Navigating Challenges of aGvHD Predictive Biomarkers in αβhaplo-HSCT Recipients: Still Waiting for MAGIC to Happen.

IF 3.3 4区医学 Q3 IMMUNOLOGY

Immunology letters Pub Date : 2025-07-15 DOI:10.1016/j.imlet.2025.107062

Raul Montiel-Esparza, Isobel Hawes, Rhonda Perriman, Giulia Barbarito, Linda Oppizzi, David Shyr, Laurel Kent, Zhenyu Yao, Alice Bertaina

引用次数: 0

Abstract

The validated Mount Sinai Acute graft-versus-host disease (aGvHD) International Consortium (MAGIC) algorithm and biomarker panels did not predict aGvHD occurrence or severity in pediatric αβT-cell/CD19 B-cell depleted haploidentical hematopoietic stem cell transplant (αβhaplo-HSCT) recipients. These findings suggest distinct aGvHD biology in the αβhaplo-HSCT setting, supporting the need for tailored biomarker studies in this unique transplant platform.

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aGvHD预测生物标志物在αβ单倍造血干细胞受体中的应用：仍在等待奇迹的发生。

经验证的西奈山急性移植物抗宿主病（aGvHD）国际联盟（MAGIC）算法和生物标志物小组不能预测儿童αβ t细胞/CD19 b细胞缺失的单倍同型造血干细胞移植（αβ单倍同型造血干细胞移植）受体中aGvHD的发生或严重程度。这些发现表明，αβ单倍体hsct环境中aGvHD具有独特的生物学特性，支持在这种独特的移植平台中进行定制生物标志物研究的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunology letters 医学-免疫学

CiteScore

7.60

自引率

0.00%

发文量

审稿时长

44 days

期刊介绍： Immunology Letters provides a vehicle for the speedy publication of experimental papers, (mini)Reviews and Letters to the Editor addressing all aspects of molecular and cellular immunology. The essential criteria for publication will be clarity, experimental soundness and novelty. Results contradictory to current accepted thinking or ideas divergent from actual dogmas will be considered for publication provided that they are based on solid experimental findings. Preference will be given to papers of immediate importance to other investigators, either by their experimental data, new ideas or new methodology. Scientific correspondence to the Editor-in-Chief related to the published papers may also be accepted provided that they are short and scientifically relevant to the papers mentioned, in order to provide a continuing forum for discussion.