Immunology letters最新文献

{"title":"Navigating Challenges of aGvHD Predictive Biomarkers in αβhaplo-HSCT Recipients: Still Waiting for MAGIC to Happen.","authors":"Raul Montiel-Esparza, Isobel Hawes, Rhonda Perriman, Giulia Barbarito, Linda Oppizzi, David Shyr, Laurel Kent, Zhenyu Yao, Alice Bertaina","doi":"10.1016/j.imlet.2025.107062","DOIUrl":"https://doi.org/10.1016/j.imlet.2025.107062","url":null,"abstract":"<p><p>The validated Mount Sinai Acute graft-versus-host disease (aGvHD) International Consortium (MAGIC) algorithm and biomarker panels did not predict aGvHD occurrence or severity in pediatric αβT-cell/CD19 B-cell depleted haploidentical hematopoietic stem cell transplant (αβhaplo-HSCT) recipients. These findings suggest distinct aGvHD biology in the αβhaplo-HSCT setting, supporting the need for tailored biomarker studies in this unique transplant platform.</p>","PeriodicalId":13413,"journal":{"name":"Immunology letters","volume":" ","pages":"107062"},"PeriodicalIF":3.3,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic and transcriptional dysregulation of innate antiviral immune pathways in type 1 diabetes","authors":"Mia Ø Mønsted ,&nbsp;Kristina Pedersen ,&nbsp;Mathias H. Jensen ,&nbsp;Simranjeet Kaur ,&nbsp;Sofía C. Sustacha ,&nbsp;Laurits J. Holm ,&nbsp;Karsten Buschard ,&nbsp;Flemming Pociot ,&nbsp;Martin Haupt-Jorgensen","doi":"10.1016/j.imlet.2025.107060","DOIUrl":"10.1016/j.imlet.2025.107060","url":null,"abstract":"<div><div>Innate antiviral immune pathways (InAIPs) are dysregulated in islets of type 1 diabetes (T1D) patients, implying how enterovirus might contribute to beta-cell autoimmunity. However, it is unclear whether similar dysregulation occurs in the intestine, contributing to pathologies like barrier dysfunction. Thus, we used a published genome-wide association study to identify polymorphisms in intestinal permeability and InAIP genes. We compared female prediabetic non-obese diabetic (NOD) and C57BL/6 mice and their jejunal epithelial RNA profile by GeneChip analysis. The potential link between dysregulation of InAIP genes and increased intestinal permeability was assessed by measuring trans-epithelial electrical resistance in intestinal Caco-2 cells upon R837 toll-like receptor 7 stimulation. There was genetic predisposition to T1D among intestinal permeability genes. However, InAIP genes contained more promising T1D-associated polymorphisms, especially for <em>TNFA, OAS3, PIGR, CD55, NOD2</em>, and <em>IFIH1</em>. Comparing prediabetic NOD with C57BL/6 mice revealed age-dependent dysregulation of several InAIP genes (<em>Ifih1, Rnase1 etc.</em>) in jejunum. Lastly, mimicking an enterovirus infection with R837 stimulation of Caco-2 cells increased intestinal permeability. We demonstrate genetic and transcriptional dysregulation of InAIPs in T1D and their potential involvement in intestinal barrier dysfunction, providing new clues to the disease-manifesting mechanisms of enterovirus infection.</div></div>","PeriodicalId":13413,"journal":{"name":"Immunology letters","volume":"276 ","pages":"Article 107060"},"PeriodicalIF":3.3,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated ascitic interleukin-36 receptor antagonist mediates CD8+ T cell exhaustion in vitro in liver cirrhotic patients with spontaneous bacterial peritonitis","authors":"Lanlan Yang,&nbsp;Siqi Liu,&nbsp;Chen Qiu,&nbsp;Qian Zhang,&nbsp;Chuanhui Zhang,&nbsp;Zhenjing Jin","doi":"10.1016/j.imlet.2025.107061","DOIUrl":"10.1016/j.imlet.2025.107061","url":null,"abstract":"<div><div>Interleukin-36 (IL-36) signaling pathway plays an important regulatory role in inflammatory and infectious diseases. However, the modulatory function of IL-36 in CD8⁺ <em>T</em> cells that are involved in liver cirrhosis with spontaneous bacterial peritonitis (SBP) has not been understood. Sixty-five liver cirrhotic patients (42 untainted ascites and 23 SBP patients) and 20 controls were included. IL-36 levels were measured by ELISA. CD8⁺ <em>T</em> cells were purified from ascites, and were stimulated with IL-36 receptor antagonist (IL-36RA). CD8⁺ <em>T</em> cells were co-cultured with HepG2 cells in direct contact and