Advances in Clinical Toxicology最新文献_第9页

More on Carboxylic Acid: One Possible Cause of Alzheimer’s 更多关于羧酸:阿尔茨海默氏症的一个可能原因

Advances in Clinical Toxicology Pub Date : 1900-01-01 DOI: 10.23880/act-16000199

P. Cusack

引用次数: 0

Protective Effects of Quercetin against Lambda Cyhalothrin Induced Hepatotoxicity and Nephrotoxicity Disorders in Mice 槲皮素对氯氟氰菊酯所致小鼠肝、肾毒性疾病的保护作用

Advances in Clinical Toxicology Pub Date : 1900-01-01 DOI: 10.23880/act-16000174

E. K.

{"title":"Protective Effects of Quercetin against Lambda Cyhalothrin Induced Hepatotoxicity and Nephrotoxicity Disorders in Mice","authors":"E. K.","doi":"10.23880/act-16000174","DOIUrl":"https://doi.org/10.23880/act-16000174","url":null,"abstract":"Although the antioxidant, anti-inflammatory actions of quercetin (QE) are well established, no study has measured its protective actions against the toxicity of cyhalothrin lambda (LCT). This study was designed to determine the acute toxicity of LCT on male mice and investigate the effect of repeated sub lethal dose (1/10 LD50) for 14 days on body and organ weights, some biomarkers and histopathological changes in liver and kidney. In addition, the regulatory effect of QE on the hepatotoxicity and nephrotoxicity induced by LCT. The results showed that oral administration of LCT significantly reduced the body weight gain while increased the relative weights of liver and kidney. In addition, LCT significantly increased the activity of the liver function parameters; aspartate aminotransferase (AST), alanine aminotransferase (ALT) and Alkaline phosphatase (ALP) and level of kidney indices; creatinine and urea as well as oxidative stress biomarkers; lipid peroxidation (LPO) level and glutathione peroxidase (GPx) activity, while, declined the glutathione content (GSH). The above findings were confirmed by histopathological examination of liver and kidney. The administration of QE can effectively prevent LCT-induced hepatotoxicity and nephrotoxicity by attenuation oxidative stress, inflammation and tissue injury. QE enhanced antioxidant defenses, suggesting that it could be used as a potential therapeutic intervention to minimize LCT hepatotoxicity and nephrotoxicity.","PeriodicalId":134434,"journal":{"name":"Advances in Clinical Toxicology","volume":"102 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121400153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Concentrations and Health Risks Related to PAHs in Indoor and Outdoor Air, A Systematic Review 室内外空气中多环芳烃浓度及其健康风险的系统综述

Advances in Clinical Toxicology Pub Date : 1900-01-01 DOI: 10.23880/act-16000253

Roohollah Rostami

引用次数: 0

Alterations in the Air Pollution Tolerance Indices and Foliar Micro - Structures of Five Medicinal Plants: Implications of Oil - Spill Pollution of Agricultural Farmland in Edugberi Community, Rivers State, Nigeria 5种药用植物的空气污染耐受指数和叶片微观结构的变化:对尼日利亚河流州Edugberi社区农田溢油污染的影响

Advances in Clinical Toxicology Pub Date : 1900-01-01 DOI: 10.23880/act-16000164

C. Otuu

引用次数: 0

Silica Assisted Charcoal Bio-Filter Designed for the Remediation of Cr(VI) Contaminated Water Bodies 二氧化硅辅助炭生物滤池对铬(VI)污染水体的修复研究

Advances in Clinical Toxicology Pub Date : 1900-01-01 DOI: 10.23880/act-16000242

Pratyush Kumar Das

引用次数: 0

Students Act as 21st Century Preventive-Pandemic-COVID-19 Model: Improved Advance-Clinical-Toxicology Biomedicine Green-Socio-Economy Science-Technology-Innovations 学生扮演21世纪预防-大流行- covid -19模型:改进先进-临床-毒理学-生物医学-绿色-社会-经济-科学-技术创新

Advances in Clinical Toxicology Pub Date : 1900-01-01 DOI: 10.23880/act-16000204

S. Datta

{"title":"Students Act as 21st Century Preventive-Pandemic-COVID-19 Model: Improved Advance-Clinical-Toxicology Biomedicine Green-Socio-Economy Science-Technology-Innovations","authors":"S. Datta","doi":"10.23880/act-16000204","DOIUrl":"https://doi.org/10.23880/act-16000204","url":null,"abstract":"The pandemic-COVID-19 adverse effects on the environment, travel, education and clinical research, and the global health of humans and animals, and the impact on human-civilization, agriculture, global socio-economy, and damage brain-tissue or long term neurological-disorder, with more than 88-million infections and more than 1.8-million death of human lives. Recently the application of vaccine starts, but its proper efficacy, longevity, cost-effectiveness, allergic-toxic-reaction, and chance of reinfection due to new variant and mutation, are not still known. Though the middle-and upper-classes are able to tackle, but the economically poor-households, the marginalized in the Purba Bardhaman district, and groups like senior-citizens and street-children and animals, are badly affected still now. So in this paper students act as a 21st-century preventive-pandemicCOVID-19 model, improving advanced-clinical-toxicology, biomedicines, green-socio-economy, and science-technologyinnovations-communication by boosting community immunity or herd-immunity, and developing policy-initiative social strategies issues, removing the adverse effects of chemicals on living organisms and clinical studies in all areas of toxicology. This paper is considered the possible pathway of future pandemic COVID-19 like’s virus-free world.","PeriodicalId":134434,"journal":{"name":"Advances in Clinical Toxicology","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132586260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Acute Dermic Toxicity Study of Controlled Hydrofluoric Acid with Gq - 300 ® Additive Gq - 300®添加剂控制氢氟酸的急性皮肤毒性研究

