Biological Reviews最新文献

{"title":"The Lego hypothesis of tissue morphogenesis: stereotypic organization of parallel orientational cell adhesions for epithelial self-assembly","authors":"Lili Zhang,&nbsp;Xiangyun Wei","doi":"10.1111/brv.13147","DOIUrl":"10.1111/brv.13147","url":null,"abstract":"<p>How tissues develop distinct structures remains poorly understood. We propose herein the Lego hypothesis of tissue morphogenesis, which states that during tissue morphogenesis, the topographical properties of cell surface adhesion molecules can be dynamically altered and polarised by regulating the spatiotemporal expression and localization of orientational cell adhesion (OCA) molecules cell-autonomously and non-cell-autonomously, thus modulating cells into unique Lego pieces for self-assembling into distinct cytoarchitectures. This concept can be exemplified by epithelial morphogenesis, in which cells are coalesced into a sheet by many types of adhesions. Among them, parallel OCAs (pOCAs) at the lateral cell membranes are essential for configuring cells in parallel. Major pOCAs include Na⁺/K⁺-ATPase-mediated adhesions, Crumbs-mediated adhesions, tight junctions, adherens junctions, and desmosomes. These pOCAs align in stereotypical orders along the apical-to-basal axis, and their absolute positioning is also regulated. Such spatial organization of pOCAs underlies proper epithelial morphogenesis. Thus, a key open question about tissue morphogenesis is how to regulate OCAs to make compatible adhesive cellular Lego pieces for tissue construction.</p>","PeriodicalId":133,"journal":{"name":"Biological Reviews","volume":"100 1","pages":"445-460"},"PeriodicalIF":11.0,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11718597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142277501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Positive species interactions structure rhodolith bed communities at a global scale","authors":"Fabio Bulleri,&nbsp;Nadine Schubert,&nbsp;Jason M. Hall-Spencer,&nbsp;Daniela Basso,&nbsp;Heidi L. Burdett,&nbsp;Ronaldo B. Francini-Filho,&nbsp;Jacques Grall,&nbsp;Paulo A. Horta,&nbsp;Nicholas A. Kamenos,&nbsp;Sophie Martin,&nbsp;Matteo Nannini,&nbsp;Pedro Neves,&nbsp;Irene Olivé,&nbsp;Viviana Peña,&nbsp;Federica Ragazzola,&nbsp;Cláudia Ribeiro,&nbsp;Eli Rinde,&nbsp;Marina Sissini,&nbsp;Fernando Tuya,&nbsp;João Silva","doi":"10.1111/brv.13148","DOIUrl":"10.1111/brv.13148","url":null,"abstract":"<p>Rhodolith beds are diverse and globally distributed habitats. Nonetheless, the role of rhodoliths in structuring the associated species community through a hierarchy of positive interactions is yet to be recognised. In this review, we provide evidence that rhodoliths can function as foundation species of multi-level facilitation cascades and, hence, are fundamental for the persistence of hierarchically structured communities within coastal oceans. Rhodoliths generate facilitation cascades by buffering physical stress, reducing consumer pressure and enhancing resource availability. Due to large variations in their shape, size and density, a single rhodolith bed can support multiple taxonomically distant and architecturally distinct habitat-forming species, such as primary producers, sponges or bivalves, thus encompassing a broad range of functional traits and providing a wealth of secondary microhabitat and food resources. In addition, rhodoliths are often mobile, and thus can redistribute associated species, potentially expanding the distribution of species with short-distance dispersal abilities. Key knowledge gaps we have identified include: the experimental assessment of the role of rhodoliths as basal facilitators; the length and temporal stability of facilitation cascades; variations in species interactions within cascades across environmental gradients; and the role of rhodolith beds as climate refugia. Addressing these research priorities will allow the development of evidence-based policy decisions and elevate rhodolith beds within marine conservation strategies.