Protective Effects of Quercetin against Lambda Cyhalothrin Induced Hepatotoxicity and Nephrotoxicity Disorders in Mice

Abstract

Although the antioxidant, anti-inflammatory actions of quercetin (QE) are well established, no study has measured its protective actions against the toxicity of cyhalothrin lambda (LCT). This study was designed to determine the acute toxicity of LCT on male mice and investigate the effect of repeated sub lethal dose (1/10 LD50) for 14 days on body and organ weights, some biomarkers and histopathological changes in liver and kidney. In addition, the regulatory effect of QE on the hepatotoxicity and nephrotoxicity induced by LCT. The results showed that oral administration of LCT significantly reduced the body weight gain while increased the relative weights of liver and kidney. In addition, LCT significantly increased the activity of the liver function parameters; aspartate aminotransferase (AST), alanine aminotransferase (ALT) and Alkaline phosphatase (ALP) and level of kidney indices; creatinine and urea as well as oxidative stress biomarkers; lipid peroxidation (LPO) level and glutathione peroxidase (GPx) activity, while, declined the glutathione content (GSH). The above findings were confirmed by histopathological examination of liver and kidney. The administration of QE can effectively prevent LCT-induced hepatotoxicity and nephrotoxicity by attenuation oxidative stress, inflammation and tissue injury. QE enhanced antioxidant defenses, suggesting that it could be used as a potential therapeutic intervention to minimize LCT hepatotoxicity and nephrotoxicity.