HPV16/HPV58 viral load is non-linearly correlated with cervical lesions and can be used as a triage marker.

IF 3.1 2区医学 Q3 IMMUNOLOGY

Infectious Agents and Cancer Pub Date : 2025-07-22 DOI:10.1186/s13027-025-00684-w

Jie Zhou, Bingbing Ma, Jinjin Ji, Jianhong Liao, Hongyan Xu, Hongbo Hu

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引用次数: 0

Abstract

The significance of viral load from high-risk human papillomavirus (HR-HPV) in the detection of cervical lesions is still debated. This study aims to assess the correlation between the viral load of the most common high-risk genotypes (HPV16, HPV18, HPV52, HPV53, HPV58, and HPV68) and cervical lesions in South China, and to ascertain the role of specific HPV viral load types as potential diagnostic biomarkers for cervical lesions. The study included 1787 patients, with HPV types and viral load measured by fluorescent PCR method. The relationship between viral load and cervical lesions was analyzed through both linear and non-linear methods. Viral loads of HPV 16/18/52/58 are risk factors for the occurrence of cervical lesions, Notably, HPV16 and HPV58 respectively demonstrated a non-linear association with the emergence of CIN1 + and CIN2 + cervical lesions, indicating that HPV viral load may serve as a stratification marker for recognizing heightened risk of cervical lesions, thus enhancing risk stratification in cervical cancer screening.

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HPV16/HPV58病毒载量与宫颈病变呈非线性相关，可作为分诊标志。

高危人乳头瘤病毒（HR-HPV）的病毒载量在宫颈病变检测中的意义仍然存在争议。本研究旨在评估华南地区最常见的高危基因型（HPV16、HPV18、HPV52、HPV53、HPV58和HPV68）的病毒载量与宫颈病变的相关性，并确定特定HPV病毒载量类型作为宫颈病变潜在诊断生物标志物的作用。本研究纳入1787例患者，采用荧光PCR法检测HPV类型和病毒载量。采用线性和非线性两种方法分析病毒载量与宫颈病变的关系。HPV 16/18/52/58的病毒载量是宫颈病变发生的危险因素，值得注意的是，HPV16和HPV58分别与CIN1 +和CIN2 +宫颈病变的出现呈非线性相关，提示HPV病毒载量可作为识别宫颈病变高危程度的分层标志，从而加强宫颈癌筛查的风险分层。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Infectious Agents and Cancer ONCOLOGY-IMMUNOLOGY

CiteScore

5.80

自引率

2.70%

发文量

期刊介绍： Infectious Agents and Cancer is an open access, peer-reviewed online journal that encompasses all aspects of basic, clinical, epidemiological and translational research providing an insight into the association between chronic infections and cancer. The journal welcomes submissions in the pathogen-related cancer areas and other related topics, in particular: • HPV and anogenital cancers, as well as head and neck cancers; • EBV and Burkitt lymphoma; • HCV/HBV and hepatocellular carcinoma as well as lymphoproliferative diseases; • HHV8 and Kaposi sarcoma; • HTLV and leukemia; • Cancers in Low- and Middle-income countries. The link between infection and cancer has become well established over the past 50 years, and infection-associated cancer contribute up to 16% of cancers in developed countries and 33% in less developed countries. Preventive vaccines have been developed for only two cancer-causing viruses, highlighting both the opportunity to prevent infection-associated cancers by vaccination and the gaps that remain before vaccines can be developed for other cancer-causing agents. These gaps are due to incomplete understanding of the basic biology, natural history, epidemiology of many of the pathogens that cause cancer, the mechanisms they exploit to cause cancer, and how to interrupt progression to cancer in human populations. Early diagnosis or identification of lesions at high risk of progression represent the current most critical research area of the field supported by recent advances in genomics and proteomics technologies.