indirect contact manners. Target cell death and cytotoxic molecules levels were investigated to assess CD8⁺ <em>T</em> cell cytotoxicity. The immune-checkpoint molecules expressions on CD8⁺ <em>T</em> cells were measured by flow cytometry. There were no significant differences in IL-36alpha, IL-36beta, or IL-36gamma levels between untainted ascites and SBP patients. SBP patients had increased ascitic IL-36RA, which positively correlated with alanine aminotransferase and ascitic neutrophil count. IL-36RA stimulation did not affect CD8⁺ <em>T</em> cell proliferation, but dampened CD8⁺ <em>T</em> cell-induced cell death and proinflammatory cytokine secretions. Perforin and granzyme B productions were down-regulated in direct contact manner. IL-36RA stimulation promoted immune-checkpoint molecules expressions on CD8⁺ <em>T</em> cells. The present findings revealed that elevated ascitic IL-36RA might inhibit ascitic CD8⁺ <em>T</em> cell cytotoxicty in liver cirrhotic patients with SBP.</div></div>","PeriodicalId":13413,"journal":{"name":"Immunology letters","volume":"276 ","pages":"Article 107061"},"PeriodicalIF":3.3,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The CSF transcriptome in adults with pneumococcal meningitis reveals compartmentalised host inflammatory responses associated with mortality","authors":"José Afonso Guerra-Assunção ,&nbsp;Probir Chakravarty ,&nbsp;Gabriele Pollara ,&nbsp;Cristina Venturini ,&nbsp;Veronica S Mlozowa ,&nbsp;Brigitte Denis ,&nbsp;Mulinda Nyirenda ,&nbsp;David G Lalloo ,&nbsp;Mahdad Noursadeghi ,&nbsp;Jeremy S Brown ,&nbsp;Robert S Heyderman ,&nbsp;Emma C Wall","doi":"10.1016/j.imlet.2025.107059","DOIUrl":"10.1016/j.imlet.2025.107059","url":null,"abstract":"<div><div>Pneumococcal meningitis (PM) has persistently poor clinical outcomes, especially in sub-Saharan Africa. To better characterise the inflammatory response and identify factors associated with mortality we compared paired peripheral blood and cerebrospinal fluid (CSF) transcriptomes before the initiation of antibiotics in Malawian adults with proven PM.</div><div>Blood transcriptional profiles were obtained in 28 patients with PM, with simultaneous paired with CSF profiles available for 13 patients. 15/28 (52 %) patients died. Comparison of the transcriptome between CSF and blood compartments showed upregulation of 2293 differentially expressed genes in CSF and 909 in blood; enriched pathways in CSF included inflammasome activity and neutrophil migration/activation, contrasting with enrichment for pathways including platelet and endothelial activation, cell cycle, cytokine release and oxidative stress in the blood transcriptome. Comparison of CSF profiles between survivors and non-survivors revealed 1829 differentially expressed genes. Non-survivor CSF was enriched for multiple innate inflammatory pathways, including IL-17A and Type 1 interferons and proteolysis. In contrast, minimal transcriptomic differences between outcome groups were detected in blood.</div><div>Inflammation in PM is characterised by compartmentalised responses in blood and CSF. Poorer outcomes are associated with an dysregulated innate immune host response to <em>S. pneumoniae</em> in the CSF compartment.</div></div>","PeriodicalId":13413,"journal":{"name":"Immunology letters","volume":"276 ","pages":"Article 107059"},"PeriodicalIF":3.3,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the biological potential of skin fibroblast: responses to TNF-α, highlighting intracellular signaling pathways and secretome","authors":"Carlota Pascoal ,&nbsp;Pedro Granjo ,&nbsp;Patrícia Mexia ,&nbsp;Diana Gallego ,&nbsp;Rita Adubeiro Lourenço ,&nbsp;Shally Sharma ,&nbsp;Bélen Pérez ,&nbsp;Margarida Castro-Caldas ,&nbsp;Ana Rita Grosso ,&nbsp;Vanessa dos Reis Ferreira ,&nbsp;Paula Alexandra Videira","doi":"10.1016/j.imlet.2025.107057","DOIUrl":"10.1016/j.imlet.2025.107057","url":null,"abstract":"<div><h3>Objective</h3><div>In this study, we examined the molecular response of human skin fibroblasts to an inflammatory cytokine to evaluate their suitability as models for immunopathology research.