Indian Journal of Pharmaceutical Education and Research最新文献_第6页

The Attitude, Knowledge, and Evaluation of Herbal Medicinal Products for Respiratory Diseases in Northern Cyprus among Pharmacists, Patients, and Pulmonologists 北塞浦路斯药剂师、患者和肺科医生对治疗呼吸道疾病的草药产品的态度、知识和评价

4区医学

Indian Journal of Pharmaceutical Education and Research Pub Date : 2023-10-04 DOI: 10.5530/ijper.57.4.148

Mehmet Dumenci, Filiz Mericli, Ozgur Tosun, Dudu Ozkum Yavuz

{"title":"The Attitude, Knowledge, and Evaluation of Herbal Medicinal Products for Respiratory Diseases in Northern Cyprus among Pharmacists, Patients, and Pulmonologists","authors":"Mehmet Dumenci, Filiz Mericli, Ozgur Tosun, Dudu Ozkum Yavuz","doi":"10.5530/ijper.57.4.148","DOIUrl":"https://doi.org/10.5530/ijper.57.4.148","url":null,"abstract":"Abstract: Background: The utilization of Complementary and Alternative Medicine (CAM) has grown remarkably over the years as people seek alternative treatment methods to conventional medicine to manage various health conditions. Aim: The study aimed to assess the utilization of herbal remedies in treating respiratory disorders, enhance the safe and efficient use of herbal medicinal products, and raise awareness of the effectiveness of CAM in respiratory tract diseases in Northern Cyprus. Materials and Methods: The study was conducted on 610 respiratory patients, 10 pulmonologists, and 150 pharmacists, who participated voluntarily in the survey. The data was collected through three tailored questionnaires distributed to the target participants face-to-face and online. The collected data were analyzed using the SPSS software. Results: The data obtained from the survey indicated that patients with lower income and educational attainment tend to use herbal medicinal products less frequently compared to those with higher income (p= 0.026) and educational levels (p= 0.003). Pharmacists aged under 45 were more knowledgeable about herbal medicinal products than pharmacists over 45 (p<0.05). It was observed that a substantial majority (96%) of pharmacists recommend herbal medicinal products to their patients, primarily for preventive purposes. Additionally, pulmonologists lacked knowledge of herbal medicinal compositions, posology, administration, indications, side effects, and usage warnings. Conclusion: The study highlights the lack of adequate information among pharmacists, patients and pulmonologists regarding using herbal medicinal products for respiratory diseases. There is a pressing need for seminars and credible resources to address this knowledge deficit. Keywords: Complementary and Alternative Medicine, Pharmacists, Herbal Medicinal Products, Respiratory Diseases.","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135646292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulation, Characterization, and Cytotoxic Effect of PVA Incorporated Iron Oxide Nanoparticles of Gramine Using HCT-116 Cell Line in vitro PVA结合Gramine氧化铁纳米颗粒的制备、表征及体外HCT-116细胞系细胞毒作用

4区医学

Indian Journal of Pharmaceutical Education and Research Pub Date : 2023-10-04 DOI: 10.5530/ijper.57.4.123

