Green biosynthesis of magnetic iron oxide nanoparticles using Mentha longifolia for imatinib mesylate delivery

IF 3.8 4区工程技术 Q1 BIOCHEMICAL RESEARCH METHODS

IET nanobiotechnology Pub Date : 2022-06-30 DOI:10.1049/nbt2.12090

Bahareh Naeimipour, Elham Moniri, Ali Vaziri Yazdi, Raheleh Safaeijavan, Hossein Faraji

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引用次数: 4

Abstract

In this work, the rapid, facile, and eco-friendly green process was introduced in the preparation of β-cyclodextrin/magnetic iron oxide nanoparticles by using the aqueous Mentha longifolia extracts of Mentha longifolia. The obtained nanoparticles were characterised by Fourier transform infrared spectroscopy, x-ray powder diffraction, field emission scanning electron microscope, and thermogravimetric analysis. Also, effective factors on the synthesis of magnetic nanocomposites including temperature, concentration of the Mentha longifolia extract, and concentration of FeSO₄ solution were optimised by Taguchi design. Moreover, important effective parameters on the adsorption efficiency; such as adsorbent dosage, pH, contact time, and temperature were investigated. The prepared magnetic nanocomposite was applied as a nanocarrier for imatinib mesylate delivery. In vitro studies confirmed imatinib mesylate release over 6 h. The nanocarrier showed pH-dependent imatinib mesylate release with higher drug release at simulated cancer fluid (pH = 5.6) compared to neural fluid (pH = 7.4). Moreover, the sorption isotherms and kinetics for the magnetic nanocomposite were fitted into Langmuir and pseudo-second order models, respectively. Based on the thermodynamic results, the adsorption of imatinib mesylate onto the nanoadsorbent was found to be spontaneous and exothermic.

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绿色生物合成磁性氧化铁纳米颗粒的薄荷甲磺酸伊马替尼递送

本文介绍了一种快速、简便、环保的绿色工艺，以长叶薄荷水提液为原料制备β-环糊精/磁性氧化铁纳米颗粒。采用傅里叶变换红外光谱、x射线粉末衍射、场发射扫描电镜和热重分析对纳米颗粒进行了表征。通过田口设计优化了温度、薄荷提取物浓度和FeSO4溶液浓度对磁性纳米复合材料合成的影响。此外，影响吸附效率的重要有效参数;考察了吸附剂用量、pH、接触时间、温度等因素的影响。将制备的磁性纳米复合材料作为甲磺酸伊马替尼的纳米载体。体外研究证实，甲磺酸伊马替尼的释放超过6小时。与神经液(pH = 7.4)相比，纳米载体在模拟癌液(pH = 5.6)中显示出pH依赖性的甲磺酸伊马替尼释放，药物释放量更高。此外，磁性纳米复合材料的吸附等温线和动力学分别拟合为Langmuir和伪二阶模型。热力学结果表明，甲磺酸伊马替尼在纳米吸附剂上的吸附是自发的、放热的。

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来源期刊

IET nanobiotechnology 工程技术-纳米科技

CiteScore

6.20

自引率

4.30%

发文量

审稿时长

1 months

期刊介绍： Electrical and electronic engineers have a long and illustrious history of contributing new theories and technologies to the biomedical sciences. This includes the cable theory for understanding the transmission of electrical signals in nerve axons and muscle fibres; dielectric techniques that advanced the understanding of cell membrane structures and membrane ion channels; electron and atomic force microscopy for investigating cells at the molecular level. Other engineering disciplines, along with contributions from the biological, chemical, materials and physical sciences, continue to provide groundbreaking contributions to this subject at the molecular and submolecular level. Our subject now extends from single molecule measurements using scanning probe techniques, through to interactions between cells and microstructures, micro- and nano-fluidics, and aspects of lab-on-chip technologies. The primary aim of IET Nanobiotechnology is to provide a vital resource for academic and industrial researchers operating in this exciting cross-disciplinary activity. We can only achieve this by publishing cutting edge research papers and expert review articles from the international engineering and scientific community. To attract such contributions we will exercise a commitment to our authors by ensuring that their manuscripts receive rapid constructive peer opinions and feedback across interdisciplinary boundaries. IET Nanobiotechnology covers all aspects of research and emerging technologies including, but not limited to: Fundamental theories and concepts applied to biomedical-related devices and methods at the micro- and nano-scale (including methods that employ electrokinetic, electrohydrodynamic, and optical trapping techniques) Micromachining and microfabrication tools and techniques applied to the top-down approach to nanobiotechnology Nanomachining and nanofabrication tools and techniques directed towards biomedical and biotechnological applications (e.g. applications of atomic force microscopy, scanning probe microscopy and related tools) Colloid chemistry applied to nanobiotechnology (e.g. cosmetics, suntan lotions, bio-active nanoparticles) Biosynthesis (also known as green synthesis) of nanoparticles; to be considered for publication, research papers in this area must be directed principally towards biomedical research and especially if they encompass in vivo models or proofs of concept. We welcome papers that are application-orientated or offer new concepts of substantial biomedical importance Techniques for probing cell physiology, cell adhesion sites and cell-cell communication Molecular self-assembly, including concepts of supramolecular chemistry, molecular recognition, and DNA nanotechnology Societal issues such as health and the environment Special issues. Call for papers: Smart Nanobiosensors for Next-generation Biomedical Applications - https://digital-library.theiet.org/files/IET_NBT_CFP_SNNBA.pdf Selected extended papers from the International conference of the 19th Asian BioCeramic Symposium - https://digital-library.theiet.org/files/IET_NBT_CFP_ABS.pdf