Infectious Agents and Cancer最新文献

{"title":"Mandatory preventive vaccines for infectious diseases expressing T-cell epitopes for cancer prevention.","authors":"Concetta Ragone, Angela Mauriello, Beatrice Cavalluzzo, Simona Mangano, Biancamaria Cembrola, Noemi Ciotola, Luigi Buonaguro, Maria Tagliamonte","doi":"10.1186/s13027-025-00683-x","DOIUrl":"https://doi.org/10.1186/s13027-025-00683-x","url":null,"abstract":"<p><p>We have previously reported that microorganism-associated antigens (MAAs) share high sequence and conformational homology with tumor-associated antigens (TAAs) as well as T cells cross-react with homologous MAA/TAA pairs. More recently, we have also shown that the SARS-CoV-2 preventive vaccine, besides the humoral response, is able to elicit also a T cell response which cross-react with homologous TAAs. In the present study we analyzed the mandatory pediatric vaccines, namely the hexavalent vaccine (Diphtheria, Tetanus, Pertussis (whooping cough), Polio, Haemophilus influenzae type b (Hib), Hepatitis B) and the MMR (measles, mumps and rubella), and the chickenpox vaccine. MHC class I epitopes (9 mers) from each of these vaccines were predicted for the most frequent 12 HLA A and B alleles. Overall, 3177 strong binders (SBs) were identified and the most frequently associated allele is the HLA-A*02:01. Of these, 397 are predicted for the hexavalent vaccine and 571 in the MMR vaccine. A molecular mimicry with 59 SBs derived from cellular proteins has been identified and 13 of these proteins are significantly overexpressed in several human cancers. All these results strongly suggest that the mandatory pediatric vaccinations may potentially elicit a CD8⁺ T cell response against several microbial epitopes in individuals with different genetic background. Such microbial epitopes show high homology with epitopes from cellular proteins overexpressed in multiple cancer types. Therefore, a potential anti-microbial CD8⁺ T cell response may cross-react against cancer cells. This would imply that the pediatric vaccinations may be a preventive measure against both microbial infections and a broad spectrum of tumors. A large-scale immune-epidemiological study will be needed to confirm the proposed suggestive results.</p>","PeriodicalId":13568,"journal":{"name":"Infectious Agents and Cancer","volume":"20 1","pages":"50"},"PeriodicalIF":3.1,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular interaction of human papilloma virus (HPV) with microRANs: insights into the development of cervical cancer and treatment approaches.","authors":"Seyedeh Mahdieh Khoshnazar, Navvabeh Salarizadeh, Maryam Mohammad-Sadeghipour, Amirhossein Shahpar, Morteza Izadi, Mohammad Javad Behzadnia, Mahdi Farhadi Khoozani, Mina Alimohammadi, Najma Farahani, Kiavash Hushmandi","doi":"10.1186/s13027-025-00677-9","DOIUrl":"https://doi.org/10.1186/s13027-025-00677-9","url":null,"abstract":"<p><p>Cervical cancer is one of the leading causes of cancer-related death among women worldwide, and high-risk human papillomavirus (HR-HPV) plays a crucial role in its development. HPV's oncogenic processes include the viral oncoproteins E6 and E7, which interfere with essential biological processes, causing DNA instability and uncontrolled cell growth. Recent research suggests that microRNAs (miRNAs) have a role in HPV-mediated tumor development, with dysregulation of particular miRNAs influencing cancer cell proliferation, immune escape, and therapy resistance. This review summarizes the most recent research on HPV's molecular interactions with host miRNAs, focusing on their functions in regulating tumor-suppressive genes and oncogenic mechanisms. Furthermore, we investigate HPV-induced epigenetic alterations that contribute to miRNA dysregulation and corresponding changes in cell cycle control, apoptosis, and metastasis. Discovering these molecular interactions provides fresh insights into personalized medicine techniques for CC detection and therapy.