</p>","PeriodicalId":133,"journal":{"name":"Biological Reviews","volume":"100 1","pages":"428-444"},"PeriodicalIF":11.0,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/brv.13148","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142258789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A synthetic review: natural history of amniote reproductive modes in light of comparative evolutionary genomics","authors":"Maggs X","doi":"10.1111/brv.13145","DOIUrl":"10.1111/brv.13145","url":null,"abstract":"<div>\u0000 \u0000 <p>There is a current lack of consensus on whether the ancestral parity mode was oviparity (egg-laying) or viviparity (live-birth) in amniotes and particularly in squamates (snakes, lizards, and amphisbaenids). How transitions between parity modes occur at the genomic level has primary importance for how science conceptualises the origin of amniotes, and highly variable parity modes in Squamata. Synthesising literature from medicine, poultry science, reproductive biology, and evolutionary biology, I review the genomics and physiology of five broad processes (here termed the ‘Main Five’) expected to change during transitions between parity modes: eggshell formation, embryonic retention, placentation, calcium transport, and maternal–fetal immune dynamics. Throughout, I offer alternative perspectives and testable hypotheses regarding proximate causes of parity mode evolution in amniotes and squamates. If viviparity did evolve early in the history of lepidosaurs, I offer the nucleation site hypothesis as a proximate explanation. The framework of this hypothesis can be extended to amniotes to infer their ancestral state. I also provide a mechanism and hypothesis on how squamates may transition from viviparity to oviparity and make predictions about the directionality of transitions in three species. After considering evidence for differing perspectives on amniote origins, I offer a framework that unifies (<i>i</i>) the extended embryonic retention model and (<i>ii</i>) the traditional model which describes the amniote egg as an adaptation to the terrestrial environment. Additionally, this review contextualises the origin of amniotes and parity mode evolution within Medawar's paradigm. Medawar posited that pregnancy could be supported by immunosuppression, inertness, evasion, or immunological barriers. I demonstrate that this does not support gestation or gravidity across most amniotes but may be an adequate paradigm to explain how the first amniote tolerated internal fertilization and delayed egg deposition. In this context, the eggshell can be thought of as an immunological barrier. If serving as a barrier underpins the origin of the amniote eggshell, there should be evidence that oviparous gravidity can be met with a lack of immunological responses <i>in utero</i>. Rare examples of two species that differentially express very few genes during gravidity, suggestive of an absent immunological reaction to oviparous gravidity, are two skinks <i>Lampropholis guichenoti</i> and <i>Lerista bougainvillii</i>. These species may serve as good models for the original amniote egg. Overall, this review grounds itself in the historical literature while offering a modern perspective on the origin of amniotes. I encourage the scientific community to utilise this review as a resource in evolutionary and comparative genomics studies, embrace the complexity of the system, and thoughtfully consider the frameworks proposed.</p>\u0000 </div>","PeriodicalId":133,"journal":{"name":"Biological Reviews","volume":"100 1","pages":"362-406"},"PeriodicalIF":11.0,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142258792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How life became colourful: colour vision, aposematism, sexual selection, flowers, and fruits","authors":"John J. Wiens,&nbsp;Zachary Emberts","doi":"10.1111/brv.13141","DOIUrl":"10.1111/brv.13141","url":null,"abstract":"<div>\u0000 \u0000 <p>Plants and animals are often adorned with potentially conspicuous colours (e.g. red, yellow, orange, blue, purple). These include the dazzling colours of fruits and flowers, the brilliant warning colours of frogs, snakes, and invertebrates, and the spectacular sexually selected colours of insects, fish, birds, and lizards. Such signals are often thought to utilize pre-existing sensitivities in the receiver's visual systems. This raises the question: what was the initial function of conspicuous colouration and colour vision? Here, we review the origins of colour vision, fruit, flowers, and aposematic and sexually selected colouration. We find that aposematic colouration is widely distributed across animals but relatively young, evolving only in the last ~150 million years (Myr). Sexually selected colouration in animals appears confined to arthropods and chordates, and is also relatively young (generally &lt;100 Myr). Colourful flowers likely evolved ~200 million years ago (Mya), whereas colourful fruits/seeds likely evolved ~300 Mya. Colour vision (<i>sensu lato</i>) appears to be substantially older, and likely originated ~400–500 Mya in both arthropods and chordates. Thus, colour vision may have evolved long before extant lineages with fruit, flowers, aposematism, and sexual colour signals. We also find that there appears to have been an explosion of colour within the last ~100 Myr, including &gt;200 origins of aposematic colouration across nine animal phyla and &gt;100 origins of sexually selected colouration among arthropods and chordates.