Immunology letters最新文献

{"title":"METTL3/YTHDC1 mediates up-regulation of lncRNA OGRU in an m6A-dependent manner involving in oxidative stress and inflammation of HG-induced Müller cells","authors":"ShuHua Fu ,&nbsp;QianQian Zhou ,&nbsp;Xin Peng ,&nbsp;YaoYun Hu ,&nbsp;Jian Xiong ,&nbsp;Fei Liu","doi":"10.1016/j.imlet.2025.106972","DOIUrl":"10.1016/j.imlet.2025.106972","url":null,"abstract":"<div><h3>Background</h3><div>Diabetic retinopathy (DR) is a common complication of diabetes, which may cause visual disturbance and even loss of sight. Oxidative stress and inflammation are two crucial pathological factors of DR; however, their specific regulatory mechanisms in DR remain obscure.</div></div><div><h3>Methods</h3><div>DR models were established in streptozotocin-challenged rats and high glucose (HG)-stimulated Müller cells. Western blotting and RT-qPCR were performed to determine target molecule levels. ROS release was evaluated by DCFH-DA staining, and the levels of MDA, GSH, SOD, and CAT were detected using commercial kits. The levels of proinflammatory factors (TNF-α, IL-1β, IL-6, MCP-1, and CXCL-1) were analyzed by RT-qPCR and ELISA. The subcellular localization of OGRU was observed by FISH. Molecular interaction was evaluated by RIP. M6A level was assessed by MeRIP and colorimetric quantification kit.</div></div><div><h3>Results</h3><div>HG stimulation or diabetic stress resulted in an elevation in the overall m6A level, as well as expression level of methyltransferase-like 3 (METTL3) in the experimental models of DR. M6A writer METTL3 stabilized lncRNA OGRU via m6A modification. Functionally, METTL3 deficiency relieved HG-induced oxidative stress damage and inflammation in Müller cells. Rescue assays demonstrated that OGRU overexpression reversed METTL3 silencing-mediated protection against HG-stimulated Müller cells. Furthermore, YTH Domain-Containing Protein 1 (YTHDC1) coordinated with METTL3 to enhance OGRU stability in an m6A-dependent manner.</div></div><div><h3>Conclusion</h3><div>METTL3-mediated m6A modification stabilized OGRU with assistance of YTHDC1, which led to oxidative stress and inflammation during DR progression. Targeting METTL3/YTHDC1/OGRU axis might be a potential therapeutic strategy for DR.</div></div>","PeriodicalId":13413,"journal":{"name":"Immunology letters","volume":"272 ","pages":"Article 106972"},"PeriodicalIF":3.3,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does atopic dermatitis increase the risk of allergic contact dermatitis?","authors":"Xingbao Luan ,&nbsp;Xiaomei Cui ,&nbsp;Yuanyuan Jia ,&nbsp;Zhaopeng Wang ,&nbsp;Yuting Yang ,&nbsp;Kunpeng Wang ,&nbsp;Dan Luo","doi":"10.1016/j.imlet.2025.106969","DOIUrl":"10.1016/j.imlet.2025.106969","url":null,"abstract":"","PeriodicalId":13413,"journal":{"name":"Immunology letters","volume":"272 ","pages":"Article 106969"},"PeriodicalIF":3.3,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142926997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"X-ray irradiation reduces ATP-dependent activation of NLRP3 inflammasome by inhibiting TWIK2 activity in macrophages","authors":"Xiaofei Huang ,&nbsp;Man Niu ,&nbsp;Tianjing Sun ,&nbsp;Mo Li ,&nbsp;Xuheng Jiang ,&nbsp;Haizhen Duan ,&nbsp;Tianxi Zhang ,&nbsp;Ji Zhang ,&nbsp;Fangke Xie ,&nbsp;Renjie Song ,&nbsp;Anyong Yu","doi":"10.1016/j.imlet.2024.106967","DOIUrl":"10.1016/j.imlet.2024.106967","url":null,"abstract":"<div><h3>Background</h3><div>The spleen, as the body's largest peripheral immune organ and a crucial source of circulating monocytes, plays a significant role in the acute inflammatory response of spleen-derived macrophages to diseases. Therefore, studying the impact and mechanism of X-ray irradiation on spleen-derived macrophages' inflammatory responses is of great importance.