Immunology letters最新文献_第3页

Maternal immunoglobulins differentially bind a diverse bacterial community in human colostrum and the stool of breastfed neonates

IF 3.3 4区医学

Immunology letters Pub Date : 2025-02-07 DOI: 10.1016/j.imlet.2025.106978

Karina Corona-Cervantes , Erick Sánchez-Salguero , Paola Berenice Zárate-Segura , Aparna Krishnakumar , Alberto Piña-Escobedo , Martín Noé Rangel-Calvillo , Tito Ramírez-Lozada , Gustavo Acosta-Altamirano , Noemí del Socorro Lázaro-Pérez , Mónica Sierra-Martínez , Leopoldo Santos-Argumedo , Jaime García-Mena

{"title":"Maternal immunoglobulins differentially bind a diverse bacterial community in human colostrum and the stool of breastfed neonates","authors":"Karina Corona-Cervantes , Erick Sánchez-Salguero , Paola Berenice Zárate-Segura , Aparna Krishnakumar , Alberto Piña-Escobedo , Martín Noé Rangel-Calvillo , Tito Ramírez-Lozada , Gustavo Acosta-Altamirano , Noemí del Socorro Lázaro-Pérez , Mónica Sierra-Martínez , Leopoldo Santos-Argumedo , Jaime García-Mena","doi":"10.1016/j.imlet.2025.106978","DOIUrl":"10.1016/j.imlet.2025.106978","url":null,"abstract":"<div><div>In the early days, maternal immunoglobulins are essential for sustaining a balanced gut environment by influencing the interaction between the host and the microbiome. The successional establishment of the pioneer strains is an interesting topic of research where maternal immunoglobulins appear to be important. This proof-of-concept study explored the binding pattern of IgA1, IgA2, IgM, and IgG classes to a commensal bacterial in human colostrum and the stool of breastfed neonates. We used flow cytometry coupled with 16S rRNA gene sequencing in human colostrum and neonatal feces samples to characterize this Ig-microbiota association. We observed that in human colostrum samples, IgA2 and IgM bind alfa and beta Proteobacteria, which can potentially stimulate neonatal immune system development in the gut. Other immunoglobulins like IgG predominantly bind facultative anaerobes belonging to the Firmicutes phylum, reported as part of human milk microbiota and pioneer colonizers of the neonatal gut. Maternal immunoglobulins also bind a wide diversity of bacteria in the neonatal stool. For instance, IgA2 and IgM bound more members of the phylum Bacteroidetes in comparison to IgG, these Bacteroidetes and some firmicutes have been reported as late colonizers of the neonatal gut, and their presence is important due to their ability to produce important short chain fatty acids like propionate and butyrate. Our results support the current view that microbial and immunoglobulin transference is crucial for developing the neonate's immune system and individual gut microbiota.</div></div>","PeriodicalId":13413,"journal":{"name":"Immunology letters","volume":"273 ","pages":"Article 106978"},"PeriodicalIF":3.3,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In virto priming of the STING signaling pathway enhances the maturation and activation of dendritic cells induced by hepatitis B vaccine

IF 3.3 4区医学

Immunology letters Pub Date : 2025-02-06 DOI: 10.1016/j.imlet.2025.106977

Chaomin Ren , Xufeng Cui , Huixin Wang , Cong Jin , Linying Gao , Yandi Li , Weigang Wang , Tian Yao , Demei Zhang , Yongliang Feng , Keke Wang , Suping Wang

