Advances in Clinical Toxicology最新文献_第8页

QSAR Studies on Some Sulfonamides as Antidiabetic Agents 磺胺类抗糖尿病药物的QSAR研究

Advances in Clinical Toxicology Pub Date : 1900-01-01 DOI: 10.23880/act-16000266

V. Agrawal

引用次数: 0

Arctic Resilience: Fire, Food, Contaminant, and Education Nexus along the Yukon River Watershed 北极复原力:育空河流域的火灾、食物、污染物和教育联系

Advances in Clinical Toxicology Pub Date : 1900-01-01 DOI: 10.23880/act-16000244

Bonita H Dainowski

{"title":"Arctic Resilience: Fire, Food, Contaminant, and Education Nexus along the Yukon River Watershed","authors":"Bonita H Dainowski","doi":"10.23880/act-16000244","DOIUrl":"https://doi.org/10.23880/act-16000244","url":null,"abstract":"River watersheds are among the most complex terrestrial features in Alaska, performing valuable ecosystem functions and providing services for human society. Rivers are vital to both estuarine and aquatic biota and play important roles in biogeochemical cycles and physical processes. The functions of watersheds have been used as indicators for ecosystem health. Running through the boreal forest, the Yukon River watershed has a long history of human activity, but has not been given the holistic and interdisciplinary research attention of the other great American river systems. By using hypothesis based monitoring of key watershed functions, we can gain insights to regime shifting stresses such as increasing fire on the movement of toxins, impact on subsistence plants and animals, as well as domestic species. The Yukon watershed provides a broad scale topic for research. More research would establish or expand: 1. A baseline against which future resilience related change can be more accurately assessed 2. Promote interdisciplinary research 3. Expand graduate and undergraduate opportunities 4. Advance rural education opportunities and sustainable regional economic analysis 5. Promote citizen science.","PeriodicalId":134434,"journal":{"name":"Advances in Clinical Toxicology","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129930201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Acetylcholinesterase Inhibition of Marine Fish (Rastrelliger kanagurta) by Organophosphorus Pesticides as Biomarker of Neurotoxicants 有机磷农药对海鱼乙酰胆碱酯酶抑制的生物标志物研究

Advances in Clinical Toxicology Pub Date : 1900-01-01 DOI: 10.23880/act-16000246

A. Sarkar

{"title":"Acetylcholinesterase Inhibition of Marine Fish (Rastrelliger kanagurta) by Organophosphorus Pesticides as Biomarker of Neurotoxicants","authors":"A. Sarkar","doi":"10.23880/act-16000246","DOIUrl":"https://doi.org/10.23880/act-16000246","url":null,"abstract":"This paper evaluated the inhibitory effects of various phosphorothioates (Ethyl parathion and Chlorpyriphos) and phosphates (DDVP, Monocrotophos and Phosphamidon) on acetylcholinesterase (AChE) of marine Mackerel fish (Rastrelliger kanagurta) from the Goa coast. The characteristics of the AChE enzymes isolated from different tissues of the fishes for their affinity towards the substrate were determined by the Michaelis Menten constants. The pseudocholinesterase activity was also measured in the muscle tissues in terms of Butyryl-cholinesterase (BChE) activity of the fish. The AChE activity was found to be predominant in the Brain, gills, liver and muscle tissues. However, no significant BChE activity was observed in the muscle tissue. Among the five organophosphorus pesticides, DDVP was found to be most toxic with least I50 values (0.99±0.04nM) followed by Chlorpyriphos (I50, 24.59±2.86 nM), Ethyl Parathion (I50, 183.21±11.68 nM), Monocrotophos (I50, 13536.93±1292.94 nM) and Phosphamidon (I50, 21433.1±2651.96 nM) in the decreasing order. The I50 values of all other pesticides decreased considerably with respect to DDVP. The relative neurotoxicity of the pesticides decreased by an order of magnitude in the case of Chlorpyriphos followed by Ethyl Parathion by an order of magnitude whereas in the case of Monocrotophos and Phosphamidon the toxicity decreased significantly by an order of magnitude. The variation in the muscle AChE inhibition by the organophosphorus pesticides can be attributed to the sensitivity of the enzyme for each of the pesticides as observed by the bimolecular inhibition constants (KII). The muscle AChE inhibition of Rastrelliger kanagurta can be used as biomarker for bio- monitoring of neurotoxic contaminants in the marine environment.","PeriodicalId":134434,"journal":{"name":"Advances in Clinical Toxicology","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128949204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How Bulky of Base Adducts can be Responsible for Clastogenicity rather than Mutagenicity? 庞大的碱基加合物是如何导致致裂性而非致突变性的?