Ahmed S Alnaim

{"title":"Formulation, Characterization, and Cytotoxic Effect of PVA Incorporated Iron Oxide Nanoparticles of Gramine Using HCT-116 Cell Line in vitro","authors":"Ahmed S Alnaim","doi":"10.5530/ijper.57.4.123","DOIUrl":"https://doi.org/10.5530/ijper.57.4.123","url":null,"abstract":"Abstract: Background and Objectives: Globally, Colorectal cancer is the major cause of death. The current work emphasizes the synthesis of Gramine-loaded polyvinyl alcohol (PVA) coated Iron Oxide nanoparticles (NPs) and the evaluation of the antiproliferative and anticancerous activity in the HCT 116 cell line. Materials and Methods: The physiochemical, structural, and morphological characteristics of synthesized Gramine loaded PVA coated Iron Oxide NPs were assessed by UV-Visible spectrophotometer, Fourier transform-infrared spectroscopy (FT-IR), X-ray diffraction (XRD), and scanning electron microscopy (SEM). The cytotoxic activity against HCT 116 (Colon cancer) cell line was assessed using a tetrazolium-based colorimetric assay (MTT), trypan blue exclusion assay, phase contrast microscopy, nitric oxide (NO), lipid peroxidation (LPO), and reactive oxygen species (ROS) estimation. Results: The UV spectrum revealed the synthesis of Iron Oxide NPs at the peak of 266.25 nm. The FT-IR results confirmed that Gramine was successfully conjugated and PVA was efficaciously coated to Iron Oxide NPs. The XRD data revealed that the synthesized Gramine loaded PVA coated Iron Oxide NPs are crystallite in nature. The micrograph of SEM revealed the presence of tetragonal shaped Iron Oxide NPs. In the MTT assay, the proliferation of HCT 116 cells was inhibited in a dose-dependent manner and the IC50 was fixed at 25 μg/ml which showed 52.68% of inhibition. In the trypan blue exclusion assay, the percentage of viable cells gradually decreased and the deformation of cells was seen in phase contrast microscopic analysis. In treated groups, the oxidative stress indicators such as NO, LPO, and ROS levels were substantially higher compared to the control. Conclusion: The synthesized Gramine loaded PVA coated Iron Oxide NPs exhibited outstanding anticancer activity against HCT 116 cell line. Keywords: Colorectal cancer cell line, Gramine, Polyvinyl alcohol, Iron oxide nanoparticles, Drug delivery.","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135547872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Evaluation of Anti-Depressant Activity of spirulina, a blue-green algae on Chronic Unpredictable Stress Induced Depression in Rats 蓝藻螺旋藻对大鼠慢性应激性抑郁的抗抑郁活性评价

4区医学

Indian Journal of Pharmaceutical Education and Research Pub Date : 2023-10-04 DOI: 10.5530/ijper.57.4.113

Girish Meravanige Basavarajappa, Juturu Balaraju, Nimbagal Raghavendra Naveen, Prakash Goudanavar, Vakkalagadda Siva Ganesh, Sreeharsha Nagaraja, Predeepkumar Narayanappa Shiroorkar, Mallikarjun Telsang

{"title":"Evaluation of Anti-Depressant Activity of spirulina, a blue-green algae on Chronic Unpredictable Stress Induced Depression in Rats","authors":"Girish Meravanige Basavarajappa, Juturu Balaraju, Nimbagal Raghavendra Naveen, Prakash Goudanavar, Vakkalagadda Siva Ganesh, Sreeharsha Nagaraja, Predeepkumar Narayanappa Shiroorkar, Mallikarjun Telsang","doi":"10.5530/ijper.57.4.113","DOIUrl":"https://doi.org/10.5530/ijper.57.4.113","url":null,"abstract":"Abstract: Background: Depression is a crippling and pervasive illness that can affect a person in many different ways. It can be identified by certain symptoms, such as modifications in behaviour, psychological functioning, and brain physiology. Materials and Methods: One of the animal models for depression has been the Chronic Unpredictable Mild Stress (CUMS) paradigm. In this study, spirulina algae, which contains tryptophan, was chosen and tested for its anti-depressant effectiveness in the CUS model using Fluoxetine as the gold standard. Wistar rats were chosen to undergo the CUS process for 28 days, and throughout that time, the test drug was given at doses of 400 mg/kg. Results: Behavioural and biochemical parameters were analysed, and has shown significant changes. Conclusion: When compared to the CUS group, spirulina algae at the tested doses had a substantial impact on behavioural and metabolic testing. These findings demonstrated that Spirulina algae specifically exhibited an in vivo anti-depressant-like effect. Keywords: Antidepressant, Spirulina algae, Force swim test, Tail suspensstion test, Sucrose preference test, Chronic Unpredictable Stress.","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"192 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135645308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ameliorating the Poor Dissolution Rate of Selexipag in Aqueous Acidic Conditions Following Confinement into Mesoporous Silica 改善封闭成介孔二氧化硅后Selexipag在酸性水条件下较差的溶解速率

4区医学

Indian Journal of Pharmaceutical Education and Research Pub Date : 2023-10-04 DOI: 10.5530/ijper.57.4.122

