Indian Journal of Pharmaceutical Education and Research最新文献

{"title":"Protective Effects of Hibiscetin on Ethanol-Induced Ulcers in Rats through Inhibition of Prostaglandin Synthesis/ Oxidative Stress/Caspase-3 and 9 Pathways","authors":"Faisal Alotaibi","doi":"10.5530/ijper.58.1.30","DOIUrl":"https://doi.org/10.5530/ijper.58.1.30","url":null,"abstract":"","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"4 2","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139153741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanostructured Lipid Carriers: A Potential Era of Drug Delivery Systems","authors":"Haranath Chinthaginjala, Varalakshmi Bogavalli, A. A. Hindustan, Jayasree Pathakamuri, Sai Sree Pullaganti, Aswini Gowni, Bandhavi Baktha","doi":"10.5530/ijper.58.1.3","DOIUrl":"https://doi.org/10.5530/ijper.58.1.3","url":null,"abstract":"","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"126 19","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139154742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amelioration of Lipid Metabolic Profiles by Trigonelline a Bioactive Compound of Trigonella Foenum-graecum in Alcohol Induced Albino Rats","authors":"Meesala Guru Sekhar, K. Shanmugam, Kanchi Siva Prasad, Ramakrishna Chilakala","doi":"10.5530/ijper.58.1.18","DOIUrl":"https://doi.org/10.5530/ijper.58.1.18","url":null,"abstract":"","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"27 5","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139153439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and Development of Anti-fungal Topical Gel Loaded with Solid Lipid Nanoparticles for Wound Healing","authors":"Girish Meravanige, Ranjitha Ranjitha B, P. Goudanavar, Gsn Koteswara Rao, B. N. Devi, N. Naveen, A. Asif, Sree Harsha Nagaraja, Mohammed Monirul Islam, Pavan Kumar Pavagada Sreenivasalu, Mallikarjun Telsang, Krishna Swaroop Duddi Sreehari","doi":"10.5530/ijper.58.1.13","DOIUrl":"https://doi.org/10.5530/ijper.58.1.13","url":null,"abstract":"","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"55 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139154067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibition of Phenylhydrazine-induced Hematotoxicity by Bioconverted Ginsenosides","authors":"Yuseong Chung, Kang Min Kim, Jae Seon Kang","doi":"10.5530/ijper.57.4.136","DOIUrl":"https://doi.org/10.5530/ijper.57.4.136","url":null,"abstract":"Abstract: Aim: To identify the inhibition of Phenylhydrazine (PHZ)-induced hepatotoxicity and anemia by bioconverted ginsenosides. Materials and Methods: We examined the potential benefits of bioconverted ginsenosides on anemia in a phenylhydrazine-induced rat model and described the prolonging effect of erythrocyte life span by focusing on compound K that was confirmed through ex vivo experiments. Results: Hematological analysis demonstrated that all groups treated with bioconverted ginsenosides showed significant recovery results. In the ex vivo experiments, compound K was treated in stored blood, and the erythrocytes half-life was 45 days, 15 days longer than when not treated in blood. In the ICP-OES assay, PHZ-induced erythrocyte hemolysis was significantly inhibited by bioconverted ginsenosides. Conclusion: Based on the present results, it has been demonstrated that bioconverted ginsenoside aids in prolonging the erythrocyte life span and increasing erythrocyte count in vivo. Thus, this material has the potential to develop as a promising drug candidate in the future. Keywords: Anemia, Erythrocyte, Ginsenosides, Hemolysis, Phenylhydrazine.","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135645298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In silico Discovering STRA 6 Vitamin A Receptor, as a Novel Binding Receptor of COVID-19","authors":"Mahmoud Elkazzaz, Amr Ahmed, Yousry Esam Eldin Abo Amer, Tamer Haydara, Wafa Ali ELtayb, Mohammad Shahbaz Khan, Kunal Bhattacharya, Salma Alkhammash, Hadeer Mattar, Saba Beigh, Mohammed F Abo El Magd, Abdullah Haikal, Islem Abid, Amr S Abouzied, Israa M Shamkh","doi":"10.5530/ijper.57.4.126","DOIUrl":"https://doi.org/10.5530/ijper.57.4.126","url":null,"abstract":"Abstract: A global pandemic of pneumonia caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began in Wuhan, China, at the end of 2019. Although, the ACE2 receptor has been demonstrated to be the main entry receptor of COVID-19, but our docking analysis, predicted and discovered a novel receptor termed STRA 6 that may play a critical role in the pathogenicity of COVID-19. STRA6 receptor expressed in many organs and immune cells, upregulated by retinoic acid jm6 (STRA 6) was the first protein to be identified in a novel category of proteins, cytokine signaling transporters, due to its ability to function as both a cell surface receptor and a membrane