Inhalation Toxicology最新文献_第2页

Development of a risk prediction nomogram for delayed neuropsychiatric sequelae in patients with acute carbon monoxide poisoning. 开发急性一氧化碳中毒患者迟发性神经精神后遗症的风险预测提名图。

IF 2 4区医学

Inhalation Toxicology Pub Date : 2024-07-01 Epub Date: 2024-07-10 DOI: 10.1080/08958378.2024.2374394

Ghada N El-Sarnagawy, Fatma M Elgazzar, Mona M Ghonem

{"title":"Development of a risk prediction nomogram for delayed neuropsychiatric sequelae in patients with acute carbon monoxide poisoning.","authors":"Ghada N El-Sarnagawy, Fatma M Elgazzar, Mona M Ghonem","doi":"10.1080/08958378.2024.2374394","DOIUrl":"10.1080/08958378.2024.2374394","url":null,"abstract":"Objectives: Delayed neuropsychiatric sequelae (DNS) are critical complications following acute carbon monoxide (CO) poisoning that can substantially affect the patient's life. Identifying high-risk patients for developing DNS may improve the quality of follow-up care. To date, the predictive DNS determinants are still controversial. Consequently, this study aimed to construct a practical nomogram for predicting DNS in acute CO-poisoned patients.Methods: This retrospective study was conducted on patients with acute CO poisoning admitted to the Tanta University Poison Control Center (TUPCC) from December 2018 to December 2022. Demographic, toxicological, and initial clinical characteristics data, as well as laboratory investigation results, were recorded for the included patients. After acute recovery, patients were followed up for six months and categorized into patients with and without DNS.Results: Out of 174 enrolled patients, 38 (21.8%) developed DNS. The initial Glasgow Coma Scale (GCS), carboxyhemoglobin (COHb) level, CO exposure duration, oxygen saturation, PaCO2, and pulse rate were significantly associated with DNS development by univariate analysis. However, the constructed nomogram based on the multivariable regression analysis included three parameters: duration of CO exposure, COHb level, and GCS with adjusted odd ratios of 1.453 (95% CI: 1.116-1.892), 1.262 (95% CI: 1.126-1.415), and 0.619 (95% CI: 0.486-0.787), respectively. The internal validation of the nomogram exhibited excellent discrimination (area under the curve [AUC] = 0.962), good calibration, and satisfactory decision curve analysis for predicting the DNS probability.Conclusions: The proposed nomogram could be considered a simple, precise, and applicable tool to predict DNS development in acute CO-poisoned patients.","PeriodicalId":13561,"journal":{"name":"Inhalation Toxicology","volume":" ","pages":"406-419"},"PeriodicalIF":2.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141563331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of airborne asbestos concentrations associated with the maintenance of brakes on an industrial overhead crane. 评估与维护工业桥式起重机制动器有关的空气石棉浓度。

IF 2 4区医学

Inhalation Toxicology Pub Date : 2024-07-01 Epub Date: 2024-07-02 DOI: 10.1080/08958378.2024.2367422

Tyler Ferracini, Sarah Brown, Brooke Simmons, Heather Avens, Shannon Gaffney, Scott Dotson, Jennifer Sahmel

{"title":"Evaluation of airborne asbestos concentrations associated with the maintenance of brakes on an industrial overhead crane.","authors":"Tyler Ferracini, Sarah Brown, Brooke Simmons, Heather Avens, Shannon Gaffney, Scott Dotson, Jennifer Sahmel","doi":"10.1080/08958378.2024.2367422","DOIUrl":"10.1080/08958378.2024.2367422","url":null,"abstract":"Objectives: To evaluate potential airborne asbestos exposures during brake maintenance and repair activities on a P&H overhead crane, and during subsequent handling of the mechanic's clothing.Methods: Personal (n = 27) and area (n = 61) airborne fiber concentrations were measured during brake tests, removal, hand sanding, compressed air use, removal and reattachment of chrysotile-containing brake linings, and reinstallation of the brake linings. The mechanic's clothing was used to measure potential exposure during clothes handling.Results: All brake linings contained between 19.9% to 52.4% chrysotile asbestos. No amphibole fibers were detected in any bulk or airborne samples. The average full-shift airborne chrysotile concentration was 0.035 f/cc (PCM-equivalent asbestos-specific fibers, or PCME). Average task-based personal air samples collected during brake maintenance, sanding, compressed air use, and brake lining removal tasks ranged from 0 to 0.48 f/cc (PCME). The calculated 30-minute time-weighted average (TWA) airborne chrysotile concentration associated with 5-15 minutes of clothes handling was 0-0.035 f/cc PCME.Conclusion: The results indicated that personal and area TWA fiber concentrations measured during all crane brake maintenance and clothes handling tasks were below the current OSHA 8-h TWA Permissible Exposure Limit for asbestos of 0.1 f/cc. Further, no airborne asbestos fibers were measured during routine brake maintenance tasks following the manufacturer's maintenance manual procedures. All short-term airborne chrysotile concentrations measured during non-routine tasks were below the current 30-minute OSHA excursion limit for asbestos of 1 f/cc. This study adds to the available data regarding chrysotile exposure potential during maintenance on overhead cranes.","PeriodicalId":13561,"journal":{"name":"Inhalation Toxicology","volume":" ","pages":"391-405"},"PeriodicalIF":2.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141476549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A mouse model of wildfire smoke-induced health effects: sex differences in acute and sustained effects of inhalation exposures. 野火烟雾诱发健康影响的小鼠模型：吸入暴露的急性和持续影响的性别差异。

