IIUM Medical Journal Malaysia最新文献

Effectiveness of Hypertonic Saline, Polidocanol, and Glycerol as Sclerosing Agent: An Experimental Study in Javan Rabbits (Lepus nigricollis) 高渗盐水、波利多卡诺和甘油作为硬化剂的效果：爪哇兔（Lepus nigricollis）的实验研究

IIUM Medical Journal Malaysia Pub Date : 2024-07-01 DOI: 10.31436/imjm.v23i03.2416

Harlan, Mulawardi Mulawardi, S. Laidding, Firdaus Hamid, M. H. Cangara, T. C. Adriani, M. I. Kusuma, Prihantono, Warsinggih, Muhammad Faruk

{"title":"Effectiveness of Hypertonic Saline, Polidocanol, and Glycerol as Sclerosing Agent: An Experimental Study in Javan Rabbits (Lepus nigricollis)","authors":"Harlan, Mulawardi Mulawardi, S. Laidding, Firdaus Hamid, M. H. Cangara, T. C. Adriani, M. I. Kusuma, Prihantono, Warsinggih, Muhammad Faruk","doi":"10.31436/imjm.v23i03.2416","DOIUrl":"https://doi.org/10.31436/imjm.v23i03.2416","url":null,"abstract":"INTRODUCTION: Therapeutic approaches to varicose veins include sclerotherapy, laser ablation, and surgery. Using sclerosing agents such as hypertonic saline, polidocanol, and glycerol can be an option in cases of recurrent varicose veins. This study aimed to assess the effectiveness of hypertonic saline, polidocanol, and glycerol as sclerosant agents in an in vivo study. MATERIAL AND METHODS: This was an experimental study on 24 Javan rabbits, divided into three treatment groups: hypertonic saline (group I, n=8), polidocanol (group II, n=8), and glycerol (group III, n=8). All animals received treatment by injection into the vein behind the ear, then vein damming 10 minutes later. Punch tissue samples for standard histopathological examination were taken from blood vessels at 1 hour, 24 hours, 7 days, and 45 days post-treatment across all groups. The histopathology changes were scored based on inflammation, proliferation, luminal narrowing, and fibrosis. RESULT: No differences were observed in the degrees of inflammation, proliferation, luminal narrowing, or fibrosis at different observation intervals. However, a significant and positive correlation was found between inflammation, vascular proliferation, and fibrosis with all sclerosing agents (p<0.005). No significant correlation exists in the scoring of luminal narrowing among any sclerosing agent (p>0.005). CONCLUSION: Hypertonic saline, polidocanol, and glycerol demonstrated comparable efficacy as sclerosing agents in vivo concerning fibrosis, vascular proliferation, and inflammation.","PeriodicalId":13474,"journal":{"name":"IIUM Medical Journal Malaysia","volume":"24 53","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141699460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Symptomatic Chronic Venous Insufficiency (CVI) on Health-Related Quality of Life (HR Qol) in A Multi-Ethnics Society in a Developing Nation 发展中国家多学科社会中无症状慢性静脉功能不全（CVI）对健康相关生活质量（HR Qol）的影响

IIUM Medical Journal Malaysia Pub Date : 2024-07-01 DOI: 10.31436/imjm.v23i03.2482

Mohd Norhisham Azmi Abdul Rahman, Dineshwary Periasammy, Hashima Nasreen, Faisal Elagili, Ahmad Faidzal Othman

