Exploration of Therapeutic Efficacy of Withania somnifera and Curcuma longa In Alzheimer’s disease - A Boon

Abstract

Alzheimer ’s disease (AD) is an age related, irreversible neurodegenerative disease which is characterized by severe memory loss, unusual behavior, personality changes and a decline in cognitive function. The main pathological hallmark of AD is decreased level of acetylcholine (Ach) and increase amyloid beta (Aβ) plaque deposition, neurofibrillary tangle (NFT) formation and decrease brain-derived neurotrophic factor (BDNF) in hippocampus area of brain. Some ayurvedic medicinal plants are proved as a boon in the treatment of AD. Ayurvedic medicinal plants have been the single most productive source for the development of new drugs over already existing allopathic medicines. Indeed, several scientific studies have described the use of Withania somnifera and Curcuma longa as potential treatment for AD. Aqueous extract of this herb has been found to increase memory by increasing cholinergic activity, decreasing Aβ plaque deposition due to presence of withanamides. The active chemical constituents of Curcuma longa i.e.; curcumin reduces the amount of Aβ plaque deposition. This review summarizes the therapeutic efficacy of Withania somnifera and Curcuma longa in treatment of Alzheimer’s Disease. © 2019 iGlobal Research and Publishing Foundation. All rights reserved. Cite this article as: Sarin, R.; Sharma, S. Exploration of Therapeutic Efficacy of Withania somnifera and Curcuma longa In Alzheimer’s disease A Boon. Indo Global J. Pharm. Sci., 2019; 9(2Suppl.): 144. DOI: http://doi.org/10.35652/IGJPS.2019.92S42 . Indo Global Journal of Pharmaceutical Sciences( ISSN 2249 1023; CODENIGJPAI; NLM ID: 101610675) indexed and abstracted in CrossRef (DOI Enabling), UGC CARE Journal List, EMBASE(Elsevier), National Library of Medicine (NLM) Catalog, ResearchGate, Publons, CAS (ACS), Index Copernicus, Google Scholar and many more. For further details, visit http://iglobaljournal.com This is a special issue as an outcome of ‘RAPSCON-2019’ sponsored by APTI and organized by Sri Sai College of Pharmacy, Manawala, Amritsar, Punjab, India. Relaxation offered in journal format.