IET nanobiotechnology最新文献

{"title":"A review of bismuth-based nanoparticles and their applications in radiosensitising and dose enhancement for cancer radiation therapy","authors":"Daryoush Shahbazi-Gahrouei,&nbsp;Yazdan Choghazardi,&nbsp;Arezoo Kazemzadeh,&nbsp;Paria Naseri,&nbsp;Saghar Shahbazi-Gahrouei","doi":"10.1049/nbt2.12134","DOIUrl":"10.1049/nbt2.12134","url":null,"abstract":"<p>About 50% of cancer patients receive radiation therapy. Despite the therapeutic benefits of this method, the toxicity of radiation in the normal tissues is unavoidable To improve the quality of radiation therapy, in addition to other methods such as IMRT, IGRT, and high radiation dose, nanoparticles have shown excellent potential when ionising radiation is applied to the target volume. Recently, bismuth-based nanoparticles (BiNPs) have become particularly popular in radiation therapy due to their high atomic numbers (Z), high X-ray attenuation coefficient, low toxicity, and low cost. Moreover, it is easy to synthesise in a variety of sizes and shapes. This study aimed to review the effects of the bismuth-based NP and its combination with other compounds, and their potential synergies in radiotherapy, discussed based on their physical, chemical, and biological interactions. Targeted and non-targeted bismuth-based NPs used in radiotherapy as radiosensitizers and dose enhancement effects are described. The results reported in the literature were categorised into various groups. Also, this review has highlighted the importance of bismuth-based NPs in different forms of cancer treatment to find the highest efficiency for applying them as a suitable candidate for various cancer therapy and future clinical applications.</p>","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"17 4","pages":"302-311"},"PeriodicalIF":2.3,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ietresearch.onlinelibrary.wiley.com/doi/epdf/10.1049/nbt2.12134","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9706085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of nanotechnology in air purifiers as a viable approach to protect against Corona virus","authors":"Ali Mahmoudi,&nbsp;Seyedeh Belin Tavakoly Sany,&nbsp;Marzieh Ahari Salmasi,&nbsp;Ali Bakhshi,&nbsp;Arad Bustan,&nbsp;Sahar heydari,&nbsp;Majid Rezayi,&nbsp;Fatemeh Gheybi","doi":"10.1049/nbt2.12132","DOIUrl":"10.1049/nbt2.12132","url":null,"abstract":"<p>The outbreak of COVID-19 disease, the cause of severe acute respiratory syndrome, is considered a worldwide public health concern. Although studies indicated that the virus could spread through respiratory particles or droplets in close contact, current research have revealed that the virus stays viable in aerosols for several hours. Numerous investigations have highlighted the protective role of air purifiers in the management of COVID-19 transmission, however, there are still some doubts regarding the efficiency and safety of these technologies. According to those observations, using a proper ventilation system can extensively decrease the spread of COVID-19. However, most of those strategies are currently in the experimental stages. This review aimed at summarising the safety and effectiveness of the recent approaches in this field including using nanofibres that prevent the spread of airborne viruses like SARS-CoV-2. Here, the efficacy of controlling COVID-19 by means of combining multiple strategies is comprehensively discussed.</p>","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"17 4","pages":"289-301"},"PeriodicalIF":2.3,"publicationDate":"2023-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1a/66/NBT2-17-289.PMC10288363.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10082694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment and evaluation of Chitosan-Metamizole nanoparticles for the fracture healing and analgesic effect: Preclinical study in rat model","authors":"Li Yin,&nbsp;Liyong Yuan,&nbsp;Chunling Peng,&nbsp;Qionghua Wang","doi":"10.1049/nbt2.12131","DOIUrl":"10.1049/nbt2.12131","url":null,"abstract":"<p>To assess and evaluate Chitosan-Metamizole nanoparticles for fracture healing and analgesic potential, nanoparticles were formulated using the ionotropic gelation method. The nanoparticles were evaluated for particle size, zeta potential, polydispersity index, loading efficiency, surface characteristics and drug release properties. The analgesic activity was determined in carrageenan-induced arthritic male Wister rats. Further fracture healing potency, mechanical testing, radiographic examination and bone histology of the femur were