IET nanobiotechnology最新文献_第7页

Human embryonic stem cells cultured on hydrogels grafted with extracellular matrix protein-derived peptides with polyethylene glycol joint nanosegments 人胚胎干细胞的水凝胶培养与细胞外基质蛋白衍生肽与聚乙二醇联合纳米段

IF 2.3 4区工程技术

IET nanobiotechnology Pub Date : 2022-10-06 DOI: 10.1049/nbt2.12091

Abdullah A. Alarfaj, Abdurahman H. Hirad, Murugan A. Munusamy, S. Suresh Kumar, Akon Higuchi

{"title":"Human embryonic stem cells cultured on hydrogels grafted with extracellular matrix protein-derived peptides with polyethylene glycol joint nanosegments","authors":"Abdullah A. Alarfaj, Abdurahman H. Hirad, Murugan A. Munusamy, S. Suresh Kumar, Akon Higuchi","doi":"10.1049/nbt2.12091","DOIUrl":"10.1049/nbt2.12091","url":null,"abstract":"Human pluripotent stem cells (hPSCs) can be proliferated on completely synthetic materials under xeno-free cultivation conditions using biomaterials grafted with extracellular matrix protein (ECM)-derived peptides. However, cell culture biomaterials grafted with ECM-derived peptides must be prepared using a high concentration of peptide reaction solution (e.g. 1000 μg/ml), whereas the ECM concentration of the ECM-coated surface for hPSC culture is typically 5 μg/ml. We designed a polyethylene glycol (PEG) joint nanosegment (linker) to be used between base cell culture biomaterials and bioactive ECM-derived peptides to enhance the probability of contact between ECM-derived peptides and cell binding receptors of hPSCs. Vitronectin-derived peptides with glycine joint nanosegments (GCGG) were conjugated onto poly (vinyl alcohol-co-itaconic acid) hydrogels via PEG joint nanosegments, and human embryonic stem cells (hESCs) were cultivated on these hydrogels. hESCs could successfully be cultivated on hydrogels while maintaining their pluripotency and differentiation potential to differentiate into cells that are induced from three germ layers in vitro and in vivo, where only a 50 μg/ml ECM-derived peptide concentration was used when the PEG joint nanosegments were introduced into peptides that were grafted onto hydrogel surfaces. The joint nanosegments between bioactive peptides and base cell culture biomaterials were found to contribute to efficient hESC attachment and proliferation.","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2022-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9667744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33491318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of Klotho protein complexed with nanomaterials on bone mesenchymal stem cell performance in the treatment of diabetic ischaemic ulcer Klotho蛋白复合纳米材料对骨间充质干细胞在糖尿病缺血性溃疡治疗中的作用

IF 2.3 4区工程技术

IET nanobiotechnology Pub Date : 2022-09-26 DOI: 10.1049/nbt2.12099

Rui Tang, Gang Zhao, Yuqiao Wang, Ruixue Zhang

{"title":"The effect of Klotho protein complexed with nanomaterials on bone mesenchymal stem cell performance in the treatment of diabetic ischaemic ulcer","authors":"Rui Tang, Gang Zhao, Yuqiao Wang, Ruixue Zhang","doi":"10.1049/nbt2.12099","DOIUrl":"10.1049/nbt2.12099","url":null,"abstract":"A lack of angiogenesis is the key problem in the healing of diabetic foot ulcers. Stem cells have already been proven to have a high potential for angiogenesis. The most important aspects of stem cell therapy are improving the microenvironment, cell homing and continuous factor stimulation. We investigated the effect of Klotho protein to heal wounds by promoting the proliferation and migration of bone mesenchymal stem cells and endothelial cells in vitro. Based on the above study, we produced a compound material by using poly(lactic-co-glycolic acid) (PLGA), chitosan microspheres and gelatin through electro spining technology. The structure of the compound material, just like a sandwich, is that two pieces of PLGA nanofiber films clamped gelatin film which contained chitosan microspheres. In the in vitro release experiment, we could detect the release of Klotho after seven days in the compound material, but the release time was approximately 40 hours for the chitosan microspheres. After seeded bone mesenchymal stem cells (BMSCs) on the surface of the compound material, we observed morphologies of the chitosan microsphere, the PLGA nanofiber and BMSCs by scanning electron microscopy. The nanofiber mesh biological tissue materials could supply an appropriate microenvironment and cell factors for the survival of BMSCs. Compared with the control group, the biological tissue material seeded with BMSCs significantly promoted angiogenesis in the lower limb of diabetic C57BL/6J mice and accelerated diabetic foot wound healing. The compound biomaterial which could continuously stimulate BMSCs through releasing Klotho protein could accelerate wound healing in the diabetic foot and other ischemic ulcers.","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2022-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/73/b4/NBT2-16-316.PMC9667746.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33486087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Biosynthesis of silver nanoparticles using Lawsonia inermis and their biomedical application 银纳米粒子的生物合成及其生物医学应用