</p>\u0000 </div>","PeriodicalId":133,"journal":{"name":"Biological Reviews","volume":"100 1","pages":"308-326"},"PeriodicalIF":11.0,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/brv.13141","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142258912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unlocking the multifaceted molecular functions and diverse disease implications of lactylation","authors":"Fengyang Jing,&nbsp;Jianyun Zhang,&nbsp;Heyu Zhang,&nbsp;Tiejun Li","doi":"10.1111/brv.13135","DOIUrl":"10.1111/brv.13135","url":null,"abstract":"<div>\u0000 \u0000 <p>In recent years, a significant breakthrough has emerged in biology, the identification of lactylation, a novel post-translational process. This intriguing modification is not limited to a specific class of proteins but occurs across a diverse range, including histones, signalling molecules, enzymes, and substrates. It can exert a broad regulatory role in various diseases, ranging from developmental anomalies and neurodegenerative disorders to inflammation and cancer. Thus, it presents exciting opportunities for exploring innovative treatment approaches. As a result, there has been a recent surge of research interest, leading to a deeper understanding of the molecular mechanisms and regulatory functions underlying lactylation within physiological and pathological processes. Here, we review the detection and molecular mechanisms of lactylation, from biological functions to disease effects, providing a systematic overview of the mechanisms and functions of this post-translational modification.</p>\u0000 </div>","PeriodicalId":133,"journal":{"name":"Biological Reviews","volume":"100 1","pages":"172-189"},"PeriodicalIF":11.0,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142258791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of invertebrates on wood decomposition across the world","authors":"Denis M. Njoroge,&nbsp;Gbadamassi G. O. Dossa,&nbsp;Douglas Schaefer,&nbsp;Juan Zuo,&nbsp;Michael D. Ulyshen,&nbsp;Sebastian Seibold,&nbsp;Amy E. Zanne,&nbsp;Brad Oberle,&nbsp;Rhett D. Harrison,&nbsp;Shengjie Liu,&nbsp;Xiaobo Li,&nbsp;Tone Birkemoe,&nbsp;Melanie K. Taylor,&nbsp;Philip J. Burton,&nbsp;David B. Lindenmayer,&nbsp;Jari Kouki,&nbsp;Yagya Adhikari,&nbsp;Johannes H. C. Cornelissen","doi":"10.1111/brv.13134","DOIUrl":"10.1111/brv.13134","url":null,"abstract":"<div>\u0000 \u0000 <p>Invertebrates and microorganisms are important but climate-dependent agents of wood decomposition globally. In this meta-analysis, we investigated what drives the invertebrate effect on wood decomposition worldwide. Globally, we found wood decomposition rates were on average approximately 40% higher when invertebrates were present compared to when they were excluded. This effect was most pronounced in the tropics, owing mainly to the activities of termites. The invertebrate effect was stronger for woody debris without bark as well as for that of larger diameter, possibly reflecting bark- and diameter-mediated differences in fungal colonisation or activity rates relative to those of invertebrates. Our meta-analysis shows similar overall invertebrate effect sizes on decomposition of woody debris derived from angiosperms and gymnosperms globally. Our results suggest the existence of critical interactions between microorganism colonisation and the invertebrate contribution to wood decomposition. To improve biogeochemical models, a better quantification of invertebrate contributions to wood decomposition is needed.