IET nanobiotechnology最新文献_第8页

Characterization of folic acid-functionalized PLA-PEG nanomicelle to deliver Letrozole: A nanoinformatics study. 叶酸功能化聚乳酸-聚乙二醇（PLA-PEG）纳米胶束递送来曲唑的特性：纳米信息学研究。

IF 3.8 4区工程技术

IET nanobiotechnology Pub Date : 2022-06-01 Epub Date: 2021-11-23 DOI: 10.1049/nbt2.12073

Neda Rostami, Reza Davarnejad

{"title":"Characterization of folic acid-functionalized PLA-PEG nanomicelle to deliver Letrozole: A nanoinformatics study.","authors":"Neda Rostami, Reza Davarnejad","doi":"10.1049/nbt2.12073","DOIUrl":"10.1049/nbt2.12073","url":null,"abstract":"Effective cancer treatment is currently the number one challenge to human health. To date, several treatment methods have been introduced for cancer cell targeting. Among the proposed new methods for attacking cancer cells, nanotechnology has attracted much attention. Hence, various nanocarriers have been developed for targeted delivery of available drugs and improve their effectiveness against malignant cells. The PLA-PEG functionalised with folic acid (PLA-PEG-FA) is one of the nanocarriers with a limited range of applications for targeting cancer cells. In this investigation, different types of in-silico methods such as molecular docking approach, molecular dynamics simulation and free energy calculations are employed to characterise the carriers studied. The effectiveness of PLA-PEG-FA and PLA-PEG in delivering Letrozole as an aromatase inhibitor in cancer cells is examined. It is found that in the presence of folic acid, the stability and cell membrane permeability of nanomicelle are increased. Therefore, PLA-PEG-FA can be considered as a versatile carrier that can increase the effectiveness of aromatase inhibitors (such as Letrozole) and reduce their side effects.","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9114444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39650565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mathematical model and nanoindentation properties of the claws of Cyrtotrachelus buqueti Guer (Coleoptera: Curculionidae) 小圆蝽爪爪的数学模型及纳米压痕特性(鞘翅目:圆蝽科)

IF 2.3 4区工程技术

IET nanobiotechnology Pub Date : 2022-05-26 DOI: 10.1049/nbt2.12089

Longhai Li, Wei Sun, Ce Guo, Huafeng Guo, Liu Lili, Ping Yu

{"title":"Mathematical model and nanoindentation properties of the claws of Cyrtotrachelus buqueti Guer (Coleoptera: Curculionidae)","authors":"Longhai Li, Wei Sun, Ce Guo, Huafeng Guo, Liu Lili, Ping Yu","doi":"10.1049/nbt2.12089","DOIUrl":"10.1049/nbt2.12089","url":null,"abstract":"Scanning electron microscopy (SEM) was used to observe the macroscopic, microscopic, and cross-sectional structures of the claws of Cyrtotrachelus buqueti Guer (Coleoptera: Curculionidae), and a mathematical model of a claw was used to investigate the structure–function relationships. To improve the quality of the SEM images, a non-local means (NLM) algorithm and an improved NLM algorithm were applied. After comparison and analysis of five classical edge-detection algorithms, the boundaries of the structural features of the claw were extracted based on a B-spline wavelet algorithm, and the results showed that the variable curvature of the beetle claw enhances its adhesion force and improves its strength. Adhesion models of the claw were established, and the mechanical properties of its biomaterials were measured using nanoindentation. Considering that the presence of water can affect the hardness and Young's modulus, both ‘dry’ and ‘wet’ samples were examined. For the dry samples, the hardness and Young's modulus were 0.197 ± 0.074 GPa and 1.105 ± 0.197 GPa, respectively, whereas the respective values for the wet samples were both lower at 0.071 ± 0.030 GPa and 0.693 ± 0.163 GPa. This study provides data that can inform the design of climbing robots.","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2022-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ietresearch.onlinelibrary.wiley.com/doi/epdf/10.1049/nbt2.12089","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44958724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Investigating preparation and characterisation of diphtheria toxoid-loaded on sodium alginate nanoparticles 藻酸钠纳米粒子负载白喉类毒素的制备及性质研究

