Molecular interaction of human papilloma virus (HPV) with microRANs: insights into the development of cervical cancer and treatment approaches.

IF 3.1 2区医学 Q3 IMMUNOLOGY

Infectious Agents and Cancer Pub Date : 2025-07-23 DOI:10.1186/s13027-025-00677-9

Seyedeh Mahdieh Khoshnazar, Navvabeh Salarizadeh, Maryam Mohammad-Sadeghipour, Amirhossein Shahpar, Morteza Izadi, Mohammad Javad Behzadnia, Mahdi Farhadi Khoozani, Mina Alimohammadi, Najma Farahani, Kiavash Hushmandi

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引用次数: 0

Abstract

Cervical cancer is one of the leading causes of cancer-related death among women worldwide, and high-risk human papillomavirus (HR-HPV) plays a crucial role in its development. HPV's oncogenic processes include the viral oncoproteins E6 and E7, which interfere with essential biological processes, causing DNA instability and uncontrolled cell growth. Recent research suggests that microRNAs (miRNAs) have a role in HPV-mediated tumor development, with dysregulation of particular miRNAs influencing cancer cell proliferation, immune escape, and therapy resistance. This review summarizes the most recent research on HPV's molecular interactions with host miRNAs, focusing on their functions in regulating tumor-suppressive genes and oncogenic mechanisms. Furthermore, we investigate HPV-induced epigenetic alterations that contribute to miRNA dysregulation and corresponding changes in cell cycle control, apoptosis, and metastasis. Discovering these molecular interactions provides fresh insights into personalized medicine techniques for CC detection and therapy.

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人乳头瘤病毒（HPV）与microRANs的分子相互作用：对宫颈癌发展和治疗方法的见解。

宫颈癌是全球妇女癌症相关死亡的主要原因之一，高危人类乳头瘤病毒（HR-HPV）在其发展中起着至关重要的作用。HPV的致癌过程包括病毒癌蛋白E6和E7，它们干扰基本的生物过程，导致DNA不稳定和不受控制的细胞生长。最近的研究表明，microRNAs （miRNAs）在hpv介导的肿瘤发展中发挥作用，特定miRNAs的失调影响癌细胞增殖、免疫逃逸和治疗抵抗。本文综述了HPV与宿主mirna分子相互作用的最新研究进展，重点介绍了其调控肿瘤抑制基因的功能和致癌机制。此外，我们还研究了hpv诱导的表观遗传改变，这些改变有助于miRNA失调和细胞周期控制、细胞凋亡和转移的相应变化。发现这些分子相互作用为CC检测和治疗的个性化医学技术提供了新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Infectious Agents and Cancer ONCOLOGY-IMMUNOLOGY

CiteScore

5.80

自引率

2.70%

发文量

期刊介绍： Infectious Agents and Cancer is an open access, peer-reviewed online journal that encompasses all aspects of basic, clinical, epidemiological and translational research providing an insight into the association between chronic infections and cancer. The journal welcomes submissions in the pathogen-related cancer areas and other related topics, in particular: • HPV and anogenital cancers, as well as head and neck cancers; • EBV and Burkitt lymphoma; • HCV/HBV and hepatocellular carcinoma as well as lymphoproliferative diseases; • HHV8 and Kaposi sarcoma; • HTLV and leukemia; • Cancers in Low- and Middle-income countries. The link between infection and cancer has become well established over the past 50 years, and infection-associated cancer contribute up to 16% of cancers in developed countries and 33% in less developed countries. Preventive vaccines have been developed for only two cancer-causing viruses, highlighting both the opportunity to prevent infection-associated cancers by vaccination and the gaps that remain before vaccines can be developed for other cancer-causing agents. These gaps are due to incomplete understanding of the basic biology, natural history, epidemiology of many of the pathogens that cause cancer, the mechanisms they exploit to cause cancer, and how to interrupt progression to cancer in human populations. Early diagnosis or identification of lesions at high risk of progression represent the current most critical research area of the field supported by recent advances in genomics and proteomics technologies.