IF 2 4区医学

Inhalation Toxicology Pub Date : 2024-07-01 Epub Date: 2024-05-20 DOI: 10.1080/08958378.2024.2354398

Mary Buford, Sarah Lacher, Matthew Slattery, Daniel C Levings, Britten Postma, Andrij Holian, Chris Migliaccio

{"title":"A mouse model of wildfire smoke-induced health effects: sex differences in acute and sustained effects of inhalation exposures.","authors":"Mary Buford, Sarah Lacher, Matthew Slattery, Daniel C Levings, Britten Postma, Andrij Holian, Chris Migliaccio","doi":"10.1080/08958378.2024.2354398","DOIUrl":"10.1080/08958378.2024.2354398","url":null,"abstract":"Due to climate change, wildfires have increased in intensity and duration. While wildfires threaten lives directly, the smoke has more far-reaching adverse health impacts. During an extreme 2017 wildfire event, residents of Seeley Lake, Montana were exposed to unusually high levels of wood smoke (WS) causing sustained effects on lung function (decreased FEV1/FVC). Objective: The present study utilized an animal model of WS exposure to research cellular and molecular mechanisms of the resulting health effects. Methods: Mice were exposed to inhaled WS utilizing locally harvested wood to recapitulate community exposures. WS was generated at a rate resulting in a 5 mg/m3 PM2.5 exposure for five days. Results: This exposure resulted in a similar 0.28 mg/m2 particle deposition (lung surface area) in mice that was calculated for human exposure. As with the community observations, there was a significant effect on lung function, increased resistance, and decreased compliance, that was more pronounced in males at an extended (2 months) timepoint and males were more affected than females: ex vivo assays illustrated changes to alveolar macrophage functions (increased TNFα secretion and decreased efferocytosis). Female mice had significantly elevated IL-33 levels in lungs, however, pretreatment of male mice with IL-33 resulted in an abrogation of the observed WS effects, suggesting a dose-dependent role of IL-33. Additionally, there were greater immunotoxic effects in male mice. Discussion: These findings replicated the outcomes in humans and suggest that IL-33 is involved in a mechanism of the adverse effects of WS exposures that inform on potential sex differences.","PeriodicalId":13561,"journal":{"name":"Inhalation Toxicology","volume":" ","pages":"367-377"},"PeriodicalIF":2.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11298299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141070893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of black soot emissions on public health in Niger Delta, Nigeria: understanding the severity of the problem. 尼日利亚尼日尔三角洲黑烟排放对公共健康的影响：了解问题的严重性。

IF 2 4区医学

Inhalation Toxicology Pub Date : 2024-05-01 Epub Date: 2023-12-25 DOI: 10.1080/08958378.2023.2297698

Osazuwa Clinton Ekhator, Fortune Chiemelie Orish, Ernest O Nnadi, Daprim Samuel Ogaji, Success Isuman, Orish Ebere Orisakwe

{"title":"Impact of black soot emissions on public health in Niger Delta, Nigeria: understanding the severity of the problem.","authors":"Osazuwa Clinton Ekhator, Fortune Chiemelie Orish, Ernest O Nnadi, Daprim Samuel Ogaji, Success Isuman, Orish Ebere Orisakwe","doi":"10.1080/08958378.2023.2297698","DOIUrl":"10.1080/08958378.2023.2297698","url":null,"abstract":"Rivers State, Niger Delta, Nigeria often referred to as the 'treasure bed of the nation' is the seat of crude oil production activities with the accompanying environmental degradation. The severity of the environmental pollution and contaminated air quality took a new turn for the worse in November 2016, when the residents of Port Harcourt city, Rivers State, a major oil producing State experienced for the first time, aerosol deposition of plumes of black soot. This systematic review paper is aimed at quantifying the severity of this public health challenge. Using appropriate search words, the following databases SCOPUS, PUBMED, Google Scholar, and AJOL were searched from 1990 to 2022 to enable comparative analyses of data before and after the emergence of black soot deposition. Air-related morbidities and mortalities such as cerebrospinal meningitis (CSM), chronic bronchitis, measles, pertussis, hemoptysis, cough, pulmonary tuberculosis, pneumonia, and upper respiratory tract infection (URTI), pneumonia, eye irritation, conjunctivitis, traumatic skin outgrowth, cancers, cardiovascular diseases, and child deformities were compared with levels of air pollutants and particulate matter. The results showed that Port Harcourt city's ambient air quality data were above the standard National Ambient Air Quality data and that of other regulatory agencies having higher levels of both inorganic and organic pollutants. There were significant relationships between air pollutants concentration with morbidities. These correlations were significant in the period covering 2016-2022. Consequently, it is concluded that the black soot emissions in Port Harcourt city, Nigeria has worsened the public health situation in the city.","PeriodicalId":13561,"journal":{"name":"Inhalation Toxicology","volume":" ","pages":"314-326"},"PeriodicalIF":2.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139037564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An introduction to the adverse health impacts of inhaled toxicants in global marginalized communities. 介绍全球边缘化社区吸入有毒物质对健康的不利影响。