{"title":"The Impact of Symptomatic Chronic Venous Insufficiency (CVI) on Health-Related Quality of Life (HR Qol) in A Multi-Ethnics Society in a Developing Nation","authors":"Mohd Norhisham Azmi Abdul Rahman, Dineshwary Periasammy, Hashima Nasreen, Faisal Elagili, Ahmad Faidzal Othman","doi":"10.31436/imjm.v23i03.2482","DOIUrl":"https://doi.org/10.31436/imjm.v23i03.2482","url":null,"abstract":"INTRODUCTION: Chronic venous insufficiency (CVI) is a common condition especially among those of advance age that is often neglected. As the disease severity progresses, it increases the healthcare cost and resources required, while diminishing the quality of life of the persons. Health-related Quality of Life (HRQoL) among CVI patients begins to decline once the symptom starts to appear, and reduces it further as the symptoms worsens. MATERIALS AND METHODS: This is a prospective, multi-centred, cross-sectional study on consenting symptomatic CVI patients who presented to the International Islamic University of Malaysia (IIUM) teaching hospital in Pahang, Malaysia. The diagnosis of CVI was confirmed on duplex imaging. Clinical grading was performed using Clinical Etiologic Anatomic Pathophysiologic (CEAP) classification. Patients completed generic validated Malay language Short Form 36 (SF36) HRQoL instrument. RESULTS: One hundred and ten patients (62% male) with a mean age of 57 years, Malays (60%), Chinese (25%) and Indian (15%) were recruited. The most frequent CVD symptoms reported were pain (42%). The clinical, aetiological, anatomical, and pathophysiological (CEAP) classification placed most patients in the C2 class (34%). Apart from partaking in social functions, all other elements of mental and physical health component of SF 36 showed a marked deterioration as the disease progressed. CONCLUSIONS: We found a significant decline in the HRQoL among symptomatic CVI patients presenting to IIUM hospital in a multi-ethnic developing country.","PeriodicalId":13474,"journal":{"name":"IIUM Medical Journal Malaysia","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141710415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Holistic Management of Diabetic Foot: Redefining Strategy 糖尿病足的综合管理：重新定义策略

IIUM Medical Journal Malaysia Pub Date : 2024-07-01 DOI: 10.31436/imjm.v23i03.2656

Prof. Dr. Aminudin Che Ahmad

引用次数: 0

“You Know How People Talk,” Reasons Behind Child Marriage among Female Youth in The North-Eastern State of West Malaysia "你知道人们是怎么说的"，西马来西亚东北部州女青年童婚背后的原因

IIUM Medical Journal Malaysia Pub Date : 2024-07-01 DOI: 10.31436/imjm.v23i03.2605

Nadiah Md Alwi, R. Muhamad, Azlina Ishak, D. Suwankhong

{"title":"“You Know How People Talk,” Reasons Behind Child Marriage among Female Youth in The North-Eastern State of West Malaysia","authors":"Nadiah Md Alwi, R. Muhamad, Azlina Ishak, D. Suwankhong","doi":"10.31436/imjm.v23i03.2605","DOIUrl":"https://doi.org/10.31436/imjm.v23i03.2605","url":null,"abstract":"INTRODUCTION: Over the past decade, Kelantan has consistently ranked among the top three states in Malaysia for the highest number of registered child marriages, garnering attention in local and international news. However, little is understood about the local factors influencing girls' decisions to marry young. This study aimed to explore these reasons from the perspective of young women involved in child marriages in Kelantan, Malaysia. MATERIALS AND METHODS: Fourteen women aged 16-30, married before 18, participated in semi-structured, in-depth interviews. The interviews were recorded, transcribed, and analysed using NVivo® software. Thematic analysis, drawing from phenomenology and socioecological theory, revealed three overlapping themes. RESULTS: Themes emerged were: (1) self-fulfilment, (2) marriage brings security, and (3) avoidance of public ridicule. CONCLUSION: The study underscores societal and familial pressures, alongside low socioeconomic status, and religious factors, as central to child marriage in Malaysia. By amplifying the voices of these women, efforts can focus on preventing the consequences and devising solutions to curb this practice in the future.","PeriodicalId":13474,"journal":{"name":"IIUM Medical Journal Malaysia","volume":"344 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141691511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Post-traumatic, Depression, Anxiety, and Stress Symptoms among Malaysian Firefighters 马来西亚消防员的创伤后、抑郁、焦虑和压力症状

IIUM Medical Journal Malaysia Pub Date : 2024-07-01 DOI: 10.31436/imjm.v23i03.2515

Huwaida Abdul Azis, Z. A Rahman, M. R. A Rashid, N. Baharom, Hamidin Awang, Nur Hafizah Mohammad Lukman, Mohd Zairi Zainal Abidin

