflammation and Regeneration最新文献

筛选
英文 中文
Studies on immune regulation for allogeneic iPSC-based transplantation. 异体ipsc移植的免疫调控研究。
IF 8.1 3区 医学
Inflammation and Regeneration Pub Date : 2022-12-30 DOI: 10.1186/s41232-022-00249-z
Ken-Ichiro Seino
{"title":"Studies on immune regulation for allogeneic iPSC-based transplantation.","authors":"Ken-Ichiro Seino","doi":"10.1186/s41232-022-00249-z","DOIUrl":"https://doi.org/10.1186/s41232-022-00249-z","url":null,"abstract":"","PeriodicalId":13588,"journal":{"name":"Inflammation and Regeneration","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9801599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10517222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Autoinflammatory disease: clinical perspectives and therapeutic strategies. 更正:自身炎症性疾病:临床观点和治疗策略。
IF 8.1 3区 医学
Inflammation and Regeneration Pub Date : 2022-12-29 DOI: 10.1186/s41232-022-00251-5
Atsushi Kawakami, Yushiro Endo, Tomohiro Koga, Koh-Ichiro Yoshiura, Kiyoshi Migita
{"title":"Correction: Autoinflammatory disease: clinical perspectives and therapeutic strategies.","authors":"Atsushi Kawakami, Yushiro Endo, Tomohiro Koga, Koh-Ichiro Yoshiura, Kiyoshi Migita","doi":"10.1186/s41232-022-00251-5","DOIUrl":"https://doi.org/10.1186/s41232-022-00251-5","url":null,"abstract":"","PeriodicalId":13588,"journal":{"name":"Inflammation and Regeneration","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2022-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9798589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10821150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Cytokines and cytokine receptors as targets of immune-mediated inflammatory diseases-RA as a role model. 校正:细胞因子和细胞因子受体是免疫介导的炎症性疾病的靶标-类风湿性关节炎是一个榜样。
IF 8.1 3区 医学
Inflammation and Regeneration Pub Date : 2022-12-28 DOI: 10.1186/s41232-022-00250-6
Tsutomu Takeuchi
{"title":"Correction: Cytokines and cytokine receptors as targets of immune-mediated inflammatory diseases-RA as a role model.","authors":"Tsutomu Takeuchi","doi":"10.1186/s41232-022-00250-6","DOIUrl":"https://doi.org/10.1186/s41232-022-00250-6","url":null,"abstract":"","PeriodicalId":13588,"journal":{"name":"Inflammation and Regeneration","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9795624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10453238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subarachnoid hemorrhage triggers neuroinflammation of the entire cerebral cortex, leading to neuronal cell death. 蛛网膜下腔出血引发整个大脑皮层的神经炎症,导致神经元细胞死亡。
IF 8.1 3区 医学
Inflammation and Regeneration Pub Date : 2022-12-14 DOI: 10.1186/s41232-022-00236-4
Hiroki Yamada, Yoshitaka Kase, Yuji Okano, Doyoon Kim, Maraku Goto, Satoshi Takahashi, Hideyuki Okano, Masahiro Toda
{"title":"Subarachnoid hemorrhage triggers neuroinflammation of the entire cerebral cortex, leading to neuronal cell death.","authors":"Hiroki Yamada,&nbsp;Yoshitaka Kase,&nbsp;Yuji Okano,&nbsp;Doyoon Kim,&nbsp;Maraku Goto,&nbsp;Satoshi Takahashi,&nbsp;Hideyuki Okano,&nbsp;Masahiro Toda","doi":"10.1186/s41232-022-00236-4","DOIUrl":"https://doi.org/10.1186/s41232-022-00236-4","url":null,"abstract":"<p><strong>Background: </strong>Subarachnoid hemorrhage (SAH) is a fatal disease, with early brain injury (EBI) occurring within 72 h of SAH injury contributes to its poor prognosis. EBI is a complicated phenomenon involving multiple mechanisms. Although neuroinflammation has been shown to be important prognosis factor of EBI, whether neuroinflammation spreads throughout the cerebrum and the extent of its depth in the cerebral cortex remain unknown. Knowing how inflammation spreads throughout the cerebrum is also important to determine if anti-inflammatory agents are a future therapeutic strategy for EBI.</p><p><strong>Methods: </strong>In this study, we induced SAH in mice by injecting hematoma into prechiasmatic cistern and created models of mild to severe SAH. In sections of the mouse cerebrum, we investigated neuroinflammation and neuronal cell death in the cortex distal to the hematoma injection site, from anterior to posterior region 24 h after SAH injury.