抑郁症的微生物组失调:叙述性综述

Nurul Aqilah Amran, M. Arzmi, Anis Fadhlina Izyani Awang, Rozanizam Zakaria, Widya Lestari, Hassan Ibrahim Sheikh Mohamed, M. Mokhtar
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引用次数: 0

摘要

对肠道微生物组成及其在抑郁症中作用的全面探索,凸显了涉及肠道微生物组、免疫途径和炎症控制改变的复杂相互作用。研究揭示了与抑郁症相关的潜在生物标志物和治疗靶点,特定细菌属与抑郁症状的严重程度相关。这种失调延伸到肠道内细菌蛋白的代谢途径和功能紊乱,导致肠道屏障功能障碍和肠道通透性增加。值得注意的是,在包括重度抑郁症(MDD)、卒中后抑郁症(PSD)和癌症新辅助治疗期间的抑郁症在内的各种抑郁症中都观察到了微生物组成的改变。肠道微生物组对中枢神经系统的影响以及抑郁症与微生物变化之间的双向关系得到了强调。包括抗抑郁药和益生菌在内的调节性干预措施在调节肠道微生物组和减轻抑郁症状方面显示出前景。益生菌与抗抑郁药物的结合是诱导微生物组平衡的一种潜在策略。然而,对于与抑郁症相关的特定细菌类群还缺乏共识,这就强调了进一步研究的必要性,以完善治疗抑郁症和相关情绪障碍的方法。本综述旨在探讨微生物群失调与抑郁症之间的关系,强调微生物群失调作为抑郁症状潜在诱因的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Microbiome Dysbiosis in Depression: A Narrative Review
The comprehensive exploration of the microbial composition of the gut and its role in depression underscores a complex interplay involving alterations in gut microbiome, immune pathways, and inflammatory control. Studies reveal potential biomarkers and therapeutic targets linked to depression, with particular bacterial genera correlated with the severity of depressive symptoms. The dysregulation extends to disruptions in metabolic pathways and functions of bacterial proteins within the gut, contributing to intestinal barrier dysfunction and increased gut permeability. Notably, alterations in microbial composition are observed in various depressive conditions, including major depressive disorder (MDD), post-stroke depression (PSD), and depression during neoadjuvant cancer treatment. The influence of the gut microbiome on the central nervous system and the bidirectional relationship between depression and microbial changes are highlighted. Regulatory interventions, including antidepressants and probiotics, show promise in modulating the gut microbiome and alleviating depressive symptoms. The combination of probiotics with antidepressants emerges as a potential strategy for inducing a balanced microbiome. However, a lack of consensus exists regarding specific bacterial taxa associated with depression, emphasizing the need for further research to refine the therapeutic approaches for managing depression and related mood disorders. This review aims to explore the relationship between microbiome dysbiosis and depression, highlighting the role of dysbiosis as a potential contributing factor to depressive symptoms.
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