{"title":"In virto priming of the STING signaling pathway enhances the maturation and activation of dendritic cells induced by hepatitis B vaccine","authors":"Chaomin Ren , Xufeng Cui , Huixin Wang , Cong Jin , Linying Gao , Yandi Li , Weigang Wang , Tian Yao , Demei Zhang , Yongliang Feng , Keke Wang , Suping Wang","doi":"10.1016/j.imlet.2025.106977","DOIUrl":"10.1016/j.imlet.2025.106977","url":null,"abstract":"<div><div>This study investigates the role of the STING signaling pathway in enhancing dendritic cells (DCs) maturation and activation in response to the hepatitis B vaccine. By analyzing the GSE52894 dataset, we compared differentially expressed genes between mature dendritic cells (mDCs) and immature dendritic cells (iDCs). In vitro, iDCs were treated with the STING agonist 2′3′-cGAMP, either alone or in combination with lipopolysaccharide (LPS) or the hepatitis B vaccine, to assess the expression of costimulatory molecules and key signaling molecules in the STING pathway, including STING, pNF-κBp65, and pIRF3. The results indicated that mDCs expressed significantly higher levels of STING mRNA compared to iDCs (<em>P</em> < 0.01). Treatment with 2′3′-cGAMP increased STING expression and activated downstream signaling molecules pNF-κBp65 and pIRF3. Co-treatment with 2′3′-cGAMP and LPS upregulated costimulatory molecules (CD80, CD86, HLA-DR, CD11c) more effectively than LPS alone (<em>P</em> < 0.05). Co-treatment with 2′3′-cGAMP and the hepatitis B vaccine resulted in significantly higher expression of costimulatory molecules compared to vaccine-only treatment. Furthermore, co-treatment with 2′3′-cGAMP and the hepatitis B vaccine enhanced STING, pNF-κBp65, and pIRF3 expression relative to vaccine alone. Mixed lymphocyte reaction assays demonstrated that the 2′3′-cGAMP and hepatitis B vaccine co-treatment group had a significantly stronger effect on the proliferation of CD4<sup>+</sup><em>T</em> cells compared to the vaccine-only treatment group. In conclusion, 2′3′-cGAMP enhances DCs maturation and promotes CD4<sup>+</sup><em>T</em> cells proliferation in response to the hepatitis B vaccine by activating the STING/IRF3 and STING/NF-κB pathways, highlighting its potential as an adjuvant to improve vaccine efficacy.</div></div>","PeriodicalId":13413,"journal":{"name":"Immunology letters","volume":"272 ","pages":"Article 106977"},"PeriodicalIF":3.3,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143350258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of microplastics on the immune system: How much should we worry?

IF 3.3 4区医学

Immunology letters Pub Date : 2025-02-01 DOI: 10.1016/j.imlet.2025.106976

Claudia Vanetti , Martina Broggiato , Stefania Pezzana , Mario Clerici , Claudio Fenizia

{"title":"Effects of microplastics on the immune system: How much should we worry?","authors":"Claudia Vanetti , Martina Broggiato , Stefania Pezzana , Mario Clerici , Claudio Fenizia","doi":"10.1016/j.imlet.2025.106976","DOIUrl":"10.1016/j.imlet.2025.106976","url":null,"abstract":"<div><div>Plastics are everywhere. It is widely recognized that they represent a global problem, the extent of which is yet to be defined. Humans are broadly exposed to plastics, whose effects and consequences are poorly characterized so far. The main route of exposure is via alimentary and respiratory intake. Plastics pollutions may come from both: water and food contamination itself, and their packaging. The smaller sizes (<em>i.e.</em> microplastics <150 µm - MPs) are considered to be the most pervasive of living organisms and, therefore, potentially the most harmful. As humans occupy one of the apex positions of the food chain, we are exposed to bioaccumulation and biomagnification effects of MPs. In fact, MPs are commonly found in human stools and blood. However, there are no data available yet on their ability to accumulate and to produce detrimental consequences on biological systems. Even though the effects of plastics pollution are poorly studied in mammals, including humans, they appear to have inflammatory effects, which is rather concerning as many etiologies of disease are based on a pro-inflammatory status.</div></div>","PeriodicalId":13413,"journal":{"name":"Immunology letters","volume":"272 ","pages":"Article 106976"},"PeriodicalIF":3.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Th1 adjuvant ARNAX, in combination with radiation therapy, enhances tumor regression in mouse tumor-implant models Th1辅助剂ARNAX与放射治疗相结合，可增强小鼠肿瘤植入模型中肿瘤的消退。