IF 2 4区医学

Inhalation Toxicology Pub Date : 2024-05-01 Epub Date: 2024-07-21 DOI: 10.1080/08958378.2024.2373094

Antonio F Saporito, Judith T Zelikoff

引用次数: 0

The effects of inhaled pollutants on reproduction in marginalized communities: a contemporary review. 吸入污染物对边缘化社区生殖的影响：当代综述。

IF 2 4区医学

Inhalation Toxicology Pub Date : 2024-05-01 Epub Date: 2023-04-19 DOI: 10.1080/08958378.2023.2197941

Ramsés Santacruz-Márquez, Alison M Neff, Vasiliki E Mourikes, Endia J Fletcher, Jodi A Flaws

{"title":"The effects of inhaled pollutants on reproduction in marginalized communities: a contemporary review.","authors":"Ramsés Santacruz-Márquez, Alison M Neff, Vasiliki E Mourikes, Endia J Fletcher, Jodi A Flaws","doi":"10.1080/08958378.2023.2197941","DOIUrl":"10.1080/08958378.2023.2197941","url":null,"abstract":"Important differences in health that are closely linked with social disadvantage exist within and between countries. According to the World Health Organization, life expectancy and good health continue to increase in many parts of the world, but fail to improve in other parts of the world, indicating that differences in life expectancy and health arise due to the circumstances in which people grow, live, work, and age, and the systems put in place to deal with illness. Marginalized communities experience higher rates of certain diseases and more deaths compared to the general population, indicating a profound disparity in health status. Although several factors place marginalized communities at high risk for poor health outcomes, one important factor is exposure to air pollutants. Marginalized communities and minorities are exposed to higher levels of air pollutants than the majority population. Interestingly, a link exists between air pollutant exposure and adverse reproductive outcomes, suggesting that marginalized communities may have increased reproductive disorders due to increased exposure to air pollutants compared to the general population. This review summarizes different studies showing that marginalized communities have higher exposure to air pollutants, the types of air pollutants present in our environment, and the associations between air pollution and adverse reproductive outcomes, focusing on marginalized communities.","PeriodicalId":13561,"journal":{"name":"Inhalation Toxicology","volume":" ","pages":"286-303"},"PeriodicalIF":2.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9773240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Health burden of sugarcane burning on agricultural workers and nearby communities. 焚烧甘蔗对农业工人和附近社区造成的健康负担。

IF 2 4区医学

Inhalation Toxicology Pub Date : 2024-05-01 Epub Date: 2024-02-13 DOI: 10.1080/08958378.2024.2316875

Arthur D Stem, Matthew Gibb, Carlos A Roncal-Jimenez, Richard J Johnson, Jared M Brown

引用次数: 0

Characterization of mass distribution in a biomimetic aerosol exposure system 仿生气溶胶暴露系统中的质量分布特征

IF 2.1 4区医学

Inhalation Toxicology Pub Date : 2024-04-26 DOI: 10.1080/08958378.2024.2341995

S. Emma Sarles, Edward C. Hensel, Caleb Nuss, Janessa Terry, Risa Robinson

引用次数: 0

IF 2.1 4区医学

Inhalation Toxicology Pub Date : 2024-04-15 DOI: 10.1080/08958378.2024.2331259

Rahanna N. Khan, Antonio F. Saporito, Jania Zenon, Lael Goodman, Judith T. Zelikoff

引用次数: 0

The presence of erionite in North American geologies and the estimated mesothelioma potency by region 北美地质中存在的麦饭石以及各地区估计的间皮瘤发病率

IF 2.1 4区医学

Inhalation Toxicology Pub Date : 2024-04-07 DOI: 10.1080/08958378.2024.2322496

Michael E. Stevens, Dennis J. Paustenbach, Noah J. Lockhart, Dalton E. Busboom, Blake M. Deckard, David W. Brew

引用次数: 0