IF 2.3 4区工程技术

IET nanobiotechnology Pub Date : 2022-08-30 DOI: 10.1049/nbt2.12096

Eman Alhomaidi, Saade Abdalkareem Jasim, Hawraz Ibrahim M. Amin, Marcos Augusto Lima Nobre, Mehrdad Khatami, Abduladheem Turki Jalil, Saja Hussain Dilfy

{"title":"Biosynthesis of silver nanoparticles using Lawsonia inermis and their biomedical application","authors":"Eman Alhomaidi, Saade Abdalkareem Jasim, Hawraz Ibrahim M. Amin, Marcos Augusto Lima Nobre, Mehrdad Khatami, Abduladheem Turki Jalil, Saja Hussain Dilfy","doi":"10.1049/nbt2.12096","DOIUrl":"10.1049/nbt2.12096","url":null,"abstract":"Developing biosynthesis of silver nanoparticles (Ag-NPs) using plant extract is an environmentally friendly method to reduce the use of harmful chemical substances. The green synthesis of Ag-NPs by Lawsonia inermis extract and its cellular toxicity and the antimicrobial effect was studied. The physical and chemical properties of synthesised Ag-NPs were investigated using UV-visible spectroscopy, infrared spectroscopy, X-ray diffraction (XRD), scanning, and transmission electron microscopy. The average size of Ag-NPs was 40 nm. The XRD result shows peaks at 2θ = 38.07°, 44.26°, 64.43°, and 77.35° are related to the FCC structure of Ag-NPs. Cytotoxicity of synthesised nanoparticles was evaluated by MTT toxicity test on breast cancer MCF7 cell line. Observations showed that the effect of cytotoxicity of nanoparticles on the studied cell line depended on concentration and time. The obtained IC50 was considered for cells at a dose of 250 μg/ml. Growth and survival rates decreased exponentially with the dose. Antimicrobial properties of Ag-NPs synthesised with extract were investigated against Escherichia coli, Salmonella typhimurium, Bacillus cereus, and Staphylococcus aureus to calculate the minimum inhibitory concentration and the minimum bactericidal concentration of (MBC). The results showed that the synthesised Ag-NPs and the plant extract have antimicrobial properties. The lowest concentration of Ag-NPs that can inhibit the growth of bacterial strains was 25 μg/ml.","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2022-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/88/c6/NBT2-16-284.PMC9469786.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33446749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Lipid-coated bismuth nanoflower as the thermos-radio sensiti for therapy of lung metastatic breast cancer: Preparation, optimisation, and characterisation 脂质包被铋纳米花作为热放射敏感性治疗肺转移性乳腺癌:制备，优化和表征

IF 2.3 4区工程技术

IET nanobiotechnology Pub Date : 2022-08-29 DOI: 10.1049/nbt2.12097

Shushu Xue, Junrong Jiao, Si Miao, Lijun Wang, Yang Liu, Qingjie Zhang, Qiyue Wang, Yu Xi, Yuanyuan Zhang

{"title":"Lipid-coated bismuth nanoflower as the thermos-radio sensiti for therapy of lung metastatic breast cancer: Preparation, optimisation, and characterisation","authors":"Shushu Xue, Junrong Jiao, Si Miao, Lijun Wang, Yang Liu, Qingjie Zhang, Qiyue Wang, Yu Xi, Yuanyuan Zhang","doi":"10.1049/nbt2.12097","DOIUrl":"10.1049/nbt2.12097","url":null,"abstract":"Lung metastatic breast cancer (LMBC) leads to a large number of deaths in women with breast cancer, and radiotherapy has been considered the common assay for tumour therapy except for surgery. However, radiotherapy still faces problems of low efficiency due to resistance and easily induced side effects. Here, the authors designed lipid-decorated bismuth-based nanoflowers (DP-BNFs) as both a radiosensitiser and a photothermal therapy agent for LMBC treatment. The BNFs were prepared by oxidation of bismuth nitrate and subsequent reduction using sodium borohydride. The preparation parameters and formulation of DP-BNFs were optimised via a single-factor experiment, with the factors including reaction temperature, a molar ratio of reducing agents, and the types and amount of decorated lipid materials. The result indicated that the BNFs prepared at 170°C with the Bi/NaBH4 ratio of 1:0.7 exhibited the best yield and particle size around 160 nm. After being spray dried with lactose to prepare dry powder inhalation (DP-BNF@Lat-MPs), their effects on improving therapeutic efficiency of the radiotherapy and photothermal therapy combination were measured using the western blot assay to determine the tumour apoptosis. In a word, DP-BNF@Lat-MPs could be a novel inhalable integrated microsphere that provides a new possibility for thermoradiotherapy of LMBC.","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2022-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9667745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33445888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of size in PEGylated liposomal doxorubicin biodistribution and anti-tumour activity 大小在聚乙二醇化脂质体阿霉素生物分布和抗肿瘤活性中的作用。