Advances in Clinical Toxicology Pub Date : 1900-01-01 DOI: 10.23880/act-16000169

M. Y

{"title":"Acute Dermic Toxicity Study of Controlled Hydrofluoric Acid with Gq - 300 ® Additive","authors":"M. Y","doi":"10.23880/act-16000169","DOIUrl":"https://doi.org/10.23880/act-16000169","url":null,"abstract":"Acute dermal toxicity is the adverse effect that occurs within a short period of 24 hours after exposure. The test provides basic information to classify and label the products, being an initial step for other more lasting exposure studies. The Test Substance is a solution composed of 24% Hydrofluoric Acid (HF), controlled with the additive GQ-300®, which is a strongly acidic chemical composition and safe for human use, obtained by mixing strong acids with the purpose of achieving a balanced mixture of acids which allows, through additivation, the control and safe handling of other strong and corrosive acids. The objective of this study is to know the effect and absorption by the cutaneous route that this mixture has, for which it is used with a fixed volume of three labeled solutions and of different concentrations of HF, administered in Female Rats BIUO: Wistar in young age, adult rats and female mice BIOU: NMRI in young adult age. In conclusion the solutions of HF Controlled with Gq-300® Additive. They cause skin irritation and the degree of irritation will depend on the type of skin, being in the most sensitive and young skin, where the irritation damage and the necrosis caused by regeneration of it will be more pronounced in a short period of time. The Controlled Fluorhydric Acid with the additive GQ-300, could provide the safest handling that the 48% pure Hydrofluoric Acid (HF), which today does not have, besides allowing a reversible effect, in case of an accident, which does not offer the pure HF of 48%.","PeriodicalId":134434,"journal":{"name":"Advances in Clinical Toxicology","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133632572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ndoor Air Quality, Cell Features and Lifestyle Characteristics: Implications on the Prevalence of Some Respiratory Tract Diseases and Symptoms among Inmates of Enugu Prison, Nigeria 室内空气质量、细胞特征和生活方式特征:对尼日利亚埃努古监狱囚犯中一些呼吸道疾病和症状流行的影响

Advances in Clinical Toxicology Pub Date : 1900-01-01 DOI: 10.23880/act-16000163

Otuu Fc

引用次数: 2

Carboxylic Acid & Alzheimer’s Disease 羧酸与阿尔茨海默病

Advances in Clinical Toxicology Pub Date : 1900-01-01 DOI: 10.23880/act-16000200

P. Cusack

引用次数: 0

Assessment of the Effects of Antiretroviral Medications on Kidney Status in Rwanda 评估卢旺达抗逆转录病毒药物对肾脏状况的影响

Advances in Clinical Toxicology Pub Date : 1900-01-01 DOI: 10.23880/act-16000257

Christian Mugabo

{"title":"Assessment of the Effects of Antiretroviral Medications on Kidney Status in Rwanda","authors":"Christian Mugabo","doi":"10.23880/act-16000257","DOIUrl":"https://doi.org/10.23880/act-16000257","url":null,"abstract":"According to the previous research, ART over different durations of time has an effect on the nephron as well as on liver hepatoxicity by inducing toxicity. Renal dysfunction by ART has been associated primarily with tenofovir disoproxil, which is actively accumulated in the proximal renal tubule. CKD is the major problem in ART patients and can lead to loss of kidney function, leading to complications and kidney failure, and development of cardiovascular disease. The main objectives of this study was to assess the effect of antiretroviral drugs on kidney function among the patients attended Nyanza DH during the period of two years. The research is retrospective study done to identify the effect of antiretroviral drugs on kidney Status in Nyanza DH. In total, 755 patients received the antiretroviral medications in Nyanza DH during a period of two years from the 1st of January 2015 to the 31st of December 2017. However 98 patients had data complying with the objective of this study. Those patients with kidney tests conducted every 6months, with elevated CD4 count, and eliminated viral charge. Furthermore nephrotoxicity incidence was considered for both higher concentration of Serum creatinine and lower creatinine Clearance. The results showed that among 98 patients, 24.4% had kidney dysfunction characterized by elevated serum creatinine level at the beginning of treatment. After 6, 12 and 18 months of treatment the percentages of patients with elevated serum creatinine increased to 41.8%, 48.9 % and 50% respectively. It was found that the severity of the problem depends on: combinations the patient is taking, duration of exposure, and other medications the patient is using in combination. In this context it was found that 96.7% of patients that developed nephrotoxicity after 18months were using TDF .The results showed a higher frequency of nephrotoxicity in the population of the study. Therefore, a systematic kidney function monitoring from the beginning of the treatment should be of a great importance, those test could help to take appropriate measures.","PeriodicalId":134434,"journal":{"name":"Advances in Clinical Toxicology","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120907409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0