IF 2.3 4区工程技术

IET nanobiotechnology Pub Date : 2022-05-24 DOI: 10.1049/nbt2.12088

Samira Aghamiri, Mojtaba Noofeli, Parvaneh Saffarian, Zahra Salehi Najafabadi, Hamid Reza Goudarzi

{"title":"Investigating preparation and characterisation of diphtheria toxoid-loaded on sodium alginate nanoparticles","authors":"Samira Aghamiri, Mojtaba Noofeli, Parvaneh Saffarian, Zahra Salehi Najafabadi, Hamid Reza Goudarzi","doi":"10.1049/nbt2.12088","DOIUrl":"10.1049/nbt2.12088","url":null,"abstract":"This paper aims to investigate the preparation and characterisation of the alginate nanoparticles (NPs) as antigen delivery system loaded by diphtheria toxoid (DT). For this purpose, both the loading capacity (LC) and Loading efficiency (LE) of the alginate NPs burdened by DT are evaluated. Moreover, the effects of different concentrations of sodium alginate and calcium chloride on the NPs physicochemical characteristics are surveyed in addition to other physical conditions such as homogenization time and rate. To do so, the NPs are characterised using particle size and distribution, zeta potential, scanning electron microscopy, encapsulation efficiency, in vitro release study and FT-IR spectroscopy. Subsequently, the effects of homogenization time and rate on the NPs are assessed. At the meantime, the NPs LC and efficiency in several DT concentrations are estimated. The average size of the NPs was 400.7 and 276.6 nm for unloaded and DT loaded, respectively. According to the obtained results, the zeta potential of the blank and DT loaded NPs are estimated as −23.7 mV and −21.2 mV, respectively. Whereas, the LC and LE were >80% and >90%, in that order. Furthermore, 95% of the releasing DT loaded NPs occurs at 140 h in the sustained mode without any bursting release. It can be concluded that the features of NPs such as morphology and particle size are strongly depended on the calcium chloride, sodium alginate concentrations and physicochemical conditions in the NPs formation process. In addition, appropriate concentrations of the sodium alginate and calcium ions would lead to obtaining the desirable NPs formation associated with the advantageous LE, LC (over 80%) and sustained in vitro release profile. Ultimately, the proposed NPs can be employed in vaccine formulation for the targeted delivery, controlled and slow antigen release associated with the improved antigen stability.","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2022-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ietresearch.onlinelibrary.wiley.com/doi/epdf/10.1049/nbt2.12088","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47319247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Retraction 收缩

IF 2.3 4区工程技术

IET nanobiotechnology Pub Date : 2022-05-08 DOI: 10.1049/nbt2.12087

引用次数: 0

Nanocomposite of electrochemically reduced graphene oxide and gold nanourchins for electrochemical DNA detection 电化学还原氧化石墨烯和金纳米海胆的纳米复合物用于电化学DNA检测

IF 2.3 4区工程技术

IET nanobiotechnology Pub Date : 2022-04-20 DOI: 10.1049/nbt2.12086

Mostafa Azimzadeh, Zahra Aghili, Behrooz Jannat, Saeid Jafari, Saeed Rafizadeh Tafti, Navid Nasirizadeh

引用次数: 2

Medicinal plants mediated the green synthesis of silver nanoparticles and their biomedical applications 药用植物介导的纳米银绿色合成及其生物医学应用

IF 2.3 4区工程技术

IET nanobiotechnology Pub Date : 2022-04-15 DOI: 10.1049/nbt2.12078

Haajira Beevi Habeeb Rahuman, Ranjithkumar Dhandapani, Santhoshini Narayanan, Velmurugan Palanivel, R. Paramasivam, Ramalakshmi Subbarayalu, Sathiamoorthi Thangavelu, S. Muthupandian