IF 2.3 4区工程技术

IET nanobiotechnology Pub Date : 2022-08-18 DOI: 10.1049/nbt2.12094

Saba Dadpour, Amin Mehrabian, Mahdieh Arabsalmani, Elaheh Mirhadi, Anis Askarizadeh, Mohammad Mashreghi, Mahmoud Reza Jaafari

{"title":"The role of size in PEGylated liposomal doxorubicin biodistribution and anti-tumour activity","authors":"Saba Dadpour, Amin Mehrabian, Mahdieh Arabsalmani, Elaheh Mirhadi, Anis Askarizadeh, Mohammad Mashreghi, Mahmoud Reza Jaafari","doi":"10.1049/nbt2.12094","DOIUrl":"10.1049/nbt2.12094","url":null,"abstract":"The size of nanoliposome-encapsulated drugs significantly affects their therapeutic efficacy, biodistribution, targeting ability, and toxicity profile for the cancer treatment. In the present study, the biodistribution and anti-tumoral activity of PEGylated liposomal Doxorubicin (PLD) formulations with different sizes were investigated. First, 100, 200, and 400 nm PLDs were prepared by remote loading procedure and characterised for their size, zeta potential, encapsulation efficacy, and release properties. Then, in vitro cellular uptake and cytotoxicity were studied by flow cytometry and MTT assay, and compared with commercially available PLD Caelyx®. In vivo studies were applied on BALB/c mice bearing C26 colon carcinoma. The cytotoxicity and cellular uptake tests did not demonstrate any statistically significant differences between PLDs. The biodistribution results showed that Caelyx® and 100 nm liposomal formulations had the most doxorubicin (Dox) accumulation in the tumour tissue and, as a result, considerably suppressed tumour growth compared with 200 and 400 nm PLDs. In contrast, larger nanoparticles (200 and 400 nm formulations) had more accumulation in the liver and spleen. This study revealed that 90 nm Caelyx® biodistribution profile led to the stronger anti-tumour activity of the drug and hence significant survival extension, and showed the importance of vesicle size in the targeting of nanoparticles to the tumour microenvironment for the treatment of cancer.","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2022-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b2/43/NBT2-16-259.PMC9469787.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40708168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Functional characteristics of the rigid elytra in a bamboo weevil beetle Cyrtotrachelus buqueti 竹象鼻虫硬翅的功能特征

IF 2.3 4区工程技术

IET nanobiotechnology Pub Date : 2022-08-12 DOI: 10.1049/nbt2.12095

Xin Li, Yu Zheng

{"title":"Functional characteristics of the rigid elytra in a bamboo weevil beetle Cyrtotrachelus buqueti","authors":"Xin Li, Yu Zheng","doi":"10.1049/nbt2.12095","DOIUrl":"10.1049/nbt2.12095","url":null,"abstract":"The bamboo weevil beetle, Cyrtotrachelus buqueti, has evolved a particular flight pattern. When crawling, the beetle folds the flexible hind wings and stuffs under the rigid elytra. During flight, the hind wings are deployed through a series of deployment joints that are passively driven by flapping forces. When the hind wings are fully expanded, the unfolding joint realises self-locking. At this time, the hind wings act as a folded wing membrane and flap simultaneously with the elytra to generate aerodynamics. The functional characteristics of the elytra of the bamboo weevil beetle were investigated, including microscopic morphology, kinematic properties and aerodynamic forces of the elytra. In particular, the flapping kinematics of the elytra were measured using high-speed cameras and reconstructed using a modified direct linear transformation algorithm. Although the elytra are passively flapped by the flapping of the hind wings, the analysis shows that its flapping wing trajectory is a double figure-eight pattern with flapping amplitude and angle of attack. The results show that the passive flapping of elytra produces aerodynamic forces that cannot be ignored. The kinematics of the elytra suggest that this beetle may use well-known flapping mechanisms such as a delayed stall and clap and fling.","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2022-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3e/75/NBT2-16-273.PMC9469788.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40610177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Enhancement of antibacterial activity through phyto-fabrication of silver nanoparticles with Ficus thonningii aqueous extracts 无花果水提物制备纳米银增强抗菌活性的研究

