Biological Reviews最新文献

{"title":"Dynamic molecular networks unveil the mechanism behind hypoxia-induced tumour cell dormancy.","authors":"Ping Wang, Hao Xuan Li, Yang Shun Lan, Hong Gang Zhang, Chuan Fu Li, Xiao-Peng Zhang, Wei Wang","doi":"10.1002/brv.70195","DOIUrl":"https://doi.org/10.1002/brv.70195","url":null,"abstract":"<p><p>Tumour cell dormancy is a reversible, non-proliferative state in which cancer cells arrest in the G0 phase of the cell cycle. Increasingly recognized as a critical survival strategy, dormancy enables cancer cells to withstand therapeutic insult, escape immune surveillance, and endure hostile microenvironments. Clinically, dormant cells underlie extended asymptomatic intervals following primary treatment and are notably implicated in estrogen receptor-positive (ER⁺) breast cancer, prostate cancer, and clear cell renal cell carcinoma. In this review, we synthesize recent insights into hypoxia-mediated dormancy and, using breast cancer bone metastasis as an archetypal model, delineate how spatiotemporally heterogeneous hypoxia shapes the metastatic cascade. Specifically, we show that graded hypoxia in the primary tumour initiates dormancy traits, while persistent hypoxia within metastatic niches - such as the bone marrow - reinforces and deepens quiescence. These transitions are orchestrated by stage-specific activation of hypoxia-inducible factor 1α (HIF-1α) and its dynamic transcriptional outputs. We further argue that a mechanistic understanding of dormancy requires integrative frameworks that bridge single-cell level regulatory programs - including cell-cycle arrest, translational inhibition, and metabolic reprogramming - with systems-level networks capturing the dynamic, multistage nature of metastasis. Such integration may uncover actionable vulnerabilities within dormant cell populations and guide the development of precision therapies targeting minimal residual disease.</p>","PeriodicalId":133,"journal":{"name":"Biological Reviews","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148300240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kin discrimination in plants: overview and implications for population and community ecology.","authors":"Akira Yamawo","doi":"10.1002/brv.70194","DOIUrl":"https://doi.org/10.1002/brv.70194","url":null,"abstract":"<p><p>Following the discovery of identity discrimination, particularly self and kin discrimination amongst plant competitors, research on interplant interactions has advanced significantly within plant physiology and evolutionary ecology. This review synthesizes current knowledge on how both self and kin discrimination influence plant growth, resource allocation, defence, and reproduction. I highlight their ecological and evolutionary consequences for population dynamics, community structure, and multi-trophic interactions. A key insight is that, under some circumstances, identity discrimination may shape the maintenance or erosion of genetic diversity by modulating competitive interactions and spatial genetic structure within populations. Finally, I present several open questions, such as how identity discrimination operates across gradients of plant competition and trophic levels, and propose a few testable hypotheses and experimental approaches regarding the role of competitive identity discrimination under natural settings.</p>","PeriodicalId":133,"journal":{"name":"Biological Reviews","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148275363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review of the fauna associated with wild and farmed mussels and oysters in the Mediterranean.","authors":"Barbara Mikac, Marina Antonia Colangelo, Alessandro Tarullo, Marco Abbiati, Eugenio Fossi, Federica Costantini","doi":"10.1002/brv.70193","DOIUrl":"https://doi.org/10.1002/brv.70193","url":null,"abstract":"&lt;p&gt;&lt;p&gt;Mussels and oysters are important ecosystem engineers which modify the physical and chemical characteristics of the environment and create habitats that support highly diverse associated communities. In the Mediterranean Sea, the native Mediterranean mussel Mytilus galloprovincialis and the European flat oyster Ostrea edulis, together the introduced Pacific cupped oyster Magallana gigas, are among the most important habitat builders and farmed molluscs. The widespread disappearance of natural beds of mussels and flat oysters, driven by multiple anthropogenic disturbances, disease outbreaks, and harmful invasive species, has led to the loss of the diverse communities they support. Moreover, the proliferation of harmful invasive species is exacerbated by mollusc aquaculture, which represents one of the main vectors for the introduction and spread of non-native species (NNS) in the Mediterranean. The aim of this review is to compile the first comprehensive database of macrofauna associated with wild and farmed M. galloprovincialis, O. edulis and M. gigas in the Mediterranean Sea, based on an extensive literature review. Specifically, we aimed to identify differences in the diversity of associated fauna among the three mollusc species, assess variability of the fauna between wild and farmed systems, highlight associated non-native species, reveal knowledge gaps, and provide directions for future research. Overall, we recorded 782 taxa, with polychaetes, molluscs, arthropods, and ascidians representing the most species-rich groups. Fauna associated