Indo Global Journal of Pharmaceutical Sciences最新文献

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UV-Spectrophotometric Estimation and Forced Degradation Studies of Tenofovir Alafenamide Fumarate (TAF) in its Bulk and Tablet Dosage Form 富马酸替诺福韦阿拉那胺(TAF)原料药和片剂的紫外分光光度测定及强制降解研究
Indo Global Journal of Pharmaceutical Sciences Pub Date : 2020-03-01 DOI: 10.5958/0974-360x.2020.00227.9
K. Bhavyasri, M. Manisha
{"title":"UV-Spectrophotometric Estimation and Forced Degradation Studies of Tenofovir Alafenamide Fumarate (TAF) in its Bulk and Tablet Dosage Form","authors":"K. Bhavyasri, M. Manisha","doi":"10.5958/0974-360x.2020.00227.9","DOIUrl":"https://doi.org/10.5958/0974-360x.2020.00227.9","url":null,"abstract":"A simple, sensitive and reproducible Spectrophotometric method is developed for estimation of Tenofovir Alafenamide Fumarate (TAF) in bulk and its tablet dosage form. Forced degradation studies are also conducted on standard TAF and % degradation of drug under various stress conditions is reported. Different concentrations of TAF are prepared using distilled water: acetonitrile as diluent. The absorption maximum of TAF is found to be at 261nm. Linearity was established in the range of 6.25-37.5 μg/ml with regression coefficient of 0.999. The drug was subjected to acid and alkali hydrolysis, oxidation degradation, thermal and photo degradation conditions. © 2020 iGlobal Research and Publishing Foundation. All rights reserved. Cite this article as: Bhavyasri, K.; Manisha, M.; Rambabu, D. UV-spectrophotometric estimation and forced degradation studies of tenofovir alafenamide fumarate (TAF) in its bulk and tablet dosage form. Indo Global J. Pharm. Sci., 2020; 10(4): 1-5. DOI: http://doi.org/10.35652/IGJPS.2020.10401 . Indo Global Journal of Pharmaceutical Sciences, 2020; 10(4): 1-5 2 Simultaneous estimation of TAF and Emtricitabine by UV spectroscopic method is found in a literature. The method involving determination of TAF and Emtricitabine at 260nm and 280nm over the concentration ranges of 5-30μg/ml for both drugs has been described [6]. Most of the reported methods are often time consuming, expensive, use multi or expensive reagents, cumbersome and required expertise operational personnel. UV spectrophotometry, because of simplicity, reproducibility and speed and also it requires minimum solvent/reagent system and less analysis time, is widely used for the assay of the therapeutic compounds used as medications. MATERIALS AND METHODS Apparatus The Spectrophotometric measurements were carried out using Elico SL 210 UV/Visible spectrophotometer.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77183817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A Stability Indicating Method Development of Atorvastatin Calcium and Amlodipine Besylate in Combined Tablet Dosage Forms by RPHPLC 阿托伐他汀钙与苯磺酸氨氯地平复合片剂稳定性指示方法的RPHPLC建立
Indo Global Journal of Pharmaceutical Sciences Pub Date : 2020-01-01 DOI: 10.35652/igjps.2020.10111
A. Indira, N. Sreedhar
{"title":"A Stability Indicating Method Development of Atorvastatin Calcium and Amlodipine Besylate in Combined Tablet Dosage Forms by RPHPLC","authors":"A. Indira, N. Sreedhar","doi":"10.35652/igjps.2020.10111","DOIUrl":"https://doi.org/10.35652/igjps.2020.10111","url":null,"abstract":"A new stability indicating RP-HPLC method was developed for simultaneous estimation of atorvastatin and amlodipine in combined tablet formulations. Chromatography was carried out on a Kromasil C18 HPLC Column (250 x 4.6 mm; 5μm) eluting with a mobile phase consisting of a 60:40 v/v mixture of 0.1% orthophosphoric acid in water and acetonitrile (ACN) at a flow rate of 1.0 mL/ minute. The detection wavelength was set at 240 nm. Accuracy was assessed by using standard addition method. The developed HPLC method was validated with respect to precision, specificity, accuracy, linearity and robustness. Forced degradation studies on the formulation were conducted by adopting the proposed method to assess the stability of the analytes under acid, base, peroxide, thermal and photolytic conditions and suitability of the method to resolve the degradation products. © 2020 iGlobal Research and Publishing Foundation. All rights reserved. Cite this article as: Indira, A.; Sreedhar, N.Y. A stability indicating method development of atorvastatin calcium and amlodipine besylate in combined tablet dosage forms by RP-HPLC. Indo Global J. Pharm. Sci., 2020; 10(1): 79-84. DOI: http://doi.org/10.35652/IGJPS.2020.10111 . Indo Global Journal of Pharmaceutical Sciences, 2020; 10(1): 79-84 80 atorvastatin and amlodipine in bulk and pharmaceutical dosage forms. Fig. 1: Structure of a) Atorvastatin b) Amlodipine MATERIALS AND METHODS Chemicals and Reagents Amlodipine besylate and Atorvastatin calcium were obtained as gift samples from Mylan Laboratories Ltd., Hyderabad. Methanol AR grade, HCl, NaOH and hydrogen peroxide were procured from SD Fine Chem limited, Mumbai. HPLC water and Methanol were purchased from Merck specialties private limited, Mumbai. The combination tablets AMTR 10 were purchased from local pharmacy.