{"title":"Post-traumatic, Depression, Anxiety, and Stress Symptoms among Malaysian Firefighters","authors":"Huwaida Abdul Azis, Z. A Rahman, M. R. A Rashid, N. Baharom, Hamidin Awang, Nur Hafizah Mohammad Lukman, Mohd Zairi Zainal Abidin","doi":"10.31436/imjm.v23i03.2515","DOIUrl":"https://doi.org/10.31436/imjm.v23i03.2515","url":null,"abstract":"INTRODUCTION: Emergency responders, including firefighters are frequently exposed to life-threatening situations in their daily lives causing an increased risk for occupational stress, anxiety, depression and post-traumatic stress symptoms (PTSS). Hence, this study aimed to determine the prevalence, and correlation of PTSS with stress, anxiety, and depression among Malaysian firefighters. MATERIALS AND METHODS: A cross-sectional study was conducted among firefighters stationed in 20 fire and rescue stations in Penang, Malaysia using self-administered online survey through a purposive sampling. Information collected were sociodemographic data, measurement of severity of PTSS via Post-Traumatic Checklist-5 (PCL-5), and assessment of depression, anxiety, and stress via Depression, Anxiety, and Stress Scale (DASS-21). A descriptive analysis and Pearson's correlation coefficient analyses were employed in study analysis. RESULTS: Out of 562 firefighters participated in the study, the prevalence of PTSS, stress, anxiety, and depression was 5.0%, 2.1%, 13.0%, and 8.5%, respectively. Among those with PTSS, 28.6%, 78.6%, and 67.9% suffered from stress, anxiety, and depression, respectively. Hence, anxiety was highly coexisted with PTSS. There was significant positive correlation between PTSS score and the score of stress (r=0.656, P< 0.001), anxiety (r=0.699, P< 0.001), and depression (r=0.700, P< 0.001). CONCLUSION: Our study findings suggested that stress, anxiety, and depression can co-occur with PTSS. Hence, firefighters should have regular mental health assessments as the concurrent effect of multiple medical conditions may require comprehensive treatment to address the various aspects of each condition.","PeriodicalId":13474,"journal":{"name":"IIUM Medical Journal Malaysia","volume":"72 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141691366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microbiome Dysbiosis in Depression: A Narrative Review 抑郁症的微生物组失调：叙述性综述

IIUM Medical Journal Malaysia Pub Date : 2024-07-01 DOI: 10.31436/imjm.v23i03.2293

Nurul Aqilah Amran, M. Arzmi, Anis Fadhlina Izyani Awang, Rozanizam Zakaria, Widya Lestari, Hassan Ibrahim Sheikh Mohamed, M. Mokhtar

{"title":"Microbiome Dysbiosis in Depression: A Narrative Review","authors":"Nurul Aqilah Amran, M. Arzmi, Anis Fadhlina Izyani Awang, Rozanizam Zakaria, Widya Lestari, Hassan Ibrahim Sheikh Mohamed, M. Mokhtar","doi":"10.31436/imjm.v23i03.2293","DOIUrl":"https://doi.org/10.31436/imjm.v23i03.2293","url":null,"abstract":"The comprehensive exploration of the microbial composition of the gut and its role in depression underscores a complex interplay involving alterations in gut microbiome, immune pathways, and inflammatory control. Studies reveal potential biomarkers and therapeutic targets linked to depression, with particular bacterial genera correlated with the severity of depressive symptoms. The dysregulation extends to disruptions in metabolic pathways and functions of bacterial proteins within the gut, contributing to intestinal barrier dysfunction and increased gut permeability. Notably, alterations in microbial composition are observed in various depressive conditions, including major depressive disorder (MDD), post-stroke depression (PSD), and depression during neoadjuvant cancer treatment. The influence of the gut microbiome on the central nervous system and the bidirectional relationship between depression and microbial changes are highlighted. Regulatory interventions, including antidepressants and probiotics, show promise in modulating the gut microbiome and alleviating depressive symptoms. The combination of probiotics with antidepressants emerges as a potential strategy for inducing a balanced microbiome. However, a lack of consensus exists regarding specific bacterial taxa associated with depression, emphasizing the need for further research to refine the therapeutic approaches for managing depression and related mood disorders. This review aims to explore the relationship between microbiome dysbiosis and depression, highlighting the role of dysbiosis as a potential contributing factor to depressive symptoms.","PeriodicalId":13474,"journal":{"name":"IIUM Medical Journal Malaysia","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141696811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overview of the Prevalence and Contributing Factors for Occupational Noise-Induced Hearing Loss (NIHL) in Malaysia 马来西亚职业性噪声诱发听力损失（NIHL）的发病率和诱因概述

IIUM Medical Journal Malaysia Pub Date : 2024-07-01 DOI: 10.31436/imjm.v23i03.2436