IF 3.3 4区医学

Immunology letters Pub Date : 2025-02-01 DOI: 10.1016/j.imlet.2024.106947

Aya Miyazaki , Sumito Yoshida , Yohei Takeda , Utano Tomaru , Misako Matsumoto , Tsukasa Seya

{"title":"Th1 adjuvant ARNAX, in combination with radiation therapy, enhances tumor regression in mouse tumor-implant models","authors":"Aya Miyazaki , Sumito Yoshida , Yohei Takeda , Utano Tomaru , Misako Matsumoto , Tsukasa Seya","doi":"10.1016/j.imlet.2024.106947","DOIUrl":"10.1016/j.imlet.2024.106947","url":null,"abstract":"<div><div>Radiation therapy (RT) rarely induces tumor regression at untreated metastatic sites, the so-called abscopal effect. A syngeneic tumor (EG7) transplanted into a Th1-dominant mouse strain (C57BL/6) regressed significantly on the treated side and less on the contralateral side after RT. Additional subcutaneous administration of ARNAX, a non-inflammatory adjuvant, further accelerated tumor regression on the untreated side. This suggests that ARNAX after RT significantly enhances the tumor regression effect on the irrelevant tumor.</div><div>Based on this setting, we next observed similar tumor shrinkage after RT and ARNAX by transplanting syngeneic breast cancer tumors (4T1) into a Th2-dominant mouse strain (BALB/c). The results were as follows: 1. ARNAX enhanced RT-mediated tumor shrinkage comparable to polyI:C; 2. In the Th2 mouse strain, little tumor regression occurred on the untreated side compared to tumor regression on the treated side after RT alone; 3. RT+ARNAX treatment caused additive regression on the treated side and induced slight tumor regression on the untreated side; 4. PD-L1 antibody + RT combination therapy caused tumor regression and further induced additive regression with ARNAX; 5. The combination of RT and ARNAX reduced the number and volume of lung metastases compared to RT alone. However, tumor regression was not always accompanied by a significant prolongation of survival in the mice receiving our regimen and protocol (one 10Gy radiation and a single ARNAX treatment). In conclusion, RT therapy promoted abscopal tumor regression in both Th2 and Th1 models with the addition of the non-inflammatory adjuvant ARNAX.</div></div>","PeriodicalId":13413,"journal":{"name":"Immunology letters","volume":"271 ","pages":"Article 106947"},"PeriodicalIF":3.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Could there be a relationship between type III hypersensitivity reactions and graft rejections?

IF 3.3 4区医学

Immunology letters Pub Date : 2025-01-22 DOI: 10.1016/j.imlet.2025.106975

Rebeca Alessi Tedeschi-Pachega, Renata Vaz Voltareli, Graziela Garrido Mori

引用次数: 0

Post hoc analysis: 6 Months immunogenicity after third dose of BNT162b2 vs JNJ-78,436,735 after two doses of BNT162b2 vaccine in solid organ transplant recipients 事后分析：实体器官移植受者第三剂BNT162b2与两剂BNT162b2疫苗后JNJ-78436735的6个月免疫原性

IF 3.3 4区医学

Immunology letters Pub Date : 2025-01-09 DOI: 10.1016/j.imlet.2024.106968

Yoichiro Natori , Eric Martin , Adela Mattiazzi , Leopoldo Arosemena , George William Burke , Mrudula R. Munagala , Suresh Manickavel , Katherine Sota , Suresh Pallikkuth , Jessie Chen , Julia Bini , Jacques Simkins , Shweta Anjan , Rodrigo M. Vianna , Giselle Guerra