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74170863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Molecular Docking Studies of Deva Chooranam against the Target Protein 6LU7 of Novel Corona Virus 2019 Deva Chooranam抗新型冠状病毒靶蛋白6LU7的分子对接研究
Indo Global Journal of Pharmaceutical Sciences Pub Date : 2020-01-01 DOI: 10.35652/IGJPS.2020.10204
K. Thangadurai, Rengasundari, P SaravanaSiva, N Vithyavani, K. Sivasankari, R. Ramya, R JeevaGladys, K. Kannan
{"title":"Molecular Docking Studies of Deva Chooranam against the Target Protein 6LU7 of Novel Corona Virus 2019","authors":"K. Thangadurai, Rengasundari, P SaravanaSiva, N Vithyavani, K. Sivasankari, R. Ramya, R JeevaGladys, K. Kannan","doi":"10.35652/IGJPS.2020.10204","DOIUrl":"https://doi.org/10.35652/IGJPS.2020.10204","url":null,"abstract":"Plants and bioactive compounds have played an important role in the development of several clinically useful therapeutic agents since time immemorial. In the recent years, more emphasis has been placed on identifying plant-derived compounds that can be used as an effective treatment for life-threatening diseases. COVID-19, a new strain of coronavirus (CoV), was identified in Wuhan, China, in 2019. No specific therapies are available and investigations regarding COVID-19 treatment are lacking. Bioactive compounds found in Siddha herbal formulation Deva Chooranam which was previously confirmed through molecular docking to have antiviral effects against HIV -RT. The present study aimed to assess Deva Chooranam as potential COVID-19 Mpro inhibitor. Molecular docking was performed using Autodock 4.2, with the Lamarckian Genetic Algorithm and results were visualized using pymol. The physiochemical and ADMET(Adsorption, distribution, metabolism and excretion) properties were also analysed.COVID-19 Mpro was docked with several compounds, Eugenol A-Pinene, Atlantone, Myrcene, Luteolin, Apigenin, Kaempferol and docking was analysed using Pymol. The results showed that out of the 7 compounds screened Luteolin appeared to have the best potential binding against the COVID-19 Mpro 6LU7. However, further research is necessary to investigate their potential medicinal use. © 2020 iGlobal Research and Publishing Foundation. All rights reserved.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83335882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Preparation And Evaluation Of Directly Compressible Tablets Of Ketoprofen Crystals 酮洛芬晶体直接可压片的制备及评价
Indo Global Journal of Pharmaceutical Sciences Pub Date : 2020-01-01 DOI: 10.35652/igjps.2020.10303
Pooja D. Vaghela, H. M. Tank
{"title":"Preparation And Evaluation Of Directly Compressible Tablets Of Ketoprofen Crystals","authors":"Pooja D. Vaghela, H. M. Tank","doi":"10.35652/igjps.2020.10303","DOIUrl":"https://doi.org/10.35652/igjps.2020.10303","url":null,"abstract":"Purpose: The aim of present investigation was to prepare the directly compressible tablets of Ketoprofen loaded crystals and the prepared tablets were evaluated for the improvement in drug release of Ketoprofen as compared to the pure drug. Methods: Ketoprofen crystals were prepared by solvent evaporation, a conventional method, with an excipient, saccharin sodium dihydrate at room temperature. Control batch of Ketoprofen was prepared by excluding the excipient in the preparation. The prepared crystals were converted to directly compressible tablet dosage form. Results: The crystal formation of Ketoprofen lead to improve the compressibility, mechanical properties, and tensile strength of the drug which enable to prepare directly compressible tablet dosage form. The In-vitro study demonstrated 2.71 fold increase in the drug release rate from tablets of Ketoprofen crystals compared to the pure drug after one hour. The characterization was done by Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC), Powder X-Ray Diffractometry (pXRD), and Headspace Gas