with mussels is the most extensively studied and consequently the most diverse, with a considerably higher number of taxa reported from wild mussel habitats (647) than from mussel farms (204), likely reflecting higher environmental heterogeneity in natural contexts. By contrast, the higher diversity of fauna reported from farmed European oysters (163 taxa) compared to wild ones (50 taxa), is consistent with greater research effort focused on aquaculture systems. Fauna associated with naturalized populations of Pacific oysters (M. gigas) remains severely understudied, with only a few species reported to date. Information on fauna associated with molluscs is particularly lacking along much of the African coastline. Future research should therefore prioritize these understudied habitats and regions. To date, a total of 52 non-native species have been reported from mussel and oyster habitats, with arthropods, molluscs and ascidians comprising the majority. Mussels host the highest number of NNS. Reports of NNS from mollusc habitats are increasing, particularly in mussel and oyster farms, suggesting that research efforts should focus on the detection and monitoring of NNS in Mediterranean aquaculture systems. Particular attention should be given to key groups such as non-native ascidians and shell-boring polychaetes, which are known pests and parasites of molluscs. This review provides a baseline for monit","PeriodicalId":133,"journal":{"name":"Biological Reviews","volume":" ","pages":""},"PeriodicalIF":11.7,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148256663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What drives animal responses to high severity fire? The role of functional traits.","authors":"Grace A Vielleux, Trent D Penman, Victoria A Reynolds, Matthew H Swan","doi":"10.1002/brv.70192","DOIUrl":"https://doi.org/10.1002/brv.70192","url":null,"abstract":"<p><p>Fire regimes are changing worldwide, with increases in the frequency, extent, and severity of fires posing growing risks to biodiversity. Fire severity - the degree of habitat alteration following fire - strongly influences both immediate survival and long-term recovery of fauna. Yet species' responses to severe fire are highly variable, shaped by traits, time since fire, and ecosystem context. We conducted a global systematic review of studies quantifying terrestrial vertebrate responses across fire-severity gradients. Using ordinal logistic regression, we assessed the predictive value of functional traits, time since fire, taxonomy, and ecosystem type for species' abundance and occurrence after fire. Across all severity comparisons, most species showed neutral responses; however, high severity fires elicited both more negative and more positive responses than low severity fires. Species with weak shelter, canopy-foraging habits, and preferences for closed canopies were more likely to decline after high severity fire. Negative responses diminished with increasing time since fire, highlighting opportunities for population recovery. Our findings identify functional traits that confer vulnerability to severe fire and provide a basis for predicting species' responses in unstudied taxa or regions. Targeted management, particularly within the first few years post-fire, will be critical to safeguard susceptible species as high severity fires become more frequent.</p>","PeriodicalId":133,"journal":{"name":"Biological Reviews","volume":" ","pages":""},"PeriodicalIF":11.7,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148215705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Partners or passengers? Revisiting the association between diatoms and aquatic animals.","authors":"Gianluca Vacca, Elisa Falasco, Francesca Bona","doi":"10.1002/brv.70191","DOIUrl":"https://doi.org/10.1002/brv.70191","url":null,"abstract":"<p><p>Numerous studies have revealed the importance of research on the communities capable of colonizing animal surfaces (epibionts) and the animals on which they live (basibionts). Very few studies have considered epizoic diatoms, and there are gaps and biases in our knowledge, including the choice of basibionts, the methods used, and the habitats in which they live. This literature review aims to (i) identify the main basibionts that host diatom communities and the diatom taxa associated with them, in both marine and freshwater environments; (ii) explore the key ecological factors shaping these diatom assemblages; and (iii) reassess critically the commonly applied concept of commensalism in epibiont-host relationships. Our literature review revealed that most research has been focused on charismatic basibiont groups, especially Chordata (notably Testudines and Cetacea), followed by Arthropoda and Mollusca, while taxa such as Bryozoa, Porifera, Cnidaria, Echinodermata, and Annelida have received far less attention. Most studies were carried out in marine settings, particularly in the Americas, and the number of publications has increased since the early 2000s. Taxonomic data on diatom communities shows that the genera Navicula, Nitzschia, Cocconeis and Amphora are the most frequently found as epizoic diatoms. In some cases, highly host-specific diatoms have been documented, for example Pseudohimantidium pacificum, Protoraphis atlantica, Falcula hyalina, and Sceptronema orientale on copepods. From a functional point of view, 'motile' diatoms were dominant on Chordata, Mollusca, and