</div></div><div><h3>Method</h3><div>Extracted and identified mice splenic macrophages were divided into four groups: control group, LPS and ATP co-stimulated non-irradiated group, LPS and ATP co-stimulated group irradiated after 6 h, and LPS and ATP co-stimulated group irradiated after 12 h In the LPS and ATP co-stimulated groups, LPS (1μg/ml) and ATP (5mmol/L) were added to establish an inflammatory model in mice splenic macrophages. The irradiated groups were exposed to a medical linear accelerator (Elekta Synergy), while the non-irradiated groups were placed under the light source for the same duration without irradiation. Protein extraction was performed in each group at 6 h and 12 h post-treatment for subsequent analysis using Western blot, ELISA, RT-qPCR and other relevant methods.</div></div><div><h3>Results</h3><div>(1) Compared with the non-irradiated group, the cell activity in the groups irradiated for 6 h and 12 h at 8 Gy showed a significant increase (<em>P</em>&lt;0.01). (2) In the LPS and ATP co-stimulated groups irradiated after 6 h and 12 h, the expression of NLRP3 mRNA and protein, IL-18 and IL-1β showed a notable decrease compared to the LPS and ATP co-stimulated non-irradiated group (<em>P</em>&lt;0.05). Additionally, caspase-1 expression of caspase-1 mRNA and protein in the 12 h post-irradiation group also decreased considerably when compared with the LPS and ATP co-stimulated non-irradiated group (<em>P</em> &lt; 0.05). In the groups irradiated after 6 h and 12 h, (3) there was a remarkable decrease in the expression of TWIK mRNA and TWIK2, (4) as well as Gq mRNA and protein, when compared to the LPS and ATP co-stimulated non-irradiated group (<em>P</em> &lt; 0.05). Particularly, the 12 h post-irradiation group exhibited a notable reduction in PKC expression (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>X-ray irradiation is capable of inhibiting the activation of ATP-dependent NLRP3 inflammasomes in splenic macrophages.</div></div>","PeriodicalId":13413,"journal":{"name":"Immunology letters","volume":"272 ","pages":"Article 106967"},"PeriodicalIF":3.3,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seasonal patterns of myositis-specific and myositis-associated autoantibodies in Italy","authors":"Boaz Palterer ,&nbsp;Alessio Mazzoni ,&nbsp;Maria Infantino ,&nbsp;Roberto Semeraro ,&nbsp;Mariangela Manfredi ,&nbsp;Giampaola Pesce ,&nbsp;Brunetta Porcelli ,&nbsp;Lucia Terzuoli ,&nbsp;Gaia Deleonardi ,&nbsp;Giulia Previtali ,&nbsp;Maria Grazia Alessio ,&nbsp;Emirena Garrafa ,&nbsp;Sara Ghisellini ,&nbsp;Michela Boni ,&nbsp;Pierluigi Anzivino ,&nbsp;Teresa Carbone ,&nbsp;Maria Cristina Sacchi ,&nbsp;Maria Concetta Sorrentino ,&nbsp;Ignazio Brusca ,&nbsp;Nunzia Rita Tarricone ,&nbsp;Nicola Bizzaro","doi":"10.1016/j.imlet.2024.106966","DOIUrl":"10.1016/j.imlet.2024.106966","url":null,"abstract":"<div><h3>Objective</h3><div>Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of systemic autoimmune disorders affecting skeletal muscles but also other organs. There are different forms of IIM, each with peculiar clinical manifestations and prognosis. Accordingly, several autoantibodies have been described in IIM, with different prevalence in the different forms of the disease. The etiopathogenesis of IIM is still unclear, although environmental agents play certainly a role to trigger disease development in genetically predisposed individuals. Supporting this notion, some reports suggest that the incidence of IIM may be different throughout the year. In this work, we tested if the detection of autoantibodies typically observed in IIM has a seasonal pattern.</div></div><div><h3>Methods</h3><div>We collected serological data from line immunoassays (LIA) performed on 4277 patients with suspected IIM from January 2018 to December 2020 in ten Italian hospitals. Myositis-specific and myositis-associated autoantibodies were evaluated by line-immunoassay.</div></div><div><h3>Results</h3><div>Our findings demonstrate that absolute numbers of anti-MDA5, anti-PM-Scl75, anti-Mi2b and anti-TIF1ɣ autoantibodies are more frequently detected in autumn-winter than in spring-summer. However, only anti-PM-Scl75 and anti-MDA5 display a similar pattern when analyzing frequencies of positive tests (for anti-PM-Scl75 100 positive tests and 2107 negative tests from September to February; 55 positive tests and 1903 negative tests from March to August, <em>p</em> = 0.003; for anti-MDA5 34 positive tests and 1983 negative tests from September to February; 17 positive tests and 1760 negative tests from March to August, <em>p</em> = 0.051).