</p>","PeriodicalId":13568,"journal":{"name":"Infectious Agents and Cancer","volume":"20 1","pages":"49"},"PeriodicalIF":3.1,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HPV16/HPV58 viral load is non-linearly correlated with cervical lesions and can be used as a triage marker.","authors":"Jie Zhou, Bingbing Ma, Jinjin Ji, Jianhong Liao, Hongyan Xu, Hongbo Hu","doi":"10.1186/s13027-025-00684-w","DOIUrl":"https://doi.org/10.1186/s13027-025-00684-w","url":null,"abstract":"<p><p>The significance of viral load from high-risk human papillomavirus (HR-HPV) in the detection of cervical lesions is still debated. This study aims to assess the correlation between the viral load of the most common high-risk genotypes (HPV16, HPV18, HPV52, HPV53, HPV58, and HPV68) and cervical lesions in South China, and to ascertain the role of specific HPV viral load types as potential diagnostic biomarkers for cervical lesions. The study included 1787 patients, with HPV types and viral load measured by fluorescent PCR method. The relationship between viral load and cervical lesions was analyzed through both linear and non-linear methods. Viral loads of HPV 16/18/52/58 are risk factors for the occurrence of cervical lesions, Notably, HPV16 and HPV58 respectively demonstrated a non-linear association with the emergence of CIN1 + and CIN2 + cervical lesions, indicating that HPV viral load may serve as a stratification marker for recognizing heightened risk of cervical lesions, thus enhancing risk stratification in cervical cancer screening.</p>","PeriodicalId":13568,"journal":{"name":"Infectious Agents and Cancer","volume":"20 1","pages":"48"},"PeriodicalIF":3.1,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics and prognostic impact of HPV infection in head and neck cancer patients in china: a nationwide multicenter study.","authors":"Qi-Jian Zheng, Hong-Hao Wang, Chao Ding, Guang Han, Li Li, Xiao-Li Cui, Shao-Kai Zhang, Hong-Ying Yang, Yan Wang, Yong-Zhen Zhang, Wen-Jun Wang, Yu-Ting Hong, Mei-Wen Yuan, Xue-Lian Zhao, Shang-Ying Hu, Jun-Ling Wang, Fang-Hui Zhao","doi":"10.1186/s13027-025-00680-0","DOIUrl":"10.1186/s13027-025-00680-0","url":null,"abstract":"<p><strong>Background: </strong>Human papillomavirus (HPV) has emerged as a major cause of head and neck cancer (HNC), yet nationwide HPV-stratified disease data are still lacking in China. The literature remains divided on the prognostic impact of HPV infection.</p><p><strong>Methods: </strong>The HNC patients treated from 1 January 2017 to 30 June 2021 were retrospectively identified at nine tertiary A centers representing the seven geographic regions of China. Event-free survival (EFS) and cancer-specific survival (CSS) were estimated with the Kaplan-Meier method and compared using the log-rank test. Early survival differences by subsite and HPV status were assessed using restricted mean survival time differences for EFS (ΔRMEFST) and CSS (ΔRMCSST), adjusting for confounders with pseudo-value regression.</p><p><strong>Results: </strong>The study included 345 cases. Most of the Chinese HNC patients in this study were male (84.64%), and more than one-third were already at clinical Tumor-Node-Metastasis (cTNM) stage IV at diagnosis. Among the 237 patients who underwent HPV testing, 18.99% were HPV-positive, with the highest prevalence in oropharyngeal cancers (37.29%) and the lowest in laryngeal cancers (7.48%; p < 0.001). A higher proportion of HPV‑positive patients consumed alcohol (44.44%), received radiotherapy (53.33%) and chemotherapy (88.89%), whereas a lower proportion underwent surgery (62.22%) (all p < 0.001). In oral cancer, EFS was higher in the HPV-positive group (log-rank p = 0.002); after adjustment for confounders, the 12-month ΔRMEFST was 1.576 months (95%CI = 0.157, 2.996; p = 0.029). Among patients with oropharyngeal cancer, both EFS and CSS were higher in the HPV-positive group than in the HPV-negative group (all log-rank p < 0.050). After multivariable adjustment, the 12-month ΔRMCSST was 0.629 months (95%CI = 0.019, 1.238; p = 0.043). Laryngeal cancer patients showed no HPV-related differences in EFS or CSS (all p > 0.050). A 24-month landmark sensitivity analysis confirmed the survival advantage in oral and oropharyngeal cancer.