studied. The drug loading efficiency of 11.38%–17.45%, particle size of 140–220 nm, and zeta potential of 19.12–23.14 mV were observed with a spherical, smooth appearance. Nanoparticles showed sustained release behaviour over a longer period. Nearly 4-fold inhibition of oedema was observed in animals treated with nanoparticles with excellent fracture healing potential. The femurs treated with nanoparticles required greater force to fracture. Nanoparticles significantly improved the strength and healing process. Histopathological studies showed the potential of nanoparticles in the healing process. The study confirmed the potential of nanoparticles in fracture healing and enhancement of analgesic activity.</p>","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"17 4","pages":"360-367"},"PeriodicalIF":2.3,"publicationDate":"2023-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/69/ef/NBT2-17-360.PMC10288353.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9697427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiosensitising effect of iron oxide-gold nanocomplex for electron beam therapy of melanoma in vivo by magnetic targeting","authors":"Mahshad Mohamadkazem,&nbsp;Ali Neshastehriz,&nbsp;Seyed Mohammad Amini,&nbsp;Ali Moshiri,&nbsp;Atousa Janzadeh","doi":"10.1049/nbt2.12129","DOIUrl":"10.1049/nbt2.12129","url":null,"abstract":"<p>Melanoma is a dangerous type of skin cancer sometimes treated with radiotherapy. However, it induces damage to the surrounding healthy tissue and possibly further away areas. Therefore, it is necessary to give a lower dose to the patient with targeted therapy. In this study, the radio-sensitising effect of gold-coated iron oxide nanoparticles on electron beam radiotherapy of a melanoma tumour with magnetic targeting in a mouse model was investigated. Gold-coated iron oxide nanoparticles were prepared in a steady procedure. The melanoma tumour model was induced in mice. Animals were divided into five groups: (1) normal; (2) melanoma; (3) gold-coated iron oxide nanoparticles alone; (4) electron beam radiotherapy; (5) electron beam radiotherapy plus gold-coated iron oxide nanoparticles. The magnet was placed on the tumour site for 2 h. The tumours were then exposed to 6 MeV electron beam radiotherapy for a dose of 8 Gy. Inductively coupled plasma optical emission spectrometry test, hematoxylin and eosin staining, and enzyme-linked immunosorbent assay blood test were also performed. Gold-coated iron oxide nanoparticles with magnetic targeting before electron beam radiotherapy reduced the growth of the tumour compared to the control group. Blood tests did not show any significant toxicity. Deposition of nanoparticles was more in the tumour and spleen tissue and to a lesser extent in the liver, kidney, and lung tissues. The synergistic effect of nanoparticles administered by the intraperitoneal route and then concentrated into the tumour area by application of an external permanent magnet, before delivery of the electron beam radiotherapy improved the overall cancer treatment outcome and prevented metal distribution side effects.</p>","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"17 3","pages":"212-223"},"PeriodicalIF":2.3,"publicationDate":"2023-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ietresearch.onlinelibrary.wiley.com/doi/epdf/10.1049/nbt2.12129","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9488210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Micromechanics in biology and medicine","authors":"David B. MacManus,&nbsp;Majid Akbarzadeh Khorshidi,&nbsp;Mazdak Ghajari,&nbsp;Hamid M. Sedighi","doi":"10.1049/nbt2.12130","DOIUrl":"10.1049/nbt2.12130","url":null,"abstract":"&lt;p&gt;Micromechanics is the study of materials at the level of their constituents to describe the interactions of the microstructures and other micro-scale effects. Micromechanical approaches have wide applications in biology and medicine due to the nature of biological tissues and the size of micro-biomedical devices. Micromechanical experiments, continuum micromechanics, and computational multi-scale models of materials with an emphasis on the connections between material properties and mechanical responses at a micron length scale are significantly essential to design and manufacture the mechanical components of micro-biomedical devices and comprehend the behaviour of biological tissues. The micro-scale mechanics of biological tissues is a multidisciplinary and rapidly expanding area of research, which deals with the lower-scale effects on the mechanical behaviour of biological tissues, such as