</p>\u0000 </div>","PeriodicalId":133,"journal":{"name":"Biological Reviews","volume":"100 1","pages":"158-171"},"PeriodicalIF":11.0,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142258796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rewilded horses in European nature conservation – a genetics, ethics, and welfare perspective","authors":"Lilla Lovász,&nbsp;Carolin Sommer-Trembo,&nbsp;Julia M.I. Barth,&nbsp;John D. Scasta,&nbsp;Ralitsa Grancharova-Hill,&nbsp;Rhys T. Lemoine,&nbsp;Viola Kerekes,&nbsp;Léa Merckling,&nbsp;Amos Bouskila,&nbsp;Jens-Christian Svenning,&nbsp;Antoine Fages","doi":"10.1111/brv.13146","DOIUrl":"10.1111/brv.13146","url":null,"abstract":"<p>In recent decades, the integration of horses (<i>Equus ferus</i>) in European rewilding initiatives has gained widespread popularity due to their potential for regulating vegetation and restoring natural ecosystems. However, employing horses in conservation efforts presents important challenges, which we here explore and discuss. These challenges encompass the lack of consensus on key terms inherent to conservation and rewilding, the entrenched culture and strong emotions associated with horses, low genetic diversity and high susceptibility to hereditary diseases in animals under human selection, as well as insufficient consideration for the social behaviour of horses in wild-living populations. In addition, management of wild-living horses involves intricate welfare, ethics and legislative dimensions. Anthropocentric population-control initiatives may be detrimental to horse group structures since they tend to prioritise individual welfare over the health of populations and ecosystems. To overcome these challenges, we provide comprehensive recommendations. These involve a systematic acquisition of genetic information, a focus on genetic diversity rather than breed purity and minimal veterinary intervention in wild-living populations. Further, we advise allowing for natural top-down and bottom-up control – or, if impossible, simulating this by culling or non-lethal removal of horses – instead of using fertility control for population management. We advocate for intensified collaboration between conservation biologists and practitioners and enhanced communication with the general public. Decision-making should be informed by a thorough understanding of the genetic makeup, common health issues and dynamics, and social behaviour in wild-living horse populations. Such a holistic approach is essential to reconcile human emotions associated with horses with the implementation of conservation practices that are not only effective but also sustainable for the long-term viability of functional, biodiverse ecosystems, while rehabilitating the horse as a widespread wild-living species in Europe.</p>","PeriodicalId":133,"journal":{"name":"Biological Reviews","volume":"100 1","pages":"407-427"},"PeriodicalIF":11.0,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/brv.13146","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142258790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the function and origin of the avian renal portal shunt and its potential significance throughout evolution","authors":"Kobe Buyse,&nbsp;Koen Stein,&nbsp;Ward De Spiegelaere,&nbsp;Pieter Cornillie,&nbsp;Marcus Clauss,&nbsp;Geert P.J. Janssens","doi":"10.1111/brv.13144","DOIUrl":"10.1111/brv.13144","url":null,"abstract":"<div>\u0000 \u0000 <p>All birds possess a unique venous architecture surrounding the kidneys known as the renal portal system. In veterinary medicine, this system is well known for causing a first-pass effect when medication is administered parenterally <i>via</i> the leg veins, that is venous blood from the leg is filtered before entering general circulation, thus possibly compromising adequate dosage. Additionally, bilateral valves are present in these veins, and it has been hypothesized that they play a crucial role in regulating flow through the kidneys to protect them against increases in blood pressure. While this hypothesis has been acknowledged, it has not been thoroughly explored. We propose that the function of the renal portal valve extends beyond its significance for kidney function, potentially impacting general hemodynamics. Examining anatomical similarities with extant non-avian reptiles, which lack the renal portal shunt with valve, could reveal additional functionalities of this system in birds. Given the endothermic metabolism and the energetically expensive locomotor activity of birds, the resistance of the hepatic and renal portal system might constrain the blood flow from splanchnic to non-splanchnic blood vessels necessary for (sustained) peak performance. Therefore, diverting blood from the renal portal system using the renal portal valve as a regulatory structure might represent a key adaptation to facilitate sustained peak performance. In addition, we hypothesize that this shunt and valve represents a very early adaptation in amniotes, possibly lost in extant non-avian reptiles but enhanced in birds, with a pivotal role in maintaining hemodynamic homeostasis to support the high metabolic rates characteristic of birds.