{"title":"Post hoc analysis: 6 Months immunogenicity after third dose of BNT162b2 vs JNJ-78,436,735 after two doses of BNT162b2 vaccine in solid organ transplant recipients","authors":"Yoichiro Natori , Eric Martin , Adela Mattiazzi , Leopoldo Arosemena , George William Burke , Mrudula R. Munagala , Suresh Manickavel , Katherine Sota , Suresh Pallikkuth , Jessie Chen , Julia Bini , Jacques Simkins , Shweta Anjan , Rodrigo M. Vianna , Giselle Guerra","doi":"10.1016/j.imlet.2024.106968","DOIUrl":"10.1016/j.imlet.2024.106968","url":null,"abstract":"<div><h3>Introduction</h3><div>In Solid Organ Transplant (SOT) recipients, due to immunosuppression, the immunogenicity after COVID-19 vaccination is suboptimal and its durability is unknown.</div></div><div><h3>Methods</h3><div>We conducted a post-hoc analysis of a patient-blinded, single center, randomized controlled trial comparing BNT162b2 vs JNJ-78,436,735 as the third dose after two doses of BNT162b2 in adult SOT recipients with active graft to compare long-term immunogenicity.</div></div><div><h3>Results</h3><div>Forty-one recipients were analyzed. Median IgG levels against SARS-CoV-2 at 6 months were 53,747 (range 949 – 657,558) and 7,632 (range 642 – 672,000) AU/ml for BNT162b2 vs JNJ-78,436,735, respectively (<em>p</em> = 0.017). The median geometric mean fold increase ratio at 6 months was 37.2 (0.12–618.5) and 4.30 (0.1–204.2) for BNT162b2 vs JNJ-78,436,735, respectively (<em>p</em> < 0.05). After two doses of BNT162b2, homologous approach with BNT162b2 achieved a superior immunogenicity compared to heterologous approach with JNJ-78,436,735.</div></div><div><h3>Conclusion</h3><div>In this post hoc analysis, we report durability of specific IgG between two vaccine strategies and found no statistically significant difference between two groups. (Clinical Trial Registry: NCT05047640)</div></div>","PeriodicalId":13413,"journal":{"name":"Immunology letters","volume":"273 ","pages":"Article 106968"},"PeriodicalIF":3.3,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic value of CD163+ macrophages in solid tumor malignancies: A scoping review CD163+巨噬细胞在实体恶性肿瘤中的预后价值：范围综述。

IF 3.3 4区医学

Immunology letters Pub Date : 2025-01-06 DOI: 10.1016/j.imlet.2025.106970

Henriette Mathiesen , Kristian Juul-Madsen , Trine Tramm , Thomas Vorup-Jensen , Holger Jon Møller , Anders Etzerodt , Morten Nørgaard Andersen

{"title":"Prognostic value of CD163+ macrophages in solid tumor malignancies: A scoping review","authors":"Henriette Mathiesen , Kristian Juul-Madsen , Trine Tramm , Thomas Vorup-Jensen , Holger Jon Møller , Anders Etzerodt , Morten Nørgaard Andersen","doi":"10.1016/j.imlet.2025.106970","DOIUrl":"10.1016/j.imlet.2025.106970","url":null,"abstract":"<div><div>Tumor-associated macrophages (TAMs) play crucial roles in development and progression of malignant diseases. Notably, CD163<sup>+</sup> TAMs likely perform specific pro-tumorigenic functions, suggesting that this subset may serve as both prognostic biomarkers and targets for future anti-cancer therapy.</div><div>We conducted a scoping review to map the current knowledge on the prognostic role of CD163<sup>+</sup> TAMs in the five most lethal cancers worldwide: Lung, colorectal, gastric, liver, and breast cancer. For all cancer types, most studies showed that high tumoral presence of CD163<sup>+</sup> cells was associated with poor patient outcome, and this association was more frequently observed when CD163<sup>+</sup> cells were measured at the tumor periphery compared to more central parts of the tumor.</div><div>These results support that CD163<sup>+</sup> TAMs represent a biomarker of poor patient outcome across a variety of solid tumors, and highlight the relevance of further investigations of CD163<sup>+</sup> TAMs as targets of future immunotherapies.</div></div>","PeriodicalId":13413,"journal":{"name":"Immunology letters","volume":"272 ","pages":"Article 106970"},"PeriodicalIF":3.3,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142948210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The benefits of Lactiplantibacillus plantarum: From immunomodulator to vaccine vector 植物乳杆菌的益处：从免疫调节剂到疫苗载体。