Advances in Clinical Toxicology Pub Date : 1900-01-01 DOI: 10.23880/act-16000256

Y. Sasaki

{"title":"How Bulky of Base Adducts can be Responsible for Clastogenicity rather than Mutagenicity?","authors":"Y. Sasaki","doi":"10.23880/act-16000256","DOIUrl":"https://doi.org/10.23880/act-16000256","url":null,"abstract":"Two types of TK mutants are induced by genotoxic factors; normally growing (NG) TK mutants due to point mutations of targeted TK locus, and slowly growing (SG) mutants due to gross structural changes involving the growth-regulating gene outside targeted TK locus. In this study, human lymphoblstoid WTK1 cells were used to consider how bulky n- alkylated bases can induce SG mutants. For this purpose, n-alkyl methanesulfonates (AMS) having an n-alkyl group with 3-7 carbons [n-propy methanesulfonate (PMS), n-butyl methanesulfonate (BMS), n-pentyl methanesulfonate (PeMS), n- hexyl methanesulfonate (HexMS), and heptyl methanesulfonate(HepMS)] were synthesized. n-alkyl methanesulfonates having n-alkyl groups with 1-7 carbons induced NG mutants, but n-alkyl methanesulfonates having n-alkyl groups with ≥4 carbons but not with ≤3 carbons induced SG mutants. n-Alkyl methanesulfonates having n-Alkyl groups with ≥4 carbons have been shown to induce bulky adducts that cause disturbances to the helical DNA structure and are removed by nucleotide excision repair. It could be considered that n-alkyl groups with ≥4 carbons causing disturbances to the helical DNA structure induce SG mutants to result in clastogenicity rather than mutagenicity.","PeriodicalId":134434,"journal":{"name":"Advances in Clinical Toxicology","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125384346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Data Toxicology in Portugal: Where are we? 数据毒理学在葡萄牙:我们在哪里?

Advances in Clinical Toxicology Pub Date : 1900-01-01 DOI: 10.23880/act-16000261

A. R. Araujo

{"title":"Data Toxicology in Portugal: Where are we?","authors":"A. R. Araujo","doi":"10.23880/act-16000261","DOIUrl":"https://doi.org/10.23880/act-16000261","url":null,"abstract":"Despite the efforts of the World Health Organization (WHO), there are no global statistics on clinical intoxications. While WHO recommends that all countries establish and strengthen poison centers, less than half of WHO member states have only one of these centers. Due the lack of information, this article aims to give a current and critical view of the situation of clinical toxicology in Portugal. Studies and data about clinical intoxications in hospital emergency services in Portugal between 2010 and 2022 were analyzed. In Portugal, there are only some punctual national studies concentrated in certain geographic areas. Different poisoning parameters were regarded. In those studies, differences were found concerning the route of administration, the time distribution of poisonings and the toxic substances involved. The results are in line with the statistics of the official Poison Center of Portugal Centro de Informação Antivenenos. There is still a lot to be done by the Portuguese authorities to emulate other countries’ situation. This is the only way to get to know the country’s profile, through comparison with data from other countries, and also allowing establishing public health policies and alert systems.","PeriodicalId":134434,"journal":{"name":"Advances in Clinical Toxicology","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121571189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perspectives on the Global Impact and Effectiveness of Covid-19 Vaccines against Emerging SARS-Cov-2 variant Omicron 针对新出现的SARS-Cov-2变异Omicron的Covid-19疫苗的全球影响和有效性展望

Advances in Clinical Toxicology Pub Date : 1900-01-01 DOI: 10.23880/act-16000230

Upendarrao Golla

引用次数: 0

The ‘Ginger-Biomedicines’ Act as ‘Preventive-Natural-Gifts’ against ‘Omicron-Deltacron-Rupacron-Futuracron-Like-any- New-Variants’: Advanced Clinical-Toxicology-Drug-Discovery- Agriculture-Environment-Biodiversity-Wildlife-Conservation- Science-Technology-Communications-Innovations-Socio- -Economy-I “姜-生物医学”作为“预防-自然礼物”对抗“奥米克隆-三角洲克隆-鲁帕克隆-未来克隆-任何-新变种”:先进临床-毒理学-药物发现-农业-环境-生物多样性-野生动物保护-科学-技术-通信-创新-社会-经济- 1