Chromatography (HSGC) study of Ketoprofen treated crystals illustrated the improvement in physicochemical, manufacturability, and pharmacotechnical parameters of Ketoprofen. Conclusions: The crystal engineering approach can be used to improve the physicomechanical and pharmacotechnical parameters of BCS Class-II drugs which enable to prepare directly compressible tablet dosage form. © 2020 iGlobal Research and Publishing Foundation. All rights reserved. Cite this article as: Vaghela, P.D.; Tank, H.M. Preparation and evaluation of directly compressible tablets of ketoprofen crystals. Indo Global J. Pharm. Sci., 2020; 10(3): 21-34. DOI: http://doi.org/10.35652/IGJPS.2020.10303 . Indo Global Journal of Pharmaceutical Sciences, 2020; 10(3): 21-34 22 Dissolution Study 1. In-Vitro drug release study of directly compressible tablets of pure drug, its control batch, and Ketoprofen","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88688743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Viral Diseases, N-COVID-19, and Evolution: A Commentary 病毒性疾病,N-COVID-19和进化:评论
Indo Global Journal of Pharmaceutical Sciences Pub Date : 2020-01-01 DOI: 10.35652/IGJPS.2020.10203
S. Ghosh
{"title":"Viral Diseases, N-COVID-19, and Evolution: A Commentary","authors":"S. Ghosh","doi":"10.35652/IGJPS.2020.10203","DOIUrl":"https://doi.org/10.35652/IGJPS.2020.10203","url":null,"abstract":"Viruses originated from 'Primordial Nucleic Acids' with lipid and protein encapsulations. Chance fusion with cellular entities and intracellular replication of exogenotes started the journey of viruses on this planet. While replicating, pairing occurred in between the viral exogenotes and the host endogenote at their homologous sites. Therefore, both of the genes become recombined. Sometimes the viral exogenotes get integrated into the host genome resulting in a new reading frame in gene sequences. So, at every cycle of cellular infection with a viral particle, both the host and the parasite genes are recombined. The virulent the viral infection, the better is the chance of gene recombination of the host. Every stratum of cellular living forms has its viral pathogen. In lower living forms, depending on the habitats, a complete gene or its fragments may enter a cell using membrane receptors from the nucleic acid pool resulted from the lysis of cellular entities or viral particles, and gene recombination occurs. These are Transforming Principles or Transposable Elements. This lateral passage of genes through individuals is called Horizontal Gene Transfer. When mediated by viruses, it is called Transduction. Eventually, gene recombination occurs at the cellular level. Genetic Recombination is the basis of speciation, survival, evolution, and a way out of genetic bottleneck in cellular life. Humans too are facing a genetic bottleneck and living on the edge of extinction. Therefore, the viral infections in humans might be one of mother nature's designs to find a way out of this genetic bottleneck and survive and evolve further. © 2020 iGlobal Research and Publishing Foundation. All rights reserved.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"13 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91554011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacological Effects of Physalis minima Linn 小檗的药理作用
Indo Global Journal of Pharmaceutical Sciences Pub Date : 2019-01-01 DOI: 10.35652/igjps.2019.92s35
Mandeep S. Singh
{"title":"Pharmacological Effects of Physalis minima Linn","authors":"Mandeep S. Singh","doi":"10.35652/igjps.2019.92s35","DOIUrl":"https://doi.org/10.35652/igjps.2019.92s35","url":null,"abstract":"","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81535520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic Management of AIDS using Ethnomedicinal Plants 民族药材治疗艾滋病的管理
Indo Global Journal of Pharmaceutical Sciences Pub Date : 2019-01-01 DOI: 10.35652/igjps.2019.92s41
R. Kaur, Pooja Sharma, Dinesh Kumar