Mohamed S Attia, Fakhr Eldin S Ghazy

{"title":"Ameliorating the Poor Dissolution Rate of Selexipag in Aqueous Acidic Conditions Following Confinement into Mesoporous Silica","authors":"Mohamed S Attia, Fakhr Eldin S Ghazy","doi":"10.5530/ijper.57.4.122","DOIUrl":"https://doi.org/10.5530/ijper.57.4.122","url":null,"abstract":"Abstract: Background: Pulmonary Arterial Hypertension (PAH) is a serious condition with available treatment options, including Selexipag (SXP), a selective prostacyclin receptor agonist that has effectively reduced patient morbidity and mortality. SXP is limited by poor water solubility, especially in acidic solutions, which can affect its bioavailability and therapeutic efficacy. Therefore, strategies to tackle the solubility of SXP, such as nano-based Drug Delivery Systems (DDSs), should be explored. Objectives: The study aimed to tackle the poor dissolution rate of SXP and, consequently, improving the clinical efficacy and treatment outcomes of PAH patients. Materials and Methods: Three forms of Mesoporous Silica Nanoparticles (MSNs) were investigated as a DDS. SXP was loaded to MSNs (SBA-15, MCM-41, and KIT-6) via rotary evaporation technique and characterized for in vitro dissolution rates, drug release kinetics, morphology, crystallinity, interaction and surface properties. Results and Conclusion: Incorporating SXP as a monolayer to SBA-15 formulations significantly improved its dissolution rate, achieving an enhancement ratio of 9.48 at pH 1.2 compared to the pure drug. Notably, the monolayer and double-layer-loaded SBA-15 formulations exhibited the highest dissolution efficiency percentages, with values of 72.85% and 69.01%, respectively, surpassing that of raw SXP. The entrapment of SXP within SBA-15 mesopores was evident from pore volume reduction. The enhancement in dissolution rates was ascribed to the conversion of SXP into an amorphous state upon confinement within the nanostructure, which was indicated through X-ray diffraction and scanning electron microscopy analyses. Keywords: Mesoporous silica, Drug dissolution, Selexipag, Solubility, Pulmonary arterial hypertension, Crystallinity.","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135646283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of the Suitability of the Delphi Method for Assessing the Needs of Pharmacoeconomic Studies in the Decision-Making Process 德尔菲法在决策过程中评估药物经济学研究需求的适用性评价

4区医学

Indian Journal of Pharmaceutical Education and Research Pub Date : 2023-10-04 DOI: 10.5530/ijper.57.4.147

Sabina Becirovic, Valentina Marinkovic, Dragana Lakic

{"title":"Assessment of the Suitability of the Delphi Method for Assessing the Needs of Pharmacoeconomic Studies in the Decision-Making Process","authors":"Sabina Becirovic, Valentina Marinkovic, Dragana Lakic","doi":"10.5530/ijper.57.4.147","DOIUrl":"https://doi.org/10.5530/ijper.57.4.147","url":null,"abstract":"Abstract: Background: Increasing need for control in healthcare spendings and for publicly available services, opens new areas and topics that needs to be discussed. The aim of this paper is assessment of the technic adequacy for evaluation of knowledge level in the subject territory. Materials and Methods: Systematic review has been performed with electronic database PubMed and MEDLINE. The SPIDER model (Sample, Phenomenon of Interest, Design, Evaluation, Research Type) was used to create the search strategy, which is more suitable for qualitative research. Results: After the initial check by title and the introductory part of the abstract, 1,282 published articles were eliminated due to inadequate study design. 249 articles that were checked by abstract with a focus on methodology and sample went for additional checking. During this step, 50 articles were selected for checking the complete research, i.e., the published content. Given results has enabled us insight in Delphi method with assessment of advantages and disadvantages. Keywords: Delphi method, Qualitative methods, Pharmacoeconomic, Decision-making","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135646291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Overview on Development, Approval and Post Registration Activities for Pharmaceuticals in European Union 欧盟药品开发、批准和注册后活动综述

4区医学

Indian Journal of Pharmaceutical Education and Research Pub Date : 2023-10-04 DOI: 10.5530/ijper.57.4.144

Thanush Thanush D, Balamuralidhara Balamuralidhara V, Thoyajaksha Thoyajaksha V, Deeksha Deeksha KS, Gowthami Gowthami KR