</p><p><strong>Conclusions: </strong>Demographics, risk profiles, presentation, and treatment patterns differ sharply by HPV status. Early survival is better for HPV-positive oral and oropharyngeal cancers but not for laryngeal cancer.</p>","PeriodicalId":13568,"journal":{"name":"Infectious Agents and Cancer","volume":"20 1","pages":"47"},"PeriodicalIF":3.1,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12273054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of risk factors of cholangiocarcinoma, role of diabetes mellitus and hepatitis B virus infection in the intrahepatic and extrahepatic cholangiocarcinoma: a retrospective case-based study in China.","authors":"Hasan Md Rasadul, Peng-Cheng Kang, Jing-Lin Li, Shi-Hui Ma, Cheng-Hong Duan, Xu-Dong Zhao, Yun-Fu Cui","doi":"10.1186/s13027-025-00681-z","DOIUrl":"10.1186/s13027-025-00681-z","url":null,"abstract":"<p><strong>Background: </strong>The cause and carcinogenesis of cholangiocarcinoma (CCA) remain unclear. In this study, we conducted a population-based case-control study in China to evaluate the effects of diabetes mellitus (DM), hepatitis B virus (HBV) infection, and other potential risk factors for cholangiocarcinoma (CCA).</p><p><strong>Methods: </strong>A hospital-based, case-control study was conducted, including 245 CCA patients (168 with extrahepatic cholangiocarcinoma (eCCA) and 77 with intrahepatic cholangiocarcinoma (iCCA), diagnosed at The Second Affiliated Hospital of Harbin Medical University in China between January 2019 and June 2024, along with 490 healthy controls matched in a 2:1 ratio. Conditional logistic regression and the synergism index were used to analyze risk factors for cholangiocarcinoma and their potential correlations.</p><p><strong>Results: </strong>There was an association between DM, HBV infection, cholelithiasis, choledocholithiasis, hepatolithiasis, and thyroid diseases were significantly and positively correlated with CCA, with adjusted odds ratios (AOR = 1.53; 95% CI = 1.26-1.85; P < 0.001), (AOR = 2.55; 95% CI = 1.25-5.20; P < 0.010), (AOR = 1.71; 95% CI = 1.14-2.58; P < 0.009), (AOR = 4.67; 95% CI = 1.76-12.37; P < 0.002), (AOR = 3.00; 95% CI = 1.24-7.25; P < 0.015), and (AOR = 5.46; 95% CI = 2.04-14.60; P < 0.001) respectively. A synergistic interaction between HBV infection and DM was investigated using an interactive bar chart. In the subgroup analyses, the results for eCCA included DM (AOR = 1.40; 95% CI = 1.10-1.78; P < 0.006), cholelithiasis (AOR = 1.60; 95% CI = 1.14-2.31; P < 0.013), CBD stones (AOR = 4.05; 95% CI = 1.47-11.12; P < 0.007), hepatolithiasis (AOR = 5.80; 95% CI = 1.50-22.40; P < 0.010), and thyroid diseases (AOR = 11.18; 95% CI = 2.57-48.5; P < 0.001), all of which were significant for eCCA. Whereas DM (AOR = 2.61; 95%CI = 1.52-4.48; P < 0.001), cholelithiasis (AOR = 4.34; 95%CI = 1.53-12.34; P < 0.006), hepatolithiasis (AOR = 3.55; 95%CI = 1.05-12.00; P < 0.042), and HBV infection (AOR = 3.55; 95%CI = 1.55-8.15; P < 0.003) were significant risk factors for iCCA. Synergistic interaction between HBV infection and DM was also observed, resulting in a stronger association. Furthermore, a history of cholecystectomy (AOR = 0.39; 95%CI = (0.15-0.99); p < 0.048) demonstrates a protective function.</p><p><strong>Conclusion: </strong>This Chinese study found that DM is an independent risk factor for CCA, particularly iCCA, and also increases the risk of eCCA. HBV infection is exclusively associated with iCCA, whereas choledocholithiasis, hepatolithiasis, and DM can cause both eCCA and iCCA. CBD stones enhance CCA risk, especially eCCA. By understanding this synergy, effective prevention methods for high-risk CCA may be established.</p>","PeriodicalId":13568,"journal":{"name":"Infectious Agents and Cancer","volume":"20 1","pages":"46"},"PeriodicalIF":3.1,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12265379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HPV prevalence and genotype distribution among women in sanming, China: a retrospective analysis before large-scale vaccination.","authors":"Xiang Jiang, Jia Luo, Dexiang Zhuo, Chunjing Chen, Yaru Li, Shiying Chen, Yingming Sun, Huanming Lin","doi":"10.1186/s13027-025-00678-8","DOIUrl":"10.1186/s13027-025-00678-8","url":null,"abstract":"<p><strong>Background: </strong>To study the prevalence of HPV in Sanming, China before conducting large-scale HPV vaccination is important to guide public health preventive measures and maximize the effectiveness of vaccination.