{"title":"Therapeutic Management of AIDS using Ethnomedicinal Plants","authors":"R. Kaur, Pooja Sharma, Dinesh Kumar","doi":"10.35652/igjps.2019.92s41","DOIUrl":"https://doi.org/10.35652/igjps.2019.92s41","url":null,"abstract":"Acquired Immunodeficiency Syndrome (AIDS) which is chiefly originated by a retrovirus named as Human Immunodeficiency Virus (HIV), has influenced about 70 million populations worldwide. Even though several advancements have been invented in the field of antiretroviral combination therapy, still HIV has become the dominant reason of death in South Africa. The current antiretroviral therapies have achieved success in providing instant HIV suppression but with countless undesirable adverse effects. In the present day, the biodiversity of plant kingdom is being explored by several researchers for the discovery of potent anti-HIV drugs with different mechanisms of action. The primary challenge is to afford a treatment that is free from any sort of risk of the drug resistance and serious side effects. Hence, there is a strong demand to evaluate the drugs obtained from natural plants as well as the synthetic derivatives that have been derived from the natural compounds by various chemical reactions. Several natural plants such as Andrographis paniculata, Dioscorea bulbifera, Aegle marmelos, Wistaria floribunda, Lindera chunii, Xanthoceras sorbifolia and others have displayed significant anti-HIV activity and were researched for their therapeutic principles. The synthetic derivatives of natural compounds have shown more potent anti-HIV potential with improved pharmacokinetic profile. These include the synthetic derivatives of artemisinin, andrographolide, calanolides, maslinic acid and ingenol synthetic derivatives. © 2019 iGlobal Research and Publishing Foundation. All rights reserved. Cite this article as: Kaur, R.; Sharma, P.; Kumar, D. Therapeutic Management of AIDS using Ethnomedicinal Agents. Indo Global J. Pharm. Sci., 2019; 9(2Suppl.): 143. DOI: http://doi.org/10.35652/IGJPS.2019.92S41 . Indo Global Journal of Pharmaceutical Sciences( ISSN 2249 1023; CODENIGJPAI; NLM ID: 101610675) indexed and abstracted in CrossRef (DOI Enabling), UGC CARE Journal List, EMBASE(Elsevier), National Library of Medicine (NLM) Catalog, ResearchGate, Publons, CAS (ACS), Index Copernicus, Google Scholar and many more. For further details, visit http://iglobaljournal.com This is a special issue as an outcome of ‘RAPSCON-2019’ sponsored by APTI and organized by Sri Sai College of Pharmacy, Manawala, Amritsar, Punjab, India. Relaxation offered in journal format.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80992157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploration of Therapeutic Efficacy of Withania somnifera and Curcuma longa In Alzheimer’s disease - A Boon Withania somnifera和姜黄longa治疗阿尔茨海默病的疗效探讨
Indo Global Journal of Pharmaceutical Sciences Pub Date : 2019-01-01 DOI: 10.35652/igjps.2019.92s42
Rajat V. Sarin, S. Sharma
{"title":"Exploration of Therapeutic Efficacy of Withania somnifera and Curcuma longa In Alzheimer’s disease - A Boon","authors":"Rajat V. Sarin, S. Sharma","doi":"10.35652/igjps.2019.92s42","DOIUrl":"https://doi.org/10.35652/igjps.2019.92s42","url":null,"abstract":"Alzheimer ’s disease (AD) is an age related, irreversible neurodegenerative disease which is characterized by severe memory loss, unusual behavior, personality changes and a decline in cognitive function. The main pathological hallmark of AD is decreased level of acetylcholine (Ach) and increase amyloid beta (Aβ) plaque deposition, neurofibrillary tangle (NFT) formation and decrease brain-derived neurotrophic factor (BDNF) in hippocampus area of brain. Some ayurvedic medicinal plants are proved as a boon in the treatment of AD. Ayurvedic medicinal plants have been the single most productive source for the development of new drugs over already existing allopathic medicines. Indeed, several scientific studies have described the use of Withania somnifera and Curcuma longa as potential treatment for AD. Aqueous extract of this herb has been found to increase memory by increasing cholinergic activity, decreasing Aβ plaque deposition due to presence of withanamides. The active chemical constituents of Curcuma longa i.e.; curcumin reduces the amount of Aβ plaque deposition. This review summarizes the therapeutic efficacy of Withania somnifera and Curcuma longa in treatment of Alzheimer’s Disease. © 2019 iGlobal Research and Publishing Foundation. All rights reserved. Cite this article as: Sarin, R.; Sharma, S. Exploration of Therapeutic Efficacy of Withania somnifera and Curcuma longa In Alzheimer’s disease A Boon. Indo Global J. Pharm. Sci., 2019; 9(2Suppl.): 144. DOI: http://doi.org/10.35652/IGJPS.2019.92S42 . Indo Global Journal of Pharmaceutical Sciences( ISSN 2249 1023; CODENIGJPAI; NLM ID: 101610675) indexed and abstracted in CrossRef (DOI Enabling), UGC CARE Journal List, EMBASE(Elsevier), National Library of Medicine (NLM) Catalog, ResearchGate, Publons, CAS (ACS), Index Copernicus, Google Scholar and many more. For further details, visit http://iglobaljournal.com This is a special issue as an outcome of ‘RAPSCON-2019’ sponsored by APTI and organized by Sri Sai College of Pharmacy, Manawala, Amritsar, Punjab, India. Relaxation offered in journal format.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84116122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Preliminary Survey on Home and Kitchen Herbal Remedies for Primary Health Care at Bichkunda, Kamareddy District, Telangana State 在泰伦加纳邦卡马雷迪区比昆达对初级保健家庭和厨房草药的初步调查