IF 3.3 4区医学

Immunology letters Pub Date : 2025-01-05 DOI: 10.1016/j.imlet.2025.106971

Joshua Tobias , Stefan Heinl , Kristina Dendinovic , Ajša Ramić , Anna Schmid , Catherine Daniel , Ursula Wiedermann

{"title":"The benefits of Lactiplantibacillus plantarum: From immunomodulator to vaccine vector","authors":"Joshua Tobias , Stefan Heinl , Kristina Dendinovic , Ajša Ramić , Anna Schmid , Catherine Daniel , Ursula Wiedermann","doi":"10.1016/j.imlet.2025.106971","DOIUrl":"10.1016/j.imlet.2025.106971","url":null,"abstract":"<div><div>Probiotics have been increasingly recognized for positively influencing many aspects of human health. <em>Lactiplantibacillus plantarum</em> (<em>L. plantarum)</em>, a non-pathogenic bacterium, previously known as Lactobacillus plantarum, is one of the lactic acid bacteria commonly used in fermentation. The probiotic properties of <em>L. plantarum</em> have highlighted its health benefits to humans when consumed in adequate amounts. <em>L. plantarum</em> strains primarily enter the body orally and alter intestinal microflora and modulate the immune responses in their host; thereby benefiting human health. Furthermore, the use of <em>L. plantarum</em> as vaccine vectors delivering mucosal antigens has been shown to be a promising strategy. These aspects, from Immunomodulation to vaccine delivery by <em>L. plantarum</em> in preclinical settings, are highlighted in this review. Along these lines, construction of a recombinant <em>L. plantarum</em> strain expressing a B cell multi-peptide, as a future vaccine to modulate immunity and confer anti-tumor effect by targeting Her-2/neu-overexpressing cancers in local and distal sites, is also presented and discussed.</div></div>","PeriodicalId":13413,"journal":{"name":"Immunology letters","volume":"272 ","pages":"Article 106971"},"PeriodicalIF":3.3,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142962046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inhibition of glutaminase 1 reduces M1 macrophage polarization to protect against monocrotaline-induced pulmonary arterial hypertension 抑制谷氨酰胺酶1可减少M1巨噬细胞极化，以保护免受单芥碱诱导的肺动脉高压。

IF 3.3 4区医学

Immunology letters Pub Date : 2025-01-05 DOI: 10.1016/j.imlet.2025.106974

Xing Chen, Lixiang Li, Yan Deng, Juan Liao, Hui Meng, Limei Liang, Jie Hu, Dongwei Xie, Guizi Liang