Nur Faiza Abdul Razak, Mohd Shukri MOHD ARIS

{"title":"Overview of the Prevalence and Contributing Factors for Occupational Noise-Induced Hearing Loss (NIHL) in Malaysia","authors":"Nur Faiza Abdul Razak, Mohd Shukri MOHD ARIS","doi":"10.31436/imjm.v23i03.2436","DOIUrl":"https://doi.org/10.31436/imjm.v23i03.2436","url":null,"abstract":"INTRODUCTION: This manuscript aims to provide a synopsis of the current situation surrounding noise exposure at work and the risk of noise-induced hearing loss (NIHL) in Malaysia. NIHL is an occupational illness that affects most many people and can be prevented in many countries in the world. The production and agriculture businesses and the extraction of natural resources and urban traffic all contribute to ambient noise levels. Working in a noisy environment is the main occupational risk factor for adult-onset hearing loss. In this study, we investigate the prevalence of NIHL across different industries, as well as research publication trends on NIHL. MATERIAL AND METHODS: Conducted thorough several online databases, like Science Direct, Web of Science, and Google Scholar, for related research that had already been published. The review phases were carried out according to the recommendations laid out by the preferred reporting items for systematic reviews. A set of criteria was developed for selecting relevant studies. RESULTS: The prevalence of NIHL among workers in Malaysia, varies across different industries and has been reported to range from 5.0% to 82.6%. NIHL has multiple contributing factors, including noise intensity, long-term exposure to daily noise, hearing protection devices and age. A review of these studies found varying percentages of individuals affected by each contributing factor. CONCLUSION: Occupational NIHL is a preventable health risk for workers across industries. Employers must adopt engineering and administrative controls (education and training) and provide personal hearing protectors to protect workers from noise.","PeriodicalId":13474,"journal":{"name":"IIUM Medical Journal Malaysia","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141703936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence of Fall and its Associated Factor: A Single Centre Experience 跌倒发生率及其相关因素：单个中心的经验

IIUM Medical Journal Malaysia Pub Date : 2024-07-01 DOI: 10.31436/imjm.v23i03.2368

Bee Chiu Lim, Fatihah Mahmud, Bunyamin Abdullah, Muhammad Hazrul Badrul Hisham, Shanti Nalalingam, Fariz Safhan Mohamad Nor

{"title":"Incidence of Fall and its Associated Factor: A Single Centre Experience","authors":"Bee Chiu Lim, Fatihah Mahmud, Bunyamin Abdullah, Muhammad Hazrul Badrul Hisham, Shanti Nalalingam, Fariz Safhan Mohamad Nor","doi":"10.31436/imjm.v23i03.2368","DOIUrl":"https://doi.org/10.31436/imjm.v23i03.2368","url":null,"abstract":"INTRODUCTION: Patient falls during hospitalisation can cause catastrophic injuries and remain one of the major patient-safety issues faced by hospitals. This study was designed to determine the inpatient falls rate and the association between fall-related injury and sociodemographic variables. MATERIALS AND METHODS: A retrospective record review was conducted for a one-time inpatient fall in a single centre between January 2017 and December 2019. Pearson chi-square or Fisher's exact test were performed to assess association between the categorical variables. RESULTS: There were 44 inpatient falls who fell one time between January 2017 and December 2019. The inpatients fall rate was 3.0 per 10000 patient-days from 2017 to 2019. Overall, the patients who fell experienced an injury (n=24, 55%). There was no significant difference between age group, gender, time of fall, assisted type, history of fall, fall risk assessment, mental status, the department involved, and injurious fall outcome. CONCLUSION: Our study showed a low incidence of fall rate per 10000 patient-days for 2017-2019. More than half of the fallers experienced an injurious fall. The highest fall rate was noted in the surgical based departments. However, there was no significant difference between injurious fall outcomes and sociodemographic variables. Risk assessments and management strategies should focus on education, particularly bed safety.","PeriodicalId":13474,"journal":{"name":"IIUM Medical Journal Malaysia","volume":"69 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141708955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design and Usability Testing of a Web-Based Intervention Module for Obesity: CoPT Nutri Trail 肥胖症网络干预模块的设计和可用性测试：CoPT Nutri Trail

IIUM Medical Journal Malaysia Pub Date : 2024-07-01 DOI: 10.31436/imjm.v23i03.2457