IF 2.3 4区工程技术

IET nanobiotechnology Pub Date : 2022-08-09 DOI: 10.1049/nbt2.12093

Dickens A. Ondigo, Were L. L. Munyendo, Dickson Andala, Apollo O. Maima, Josephat M. Mosweta, Kevin W. Odhiambo

{"title":"Enhancement of antibacterial activity through phyto-fabrication of silver nanoparticles with Ficus thonningii aqueous extracts","authors":"Dickens A. Ondigo, Were L. L. Munyendo, Dickson Andala, Apollo O. Maima, Josephat M. Mosweta, Kevin W. Odhiambo","doi":"10.1049/nbt2.12093","DOIUrl":"10.1049/nbt2.12093","url":null,"abstract":"The World Health Organisation reports higher levels of bacterial resistance to cephalosporins and carbapenems of above 54%. The sufficient redox capabilities of Ficus thonningii phytochemicals for Ag+ reduction to Ag0 and ultimately aggregation to nucleation are exploited for the first time in attempting to enhance the antibacterial activity. Solution colour change to brown due to surface plasmon resonance phenomenon confirmed nanoparticle fabrication with a UV/Vis absorption peak at 426 nm. Fourier Transform Infrared spectra revealed functional groups (C=C at 1620–1680 cm−1; C=H at 1400–1600 cm−1 aromatics) for encapsulation, stabilisation, and reduction of the silver ion. The Dynamic Light Scattering technique verified F. thonningii encapsulated silver nanoparticles particle size of 57.84 nm with a negative zeta potential (−19.8 mV) as proof of stability. The surface, shape and topographical features were shown by Scanning Electron Microscopy as spherical orientations. An enhanced antimicrobial efficacy was displayed by the nanoparticles (inhibition zones of 26.1, 24.1 and 15.2 mm from 11.5, 10.6 and 6.5 mm) for Staphylococcus aureus, Streptococcus pyrogenes and Escherichia coli, respectively, compared to Flucloxacillin standard that was in the ranges of 21.5, 23.5 and 25.7 mm. The enhanced potency provides a basis for diversified approaches of generating novel drugs for treating bacterial infections.","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2022-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4b/b7/NBT2-16-250.PMC9469791.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40681654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Preparation and characterisation of polycaprolactone–fibroin nanofibrous scaffolds containing allicin 蒜素聚己内酯-丝素纳米纤维支架的制备与表征

IF 2.3 4区工程技术

IET nanobiotechnology Pub Date : 2022-08-05 DOI: 10.1049/nbt2.12092

Bita Mollaghadimi

{"title":"Preparation and characterisation of polycaprolactone–fibroin nanofibrous scaffolds containing allicin","authors":"Bita Mollaghadimi","doi":"10.1049/nbt2.12092","DOIUrl":"10.1049/nbt2.12092","url":null,"abstract":"Polycaprolactone (PCL) and silk fibroin are used to make nanofiber wound dressings, and then allicin is added to PCL and silk fibroin to expand antibacterial properties. The polymer solutions are subjected to various electrospinning parameters, and allicin-containing and non-allicin fibres are prepared. Fibres are examined by scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), contact angle analysis, mechanical testing, bacterial culture, and 3-(4 5-dimethylthiazol-2-yl)-2 5-diphenyltetrazolium bromide (MTT). The SEM results show that the addition of fibroin and allicin at a constant voltage provides a direct relationship between the distance and the diameter of the fibres. Also, the total variation algorithm is used for denoising the signal of FTIR that the results confirm the functional groups present in the fibres. Furthermore, the contact angle test for allicin-free fibres shows that the contact angle of these fibres is 133.3° that decreases to 85.5° by adding allicin to the structure. Moreover, the tensile test of allicin-free fibres shows that Young's modulus of these fibres is 2.06 MPa, while the value increases to 5.12 MPa with the addition of allicin to the structure and at the end of the bacterial culture test, a growth inhibition zone is seen after 17 and 24 h. According to the obtained results, these fibres have the potential to be used in burn applications.","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2022-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/21/5f/NBT2-16-239.PMC9469789.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40683326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Green biosynthesis of magnetic iron oxide nanoparticles using Mentha longifolia for imatinib mesylate delivery 绿色生物合成磁性氧化铁纳米颗粒的薄荷甲磺酸伊马替尼递送