</div></div><div><h3>Methods</h3><div>Skin fibroblasts were stimulated with tumour necrosis factor (TNF)-α, and the transcriptome was profiled via RNA-Seq. The differentially expressed genes were screened to predict immunological pathways and interactions. The cytokines and signaling pathways were validated at protein level. Similarly to immune cells, TNF-α caused transcriptional and transductional changes in fibroblasts.</div></div><div><h3>Results</h3><div>Functional analysis revealed significant enrichment of TNF-α signaling and cell chemotaxis (normalized enrichment score = 2.59 and 3.42). We also detected enrichment of nuclear factor kappa B (NF-κB) target genes and NF-kB activation, confirmed by complete protein degradation of its inhibitor IκBa (<em>p</em> = 0.0019). The MAPK/ERK and p38 MAPK pathways were also activated. Finally, we observed significant secretion of proinflammatory cytokines and chemokines, such as interleukin 6 (<em>p</em> = 0.02), CXCL8 (<em>p</em> = 0.027), CCL2 (<em>p</em> = 0.028) and CCL5 (<em>p</em> = 0.016).</div></div><div><h3>Conclusion</h3><div>This study advances the biological understanding of skin fibroblast responses to TNF-α, revealing their intracellular pathways and secretome. It discloses techniques for leveraging fibroblasts' potential as <em>in vitro</em> models to identify inflammatory drivers, particularly when alternative models are inaccessible.</div></div>","PeriodicalId":13413,"journal":{"name":"Immunology letters","volume":"276 ","pages":"Article 107057"},"PeriodicalIF":3.3,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Splenomegaly in CVID patients associates with CMV replication and alterations of immune cells and functions","authors":"Luca Marri ,&nbsp;Paola Contini ,&nbsp;Federico Ivaldi ,&nbsp;Chiara Schiavi ,&nbsp;Ottavia Magnani ,&nbsp;Chiara Vassallo ,&nbsp;Andrea Guastalla ,&nbsp;Noemi Traversone ,&nbsp;Davide Deraco ,&nbsp;Claudia Angelini ,&nbsp;Genny Del Zotto ,&nbsp;Raffaele De Palma ,&nbsp;Andrea De Maria","doi":"10.1016/j.imlet.2025.107058","DOIUrl":"10.1016/j.imlet.2025.107058","url":null,"abstract":"<div><h3>Background</h3><div>Splenomegaly represents a frequent non-infectious manifestation in Common Variable Immunodeficiency (CVID) and associates with specific clinical and immunophenotypic characteristics.</div></div><div><h3>Objective</h3><div>To investigate the association between splenomegaly, infections, and immunophenotype in CVID patients.</div></div><div><h3>Methods</h3><div>A cohort of 32 CVID patients (13 with splenomegaly) was enrolled. Infectious workup encompassed a detailed medical history and data derived from routine diagnostic assessments including specific virological analysis of blood and stool samples, and QuantiFERON assay for tuberculosis. Immunophenotype was assessed by multiparametric flow cytometry. Statistical analyses were performed using Prism and Jamovi software.</div></div><div><h3>Results</h3><div>CMV viraemia was detected in 40 % of splenomegalic CVID (sCVID) and was absent in non-sCVID patients. Of all infectious agents, CMV was the only one associated with splenomegaly (<em>p</em> = 0.009). The inclusion of CMV replication as a causative factor for splenomegaly in CVID is in line with the knowledge that splenomegaly is a hallmark of acute CMV infection and could help explain in the present CVID cohort 75 % of otherwise unexplained splenomegalies. Flow cytometric analysis in sCVID vs. non-sCVID confirmed decreases in NK cell numbers and activation, in circulating inflammatory precursors (Lin⁻CD16⁺), and increased T cell activation as defined by HLA-DR/CD69/CD38 expression.</div></div><div><h3>Conclusion</h3><div>Splenomegaly in CVID patients may associate also with CMV replication. The combined identification in CMV⁺ sCVID of NK cell, inflammatory precursor and T cell imbalances suggests a possible combined cellular defect at precursor level in a subset of sCVID patients. When integrated into everyday clinical management, CMV viraemia could become a useful additional parameter for patient characterization and stratification.