Norhasniza Yaacob, Amirah Ismail, Mohd Izwan Mahmud, Ruzita Abd Talib

{"title":"Design and Usability Testing of a Web-Based Intervention Module for Obesity: CoPT Nutri Trail","authors":"Norhasniza Yaacob, Amirah Ismail, Mohd Izwan Mahmud, Ruzita Abd Talib","doi":"10.31436/imjm.v23i03.2457","DOIUrl":"https://doi.org/10.31436/imjm.v23i03.2457","url":null,"abstract":"INTRODUCTION: Online interventions have emerged as innovative solutions to address health issues, notably obesity, while minimizing the necessity for in-person interactions during the recent COVID-19 pandemic. There is urgency in designing and developing an appropriate online intervention module within a web-based application. This study aims to describe the design process and usability of the online Canteen Operators, Parents, and Teachers (CoPT Nutri Trail) module for an upcoming school-based obesity intervention. MATERIALS AND METHODS: The design methodology consists of four phases: content development, design, web app development, and usability testing. The web application was designed to personalize usage for teachers, parents, and canteen operators to foster healthy environments for children. Thirteen experts, including teachers, nutritionists, and IT professionals, participated in the usability testing. RESULTS: All experts agreed that the design of the web application met the requirements of target users, requiring slight improvements in graphic design, language, and information elements. The web application tool was found acceptable, as the usability of alpha scores for all interface elements ranged from 68.2% to 86.6%, falling between good and very good scores. The content validation indices indicate good levels of validity (ranging from 0.83 to 1.00). CONCLUSION: The CoPT Nutri Trail web application is ready to be launched as a school-based intervention for obesity.","PeriodicalId":13474,"journal":{"name":"IIUM Medical Journal Malaysia","volume":"27 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141713896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Serum Programmed Cell Death Protein 1 (PD-1) and Gene Polymorphism with Some Valid Predictors for Systemic Lupus Erythematosus (SLE) Patients in Basra Province, Iraq 血清程序性细胞死亡蛋白 1 (PD-1) 和基因多态性与伊拉克巴士拉省系统性红斑狼疮 (SLE) 患者的一些有效预测指标的关系

IIUM Medical Journal Malaysia Pub Date : 2024-07-01 DOI: 10.31436/imjm.v23i03.2478

Sadoun Abbas Alsalimi, A. J. Al-Fartosy

{"title":"Association of Serum Programmed Cell Death Protein 1 (PD-1) and Gene Polymorphism with Some Valid Predictors for Systemic Lupus Erythematosus (SLE) Patients in Basra Province, Iraq","authors":"Sadoun Abbas Alsalimi, A. J. Al-Fartosy","doi":"10.31436/imjm.v23i03.2478","DOIUrl":"https://doi.org/10.31436/imjm.v23i03.2478","url":null,"abstract":"INTRODUCTION: Systemic Lupus Erythematosus (SLE) is a systematic autoimmune disorder characterized by the production of autoantibodies against nuclear antigens and inflammation initiation. We aimed to examine the correlation between IL-18, IL-37, and PD-1, and the potential link between polymorphisms in the PD-1 gene located in intron-4 and the susceptibility to SLE. MATERIALS AND METHODS: This cross-sectional study included 43 SLE and 53 healthy individuals. Blood samples were obtained and underwent biochemical examination. The polymorphisms were screened by amplifying the intron-4 of the PD-1 gene using particular primers and then verified through sequencing. RESULTS: Our findings demonstrated statistically significant positive correlations between IL-18, IL-37, and PD-1, while the AUC of the ROC curve is 0.985, 0.968, and 0.940, and cut-off concentration is ≥132.87, ≥62.98, and ≥169.02, respectively. Moreover, two separate SNPs (rs6705653 and rs41386349) were discovered within intron-4 of the PD-1 gene. The genotype AA of the +7499 (G/A) SNP was significantly related with an increased risk of SLE (OR=3.11, 95%CI=1.52–5.94, p-value=0.031). Additionally, the A allele was identified as a risk allele (OR=1.59, 95%CI=1.09–2.31, p-value=0.043). Nevertheless, our study didn’t find any noteworthy connection between the allele and genotype of the +7209 (C/T) polymorphism region of the PD-1 gene frequencies and the susceptibility to SLE. CONCLUSION: IL-18, IL-37, and PD-1 may play significant roles in SLE immune responses and processes. Furthermore, the sequencing examination of intron-4 within the PD-1 gene demonstrated a noteworthy correlation between the A allele and the AA genotypes of PD-1 +7499 (G/A) SNP presence with the increased SLE susceptibility.","PeriodicalId":13474,"journal":{"name":"IIUM Medical Journal Malaysia","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141706698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0