IF 2.3 4区工程技术

IET nanobiotechnology Pub Date : 2022-06-30 DOI: 10.1049/nbt2.12090

Bahareh Naeimipour, Elham Moniri, Ali Vaziri Yazdi, Raheleh Safaeijavan, Hossein Faraji

{"title":"Green biosynthesis of magnetic iron oxide nanoparticles using Mentha longifolia for imatinib mesylate delivery","authors":"Bahareh Naeimipour, Elham Moniri, Ali Vaziri Yazdi, Raheleh Safaeijavan, Hossein Faraji","doi":"10.1049/nbt2.12090","DOIUrl":"10.1049/nbt2.12090","url":null,"abstract":"In this work, the rapid, facile, and eco-friendly green process was introduced in the preparation of β-cyclodextrin/magnetic iron oxide nanoparticles by using the aqueous Mentha longifolia extracts of Mentha longifolia. The obtained nanoparticles were characterised by Fourier transform infrared spectroscopy, x-ray powder diffraction, field emission scanning electron microscope, and thermogravimetric analysis. Also, effective factors on the synthesis of magnetic nanocomposites including temperature, concentration of the Mentha longifolia extract, and concentration of FeSO4 solution were optimised by Taguchi design. Moreover, important effective parameters on the adsorption efficiency; such as adsorbent dosage, pH, contact time, and temperature were investigated. The prepared magnetic nanocomposite was applied as a nanocarrier for imatinib mesylate delivery. In vitro studies confirmed imatinib mesylate release over 6 h. The nanocarrier showed pH-dependent imatinib mesylate release with higher drug release at simulated cancer fluid (pH = 5.6) compared to neural fluid (pH = 7.4). Moreover, the sorption isotherms and kinetics for the magnetic nanocomposite were fitted into Langmuir and pseudo-second order models, respectively. Based on the thermodynamic results, the adsorption of imatinib mesylate onto the nanoadsorbent was found to be spontaneous and exothermic.","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9353862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40411319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Toxicity of Ulva lactuca and green fabricated silver nanoparticles against mosquito vectors and their impact on the genomic DNA of the dengue vector Aedes aegypti. 紫叶树和绿色纳米银对登革热媒介蚊子的毒性及其对埃及伊蚊基因组DNA的影响。

IF 2.3 4区工程技术

IET nanobiotechnology Pub Date : 2022-06-01 DOI: 10.1049/nbt2.12082

Al Thabiani Aziz

{"title":"Toxicity of Ulva lactuca and green fabricated silver nanoparticles against mosquito vectors and their impact on the genomic DNA of the dengue vector Aedes aegypti.","authors":"Al Thabiani Aziz","doi":"10.1049/nbt2.12082","DOIUrl":"https://doi.org/10.1049/nbt2.12082","url":null,"abstract":"Marine seaweeds are known to have a potential role against microbial and pesticidal activities. Ulva lactuca, a green macroalgae extract analysed through gas chromatography mass spectrometry reveals 31 compounds. Resistance of mosquito vectors to synthetic insecticides remains a major problem. Discovering and applying natural agents to act against disease vectors is challenging. The activities of the extract and nano-fabricated green synthesised silver nanoparticles were checked for use against Aedes aegypti and Culex pipiens. The crude extract and synthesised silver nanoparticles exhibited a notable larvicidal effect, and very effective inhibition of pupal and adult emergence. Inhibition of adult emergence of Ae.aegypti was 97.7% and in Cu.pipiens, it was 93.3%. Our genotypic study of Deoxyribonucleic acid from treated larvae utilising random primers MA-09, MA-12 and MA-26 revealed damaged nucleotide sequences when compared with the controls. The antimicrobial activity of both the extract and green synthesised nanomaterials showed prominent activity against pathogenic drug resistant bacteria. Our results contribute to further development of eco-friendly insecticides with lower cost of preparation. This could further contribute to further research helping future generations to be free from these deadly disease-causing vectors and pathogenic microbes.","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9114447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10249556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4