</div></div>","PeriodicalId":13413,"journal":{"name":"Immunology letters","volume":"276 ","pages":"Article 107058"},"PeriodicalIF":3.3,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune cells and functions in patients with restless legs syndrome","authors":"Aysenur Kokoglu ,&nbsp;Ayse Engin ,&nbsp;Metin Yusuf Gelmez ,&nbsp;Esin Aktas Cetin ,&nbsp;Gulcin Benbir Senel ,&nbsp;Derya Karadeniz ,&nbsp;Gunnur Deniz","doi":"10.1016/j.imlet.2025.107056","DOIUrl":"10.1016/j.imlet.2025.107056","url":null,"abstract":"<div><div>Restless legs syndrome (RLS) is a sleep-related disorder, and some evidence suggests that inflammation contributes to its pathophysiology. This study aimed to investigate the relationship between RLS and immune cells.</div><div>Fourteen RLS patients, and 10 healthy subjects were included in the study. The percentages of T, B, natural killer (NK), natural killer T (NKT) and innate lymphoid cells (ILCs) were analyzed, along with intracellular levels of interferon-gamma (IFN-γ), interleukin (IL)-6, IL-10, and IL-13 in T, B and NK cells. Additionally, CD8⁺ T and NK cell cytotoxic activities were assessed using flow cytometry. Plasma levels of IFN-γ, tumor necrosis factor-alpha (TNF-α), IL-2, IL-4, IL-6, IL-10, and IL-13 were evaluated with bead-based soluble molecule assay.</div><div>Compared to healthy subjects, the ratio of ILC-1 subset and IL-13⁺CD4⁺ T cells were significantly increased in RLS patients, while the levels of ILC-2 subset were significantly decreased. When the NK cell cytotoxic activity of RLS patients was evaluated, it was found that the NK cell perforin levels were lower than healthy subjects. Plasma IL-13 levels were also significantly elevated in RLS patients compared to healthy individuals.</div><div>These findings suggest that both innate and adaptive immune responses may play a role in RLS pathophysiology. Alterations in ILC subsets, along with elevated IL-13, IL-10, and IL-6 levels, as well as NK and CD8⁺ T cell cytotoxic activity, indicate that immune dysregulation might contribute to the disease mechanism. Furthermore, the observed correlation between efficient sleep and immune markers highlights the potential role of immune system modulation in RLS management.</div></div>","PeriodicalId":13413,"journal":{"name":"Immunology letters","volume":"276 ","pages":"Article 107056"},"PeriodicalIF":3.3,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alterations in chemokine receptor-ligand interactions and costimulatory molecules in DC-NK crosstalk: A novel therapeutic approach for pemphigus vulgaris","authors":"Vishakha Hooda ,&nbsp;Divya Sharma ,&nbsp;Ashu Singh ,&nbsp;Dayasagar Das ,&nbsp;Somesh Gupta ,&nbsp;Sudheer Arava ,&nbsp;Alpana Sharma","doi":"10.1016/j.imlet.2025.107055","DOIUrl":"10.1016/j.imlet.2025.107055","url":null,"abstract":"<div><div>Innate immune cells, particularly natural killer (NK) cells and dendritic cells (DCs), play a crucial role in the immunopathogenesis of Pemphigus Vulgaris (PV), an autoimmune blistering disorder. Dysregulation of these innate cells can lead to significant consequences in the adaptive immune response, contributing to disease progression. This study investigates the crosstalk between NK cells and DCs as a potential therapeutic target for PV. Our findings reveal an increased frequency of DCs (mDCs and pDCs) and NK cells (CD56^dim and CD56^bright) in the peripheral circulation of PV patients. NK cells exhibited elevated granzyme activity and IFNγ production, while DCs displayed enhanced phagocytic capabilities. In vitro, we observed upregulated mRNA expression of potentially interacting co-stimulatory markers (CD40 and CD80) and chemokines (CXCL10 and CXCL8) in DCs, alongside increased expression of their corresponding receptors (CD40L, CD80L, CXCR3, and CXCR1) on NK cells. Lesional tissues from PV patients also showed heightened expression of these receptor-ligand pairs. Co-culture experiments further demonstrated increased granzyme activity in NK cells and enhanced phagocytosis in DCs, however, blocking of CXCR3 resulted in decreased granzyme activity, suggesting a functional modulation through their interaction. These findings highlight the significant role of NK-DC crosstalk in PV pathogenesis and suggest that targeting this interaction could offer a novel therapeutic strategy to modulate immune responses in PV, offering the potential for more effective treatment approaches.