Arthropoda, followed by the 'high-profile' ecological guild. This dominance suggests active interaction between the organisms, supporting the development of well-structured communities on the hosts. There are several types of interaction, depending on the host and epibiont considered. We propose the concepts of triggers and drivers as a framework to describe the initial diversity and development of the epibiont community on the host, and we interpret the nature of these relationships as falling along a continuum from commensalism to parasitism and mutualism. Although diatoms are considered valuable tools for environmental monitoring, we suggest that host displacement and interactions with substrates may be considered as limiting factors for the use of epizoic diatoms in environmental monitoring. However, they may provide useful insights into host ecology, such as the range of host displacement and habits, feeding behaviour, and ecological traits, helping to clarify the trophic and behavioural interactions among basibionts and epibionts. This integrative perspective enhances our understanding of both diatom dispersal and their ecological tolerance and adaptability across diverse environmental contexts.</p>","PeriodicalId":133,"journal":{"name":"Biological Reviews","volume":" ","pages":""},"PeriodicalIF":11.7,"publicationDate":"2026-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148175043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamics of biotic resistance to plant invasions.","authors":"Christine S Sheppard, Joshua I Brian, Wayne Dawson, Petr Dostál, Franz Essl, Michal Gruntman, Tina Heger, Mark van Kleunen, Mialy Razanajatovo, Lena C Reimann, Frank M Schurr, Montserrat Vilà, Florencia A Yannelli, Marina Golivets","doi":"10.1002/brv.70190","DOIUrl":"10.1002/brv.70190","url":null,"abstract":"&lt;p&gt;&lt;p&gt;Biotic resistance, the reduction in invasion success caused by native communities, plays an important role in the long-term dynamics of biological invasions. A large body of empirical research on biotic resistance has accumulated since the last comprehensive review on the subject 20 years ago, enabling us to achieve a refined understanding of biotic resistance and its dynamics. Here, we aim to reshape research on biotic resistance to alien plant invasions by (i) synthesizing existing evidence on biotic resistance and (ii) exploring the so far rarely considered interplay between biotic resistance mechanisms (i.e. competition, aboveground and belowground antagonisms, and diversity-invasibility effects) and the potential eco-evolutionary changes in biotic resistance over time. To address the first aspect, we conducted a global meta-analysis of 240 experimental studies to assess the mechanisms by which and the extent to which biotic resistance of native communities affects the performance of alien plant species. We show that competition with native plant species, aboveground antagonism (e.g. herbivores) and diversity-invasibility effects significantly reduced alien plant performance, whereas there was no evidence for consistent effects of belowground antagonism (e.g. soil pathogens). Competition exerted the strongest biotic resistance, followed by aboveground antagonism. However, the strength of biotic resistance also depended on the alien plant performance measure considered (vegetative performance, survival, reproductive performance, or population growth). From the small set of studies that considered more than one biotic resistance mechanism, we did not detect an overall synergistic effect of combined mechanisms. The meta-analysis results also revealed that biotic resistance first decreased with the residence time of the alien plant species but increased again after approximately 200 years. In a subset of studies directly comparing species of different origin, we did not detect a difference in biotic resistance to alien versus native species. To address the second aspect, we expanded the limited empirical evidence on temporal dynamics by presenting a conceptual causal network and an accompanying mathematical model to explore the eco-evolutionary dynamics of biotic resistance mechanisms. Our conceptual and mathematical models highlight that biotic resistance is determined by both the attributes of the alien species (i.e. invasiveness) and of the recipient community (i.e. invasibility). Both factors can change over time as inter- and/or intraspecific selection cause changes in the composition and overall density of the native community and the alien species. As invaders evolve and the successful ones persist, biotic resistance initially decreases, then increases again due to intra- and interspecific adaptation of the native community. Using the findings from the comprehensive synthesis of empirical studies and our modelling approach, we highli","PeriodicalId":133,"journal":{"name":"Biological Reviews","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148154415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to 'The macroecology of spines on woody plants'.","authors":"","doi":"10.1002/brv.70169","DOIUrl":"10.1002/brv.70169","url":null,"abstract":"","PeriodicalId":133,"journal":{"name":"Biological Reviews","volume":" ","pages":"1621-1622"},"PeriodicalIF":11.