{"title":"Inhibition of glutaminase 1 reduces M1 macrophage polarization to protect against monocrotaline-induced pulmonary arterial hypertension","authors":"Xing Chen, Lixiang Li, Yan Deng, Juan Liao, Hui Meng, Limei Liang, Jie Hu, Dongwei Xie, Guizi Liang","doi":"10.1016/j.imlet.2025.106974","DOIUrl":"10.1016/j.imlet.2025.106974","url":null,"abstract":"<div><div>(1)</div></div><div><h3>Background</h3><div>Metabolic abnormalities and immune inflammation are key elements within pathogenesis of pulmonary arterial hypertension (PAH). And in PAH patients, aberrant glutamine metabolism has been observed; however, the function of glutaminase 1 (GLS1) in macrophage is still unknown. So we aims to investigate GLS1′s impact upon macrophages in PAH. (2)</div></div><div><h3>Methods</h3><div>We firstly constructed an monocrotaline (MCT)-induced PAH rat model. Briefly, the PAH rats were treated with the GLS1 inhibitor BPTES, and various index were evaluated, including hemodynamics, right ventricular function, pulmonary vascular remodeling, macrophage markers, and glutamine metabolism. After that, we polarized bone marrow-derived macrophages (BMDMs) into M1 phenotype and then subjected to BPTES intervention. Finally, we assessed macrophage phenotype, inflammatory markers, and glutamine metabolism indicators, along with the impact of BMDM supernatant on the behavior of pulmonary arterial smooth muscle cells (PASMCs). (3)</div></div><div><h3>Results</h3><div>GLS1 was significantly upregulated in both PAH patients and rats. Treatment with the GLS1 inhibitor BPTES markedly improved pulmonary arterial pressure, right ventricular function, and pulmonary vascular remodeling in PAH rats, while inhibiting M1 macrophage polarization, NLRP3 activation, and the release of pro-inflammatory cytokines. This, in turn, alleviated the proliferation and migration of PASMCs induced by inflammatory stimuli. (4)</div></div><div><h3>Conclusion</h3><div>We propose that targeting GLS1 to reduce M1 macrophage polarization and inflammatory responses may represent a promising therapeutic approach for PAH.</div></div>","PeriodicalId":13413,"journal":{"name":"Immunology letters","volume":"272 ","pages":"Article 106974"},"PeriodicalIF":3.3,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut TLRs and IFN pathways mRNA expression and frequencies of CD4+ T cell expressing CD38 or HLA-DR go in parallel during HIV immunopathogenesis 在HIV的免疫发病过程中，表达CD38或HLA-DR的CD4+T细胞的mRNA表达和频率是平行的。

IF 3.3 4区医学

Immunology letters Pub Date : 2025-01-05 DOI: 10.1016/j.imlet.2025.106973

Luca Maddaloni , Ginevra Bugani , Letizia Santinelli , Alessandro Lazzaro , Federica Frasca , Matteo Fracella , Giancarlo Ceccarelli , Claudio M. Mastroianni , Carolina Scagnolari , Gabriella d'Ettorre

{"title":"Gut TLRs and IFN pathways mRNA expression and frequencies of CD4+ T cell expressing CD38 or HLA-DR go in parallel during HIV immunopathogenesis","authors":"Luca Maddaloni , Ginevra Bugani , Letizia Santinelli , Alessandro Lazzaro , Federica Frasca , Matteo Fracella , Giancarlo Ceccarelli , Claudio M. Mastroianni , Carolina Scagnolari , Gabriella d'Ettorre","doi":"10.1016/j.imlet.2025.106973","DOIUrl":"10.1016/j.imlet.2025.106973","url":null,"abstract":"<div><div>While much is known about the expression of interferon (IFN) pathways in the blood of people living with HIV (PLWH), their role in the intesinal tract has only recently been appreciated. The aim of this study was to evaluate gut mRNA expression levels of innate immune genes involved in the HIV-host interaction and their association with CD4<sup>+</sup> <em>T</em> cell immune activation in long-term HAART-experienced PLWH. PLWH had increased intestinal levels of <em>TLR4, type I IFN</em> (<em>IFN-α2, IFN-α14, IFN-β</em>) and <em>IFNAR1</em> mRNAs, as well as increased frequencies of CD4<sup>+</sup> <em>T</em> lymphocytes expressing CD38 or HLA-DR compared to the healthy donors. Moreover, <em>TLR4, TLR9, IRF3, IRF7</em> and <em>IFN-α14</em> mRNA expression was positively correlated with the frequency of CD4<sup>+</sup> <em>T</em> cells expressing CD38 or HLA-DR. These findings suggest a dysregulation of innate immunity, particularly of the TLRs and IFN pathways in the gut of PLWH. Genes in these pathways also appear to correlate with the levels of CD4<sup>+</sup> <em>T</em> cell immune activation.</div></div>","PeriodicalId":13413,"journal":{"name":"Immunology letters","volume":"272 ","pages":"Article 106973"},"PeriodicalIF":3.3,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0