</p><p><strong>Objective: </strong>Provide an overall understanding of the prevalence of HPV in Sanming to help guide HPV screening and vaccine selection in the future.</p><p><strong>Methods: </strong>A retrospective analysis of 11,886 female patients who underwent cervical screening was performed. We analyzed the overall HPV prevalence in the region, the prevalence based on each age group and different genotypes and the distribution of HPV with different pathological diagnoses.</p><p><strong>Results: </strong>The overall HPV prevalence was 17.85%, with peak positivity in the ≤ 20-year group (42.24%) and secondary elevation in 61-70-year-olds (31.90%). HPV52 (23.37%), HPV58 (14.00%), and HPV16 (11.40%) constituted the dominant genotypes. Among 2,122 HPV-positive patients, pathological diagnoses included: chronic cervicitis (83.22%, 1,766/2,122; predominantly HPV52 [22.88%]), low-grade squamous intraepithelial lesions (LSIL, 11.50%, 244/2,122; HPV52 [29.92%]), high-grade SIL (HSIL, 3.49%, 74/2,122; HPV16 [40.54%]), and cervical cancer (1.79%, 38/2,122; HPV16 [52.63%]). Notably, HPV16 prevalence increased significantly with lesion severity.</p><p><strong>Conclusion: </strong>This study found that the overall HPV infection rate in Sanming, China, was slightly higher than in other regions of the country, and the main prevalent genotypes were HPV52 and HPV58. In order to maximize patient benefit, vaccine selection should ideally cover other common genotypes in the region, in addition to HPV16 and HPV18.</p>","PeriodicalId":13568,"journal":{"name":"Infectious Agents and Cancer","volume":"20 1","pages":"45"},"PeriodicalIF":3.1,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12243287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge and attitudes toward HPV, cervical cancer and HPV vaccine among healthcare providers in Ahvaz, Southwest Iran.","authors":"Abdolhussein Shakurnia, Farinam Salehpoor, Mehri Ghafourian, Roohangiz Nashibi","doi":"10.1186/s13027-025-00669-9","DOIUrl":"10.1186/s13027-025-00669-9","url":null,"abstract":"","PeriodicalId":13568,"journal":{"name":"Infectious Agents and Cancer","volume":"20 1","pages":"44"},"PeriodicalIF":3.1,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12239419/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of bovine leukemia virus, Epstein-Barr virus and human papillomavirus in breast cancer tissues of Egyptian patients.","authors":"May Raouf, Salwa Kamal, Rawan Elsayed, Inass Zaki, Dina Kholeif","doi":"10.1186/s13027-025-00674-y","DOIUrl":"10.1186/s13027-025-00674-y","url":null,"abstract":"<p><strong>Background: </strong>Breast cancer (BC) remains one of the most common malignancies worldwide. Many viruses have been linked to BC; namely, Human papillomavirus (HPV), Epstein-Barr virus (EBV) and Bovine leukemia virus (BLV). However, a causal role is yet to be established.</p><p><strong>Objectives: </strong>To detect the prevalence of BLV, EBV and HPV sequences in BC tissue compared to BC-free tissue and correlate their presence with different pathological features of BC.</p><p><strong>Subjects and methods: </strong>A retrospective case-control study was conducted on 75 FFPE (formalin fixed paraffin embedded) blocks of BC tissues and 25 of BC-free tissues obtained from Alexandria Main University Hospital pathology department archive. Demographic, medical, pathological data were retrieved from patients' archival records. Hormonal receptor status, Real-time PCR for viral detection and HPV genotyping were done. Statistical analysis was done using SPSS software. The Chi-square test, Fisher's Exact correction and Monte Carlo simulation were used for quantitative variables.