protein that binds to retinol binding protein facilitating cellular uptake of retinol. The primary ligand of STRA6 (vitamin/retinol) was shown to be drastically reduced during COVID-19 infection, which agrees with our findings. We analyze the STRA6 and ACE2 receptor networks to predict the specific association among certain other proteins which might rely on similar functionality. Molecular docking showed a high affinity between the Spike protein with STRA6, the docking score of COVID-19 spike protein with STRA6 (-354.68) kcal/mol was higher than the docking score of spike protein with ACE2 (-341.21) kcal/mol. Results of MD simulations revealed significant stability of the spike protein with STRA6 up to 100 ns. SARS-CoV-2 spike protein binds strongly and directly to STRA6. Which are highly expressed in Lymphatic system and Immune cells. This study paves the way towards understanding the complex mechanism of existing of covid-19 infection complications such as immune suppression and ineffective RIG-I pathway. Restoring the balance between the STRA6 and ACE2 in the context of spike protein RBD may be promising target in SARS CoV-2 Pathogenesis and may reveal new drug targets for new variants of COVID-19. Keywords: COVID-19, STRA6, ACE2, Molecular docking.","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135645395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Multi-element Integrated Teaching in the Human Anatomy and Physiology Course in Pharmacy Majors","authors":"Hong Zhang, Jinghua Xu, Jiahong Wang, Yanting Gu, Guoxiang Sun","doi":"10.5530/ijper.57.4.142","DOIUrl":"https://doi.org/10.5530/ijper.57.4.142","url":null,"abstract":"Abstract: Background: A professional foundational course in human anatomy and physiology is required of pharmacy students to establish their understanding of the field. Since it includes human anatomy and human physiology, two crucial theoretical courses for medical students, the teaching material for these subjects was employed to adhere to the standards of medical disciplines rather than those of pharmacy. Objectives: This study aimed to establish a multi-element integrated teaching method for human anatomy and physiology to address the training requirements of pharmacy students. Materials and Methods: For pharmacy majors, we designed a multi-element integrated teaching method of human anatomy and physiology from the viewpoints of medicine, pharmacy, and professional ethics. We also summarized the feasibility, significance, and issues associated with multi-element integrated teaching of human anatomy and physiology. Conclusion: Our multi-element integrated teaching method for human anatomy and physiology increased student interest and enhanced the effectiveness of lessons. This approach will promote the development of skilled pharmaceutical workers who are enthusiastic about scientific research and have a sense of social responsibility. Keywords: Human anatomy and physiology, Pharmacy characteristics, Integrated teaching, Pharmaceutical students growing.","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135645397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Extraction Techniques on Betalain Yield and Bioactive Phytochemical Analysis of Nopal Fruit Peels","authors":"Anbarasi Karunanithi","doi":"10.5530/ijper.57.4.130","DOIUrl":"https://doi.org/10.5530/ijper.57.4.130","url":null,"abstract":"Background: Nopal fruits ( Opuntia ficus-indica) and their peels contain significant amount of natural colorants which can be used in food and pharmaceutical applications instead of using synthetic dyes. Materials and Methods: The present study focuses on the extraction of betalain from nopal fruit peel by conventional and Ultrasound-Assisted Extraction (UAE) and optimizing the UAE process variables using Box Box-Behnken surface design, as well as a preliminary screening of valuable phytochemicals using Gas-Chromatography and Mass Spectroscopy (GC-MS) which contribute to the medicinal potential of nopal fruits. Results: Soxhlet extraction of Betacyanin and Betaxanthin (BC and BX) was found to be 4.51 mg/g of BC and 0.67 mg/g of BX. The extraction yield of betacyanin and betaxanthin for UAE was extracted at 16 min, 40°C, 1/22 g/mL, and the yield was found to be 3.00 ± 0.23 mg/g BC, 0.225 ± 0.02 mg/g BX. Conclusion: GC-MS analysis of nopal fruit ( Opuntia ficus-indica) peel revealed that ethanol extracts of nopal fruit peel revealed two fold higher results of - (+)-Ascorbic acid 2, 6-dihexadecanoate of UAE than soxhlet. Also other phytochemicals such as n-Hexadecanoic acid (Palmitic acid) which posses anti-inflammatory, antibacterial and antifungal activity are found to be higher.","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"219 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135645437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the