</p><p><strong>Results: </strong>Neuroinflammation caused by SAH spread to all layers of the cerebral cortex from the anterior to the posterior part of the cerebrum via the invasion of activated microglia, and neuronal cell death increased in correlation with neuroinflammation. This trend increased with the severity of the disease.</p><p><strong>Conclusions: </strong>Neuroinflammation caused by SAH had spread throughout the cerebrum, causing neuronal cell death. Considering that the cerebral cortex is responsible for long-term memory and movement, suppressing neuroinflammation in all layers of the cerebral cortex may improve the prognosis of patients with SAH.</p>","PeriodicalId":13588,"journal":{"name":"Inflammation and Regeneration","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10361948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
State-of-the-art liver disease research using liver-on-a-chip. 利用片上肝脏进行最先进的肝病研究。
IF 5 3区 医学
Inflammation and Regeneration Pub Date : 2022-12-09 DOI: 10.1186/s41232-022-00248-0
Sayaka Deguchi, Kazuo Takayama
{"title":"State-of-the-art liver disease research using liver-on-a-chip.","authors":"Sayaka Deguchi, Kazuo Takayama","doi":"10.1186/s41232-022-00248-0","DOIUrl":"10.1186/s41232-022-00248-0","url":null,"abstract":"<p><p>To understand disease pathophysiologies, models that recapitulate human functions are necessary. In vitro models that consist of human cells are preferred to ones using animal cells, because organ functions can vary from species to species. However, conventional in vitro models do not recapitulate human organ functions well. Organ-on-a-chip technology provides a reliable in vitro model of the functional units of human organs. Organ-on-a-chip technology uses microfluidic devices and their accessories to impart organ functions to human cells. Using microfluidic devices, we can co-culture multiple cell types that compose human organs. Moreover, we can culture human cells under physiologically relevant stresses, such as mechanical and shear stresses. Current organ-on-a-chip technology can reproduce the functions of several organs including the liver. Because it is difficult to maintain the function of human hepatocytes, which are the gold standard of in vitro liver models, under conventional culture conditions, the application of liver-on-a-chips to liver disease research is expected. This review introduces the current status and future prospects of liver-on-a-chips in liver disease research.</p>","PeriodicalId":13588,"journal":{"name":"Inflammation and Regeneration","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2022-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9733013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10328315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research hotspots and trends for axon regeneration (2000-2021): a bibliometric study and systematic review. 轴突再生研究热点与趋势(2000-2021):文献计量学研究与系统评价。
IF 8.1 3区 医学
Inflammation and Regeneration Pub Date : 2022-12-07 DOI: 10.1186/s41232-022-00244-4
Yuyu Chou, Homaira Nawabi, Jingze Li
{"title":"Research hotspots and trends for axon regeneration (2000-2021): a bibliometric study and systematic review.","authors":"Yuyu Chou,&nbsp;Homaira Nawabi,&nbsp;Jingze Li","doi":"10.1186/s41232-022-00244-4","DOIUrl":"https://doi.org/10.1186/s41232-022-00244-4","url":null,"abstract":"<p><strong>Background: </strong>Axons play an essential role in the connection of the nervous system with the rest of the body. Axon lesions often lead to permanent impairment of motor and cognitive functions and the interaction with the outside world. Studies focusing on axon regeneration have become a research field with considerable interest. The purpose of this study is to obtain an overall perspective of the research field of axonal regeneration and to assist the researchers and the funding agencies to better know the areas of greatest research opportunities.