</p><p><strong>Results: </strong>Invasive ductal carcinoma was the most predominant histologic type (85.3%). BLV, EBV and HPV were detected in (22.7% vs. 16%, 14.7% vs. 8%, 6.7% vs. 0%) BC vs. non-BC tissues respectively with HR HPV 16 detection. Lymphovascular invasion (LVI) and stage III were more commonly seen among tissues with positive viral detection vs. those which were negative (64.3% vs. 53% and 39% vs. 17% respectively). However, no single viral detection was found to be statistically significant in relation to clinicopathological parameters. Multiple viral co-existence was found in 18% of PCR positive cases which was significantly associated with younger age (P = 0.026).</p><p><strong>Conclusion: </strong>Low rate of viral presence was found in BC tissues. Nevertheless, LVI and stage III were more commonly seen in tissues with positive viral detection. Moreover, a synergetic relation between multiple viral existence and BC development in young age could be possible yet to be verified.</p>","PeriodicalId":13568,"journal":{"name":"Infectious Agents and Cancer","volume":"20 1","pages":"43"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12218089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The incidence of high-risk HPV infections in Slovakia at the start of the national organized screening for cervical cancer.","authors":"Erik Kudela, Katarina Berakova, Tomas Rokos, Erik Kozubik, Terezia Pribulova, Kamil Biringer, Marian Grendar","doi":"10.1186/s13027-025-00675-x","DOIUrl":"10.1186/s13027-025-00675-x","url":null,"abstract":"","PeriodicalId":13568,"journal":{"name":"Infectious Agents and Cancer","volume":"20 1","pages":"42"},"PeriodicalIF":3.1,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12182681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DC-SIGN (CD209)-mediated interactions between bacteria, lung cancer tissues, and macrophages promote cancer metastasis.","authors":"Qiao Li, Nihal Hasan, Fei Zhao, Ying Xue, Sizhe Zhu, Yin Lv, Ling-Yu Jiang, Kun Yang, Wenjin Li, Yingmiao Zhang, Yingxia He, Huahua Cai, Honghui Ding, John D Klena, Andrey P Anisimov, Shao-Gang Wang, Hongxiang Chen, Chenglin Ye, Jingping Yuan, Tie Chen","doi":"10.1186/s13027-025-00667-x","DOIUrl":"10.1186/s13027-025-00667-x","url":null,"abstract":"<p><p>One of the hallmarks of lung cancers is the earlier metastasis resulting from the dissemination of cancer cells. Although accumulating evidence suggests that bacterial infection may be involved in the development of the metastasis of lung cancer, few studies have explored the molecular mechanisms of bacterial infection in the dissemination of lung cancer cells. A series of studies have indicated that certain Gram-negative bacteria are able to hijack antigen-presenting cells (APCs) via interaction with DC-SIGN (CD209) receptors to facilitate the dissemination of pathogens, including viruses, bacteria, fungi, and parasites. Therefore, in the present work, it was hypothesized that bacterial infection may promote the dissemination of cancer cells via the utilization of a similar mechanism. It was first discovered that human lung cancer tissues contain a very high diversity of bacterial DNAs, indicating the co-existence of lung cancer tissues and microbial organisms. It was then found that lung cancer tissues express DC-SIGN, leading to binding with a Gram-negative bacterium, Shigella sonnei. Further, this bacterium was found to be able not only to induce the expression of DC-SIGN on macrophages but also to enhance the migration ability of lung cancer cells in vitro. The in vivo experiments supported these observations, showing that in wild-type (WT) mice, Shigella sonnei infection significantly increased tumor size, weight, and metastatic nodules compared to SIGNR1 knockout (KO) mice. These observations were associated with increasing DC-SIGN expression in WT mice. Finally, these results suggest that bacterial infections could play a significant role in promoting lung cancer progression and metastasis via DC-SIGN-mediated mechanisms.</p>","PeriodicalId":13568,"journal":{"name":"Infectious Agents and Cancer","volume":"20 1","pages":"40"},"PeriodicalIF":3.1,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12181914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}