</div></div><div><h3>Conclusions</h3><div>These findings suggests that triggering agents promoting the development of these autoantibodies have a specific seasonal pattern.</div></div>","PeriodicalId":13413,"journal":{"name":"Immunology letters","volume":"272 ","pages":"Article 106966"},"PeriodicalIF":3.3,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142835548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Soluble CTLA-4 – A confounding factor in CTLA-4 based checkpoint immunotherapy in cancer","authors":"Parviz Azimnasab-sorkhabi ,&nbsp;Maryam Soltani-asl ,&nbsp;Musab Bouhajra ,&nbsp;Ephraim A. Ansa-Addo ,&nbsp;Jose Roberto Kfoury Junior","doi":"10.1016/j.imlet.2024.106965","DOIUrl":"10.1016/j.imlet.2024.106965","url":null,"abstract":"<div><div>Cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4) is a receptor that inhibits the activity of T cells. The CTLA-4 gene consists of four different exons that enable four different isoforms of CTLA-4 to be generated through alternative splicing. Although sCTLA-4 might impede the therapeutic effect of anti-CTLA-4 treatments, the role of sCTLA-4 in the tumor microenvironment (TME) is not well understood. Here, we provide novel perspectives on the inhibitory characteristics of sCTLA-4 in TME.</div></div>","PeriodicalId":13413,"journal":{"name":"Immunology letters","volume":"272 ","pages":"Article 106965"},"PeriodicalIF":3.3,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early decrease of T-bet+ B cells during subcutaneous belimumab predicts response to therapy in systemic lupus erythematosus patients","authors":"Francesca La Gualana ,&nbsp;Giulio Olivieri ,&nbsp;Begi Petriti ,&nbsp;Licia Picciariello ,&nbsp;Francesco Natalucci ,&nbsp;Maddalena Sciannamea ,&nbsp;Laura Gragnani ,&nbsp;Umberto Basile ,&nbsp;Milvia Casato ,&nbsp;Francesca Romana Spinelli ,&nbsp;Lucia Stefanini ,&nbsp;Stefania Basili ,&nbsp;Marcella Visentini ,&nbsp;Fulvia Ceccarelli ,&nbsp;Fabrizio Conti","doi":"10.1016/j.imlet.2024.106962","DOIUrl":"10.1016/j.imlet.2024.106962","url":null,"abstract":"<div><div>Systemic lupus erythematosus (SLE) is characterized by B cell dysregulation and expansion of atypical B cells that may correlate with disease manifestations and activity. This study investigated the impact of subcutaneous (sc) Belimumab (BLM) on the peripheral B cell compartment and on the functional properties of CD21^low, T-bet⁺ and CD11c⁺ atypical B cells, in 21 active SLE patients over a 12-month period. At baseline, active SLE patients displayed reduced unswitched IgM memory B cells and expansion of atypical B cells, compared to healthy donors and to SLE patients in remission. <em>sc</em> BLM therapy promptly restored B cell homeostasis with a reduction of T-bet⁺ B cells, observed early in patients responsive to therapy. These findings highlight the pathogenic role of T-bet⁺ B cells in SLE disease and suggest their potential utility as biomarker of clinical response.</div></div>","PeriodicalId":13413,"journal":{"name":"Immunology letters","volume":"272 ","pages":"Article 106962"},"PeriodicalIF":3.3,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NLRC3 affects the development of psoriasis by modulating the NF-κB signaling pathway mediated inflammatory response through its interaction with TRAF6","authors":"Wanlu Zhang,&nbsp;Gege Zhu,&nbsp;Huiya Sun,&nbsp;Congjun Jiang","doi":"10.1016/j.imlet.2024.106949","DOIUrl":"10.1016/j.imlet.2024.106949","url":null,"abstract":"<div><h3>Objective</h3><div>The function and mechanism of NOD-like receptor family CARD-containing 3 (NLRC3) in psoriasis are not yet reported, even though it plays a crucial role in innate and adaptive immunity by inhibiting inflammation. Therefore, this research aims to investigate the role and mechanism of NLRC3 in psoriasis.</div></div><div><h3>Methods</h3><div>HaCaT cells were induced to form a psoriasis cell model using 20 ng/mL IL-1β, 20 ng/mL IL-17A, 20 ng/mL IL-23, 50 ng/mL TNF-α, and 20 ng/mL oncostatin M. Cell Counting Kit-8 (CCK-8) assay and flow cytometry were assessed to determine the proliferation, cell cycle, and apoptosis of HaCaT cells. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was utilized to measure the knockdown efficiency of NLRC3 and TRAF6 interfering RNA in HaCaT cells. Western blot analysis was performed to determine the expression levels of NLRC3, TRAF6, and proteins associated with the NF-κB signaling pathway. A mouse model of psoriasis-like dermatitis was established by evenly applying miquimod cream (62.5 mg/day) to both ears. Hematoxylin-eosin staining was used to measure ear thickness and inflammatory infiltrates in mice. Histological analysis, immunohistochemistry, and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL were performed to detect cell proliferation and apoptosis. Interactions between NLRC3 and TRAF6 were predicted using the STRING database (<span><span>https://cn.string-db.org/</span><svg><path></path></svg></span>). Co-Immunoprecipitation was used to confirm interactions between NLRC3 and TRAF6. Ubiquitination of TRAF6 was assessed by Western blot.</div></div><div><h3>Results</h3><div>Knockdown of NLRC3 expression promoted cell proliferation and inhibited cell apoptosis in HaCaT cells. In vivo, knockdown of NLRC3 expression significantly increased the infiltration of inflammatory cells and the proliferation of Ki-67 positive cells within mouse ear epidermis, while decreasing the number of apoptotic cells. NLRC3 interacted with TRAF6 and influenced its K63 ubiquitination level. Knockdown of TRAF6 expression resulted in increased cell proliferation and decreased cell apoptosis in HaCaT cells. In vivo, knockdown of TRAF6 expression led to a significant increase in inflammatory cell infiltration and Ki-67 positive cells in mouse ear epidermis, and a decrease in apoptotic cells. Inhibiting the NF-κB signaling pathway alleviated the progression of psoriasis, and interfering with TRAF6 activated the NF-κB signaling axis, contributing to the onset and advancement of psoriasis.</div></div><div><h3>Conclusion</h3><div>NLRC3 affects the occurrence of psoriasis by regulating TRAF6 and influencing the NF-κB signaling axis-mediated inflammatory response. This finding offers a theoretical foundation for the treatment of psoriasis.</div></div>","PeriodicalId":13413,"journal":{"name":"Immunology letters","volume":"272 ","pages":"Article 106949"},"PeriodicalIF":3.3,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of leukocyte-associated Ig-like receptor-1 in the pathogenesis of Kawasaki disease and coronary artery aneurysms","authors":"Zhuo Chen ,&nbsp;Anle Zeng ,&nbsp;Penghui Yang ,&nbsp;Jing Zhang ,&nbsp;Dong Liu ,&nbsp;Mengling Li ,&nbsp;Fengchuan Jing ,&nbsp;Qijian Yi","doi":"10.1016/j.imlet.2024.106948","DOIUrl":"10.1016/j.imlet.2024.106948","url":null,"abstract":"<div><h3>Objective</h3><div>To elucidate the relationship between leukocyte-associated Ig-like receptor-1 (LAIR-1) and the pathogenesis of Kawasaki disease (KD) and coronary artery aneurysms(CAA).</div></div><div><h3>Methods</h3><div>The study cohort comprises children who were diagnosed with KD and were categorized into two groups: KD patients with CAA (KD-CAA) and KD without CAA (KD-NCAA), with healthy children serving as control group (HC). LAIR-1 on leukocytes was examined via flow cytometry, while serum LAIR-1 (sLAIR-1) was quantified using ELISA. IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70, IL-17A, IFN-α, IFN-γ and TNF-α were examined by Immunofluorescence assay.</div></div><div><h3>Results</h3><div>sLAIR-1 levels were elevated in the KD and KD-CAA groups compared with those in the HC and KD-NCAA groups (P &lt; 0.05). sLAIR-1 exhibited an area under the curve value of 0.858 for predicting KD (P &lt; 0.001) and 0.628 for predicting CAA (P = 0.055, borderline significance). LAIR-1 was increased on the neutrophils in KD group, whereas it was lower in KD-CAA than that in KD-NCAA, and decreased in KD after IVIG treatment. In contrast, LAIR-1 was reduced on CD4+ and CD8+ T lymphocyte in KD group, and increased in KD after IVIG treatment (all P &lt; 0.05). LAIR-1 on neutrophils showed a positive correlation with IL-5, while on CD4+ T cells, it was negatively correlated with IL-2, IL-6, IL-10, IFN-γ, and IL-8. On CD8+ T cells, LAIR-1 was negatively correlated with IL-2 and IFN-γ.