</p><p><strong>Methods: </strong>We conducted a bibliometric analysis and Latent Dirichlet Allocation (LDA) analysis of the global literature on axon regeneration based on the Web of Science (WoS) over the recent 22 years, to address the research hotspots, publication trends, and understudied areas.</p><p><strong>Results: </strong>A total of 21,018 articles were included, which in the recent two decades has increased by 125%. Among the top 12 hotspots, the annual productions rapidly increased in some topics, including axonal regeneration signaling pathway, axon guidance cues, neural circuits and functional recovery, nerve conduits, and cells transplant. Comparatively, the number of studies on axon regeneration inhibitors decreased. As for the topics focusing on nerve graft and transplantation, the annual number of papers tended to be relatively stable. Nevertheless, the underlying mechanisms of axon regrowth have not been completely uncovered. A lack of notable research on the epigenetic programs and noncoding RNAs regulation was observed. The significance of cell-type-specific data has been highlighted but with limited research working on that. Functional recovery from neuropathies also needs further studies.</p><p><strong>Conclusion: </strong>The last two decades witnessed tremendous progress in the field of axon regeneration. There are still a lot of challenges to be tackled in translating these technologies into clinical practice.</p>","PeriodicalId":13588,"journal":{"name":"Inflammation and Regeneration","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2022-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9727899/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10389690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Neutralizing and enhancing antibodies against SARS-CoV-2. 中和和增强针对SARS-CoV-2的抗体。
IF 8.1 3区 医学
Inflammation and Regeneration Pub Date : 2022-12-05 DOI: 10.1186/s41232-022-00233-7
Yafei Liu, Hisashi Arase
{"title":"Neutralizing and enhancing antibodies against SARS-CoV-2.","authors":"Yafei Liu,&nbsp;Hisashi Arase","doi":"10.1186/s41232-022-00233-7","DOIUrl":"https://doi.org/10.1186/s41232-022-00233-7","url":null,"abstract":"<p><p>The high transmissibility and rapid global spread of SARS-CoV-2 since 2019 has led to a huge burden on healthcare worldwide. Anti-SARS-CoV-2 neutralizing antibodies play an important role in not only protecting against infection but also in clearing the virus and are essential to providing long-term immunity. On the other hand, antibodies against the virus are not always protective. With the emergence of SARS-CoV-2 immune escape variants, vaccine design strategies as well as antibody-mediated therapeutic approaches have become more important. We review some of the findings on SARS-CoV-2 antibodies, focusing on both basic research and clinical applications.</p>","PeriodicalId":13588,"journal":{"name":"Inflammation and Regeneration","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9720987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10321660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Role of the Hippo pathway in liver regeneration and repair: recent advances. Hippo通路在肝脏再生和修复中的作用:最新进展。
IF 8.1 3区 医学
Inflammation and Regeneration Pub Date : 2022-12-05 DOI: 10.1186/s41232-022-00235-5
Monica Pibiri, Gabriella Simbula
{"title":"Role of the Hippo pathway in liver regeneration and repair: recent advances.","authors":"Monica Pibiri,&nbsp;Gabriella Simbula","doi":"10.1186/s41232-022-00235-5","DOIUrl":"https://doi.org/10.1186/s41232-022-00235-5","url":null,"abstract":"<p><p>Although the signaling pathways involved in normal liver regeneration have been well characterized, less has been done for livers affected by chronic tissue damage. These \"abnormal livers\" have an impaired regenerative response that leads to liver repair and fibrosis. The tumor suppressor Hippo pathway plays a key role in liver regeneration and repair. On this basis, this review