{"title":"Medicinal plants mediated the green synthesis of silver nanoparticles and their biomedical applications","authors":"Haajira Beevi Habeeb Rahuman, Ranjithkumar Dhandapani, Santhoshini Narayanan, Velmurugan Palanivel, R. Paramasivam, Ramalakshmi Subbarayalu, Sathiamoorthi Thangavelu, S. Muthupandian","doi":"10.1049/nbt2.12078","DOIUrl":"https://doi.org/10.1049/nbt2.12078","url":null,"abstract":"Abstract The alarming effect of antibiotic resistance prompted the search for alternative medicine to resolve the microbial resistance conflict. Over the last two decades, scientists have become increasingly interested in metallic nanoparticles to discover their new dimensions. Green nano synthesis is a rapidly expanding field of interest in nanotechnology due to its feasibility, low toxicity, eco‐friendly nature, and long‐term viability. Some plants have long been used in medicine because they contain a variety of bioactive compounds. Silver has long been known for its antibacterial properties. Silver nanoparticles have taken a special place among other metal nanoparticles. Silver nanotechnology has a big impact on medical applications like bio‐coating, novel antimicrobial agents, and drug delivery systems. This review aims to provide a comprehensive understanding of the pharmaceutical qualities of medicinal plants, as well as a convenient guideline for plant‐based silver nanoparticles and their antimicrobial activity.","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48770701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 63

Diverse biotechnological applications of multifunctional titanium dioxide nanoparticles: An up-to-date review 多功能二氧化钛纳米颗粒的多种生物技术应用:最新综述

IF 2.3 4区工程技术

IET nanobiotechnology Pub Date : 2022-04-12 DOI: 10.1049/nbt2.12085

Rabia Javed, Noor ul Ain, Ayesha Gul, Muhammad Arslan Ahmad, Weihong Guo, Qiang Ao, Shen Tian

{"title":"Diverse biotechnological applications of multifunctional titanium dioxide nanoparticles: An up-to-date review","authors":"Rabia Javed, Noor ul Ain, Ayesha Gul, Muhammad Arslan Ahmad, Weihong Guo, Qiang Ao, Shen Tian","doi":"10.1049/nbt2.12085","DOIUrl":"10.1049/nbt2.12085","url":null,"abstract":"Titanium dioxide (TiO2) nanoparticles (NPs) are one of the topmost widely used metallic oxide nanoparticles. Whether present in naked form or doped with metals or polymers, TiO2 NPs perform immensely important functions. However, the alteration in size and shape by doping results in improving the physical, chemical, and biological behaviour of TiO2 NPs. Hence, the differential effects of various TiO2 nanostructures including nanoflakes, nanoflowers, and nanotubes in various domains of biotechnology have been elucidated by researchers. Recently, the exponential growth of research activities regarding TiO2 NPs has been observed owing to their chemical stability, low toxicity, and multifaceted properties. Because of their enormous abundance, plants, humans, and environment are inevitably exposed to TiO2 NPs. These NPs play a significant role in improving agricultural attributes, removing environmental pollution, and upgrading the domain of nanomedicine. Therefore, the currently ongoing studies about the employment of TiO2 NPs in enhancement of different aspects of agriculture, environment, and medicine have been extensively discussed in this review.","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2022-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ietresearch.onlinelibrary.wiley.com/doi/epdf/10.1049/nbt2.12085","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45130538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Rheological properties of wood/bacterial cellulose and chitin nano‐hydrogels as a function of concentration and their nano‐films properties 木材/细菌纤维素和几丁质纳米水凝胶的流变性能随浓度的变化及其纳米膜特性