</div></div><div><h3>Conclusion</h3><div>sLAIR-1 may serve as a potential biomarker for KD and CAAs, while LAIR-1 might be implicated in KD pathogenesis and CAA.</div></div>","PeriodicalId":13413,"journal":{"name":"Immunology letters","volume":"271 ","pages":"Article 106948"},"PeriodicalIF":3.3,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaccine safety in children with genetically confirmed mitochondrial disease","authors":"Annemarie de Vreugd ,&nbsp;Franz A. Zimmermann ,&nbsp;Katja Steinbrücker ,&nbsp;Maaike C. de Vries ,&nbsp;Lonneke de Boer ,&nbsp;Mirian CH Janssen ,&nbsp;Martina Huemer ,&nbsp;Saskia B. Wortmann","doi":"10.1016/j.imlet.2024.106946","DOIUrl":"10.1016/j.imlet.2024.106946","url":null,"abstract":"<div><div>We here explore adverse events following immunization (AEFI) in children with mitochondrial disease (MD) recruited from two expertise centers in Austria (SALK) and The Netherlands (RUMC). Parents completed a questionnaire on the type of immunizations received and AEFI in a post-vaccination exposure period of seven days.</div><div>95 individuals were invited to this study, of whom 30 (median age 13.4 years) participated. Together these individuals had received 376 immunizations with a median of 12 vaccinations each. In 316 of 376 (84 %) vaccinations no AEFI occurred, 22 patients (73 %) never experienced any AEFI. Eight patients experienced 76 AEFI after 60 vaccinations, these were mild (redness (<em>n</em> = 9) /pain at injection site (<em>n</em> = 21), fever (<em>n</em> = 44), gastrointestinal complaints (<em>n</em> = 2)). None had a metabolic deterioration or seizures, no patient was admitted to the hospital.</div><div>Although our data is limited by the small sample size, this may aid in discussing responsible immunization decisions with parents.</div></div>","PeriodicalId":13413,"journal":{"name":"Immunology letters","volume":"271 ","pages":"Article 106946"},"PeriodicalIF":3.3,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The roles of collectins in renal diseases and transplantation","authors":"Fu Lv ,&nbsp;Wuding Zhou ,&nbsp;Ke Li","doi":"10.1016/j.imlet.2024.106945","DOIUrl":"10.1016/j.imlet.2024.106945","url":null,"abstract":"<div><div>The collectins are soluble C-type lectins and a group of proteins characterized with common structural features: a collagen-like domain and a carbohydrate-binding domain. These proteins are essential components of the innate immune system, pivotal for recognizing and eliminating pathogens to protect against infections. Over recent decades, research has significantly advanced our understanding of collectins. Beyond their fundamental role in host defense, collectins have been emerged as multifunctional proteins involved in modulating inflammatory and immune responses, facilitating the clearance of cellular debris, and even stimulating cell proliferation. These diverse roles are critical for maintaining physiological balance and hold substantial implications in various disease processes, particularly in renal diseases and transplantation. Here, we review the roles of collectins in renal diseases and transplantation focusing on four prominent members of the collectin family: mannose-binding lectin (MBL), surfactant proteins (SP-A and SP-D), and collectin-11 (CL-11). These proteins have gained considerable attention in current research due to their roles in renal diseases and transplantation, shedding light on their impact beyond traditional immune defense mechanisms. Understanding their involvement in these contexts is crucial for exploring potential therapeutic avenues and interventions aimed at mitigating renal pathology and improving outcomes in transplantation settings.</div></div>","PeriodicalId":13413,"journal":{"name":"Immunology letters","volume":"271 ","pages":"Article 106945"},"PeriodicalIF":3.3,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}