discusses recent studies focusing on the involvement of the Hippo signaling pathway during \"normal healthy liver regeneration\" (i.e., in a normal liver after 2/3 partial hepatectomy) and \"abnormal liver regeneration\" (i.e., in a liver damaged by chronic disease). This could be an important question to address with respect to new therapies aimed at improving impaired liver regenerative responses. The studies reported here have shown that activation of the Hippo coactivators YAP/TAZ during normal liver regeneration promotes the formation of a new bile duct network through direct BEC proliferation or/and hepatocyte dedifferentiation to HPCs which can trans-differentiate to BECs. Moreover, YAP/TAZ signaling interaction with other signaling pathways mediates the recruitment and activation of Kupffer cells, which release mitogenic cytokines for parenchymal and/or non-parenchymal cells and engage in phagocytosis of cellular debris. In addition, YAP-mediated activation of stellate cells (HSCs) promotes liver regeneration through the synthesis of extracellular matrix. However, in chronically diseased livers, where the predetermined threshold for proper liver regeneration is exceeded, YAP/TAZ activation results in a reparative process characterized by liver fibrosis. In this condition, YAP/TAZ activation in parenchymal and non-parenchymal cells results in (i) differentiation of quiescent HSCs into myofibroblastic HSCs; (ii) recruitment of macrophages releasing inflammatory cytokines; (iii) polarization of macrophages toward the M2 phenotype. Since accumulation of damaged hepatocytes in chronic liver injury represent a significant risk factor for the development of hepatocarcinoma, this review also discussed the involvement of the Hippo pathway in the clearance of damaged cells.</p>","PeriodicalId":13588,"journal":{"name":"Inflammation and Regeneration","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9720992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10321656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Cross-talk between nervous, immune, and metabolic systems. 神经系统、免疫系统和代谢系统之间的串扰。
IF 8.1 3区 医学
Inflammation and Regeneration Pub Date : 2022-12-03 DOI: 10.1186/s41232-022-00222-w
Yoshimitsu Nakanishi, Sujin Kang, Atsushi Kumanogoh
{"title":"Cross-talk between nervous, immune, and metabolic systems.","authors":"Yoshimitsu Nakanishi,&nbsp;Sujin Kang,&nbsp;Atsushi Kumanogoh","doi":"10.1186/s41232-022-00222-w","DOIUrl":"https://doi.org/10.1186/s41232-022-00222-w","url":null,"abstract":"","PeriodicalId":13588,"journal":{"name":"Inflammation and Regeneration","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2022-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9719111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40458350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: IL-6 production through repression of UBASH3A gene via epigenetic dysregulation of super-enhancer in CD4+ T cells in rheumatoid arthritis. 校正:类风湿关节炎患者CD4+ T细胞超增强子表观遗传失调,通过抑制UBASH3A基因产生IL-6。
IF 8.1 3区 医学
Inflammation and Regeneration Pub Date : 2022-12-02 DOI: 10.1186/s41232-022-00246-2
Kaoru Yamagata, Shingo Nakayamada, Tong Zhang, Anh Phuong Nguyen, Naoaki Ohkubo, Shigeru Iwata, Shigeaki Kato, Yoshiya Tanaka
{"title":"Correction: IL-6 production through repression of UBASH3A gene via epigenetic dysregulation of super-enhancer in CD4+ T cells in rheumatoid arthritis.","authors":"Kaoru Yamagata,&nbsp;Shingo Nakayamada,&nbsp;Tong Zhang,&nbsp;Anh Phuong Nguyen,&nbsp;Naoaki Ohkubo,&nbsp;Shigeru Iwata,&nbsp;Shigeaki Kato,&nbsp;Yoshiya Tanaka","doi":"10.1186/s41232-022-00246-2","DOIUrl":"https://doi.org/10.1186/s41232-022-00246-2","url":null,"abstract":"","PeriodicalId":13588,"journal":{"name":"Inflammation and Regeneration","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2022-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9717508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10695105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信