Synthesis and Hypolipidemic Activities of Coumarin Oxime Esters Derivatives","authors":"Haoyun Chang, Guangyao Li, Peng Liu, Supei Hu, Peng Huang, Haixia Hu, Nongzhang Xu, Yang Zhou","doi":"10.5530/ijper.57.4.138","DOIUrl":"https://doi.org/10.5530/ijper.57.4.138","url":null,"abstract":"Abstract: Aim: The major objective of this research was to synthesize and evaluate the hypolipidemic Activities of Coumarin Oxime esters and develop the possible target. Materials and Methods: Using salicylaldehyde and ethyl acetoacetate as raw materials, coumarin-3-carboxylic acid was synthesized by Knoevenagel reaction, and then reacted with hydroxylamine hydrochloride to form oxime, which was then dehydrated and condensed with niacin and acetylsalicylic acid respectively to obtain six coumarin oxime ester target compounds. MS and HNMR were MS and HNMR were employed to confirm the structures of the examined compounds. to validate the chemical structures of the investigated synthetics. The hypolipidemic effect of these compounds was evaluated by experimental mice models. The interaction of small-molecules and possible targets was assessed by Discovery Studio (v4.5). Results: The optimal reaction condition for oxime was as follows: n (3-acetyl coumarin): n (pyridine) = 1:30, the yield was 76.8%. The optimal reaction condition for synthesis oxime ester was as follows: the reaction time was 48 hr, the yield was 57.2%. The results of enzyme immunosorbent assay showed that the substances C1 and C4 both demonstrated specific lipid-lowering properties and were able to considerably decrease the triglyceride and total cholesterol levels in mice. Coumarin oxime nicotinate has a stronger effect on reducing serum triglyceride, while coumarin oxime aspirin has a stronger effect on reducing total cholesterol. The docking result indicated the 3QNT may be the possible hypolipidemic target of C1 with binding energy of -1.65 kcal/mol. Conclusion: It can be concluded that coumarin oxime esters would be carefully explored and developed as hypolipidemic drugs. The future research work should emphasis on the alteration of the coumarin oxime backbone at the mean time keeping the right-hand side of the nicotinic acid and aspirin structures. Keywords: Coumarin, Oxime esters, Synthesis, Hypolipidemic, Targets","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135645583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artemetin, A Dietary Flavonoid Inhibits the Proliferation and Induces Apoptosis in Human Gastric Carcinoma (AGS) Cells","authors":"Yuxing Lv, Yinquan Wang, Gaopeng Hao","doi":"10.5530/ijper.57.4.139","DOIUrl":"https://doi.org/10.5530/ijper.57.4.139","url":null,"abstract":"Abstract: Background: One of the most common types of recurrent carcinoma cases worldwide is gastric cancer. Even advances in treatment methods and early discoveries have not been able to significantly lower the death and morbidity rates associated with gastric cancer. On account of their multiple health benefits, apparent lack of toxicity and side effects, and the limitations of chemotherapeutic drugs, natural products have attracted a lot of interest in recent years with the aim of preventing cancer. Aim: A flavonoid class phytochemical known as Artemetin, has been discovered to be present in numerous medicinal plants. Anti-bacterial, antioxidant, and anti-inflammatory, hepatoprotective and cardioprotective actions are only a few of its many pharmacological effects. Materials and Methods: In the current investigation, the potential of Artemetin as an anticancer agent for gastric cancer was evaluated in AGS cell lines. The influence of Artemetin on the cell viability, apoptotic induction, mitochondrial ATPase activity, ROS generation, and cell cycle progression has been examined. Cisplatin was selected as the positive control for the experiments. Results: The impact of Artemetin on the cell viability revealed that its cytotoxic potential increased in a dose-dependent pattern and IC50 concentrations were chosen for further experiments. The results showed that apoptosis was induced by Artemetin in AGS cells by triggering ROS pathway and DNA damage. The cell viability of AGS cells was reduced with increased concentration of Artemetin. Conclusion: Artemtin's cytotoxic potential in cells is mediated by inducing apoptosis, which is supported by significant levels of ROS and mitochondrial ATPase as well as the findings of the AO/EB staining. All these results suggest that Artemetin can be used as a potent anticancer drug for human gastric carcinoma. Keywords: Gastric cancer, Artemetin, AGS cells, Reactive oxygen species, Apoptosis.","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135645967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}