bone, brain, muscle, vasculature, skin, etc. In fact, there are different micro-scale deformations, interactions, and movements within these tissues (e.g. microstructural or bi-phasic properties) affecting the mechanical response of the materials. The micromechanical characteristics of a material are key to find how it interacts with its physical environment, which eventually modulates the functionality of the material. Such micro-biomechanical effects stem from the structural and architectural arrangements and the hierarchical nature of biological tissues. This Virtual Collection presents the latest and cutting-edge experimental, computational, and theoretical research on the mechanical properties/behaviours of biological tissues and therapeutics to take into account the micro-scale effects, such as microstructures deformations, micro-scale inhomogeneity, micro-damage, micro-porosity, etc., and the mechanics of cells and cell-substrate interactions.&lt;/p&gt;&lt;p&gt;In this Virtual Collection, we received six manuscripts, six of which underwent peer review. Of these six manuscripts, three have been accepted for publication in the Virtual Issue demonstrating a high quality and novel insights into Micromechanics in Biology and Medicine.&lt;/p&gt;&lt;p&gt;Rostami et al. characterised folic acid-functionalised PLA-PEG nanomicelles to deliver Letrozole for the effective treatment of cancer. In silico methods including docking approach, molecular dynamics simulation, and free energy calculations were used for the characterisation studies of PEG-FA and PLA-PEG nanocarriers in delivering Letrozole as an aromatase inhibitor in cancer cells. It was demonstrated the PLA-PEG-FA can be considered a versatile nanocarrier that can increase the effectiveness of aromatase inhibitors while reducing the side effects of the drug.&lt;/p&gt;&lt;p&gt;Alahdal et al. presented a ‘green’ approach to synthesise iron/gold Auroshell nanoparticles and tested with normal HUVEC cells and glioblastoma cancer cells. The Auroshell nanoparticles were found to have minimal toxicity within a safe range for normal cells. When t","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"17 3","pages":"125-126"},"PeriodicalIF":2.3,"publicationDate":"2023-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9b/f5/NBT2-17-125.PMC10190656.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9581032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A paclitaxel prodrug nanoparticles with glutathion/reactive oxygen species dual-responsive and CD206 targeting to improve the anti-tumour effect","authors":"Changhai Wang,&nbsp;Yuwen Jiao,&nbsp;Xinyu Zhang,&nbsp;Mingxue Guo,&nbsp;Qing Zhang,&nbsp;Wenjun Hu,&nbsp;Shuang Dong,&nbsp;Tangthianchaichana Jakkree,&nbsp;Yang Lu,&nbsp;Jinling Wang","doi":"10.1049/nbt2.12119","DOIUrl":"10.1049/nbt2.12119","url":null,"abstract":"<p>As a first-line anticancer drug, paclitaxel has shortcomings, such as poor solubility and lack of tumour cell selectivity, which limit its further applications in clinical practice. Therefore, the authors aimed to utilise the characteristics of prodrug and nanotechnology to prepare a reactive oxygen species (ROS) and GSH dual-responsive targeted tumour prodrug nanoparticle Man-PEG-SS-PLGA/ProPTX to improve the clinical application status of paclitaxel limitation. The characterisation of Man-PEG-SS-PLGA/ProPTX was carried out through preparation. The cytotoxicity of nanoparticles on tumour cells and the effect on apoptosis of tumour cells were investigated by cytotoxicity assay and flow cytometry analysis. The ROS responsiveness of nanoparticles was investigated by detecting the ROS level of tumour cells. The tumour cell selectivity of the nanoparticles was further investigated by receptor affinity assay and cell uptake assay. The particle size of Man-PEG-SS-PLGA/ProPTX was (132.90 ± 1.81) nm, the dispersion coefficient Polymer dispersity index was 0.13 ± 0.03, and the Zeta potential was (−8.65 ± 0.50) mV. The encapsulation rate was 95.46 ± 2.31% and the drug load was 13.65 ± 2.31%. The nanoparticles could significantly inhibit the proliferation and promote apoptosis of MCF-7, HepG2, and MDA-MB-231 tumour cells. It has good ROS response characteristics and targeting. The targeted uptake mechanism is energy-dependent and endocytosis is mediated by non-clathrin, non-caveolin, lipid raft/caveolin, and cyclooxygenase (COX)/caveolin with a certain concentration dependence and time dependence. Man-PEG-SS-PLGA/ProPTX is a tumour microenvironment-responsive nanoparticle that can actively target tumour cells. It restricts the release of PTX in normal tissues, enhances its selectivity to tumour cells, and has significant antitumour activity, which is expected to solve the current limitations of PTX use.