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147631938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The flexible, the stereotyped and the in-between: putting together the combinatory tool use origins hypothesis.","authors":"Jennifer A D Colbourne, Alice M I Auersperg","doi":"10.1002/brv.70123","DOIUrl":"10.1002/brv.70123","url":null,"abstract":"<p><p>Tool use research has long made the distinction between tool using that is considered learned and flexible, and that which appears to be instinctive and stereotyped. However, animals with an inherited tool use specialisation can exhibit flexibility, while tool use that is spontaneously innovated can be limited in its expression and facilitated by predispositions for ecological specialisations. Furthermore, recent evidence does not support the proposed division of flexible tool use along primate-bird taxonomic lines. Instead, we hypothesise that tool use is a more complementary phenomenon than previously believed, in that the intrinsic motivation for combinatory object manipulation underlies the onset of all allocentric tool use, resulting in a spectrum. What influences the initial tool use that does emerge is the form of a species' object combinations, which is itself influenced by ecological niche. Therefore, an opportunistic extractive forager will likely develop more diverse forms of tool use than a specialist.</p>","PeriodicalId":133,"journal":{"name":"Biological Reviews","volume":" ","pages":"1235-1254"},"PeriodicalIF":10.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13149787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145861720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolution of vocal control in echolocating bats.","authors":"Shuying Chen, Yossi Yovel, Cynthia F Moss, Jinhong Luo","doi":"10.1002/brv.70122","DOIUrl":"10.1002/brv.70122","url":null,"abstract":"<p><p>Echolocating bats display a large repertoire of behavioural plasticity, with vocal flexibility as a core constituent. The speed and accuracy of vocal adjustments executed by echolocating bats are unparalleled by other mammals, including humans. However, the evolutionary pressures behind the extraordinary vocal flexibility of echolocating bats remains elusive. Here we conducted a synthetic review to evaluate critically the probable drivers for all forms of vocal flexibility in echolocating bats. We show that many forms of bat echolocation flexibility, accounting for approximately 60% of vocal adjustment behaviours, function to mitigate acoustic interference, and thus can be attributed to auditory masking. Importantly, half of these anti-interference strategies are related to reafferent masking that is specific to active-sensing animals. We propose that auditory masking mitigation represents a strong selection pressure for the remarkable repertoire of vocal flexibility in echolocating bats.</p>","PeriodicalId":133,"journal":{"name":"Biological Reviews","volume":" ","pages":"1181-1196"},"PeriodicalIF":11.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145831815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The nature of gain curves.","authors":"Martin Burd","doi":"10.1002/brv.70136","DOIUrl":"10.1002/brv.70136","url":null,"abstract":"<p><p>Gain curves have been a staple of sex allocation theory for decades. They represent patterns in which fitness is obtained from resource investments in reproductive functions. The monotonic forms that have been used for gain curves can represent fitness accrual by individuals, but only on the assumption that sufficient mates are always available to allow the stipulated monotonic pattern of reproductive success to occur. However, sexual populations do not have external banks of mating opportunities that lie outside the dynamics of the population (such opportunities would, by definition, be part of the population). Thus, the reproductive behaviour of whole populations cannot be simple scaled-up versions of individual gain curves. As sex allocation evolves within a breeding population, frequency-dependent selection creates a shifting advantage for the rarer sex. Individual gain curves cannot then remain stable possibilities at the population level. Evolutionary models based on fixed gain curves can predict evolutionary outcomes with unequal total fitness for male and for female function, an outcome that the biology of syngamy does not allow. Such biologically impossible outcomes are easily demonstrated. Gain curves have also been widely used as a framework for interpretation of interspecific empirical patterns, such as low male allocation in monogamously mating hermaphroditic animals or self-pollinating plants, and higher male allocation in wind-pollinated than in animal-pollinated plants. However, if gain curves incorrectly characterize whole populations or species, interspecific differences in gain curves cannot explain these patterns. Even if they superficially appear to predict the empirical pattern, other processes must be operating. The selective effects of local mating competition and sex-specific dispersal patterns have long been known. They are likely replacements for gain curves as explanations of many broad interspecific patterns, but the predominance of gain-curve explanations has distracted attention from these alternatives. A revision of our understanding of gain curves seems needed.</p>","PeriodicalId":133,"journal":{"name":"Biological Reviews","volume":" ","pages":"1554-1567"},"PeriodicalIF":10.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146083646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}