Indo Global Journal of Pharmaceutical Sciences Pub Date : 2019-01-01 DOI: 10.35652/igjps.2019.9205
D. Rajesh, Ahmed Khan
{"title":"A Preliminary Survey on Home and Kitchen Herbal Remedies for Primary Health Care at Bichkunda, Kamareddy District, Telangana State","authors":"D. Rajesh, Ahmed Khan","doi":"10.35652/igjps.2019.9205","DOIUrl":"https://doi.org/10.35652/igjps.2019.9205","url":null,"abstract":": The present paper focused on traditional medicine system like folk medicine, sida, unani, ayurvedha and homeopathy practice with in the home and kitchen herbal remedies for primary health care. Traditional medicine practicing from generations to generations for hundreds of years. Thousands of years of traditional medicine can gives valuable information about our daily life. The traditional medicine system depends large number of medicinal plant species and animal species. For knowing of traditional knowledge we were conducted the surveyed (June-2018 to December-2018) local people and tribal people,","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80290010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Potential Effects of Phytoconstituents in Symptomatic Relief of Alzheimer’s Disease 植物成分在阿尔茨海默病症状缓解中的潜在作用
Indo Global Journal of Pharmaceutical Sciences Pub Date : 2019-01-01 DOI: 10.35652/igjps.2019.92s12
Rakesh Kumar, Rajan Kumar, N. Sharma, N. Khurana
{"title":"Potential Effects of Phytoconstituents in Symptomatic Relief of Alzheimer’s Disease","authors":"Rakesh Kumar, Rajan Kumar, N. Sharma, N. Khurana","doi":"10.35652/igjps.2019.92s12","DOIUrl":"https://doi.org/10.35652/igjps.2019.92s12","url":null,"abstract":"Phytoconstituents are obtained from the various plant sources that are known for symptomatic relief of Alzheimer’s disease (AD). The phytoconstituents such as hesperidin, huperizine A, curcumin, quercetin, rutin, magnolol, myrcene, vanillic acid, gastrodin, rasmarinic acid, myricetin and other are reported to show symptomatic relief in treatment of AD. The AD is a neurodegenerative disorder that is characterized by chronic progressive loss of neuron, function or death of cell in brain. The Aggregation of amyloid-β (Aβ) and Neurofibrillary Tangles (NFTs) are two major hallmarks in hippocampus and cortex region of the brain, occurred by enhancement of β-secretase enzyme, lipid peroxidation (LPO), reactive oxygen species (ROS), acetylcholinestrase (AChE) enzyme and decrease of antioxidant defence enzymes such as glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) enzyme. The various research have been reported that phytoconstituents showed attenuation of β-secretase, LPO, ROS, AChE enzyme and amelioration of antioxidant defence enzymes. Phytoconstituents, also showed anti-inflammatory activities by reducing neuroinflammation. In this review, phytoconstituents are reported to show the potential effect in symptomatic relief of the AD.© 2019 iGlobal Research and Publishing Foundation. All rights reserved. Cite this article as: Kumar, R.; Kumar, R.; Sharma, N.; Khurana, N. Potential effects of phytoconstituents in symptomatic relief of alzheimer’s disease. Indo Global J. Pharm. Sci., 2019; 9(2Suppl.): 114. DOI: http://doi.org/10.35652/IGJPS.2019.92S12 . Indo Global Journal of Pharmaceutical Sciences( ISSN 2249 1023; CODENIGJPAI; NLM ID: 101610675) indexed and abstracted in CrossRef (DOI Enabling), UGC CARE Journal List, EMBASE(Elsevier), National Library of Medicine (NLM) Catalog, ResearchGate, Publons, CAS (ACS), Index Copernicus, Google Scholar and many more. For further details, visit http://iglobaljournal.com This is a special issue as an outcome of ‘RAPSCON-2019’ sponsored by APTI and organized by Sri Sai College of Pharmacy, Manawala, Amritsar, Punjab, India. Relaxation offered in journal format.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86270852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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