</div></div>","PeriodicalId":13413,"journal":{"name":"Immunology letters","volume":"276 ","pages":"Article 107055"},"PeriodicalIF":3.3,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144527760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced CD37 expression in B cell subsets after stimulation and its clinical relevance in primary Sjögren's syndrome","authors":"Zhonghui Zhang ,&nbsp;Jie Chen ,&nbsp;Ziqi Xiong ,&nbsp;Weijie Lin ,&nbsp;Bohao Yang ,&nbsp;Zhiwei Zong ,&nbsp;Bing Shen ,&nbsp;Hanxi Luo ,&nbsp;Chen Liu","doi":"10.1016/j.imlet.2025.107054","DOIUrl":"10.1016/j.imlet.2025.107054","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to analyse the expression of CD37 in different B cell subsets from human peripheral blood, exploring changes in CD37 expression in B cells of patients with primary Sjögren's syndrome (pSS) and assessing their clinical relevance.</div></div><div><h3>Methods</h3><div>A total of 32 pSS patients and age- and sex-matched healthy controls were included. Peripheral blood mononuclear cells (PBMCs) were isolated, and B cells were classified into five subsets using flow cytometry based on CD24 and CD38 expression. CD37 expression was evaluated, and functional differences between CD37+ and CD37- B cells were compared. Peripheral lymphocytes were stimulated with LPS to observe changes in CD37 expression. The expression of CD37 and related B cell subsets was also compared between pSS patients and healthy controls, followed by ROC curve analysis.</div></div><div><h3>Results</h3><div>CD37 was highly expressed in early-stage B cells, with a significant decrease in effector cells. CD37+ <em>B</em> cells exhibited higher proportions of CD40+, HLA-DR+, and IL-10+ cells, indicating enhanced antigen-presenting and regulatory capabilities. Post-LPS stimulation, CD37 expression significantly declined in pSS patients compared to healthy controls, suggesting increased sensitivity to differentiation into plasma cells. Additionally, CD37-related B cell subsets in pSS patients showed strong correlations with autoantibodies and immunological markers. ROC analysis revealed substantial areas under the curve, confirming the diagnostic potential of these subsets.</div></div><div><h3>Conclusion</h3><div>The expression of CD37 in B cell subsets is variable, indicating a potential regulatory role in B cell function and offering auxiliary diagnostic value in pSS.</div></div>","PeriodicalId":13413,"journal":{"name":"Immunology letters","volume":"276 ","pages":"Article 107054"},"PeriodicalIF":3.3,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal immune cell investigation from intervillous blood of placentas with chronic histiocytic intervillositis: Directions for future research","authors":"Q. Lu ,&nbsp;L.E. van der Meeren ,&nbsp;M. Eikmans ,&nbsp;M.L.P. van der Hoorn","doi":"10.1016/j.imlet.2025.107053","DOIUrl":"10.1016/j.imlet.2025.107053","url":null,"abstract":"<div><div>Chronic histiocytic intervillositis (CHI) is associated with adverse pregnancy outcome and results in placental inflammation characterized by maternal myeloid cells within the intervillous space. This intervillous space is part of the maternal-fetal interface, which provides a unique microenvironment for the immunologic crosstalk between intervillous blood and placental components. The pathophysiologic pathways of CHI are still unclear. Here, we conduct a narrative review on the current knowledge about CHI, intervillous blood sampling methods, and immune cell characteristics in the intervillous space of healthy term pregnancy. We highlight that the detailed phenotype and functional investigation of maternal immune cells from intervillous blood of placentas with CHI is expected to provide better understanding of the etiology of disease.</div></div>","PeriodicalId":13413,"journal":{"name":"Immunology letters","volume":"276 ","pages":"Article 107053"},"PeriodicalIF":3.3,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144283799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}