</p>","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"17 5","pages":"406-419"},"PeriodicalIF":2.3,"publicationDate":"2023-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ietresearch.onlinelibrary.wiley.com/doi/epdf/10.1049/nbt2.12119","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10267428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stimulus-responsive nano lipidosome for enhancing the anti-tumour effect of a novel peptide Dermaseptin-PP","authors":"Changhai Wang,&nbsp;Ziyi Dong,&nbsp;Qing Zhang,&nbsp;Mingxue Guo,&nbsp;Wenjun Hu,&nbsp;Shuang Dong,&nbsp;Tangthianchaichana Jakkree,&nbsp;Yang Lu,&nbsp;Shouying Du","doi":"10.1049/nbt2.12128","DOIUrl":"10.1049/nbt2.12128","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Dermaseptin-PP is a newly discovered anticancer peptide with a unique antitumour mechanism and remarkable effect. However, this α-helix anticancer peptide risks haemolysis when used at high doses, which limits its further application. This study aims to prepare a pH-responsive liposome, Der-loaded-pHSL, using nanotechnology to avoid the haemolysis risk of Dermaseptin-PP and increase its accumulation in tumour sites to enhance efficacy and reduce toxicity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The characterisation of Der-loaded-pHSL was carried out employing preparation. The effect of haemolysis and tumour inhibition were investigated by in vitro haemolysis assay and cytotoxicity assay. The cell uptake under different pH conditions was investigated by flow cytometry, and the effect of pH on tumour cell selectivity was evaluated. In order to evaluate the in vivo targeting and antitumour effect of Der-loaded-pHSL, the in vivo distribution experiment and the pharmacodynamic experiment were performed using the nude mouse tumour model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The preparation method of the Der-loaded-pHSL is simple, and the liposome has good nanoparticle characteristics. When Dermaseptin-PP was prepared as liposome, haemolysis was significantly decreased, and tumour cell inhibition was significantly enhanced. Compared with ordinary liposomes, this change was more significant in Der-loaded-pHSL. The uptake of pH-sensitive liposomes was higher in the simulated acidic tumour microenvironment, and the uptake showed a specific acid dependence. In vivo experiments showed that Der-loaded-pHSL had a significant tumour-targeting effect and could significantly enhance the antitumour effect of Dermaseptin-PP.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Der-loaded-pHSL designed in this study is a liposome with a quick, simple, effective preparation method, which can significantly reduce the haemolytic toxicity of Dermaseptin-PP and enhance its antitumour effect by increasing the tumour accumulation and cell intake. It provides a new idea for applying Dermaseptin-PP and other anticancer peptides with α-helical structure.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"17 4","pages":"352-359"},"PeriodicalIF":2.3,"publicationDate":"2023-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/52/fd/NBT2-17-352.PMC10288360.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10062813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of Zeolitic imidazolate frameworks-8@ layered double hydroxide polyhedral nanocomposite with designed porous voids as an effective carrier for anti-cancer drug-controlled delivery","authors":"Azita Dilmaghani,&nbsp;Kamran Hosseini,&nbsp;Vahideh Tarhriz,&nbsp;Vahid Yousefi","doi":"10.1049/nbt2.12125","DOIUrl":"10.1049/nbt2.12125","url":null,"abstract":"<p>In nanotechnology, compounds containing metal materials are used in pharmaceutical sciences. The main purpose of this research was to introduce a novel method to control the amount of zeolite imidazolate framework (ZIF) in water by forming a protective layer such as layered double hydroxide (LDH). Firstly, ZIF was synthesised as the nucleus of the nanocomposite, and then LDH was formed by in situ synthesis as a protective layer. Scanning electron microscope, Fourier-transform infrared spectroscopy, X-Ray Diffraction, and Brunauer, Emmett and Teller techniques were used to determine (ZIF-8@LDH chemical structure and morphology. Our findings revealed that the ZIF-8@LDH-MTX complex could interact with carboxyl groups and trivalent cations by creating a bifurcation bridge, clarity, and high thermal stability. The antibacterial test indicated that ZIF-8@LDH was able to inhibit pathogenic growth. 