</p>\u0000 </div>","PeriodicalId":133,"journal":{"name":"Biological Reviews","volume":"100 1","pages":"351-361"},"PeriodicalIF":11.0,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142269490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surviving global change: a review of the impacts of drought and dewatering on freshwater mussels","authors":"Kiara C. Cushway,&nbsp;Juergen Geist,&nbsp;Astrid N. Schwalb","doi":"10.1111/brv.13142","DOIUrl":"10.1111/brv.13142","url":null,"abstract":"<p>The increase in the frequency and intensity of droughts and heatwaves caused by climate change poses a major threat to biodiversity. In aquatic systems, sedentary species such as freshwater mussels are generally considered more vulnerable to changes in habitat conditions than mobile species such as fish. As mussels provide important ecosystem services, understanding the impacts of drought on freshwater mussels is of particular importance for the management of overall functioning of aquatic ecosystems. We used a comprehensive literature search to provide a systematic overview of direct and indirect effects of drought on freshwater mussels (Bivalvia: Unionida) and an evaluation of mitigation strategies. We found that drought studies were concentrated mostly in the USA, with a focus on the Unionidae family. Topics ranged from the physiological effects of high temperatures, emersion, and hypoxia/anoxia to behavioural and reproductive consequences of drought and the implications for biotic interactions and ecosystem services. Studies spanned all levels of biological organization, from individual responses to population- and community-level impacts and ecosystem-wide effects. We identified several knowledge gaps, including a paucity of trait-based evaluation of drought consequences, limited understanding of thermal and desiccation tolerance at the species level, and the synergistic effects of multiple drought stressors on mussels. Although we found many studies provided suggestions concerning management of populations, habitat conditions, and anthropogenic water use, a systematic approach and testing of recommended mitigation strategies is largely lacking, creating challenges for managers aiming to conserve freshwater mussel communities and populations in light of climate change.</p>","PeriodicalId":133,"journal":{"name":"Biological Reviews","volume":"100 1","pages":"275-307"},"PeriodicalIF":11.0,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/brv.13142","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142193137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-verbal effecting – animal research sheds light on human emotion communication","authors":"Annett Schirmer,&nbsp;Ilona Croy,&nbsp;Katja Liebal,&nbsp;Stefan R. Schweinberger","doi":"10.1111/brv.13140","DOIUrl":"10.1111/brv.13140","url":null,"abstract":"<p>Cracking the non-verbal “code” of human emotions has been a chief interest of generations of scientists. Yet, despite much effort, a dictionary that clearly maps non-verbal behaviours onto <i>meaning</i> remains elusive. We suggest this is due to an over-reliance on language-related concepts and an under-appreciation of the evolutionary context in which a given non-verbal behaviour emerged. Indeed, work in other species emphasizes non-verbal <i>effects</i> (e.g. affiliation) rather than meaning (e.g. happiness) and differentiates between signals, for which communication benefits both sender and receiver, and cues, for which communication does not benefit senders. Against this backdrop, we develop a “non-verbal effecting” perspective for human research. This perspective extends the typical focus on facial expressions to a broadcasting of multisensory signals and cues that emerge from both social and non-social emotions. Moreover, it emphasizes the consequences or effects that signals and cues have for individuals and their social interactions. We believe that re-directing our attention from verbal emotion labels to non-verbal effects is a necessary step to comprehend scientifically how humans share what they feel.</p>","PeriodicalId":133,"journal":{"name":"Biological Reviews","volume":"100 1","pages":"245-257"},"PeriodicalIF":11.0,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/brv.13140","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142193096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}