{"title":"An Overview on Development, Approval and Post Registration Activities for Pharmaceuticals in European Union","authors":"Thanush Thanush D, Balamuralidhara Balamuralidhara V, Thoyajaksha Thoyajaksha V, Deeksha Deeksha KS, Gowthami Gowthami KR","doi":"10.5530/ijper.57.4.144","DOIUrl":"https://doi.org/10.5530/ijper.57.4.144","url":null,"abstract":"Abstract: Bringing a new medicine from concept to market is costly and complex. Years of study and development go into it. Product development operations should be carried out in line with applicable regulatory standards to save time and money when bringing innovations to the marketplace. While the information on regulatory requirements is readily accessible, navigating the regulatory system is complex and becomes considerably more difficult when working with many countries. The primary goal is to improve regulatory awareness and achieve regulatory compliance in product development. An excellent place to start is with one of these ideas. The guide is not a list of laws but a discussion of the foundational ideas and principles governing regulatory policymaking and enforcement in the European Union. Throughout the drug's lifespan, these rules are consistent. Companies may standardise their processes and keep track of every action at every step of the lifecycle by developing a workflow and adhering to its stages of lifecycle compliance for each set of guidelines. Because of the current pharmaceutical market's complexity, more efficient drug research and manufacturing are required. This review article is based on the information collected from various sources from EMA and ICH websites and the articles mentioned. Despite the extreme complexity, Product Lifecycle Management has the potential to make pharmaceutical manufacturing more efficient and less risky. Pharmaceutical product lifecycle management during various phases such as research and development, regulatory submission and approval, commercialisation and marketing plays a significant role. Keywords: Product Lifecycle Management, Navigation Pathway, New Product Development, Post Approval Changes, Regulatory Review, European Union.","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135646293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of ICH-Q3D Endorsed Elemental Impurities in Macrolide Antibiotics by ICP-MS ICP-MS分析大环内酯类抗生素中ICH-Q3D载体元素杂质

4区医学

Indian Journal of Pharmaceutical Education and Research Pub Date : 2023-10-04 DOI: 10.5530/ijper.57.4.145

Ravisankar Mathesan, Alexandar Sekar, Senthil Kumar Raju, Kumar Mohan, Venkateswarlu Bendi Sri

引用次数: 0

Effect of a Herbal Formulation on Infection Prevention and Immune Regulation in Children with Frequent Relapse Nephrotic Syndrome 一种中药方剂对反复肾病综合征患儿感染预防及免疫调节的影响

4区医学

Indian Journal of Pharmaceutical Education and Research Pub Date : 2023-10-04 DOI: 10.5530/ijper.57.4.149

Haiyun Wang, Binbin Tang, Junjie Shi, Yan Wang, Qili Wang

{"title":"Effect of a Herbal Formulation on Infection Prevention and Immune Regulation in Children with Frequent Relapse Nephrotic Syndrome","authors":"Haiyun Wang, Binbin Tang, Junjie Shi, Yan Wang, Qili Wang","doi":"10.5530/ijper.57.4.149","DOIUrl":"https://doi.org/10.5530/ijper.57.4.149","url":null,"abstract":"Abstract: Objectives: This study aims to investigate the effect of a herbal formulation “Guyuan Tang” on preventing the recurrence of children with frequent relapse nephrotic syndrome and its influence on immune function. Materials and Methods: In all, 30 children with frequent relapse nephrotic syndrome were randomly divided into the Traditional Chinese Medicine (TCM) group and the control group. The control group was treated with conventional western medicine, while the TCM group was treated with Guyuan Tang for three months based a control group. The changes in the immune function indices before and after treatment were compared between the two groups, and the frequencies of infection and recurrence were compared after 12 months of follow-up. Results: The level of IgG protein, the proportion of CD3+CD4+T cells, CD4/CD8 and Treg cells in the TCM group increased after three months of Guyuan Tang treatment (p < 0.05), which showed statistical differences compared with the control group (p < 0.05). After one year of follow-up, no statistically significant difference was observed in the incidences of recurrence and infection between the two groups (p > 0.05), but the hospitalization rate and the average number of infections in the TCM group were significantly lower than those in the control group (p < 0.05). Conclusion: Guyuan Tang could reduce the frequency of infection in children with frequent relapse nephrotic syndrome, and regulating the proportion of Treg cells, CD4/CD8 and IgG may be one of its mechanisms. Keywords: Frequent relapse nephrotic syndrome, Infection, Traditional Chinese Medicine, Immune, Children.","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"219 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135645578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical Screening, Acute Toxicity Study, and Pharmacological Evaluation of Natsiatum herpeticum Buch.Ham. ex Arn. 红薯的植物化学筛选、急性毒性研究及药理评价。在攻击。

4区医学

Indian Journal of Pharmaceutical Education and Research Pub Date : 2023-10-04 DOI: 10.5530/ijper.57.4.132