2,5-Diphenyl-2H-Tetrazolium Bromide assay results showed that ZIF-8@LDH alone had no notable cytotoxic effect on Michigan Cancer Foundation-7 (MCF-7) cancer cells. However, the cytotoxicity rate was significantly increased in treated MCF-7 cells with ZIF-8@LDH-MTX compared to that of treated cells with methotrexate alone, which can be reasoned by the protection of drug structure and increasing its permeability. The drug release profile was constant at pH = 7.4. All findings indicated that the ZIF-8@LDH complex could be considered a newly proposed solution for effective anti-cancer drug delivery.</p>","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"17 4","pages":"326-336"},"PeriodicalIF":2.3,"publicationDate":"2023-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/60/84/NBT2-17-326.PMC10288356.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9697368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain targeting based nanocarriers loaded with resveratrol in Alzheimer's disease: A review","authors":"Cyrus Jalili,&nbsp;Amir Kiani,&nbsp;Mohammadreza Gholami,&nbsp;Fariborz Bahrehmand,&nbsp;Sajad Fakhri,&nbsp;Somayeh Kakehbaraei,&nbsp;Seyran Kakebaraei","doi":"10.1049/nbt2.12127","DOIUrl":"10.1049/nbt2.12127","url":null,"abstract":"<p>Alzheimer's disease (AD) is one of the chief neurological difficulties in the aged population, identified through dementia, memory disturbance, and reduced cognitive abilities. <i>β</i>-amyloid (Aβ) plaques aggregations, generation of reactive oxygen species, and mitochondrial dysfunction are among the major signs of AD. Regarding the urgent need for the development of novel treatments for neurodegenerative diseases, researchers have recently perused the function of natural phytobioactive combinations, such as resveratrol (RES), in vivo and in vitro (animal models of AD). Investigations have shown the neuroprotective action of RES. This compound can be encapsulated by several methods (e.g. polymeric nanoparticles (NPs), solid lipid nanoparticles, Micelles, and liposomes). This antioxidant compound, however, barely crosses the blood–brain barrier (BBB), thereby limiting its bioavailability and stability at the target sites in the brain. Thanks to nanotechnology, the efficiency of AD therapy can be improved by encapsulating the drugs in a NP with a controlled size (1–100 nm). This article addressed the use of RES, as a Phytobioactive compound, to decrease the oxidative stress. Encapsulation of this compound in the form of nanocarriers to treat neurological diseases to improve BBB crossing is also discussed.</p>","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"17 3","pages":"154-170"},"PeriodicalIF":2.3,"publicationDate":"2023-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ietresearch.onlinelibrary.wiley.com/doi/epdf/10.1049/nbt2.12127","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9537474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pb2+ recovery from real water samples by adsorption onto nano Fe3O4/chitosan-acrylamide hydrogel ions in real water samples","authors":"Arman Samadzadeh Mamaghani,&nbsp;Mohammadreza Manafi,&nbsp;Mohammad Hojjati","doi":"10.1049/nbt2.12126","DOIUrl":"https://doi.org/10.1049/nbt2.12126","url":null,"abstract":"<p>This study examined the removal of Pb(II) using magnetic chitosan hydrogel adsorbent from diverse sample waters. Spectrometry was used to track the effects of magnetic acrylamide nanocomposite dose, pH extraction, and contact duration on Pb(II) removal from sample water. This research also looked at adsorption isotherm models for the sorption of Pb(II). The magnetic chitosan hydrogel adsorbent Pb(II) adsorption capability was 31.74 mg/g respectively. The Freundlich isotherm model fits the removal of Pb(II) utilising magnetic chitosan hydrogel adsorbent. In addition, this adsorbent was shown to have a <i>q</i>_max value of 31.74 mg/g of Pb²⁺ ions, which is considered to be of high efficiency for Pb²⁺ ion removal. The studied kinetic models have determined that the pseudo-second-order linear model is more suitable to explain the adsorption of lead (II) on magnetic chitosan hydrogel adsorbent. Also, chemical adsorption is the rate-limiting step in the adsorption process of lead (II) ions.</p>","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"17 4","pages":"337-351"},"PeriodicalIF":2.3,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1049/nbt2.12126","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50140514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}