IET nanobiotechnology最新文献

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"2025 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148095199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gum-Assisted Magnesium Oxide Nanoparticles Using Guar Extract Focusing on Their Bioactivities","authors":"Asma Sepahdar,&nbsp;Matin Kordestani,&nbsp;Maryam Karkhane,&nbsp;Saeed Bahadori,&nbsp;Suresh Ghotekar,&nbsp;Pegah Shakib,&nbsp;Abdolrazagh Marzban","doi":"10.1049/nbt2/9924353","DOIUrl":"10.1049/nbt2/9924353","url":null,"abstract":"<p>The study aims to fabricate eco-friendly, biogenic magnesium oxide nanoparticles (MgO NPs) mediated by ethanol-guar gum extract, which acts as both a reducing and coating/stabilizing agent. The prepared MgO NPs were first synthesized and characterized by various analytical techniques, including UV–visible, FTIR spectroscopy, SEM-energy-dispersive X-ray spectroscopy (EDS) mapping, and X-ray diffraction (XRD) crystallography. Bioactivity studies included antibacterial studies focusing on the inhibition of a dental caries-causing pathogen, <i>Enterococcus faecalis</i>, by MIC, MBC, well diffusion (WD) agar, antibiofilm, and time-kill (TK) assays. Furthermore, the antioxidant activity and cytotoxicity of MgO NPs were examined. A bacterial adherence study was conducted as the main aim by exposing the bacteria to human teeth in vitro. Findings demonstrated that biogenic MgO NPs were successfully synthesized with flaky morphologies, with an average size of 20–30 nm and the desired purity. FTIR showed possible functional groups, confirming the involvement of guar metabolites in NP formation. The XRD pattern elucidated the crystalline phase of MgO NPs to be a cubic (FCC) periclase structure with a crystallite size of 16.5 nm. Antibacterial experiments showed that MgO NPs had a moderate effect on <i>Enterococcus faecalis</i>, with MIC and MBC of 32 and 64 µg/mL, respectively. In contrast, chlorhexidine (CHX), doxycycline (Dox), and sodium hypochlorite (NaClO) were more effective, while the guar extract showed the weakest inhibition; additionally, antibiofilm assessments were followed by antibacterial outcomes. However, cytotoxicity studies exhibited the least toxicity for MgO NPs compared with other compounds. The dental adherence test also showed that MgO NPs can inhibit bacterial interactions with the dental surface without inhibiting bacterial growth at sub-MIC concentrations. Meanwhile, other groups killed them rapidly before they could adhere to teeth. Here, biocompatibility and long-term antibacterial effectiveness were advantages of biogenic MgO NPs over other compounds that have been shown to be toxic to the host over long-term consumption. Therefore, guar extract-mediated MgO NPs demonstrated that they can be a favorable alternative for biofilm control in dental health without toxicity to related tissues in the oral cavity.</p>","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"2025 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ietresearch.onlinelibrary.wiley.com/doi/epdf/10.1049/nbt2/9924353","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145887527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation of Fe3O4/Chitosan–Acrylic Acid Nanocomposite as an Adsorbent for the Removal of Cu2+ Ions From Real Water Samples","authors":"Arman Samadzadeh Mamaghani,&nbsp;Ali Moghimi,&nbsp;Milad Abniki","doi":"10.1049/nbt2/9919353","DOIUrl":"10.1049/nbt2/9919353","url":null,"abstract":"<p>This study presents an environmentally friendly and nontoxic method for the selective separation and removal of trace amounts. A magnetic nanocomposite made of Fe₃O₄/chitosan–acrylic acid was utilized to separate and remove Cu²⁺ ions using its magnetic properties. Various characterization techniques, including Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), scanning electron microscope (SEM), thermogravimetric analyzer (TGA), and VSM, were employed to investigate and identify the nanocomposite. Additionally, the research discusses adsorption isotherm models related to the adsorption of Cu²⁺ ions. The maximum adsorption capacity of the biodegradable Fe₃O₄/chitosan–acrylic acid nanocomposite for Cu²⁺ ions was found to be 30.68 mg/g. The adsorption process followed the Freundlich isotherm model when using the Fe₃O₄/chitosan–acrylic acid adsorbent. The method exhibited a linear range of 10–1000 µg/L for Cu²⁺ ions, with a limit of detection (LOD) of 0.15 μg/L for the adsorption of Cu²⁺ ions by the Fe₃O₄/chitosan–acrylic acid adsorbent. These findings indicate that Fe₃O₄/chitosan–acrylic is a high-performance adsorbent for removing Cu²⁺ ions from tap, well, river, and spring water samples.</p>","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"2025 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ietresearch.onlinelibrary.wiley.com/doi/epdf/10.1049/nbt2/9919353","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145619056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"2025 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148091383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication of Algal Polysaccharides-Based Nanoparticles and Evaluation of Their Antioxidant and Anti-Inflammatory Potential","authors":"Cheng-Yuan Chen,&nbsp;Wei-Hao Huang,&nbsp;Pin-Yu Tsai,&nbsp;Chung-Hsiung Huang","doi":"10.1049/nbt2/8887357","DOIUrl":"10.1049/nbt2/8887357","url":null,"abstract":"<p>This study investigates the development of nanoparticles derived from algal polysaccharides and evaluates their physicochemical properties, antioxidant capacity, and anti-inflammatory activity in comparison to their native counterparts. Polysaccharides extracted from <i>Sargassum</i> (SP), <i>Ulva</i> (UP), and <i>Porphyra</i> (PP) were subjected to dry-heating at various temperatures to form nanoparticles. The prepared