Sangeeta Hazarika, Siva Hemalatha, Katharigatta Narayanaswamy Venugopala

{"title":"Phytochemical Screening, Acute Toxicity Study, and Pharmacological Evaluation of Natsiatum herpeticum Buch.Ham. ex Arn.","authors":"Sangeeta Hazarika, Siva Hemalatha, Katharigatta Narayanaswamy Venugopala","doi":"10.5530/ijper.57.4.132","DOIUrl":"https://doi.org/10.5530/ijper.57.4.132","url":null,"abstract":"Abstract: Background: Plants are an open treasure of diverse pharmacologically active scaffolds. Natsiatum herpeticum, a least exploited plant, is known to be consumed by various ethnic groups of Asian origin as edible or as part of traditional remedy. Materials and Methods: The Ethanolic Extract of N. herpeticum (EENH) was evaluated for acute oral toxicity using acute toxic class method (OECD 423). Here, we aimed to investigate the free radical scavenging (antioxidant) and in vitro anti-inflammatory property of the plant extract. Results: Acute toxicity result suggests the plant to be safe and can be categorised under category 5 of GHS classification. The EENH showed promising antioxidant activity in DPPH (IC50 value= 84.1 μg/mL) and ABTS (IC50 value=81.8 μg/mL) method. Similarly, the plant extract demonstrated good in vitro anti-inflammatory activity (IC50 value=80.88-93.26 μg/mL). Conclusion: The plant can be considered as safe to be consumed. The plant extract exhibited promising in vitro antioxidant and anti-inflammatory activity, which are further to be tested in in vivo models. Keywords: Acute toxicity, Antioxidant, Anti-inflammatory, Natsiatum herpeticum","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135645263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development, Evaluation, and in vitro Anti-Acne Activity of Tretinoin Nanocrystals Gel 维甲酸纳米晶体凝胶的开发、评价及体外抗痤疮活性

4区医学

Indian Journal of Pharmaceutical Education and Research Pub Date : 2023-10-04 DOI: 10.5530/ijper.57.4.114

Pottathil Shinu, Akash Sharma, Anroop B Nair, Manish Kumar, Shahzad Khan, Abdulaziz K Al Mouslem, Mohamed A Morsy, Abhishek Tiwari, Varsha Tiwari, Beena Kumari

{"title":"Development, Evaluation, and in vitro Anti-Acne Activity of Tretinoin Nanocrystals Gel","authors":"Pottathil Shinu, Akash Sharma, Anroop B Nair, Manish Kumar, Shahzad Khan, Abdulaziz K Al Mouslem, Mohamed A Morsy, Abhishek Tiwari, Varsha Tiwari, Beena Kumari","doi":"10.5530/ijper.57.4.114","DOIUrl":"https://doi.org/10.5530/ijper.57.4.114","url":null,"abstract":"Abstract: Background: Tretinoin is generally used to treat acne vulgaris and photoaging. The study aimed to develop a gel composition containing tretinoin nanocrystals and characterize and compare in vitro anti-acne activity. Materials and Methods: The anti-solvent precipitation approach was used to prepare tretinoin nanocrystals. The drug nanocrystals were optimized for parameters such as particle size, drug content, and drug release. The optimized nanocrystals (TN9) were incorporated into the gel system (TNG1-TNG5) and characterized for pharmaceutical properties. The selected formulation (TNG1) was tested for anti-acne activity using Propionibacterium acnes and Staphylococcus epidermidis and compared with Doxycycline HCl as standard. Results: Nanocrystals (TN9) showed the lowest particle size of 114.2 nm, the least value of polydispersity of 0.232, the highest drug content of 95.24%, and higher cumulative drug release of 97.2% in 10 hr. TEM and DSC images conformed to the nano-size range and crystalline nature of nanocrystals. The prepared gel composition indicates a clear, smooth, and homogeneous nature, good spreadability, suitable viscosity, pH, and drug content. The drug release from TNG1 was found to be significant (p < 0.0001) and was superior to the commercial gel. Results of anti-acne activity signify that the zone of inhibition exhibited by tretinoin nanocrystals was comparable with Doxycycline HCl (standard) for both microorganisms tested. Conclusion: These results demonstrated that the developed tretinoin nanocrystals could be a feasible approach for effective therapy in the treatment of acne. Keywords: Tretinoin, Nanocrystals, Gel, Drug release, Anti-acne activity, Propionibacterium acnes, Staphylococcus epidermidis.","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135645964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0