Advances in Clinical Toxicology Pub Date : 1900-01-01 DOI: 10.23880/act-16000234

Subhas Chandra Datta

{"title":"The ‘Ginger-Biomedicines’ Act as ‘Preventive-Natural-Gifts’ against ‘Omicron-Deltacron-Rupacron-Futuracron-Like-any- New-Variants’: Advanced Clinical-Toxicology-Drug-Discovery- Agriculture-Environment-Biodiversity-Wildlife-Conservation- Science-Technology-Communications-Innovations-Socio- -Economy-I","authors":"Subhas Chandra Datta","doi":"10.23880/act-16000234","DOIUrl":"https://doi.org/10.23880/act-16000234","url":null,"abstract":"The new-emerging fast-spreading Omicron or Deltacrons-like-any-pseudo-or-original-variants of ‘Severe-Acute-RespiratorySyndrome-Coronavirus-2 (SARS-CoV-2)’ retained active infections for more than 10 days, and in some individuals, the scientists-found-clinically-significant-levels of the SARS-CoV-2 virus for as long as 68-days with age-dependent effects in the transmission and control of COVID-19 epidemics, and in rare-cases, coronavirus-vaccines-may-cause Long-Covid–likesymptoms also, and only-in-2019, more-than-1.2-million-people-dying from drug-resistant, a “Hidden-Pandemic” that could emerge in the wake-of-Covid-19. So, it is an emergency-needed to tackle the the-worst-situation, and so, present aims and objectives are to see, record, and confirm the potentiality of the ‘Ginger-Biomedicines’ prepared from the rhizome of ginger, Zingiber officinale Rosc., at an extremely-ultra-low-doses, highly-effective against ‘Omicron-Deltacron-RupacronFuturacron-like-any-new-variants’, and other-diseases by boosting-natural-immunity-acting as ‘Preventive-Natural-Gifts and advances-in-the-‘Clinical-Toxicology-Drug-Discovery-Agriculture-Environment-Biodiversity-Wildlife-Conservation-ScienceTechnology-Communications-Innovations-Socio-Economy-Issues and developing Policy-Initiative-Toxic-Free-Cost-EffectiveLife-Saving-Potential-Universal-Natural-Eco-friendly-Preventive-Biomedicines against Future-Epidemic and it will be more effective if common-Ginger-MT-biomedicines are used-combined with the high-diluted or ultra-high-diluted Black Gingerbiomedicines (BGBM), prepared from the rhizome Black-Ginger of Kaempferia parviflora, forming the ‘Emergency-UniversalBooster-Preventive-Emergency-Vaccine (UBPEV)’ for the ‘Future-World’","PeriodicalId":134434,"journal":{"name":"Advances in Clinical Toxicology","volume":"417 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131528134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Malaria Tests-DNA PCR and Quantitative Buffy Coat (QBC) 疟疾检测- dna PCR和定量黄皮(QBC)

Advances in Clinical Toxicology Pub Date : 1900-01-01 DOI: 10.23880/act-16000232

Timothy Waje

引用次数: 0

Harmful Algal Blooms Associated Marine Bacteria: Composition and Potential 有害藻华相关的海洋细菌:组成和潜力

Advances in Clinical Toxicology Pub Date : 1900-01-01 DOI: 10.23880/act-16000235

Ismail M Al Bulushi

引用次数: 0

A Systematic Review on Concentration of Heavy Metal in the Ambient Air of Different Industries and the Health Risk Assessment 不同行业环境空气中重金属浓度及健康风险评价的系统综述

Advances in Clinical Toxicology Pub Date : 1900-01-01 DOI: 10.23880/act-16000265

Roohollah Rosami

{"title":"A Systematic Review on Concentration of Heavy Metal in the Ambient Air of Different Industries and the Health Risk Assessment","authors":"Roohollah Rosami","doi":"10.23880/act-16000265","DOIUrl":"https://doi.org/10.23880/act-16000265","url":null,"abstract":"Heavy metals are a group of pollutants that are found in ambient air of the industries. The metals can lead to cancerous and non-cancerous diseases in the exposed persons. In this systematic review, the concentration of heavy metals in the ambient air of industries and the related health risks were studied. In general, heavy metals with different average concentrations were found in various industries. Given the results, Zinc (539.96 µg/m³ ), Iron (216.04 µg/m³), Mercury (19.37 µg/m³), Lead (19.24 µg/m³), Arsenic (17/51 µg/m3), Chromium (12/18 µg/m³), Titanium (10/63 µg/m³ ), Nickel (9/09 µg/m³), Copper (8/11 µg/m³), Cadmium (6/7 µg/m³), Antimony (3/2 µg/m³), Manganese (2.99 µg/m³), Cobalt (1.32 µg/m³ ) were found in the air of the industries. For the zinc smelting, atomic energy, steel, roofing, printing, tape production, and cement, the highest concentration was for zinc (2518 µg/m³), lead (41/35 µg/m³), lead (45 µg/m³), lead (1/38 µg/m³), copper (20/20 µg/m³) and iron (216/04 µg/m³), respectively. All of the concentration in this research is reported in µg/m³. The average carcinogenic risk for the metals were 1.78×10-2, 3.32×10-3, 3.6×10-2, and 1.79×10-3 respectively for arsenic, cadmium, chromium, and nickel. The average non-carcinogenic risk of chromium, manganese, and mercury were 8.06×104 , 77×10-4, and 1.22×10-2, respectively. According to the results, the variety of heavy metals in cement industry is more than in other industries, while the concentration of heavy metals in zinc smelting and atomic energy industries was more than remain. Zinc showed the highest average concentration and chromium showed the highest expected risk of carcinogenicity for occupational exposure.","PeriodicalId":134434,"journal":{"name":"Advances in Clinical Toxicology","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126857515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0