IF 2.3 4区工程技术

IET nanobiotechnology Pub Date : 2022-04-04 DOI: 10.1049/nbt2.12083

Hesamoddin Jannatamani, A. Motamedzadegan, M. Farsi, H. Yousefi

{"title":"Rheological properties of wood/bacterial cellulose and chitin nano‐hydrogels as a function of concentration and their nano‐films properties","authors":"Hesamoddin Jannatamani, A. Motamedzadegan, M. Farsi, H. Yousefi","doi":"10.1049/nbt2.12083","DOIUrl":"https://doi.org/10.1049/nbt2.12083","url":null,"abstract":"Abstract In this study, rheological properties of the Wood Cellulose NanoFibers (WCNF), Bacterial Cellulose NanoFibers (BCNF), and Chitin NanoFibers (ChNF) as well as physical properties of films prepared from each nano‐hydrogel were investigated. Each nano‐hydrogel was prepared in 2 concentrations of 0.5 and 1 wt% for rheological study. Rheological properties were measured using a rotational rheometer. The flow behaviour data were fitted with rheological models. Apparent viscosity was higher in higher concentrations of nano‐hydrogels. Herschel‐Bulkley model was the best model for flow behaviour data fitting. BCNF nano‐hydrogels had the highest hysteresis loop while WCNF nano‐hydrogels had the best structure recovery and lowest hysteresis loop. At LVE (Linear Viscoelastic Region), G′ (storage modulus) and G″ (loss modulus) had a constant value, but as strain increased their values decreased. Storage modulus was found to be greater than loss modulus in all samples during frequency sweep test. BCNF nano‐hydrogel showed the lowest frequency dependency. Chitin nanofilms had the highest elongation and stress value.","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2022-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49143140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Measurement of polystyrene photodegradation rate using a quartz crystal microbalance. 用石英晶体微天平测量聚苯乙烯光降解率。

IF 2.3 4区工程技术

IET nanobiotechnology Pub Date : 2022-04-01 Epub Date: 2022-01-08 DOI: 10.1049/nbt2.12076

Abdullah N Alodhayb

引用次数: 1

Hypnea musciformis-mediated Ag/AgCl-NPs inhibit pathogenic bacteria, HCT-116 and MCF-7 cells' growth in vitro and Ehrlich ascites carcinoma cells in vivo in mice. Hypnea musciformis介导的Ag/AgCl-NPs在体外抑制致病性细菌、HCT-116和MCF-7细胞的生长，在体内抑制小鼠埃利希腹水癌细胞的生长。

IF 2.3 4区工程技术

IET nanobiotechnology Pub Date : 2022-04-01 Epub Date: 2022-01-11 DOI: 10.1049/nbt2.12075

Rita Ghose, A K M Asaduzzaman, Imtiaj Hasan, Syed Rashel Kabir

{"title":"Hypnea musciformis-mediated Ag/AgCl-NPs inhibit pathogenic bacteria, HCT-116 and MCF-7 cells' growth in vitro and Ehrlich ascites carcinoma cells in vivo in mice.","authors":"Rita Ghose, A K M Asaduzzaman, Imtiaj Hasan, Syed Rashel Kabir","doi":"10.1049/nbt2.12075","DOIUrl":"https://doi.org/10.1049/nbt2.12075","url":null,"abstract":"In the present study, Ag/AgCl-NPs were biosynthesised using Hypnea musciformis seaweed extract; NPs synthesis was confirmed by a change of colour and observation of a razor-sharp peak at 424 nm by UV-visible spectroscopy. Synthesised nanoparticles were characterised by transmission electron microscopy, energy-dispersive X-ray spectroscopy, X-ray powder diffraction and Fourier transform infrared spectroscopy. Bacterial cell growth inhibition proves that the Ag/AgCl-NPs have strong antibacterial activity and cell morphological alteration was observed in treated bacterial cells using propidium iodide (PI). Ag/AgCl-NPs inhibited Ehrlich ascites carcinoma (EAC) cells, colorectal cancer (HCT-116) and breast cancer (MCF-7) cell line in vitro with the IC50 values of 40.45, 24.08 and 36.95 μg/ml, respectively. Initiation of apoptosis in HCT-116 and MCF-7 cells was confirmed using PI, FITC-annexin V and Hoechst 33342 dye. No reaction oxygen species generation was observed in both treated and untreated cell lines. A significant increase of ATG-5 gene expression indicates the possibility of autophagy cell death besides apoptosis in MCF-7 cells. The initiation of apoptosis in EAC cells was confirmed by observing caspase-3 protein expression. Ag/AgCl-NPs inhibited 22.83% and 51% of the EAC cell growth in vivo in mice when administered 1.5 and 3.0 mg/kg/day (i.p.), respectively, for 5 consequent days.","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e7/30/NBT2-16-49.PMC8918923.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39810527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6