polysaccharides and nanoparticles were characterized by molecular weight distribution, monosaccharide composition, yield, morphology, particle size, sulfate content, and functional group profiles, respectively. The nanoparticles were spherical in form, with diameter less than 500 nm. Furthermore, their polydispersity index (PDI) was observed to be lower than 0.4, and their zeta potentials ranged from −5 to −30 mV. Dry-heating above 210°C induced notable alterations in functional groups, while temperatures above 150°C significantly enhanced DPPH radical scavenging and Fe²⁺ chelation activities. The nanoparticles showcased enhanced antioxidant and anti-inflammatory capabilities when juxtaposed with crude polysaccharides. Specifically, they led to a significant suppression of lipopolysaccharide (LPS)-induced generation of key pro-inflammatory molecules in macrophages. Importantly, the nanoparticles exhibited no cytotoxicity at concentrations below 1000 <i>μ</i>g/mL. These findings suggest that algal polysaccharide-based nanoparticles, particularly those formed at higher temperatures, hold considerable potential as bioactive agents in therapeutic applications.</p>","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"2025 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ietresearch.onlinelibrary.wiley.com/doi/epdf/10.1049/nbt2/8887357","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145572437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"2025 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148084313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"2025 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148070012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Radiotherapy for Hypoxic Tumors: Integrative Strategies Using Bacteria and Nanoparticles","authors":"Abolfazl Bemidinezhad,&nbsp;Abbas Al-Baghdadi,&nbsp;Anwer Alsarray,&nbsp;Yasaman Abolhassani,&nbsp;Yodgor Kenjayev,&nbsp;Fatemeh Gheybi","doi":"10.1049/nbt2/2687439","DOIUrl":"10.1049/nbt2/2687439","url":null,"abstract":"<p>Cancer remains a major global health challenge, with radiotherapy (RT) being a cornerstone of treatment. However, the efficacy of RT is significantly hindered by hypoxic tumor microenvironments (TMEs) and nonselective toxicity to healthy tissues. Recent advancements in combining bacteria and nanoparticles have shown promise in addressing these limitations. Cyanobacteria, with their oxygen-producing capabilities, alleviate tumor hypoxia, while anaerobic bacteria selectively target hypoxic regions. Nanoparticles complement these approaches by enhancing bacterial localization and amplifying radiosensitization through reactive oxygen species (ROS) generation and other synergistic therapies. Unlike previous reviews that have mainly focused on either bacterial therapy or nanoparticle-assisted radiosensitization separately, this review provides a comparative and integrative perspective on their combined use, emphasizing the novelty of synergistic strategies. This review explores innovative bacterial–nanoparticle integrations, highlighting their roles in overcoming hypoxia and improving RT outcomes. The potential of these strategies to transform cancer treatment is discussed, alongside challenges and future directions.</p>","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"2025 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ietresearch.onlinelibrary.wiley.com/doi/epdf/10.1049/nbt2/2687439","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145469794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotective Potential of Free Radical-Scavenging Nanoparticles in Addressing Inflammation and Obesity","authors":"Shampa Ghosh,&nbsp;Rakesh Bhaskar,&nbsp;Krishna Kumar Singh,&nbsp;Bhuvaneshwar Yarlagadda,&nbsp;Prashant Verma,&nbsp;Sung Soo Han,&nbsp;Shiv Dutt Purohit,&nbsp;Jitendra Kumar Sinha","doi":"10.1049/nbt2/6805313","DOIUrl":"10.1049/nbt2/6805313","url":null,"abstract":"<p>Neuroprotection is well known for its strategies and interventions that help preserve the structure and function of neurons during a myriad of neurological challenges. It is fundamental in managing the complex relationship between neuroinflammation and obesity, both of which are significant factors affecting our neurological health. In the present review, we try to merge nanoparticles with artificial intelligence (AI) to tackle the neurological implications of both conditions. This review summarizes prior studies of free radical-scavenging nanoparticles: polymeric, liposomal, ceria-based, and quantum dots, and evaluates their reported efficacy in attenuating markers of neuroinflammation and neuronal dysfunction in preclinical models. We have also discussed AI applications, such as predictive modeling and real-time monitoring, stating that they present a complementary role in themselves. There is recognition that the promise of nanoparticles in mitigating neurological problems underscores the potential of AI in upgrading neuroprotection. Early-phase clinical trials of free radical-scavenging nanoparticles have highlighted the importance of patient stratification to optimize personalized treatment regimens. Furthermore, we advocate coordinated efforts in education, awareness, and research to integrate scientific findings, public policy, and technology innovation, thereby holistically addressing neuroinflammation and obesity at the individual level.</p>","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"2025 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ietresearch.onlinelibrary.wiley.com/doi/epdf/10.1049/nbt2/6805313","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145406636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"2025 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148096471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}