Indo Global Journal of Pharmaceutical Sciences最新文献

{"title":"Cytotoxicity and Anticancer activity of Aqueous Leaf Extract of Solanum torvumon Normal Vero and Human Breast Adenocarcinoma MCF-7 Cell Line","authors":"S. Dhamodaran, Raja Kothandam, Saravanan Ramachandran","doi":"10.35652/igjps.2022.12016","DOIUrl":"https://doi.org/10.35652/igjps.2022.12016","url":null,"abstract":"Naturalherbalproducts areformulatedwitha combinationofphytoconstituentsfrom plants which play a pivotalrole becauseof their diverse medicinal properties.Limited plants have been screened for their complete biological and pharmacological nature.In the present research workan attempt wasmade to infer the medicinal value of aqueousextract of Solanumtorvum (S.torvum)leaves. Phytochemical analysis of theaqueous extracts of S.torvumleaf in the present study ascertain the presence of flavonoids, phenols, saponins, alkaloids, coumarins, sterols, proteins and reducing sugars.Further, the potentiality of aqueous extract ofS.torvumleaveswas assessedfor its cytotoxic effecton Normal Verocell lineand anticancer activityonHumanbreast adenocarcinoma cell lineby 3-(4,5dimethylthiazole-2-yl)-2,5-diphenyl tetrazoliumbromide assay.A 24-hour incubationcell proliferation studyreducedthe cell viability of MCF-7 breast cancer cell lines.In vitro studieson cytotoxicity analysis on Vero cell line revealed thattheaqueous leaf extract of S.torvumhasno toxicityand further it was foundtobeeffectiveinthepreventionofcellproliferation by MCF-7celllines.©2022iGlobal Research and PublishingFoundation. All rights reserved.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82610808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro Inhibitory Effect on Alpha Amylase Enzyme by Polyherbal Dip Tea in Diabetes","authors":"Mohsina F.P, A. Quazi, Faheem I.P, Mohammad A Kamal, Mukim M, Gulzar Ahmed Rather, bhinandan Pati","doi":"10.35652/igjps.2022.12018","DOIUrl":"https://doi.org/10.35652/igjps.2022.12018","url":null,"abstract":"The presentstudy aims to preparenovel polyherbal formulations in aunique and accessible tea bag form and also analysesthe antidiabetic potentials in vitro.Material and method:The formulation wasmade from Ichnocarpus frutescens(IC), Ficusdalhousiae (FD),Cretevamagna (CM),Alpiniagalanga (AG)andSwertiachirata (SC)herbs andused in this study. Indian medicinal plants i.e.,polyherbalwere subjected to progressivephytochemical analysis and testswere carried outfor the determination of α-amylase inhibitionactivity.The Phytochemical analysis revealedthepresence of Alkaloids,Tannins,Anthraquinone, Flavonoids,Saponinand reducing sugar, as the active compounds. The tea infusions of the aforementioned plants were prepared in differentformulations like F1, F2, F3, and F4. The formulations weretested for antidiabetic activity in vitro through the inhibition of alpha-glycosidase.Results: TheF3 (91.6%) and F4 (92.7%) showedthehigher inhibition data againstporcine pancreatic α-amylase among the Fourformulations. The minimum% alpha-amylase inhibition was recordedin F2 (90.4%)amongthe medicinalactiveplants studied.Conclusion: Hyperglycaemia level is reducedvia a controllable condition of starch breakdown through pancreaticα-amylase inhibitors.Best results were obtained by the infusion containing The F2 formulation which showed significant antidiabetic activity.©2022iGlobal Research and PublishingFoundation. All rights reserved.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86573111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbapenemase Detection Among Carbapenem-Resistant Acinetobacter baumannii Clinical Isolates Using a Modified Blue-Carba Test","authors":"E. Tjoa, Shikha Joon, Dianita Angeline, Andrew A. Lieputra, Daniel Edbert, L. Moehario","doi":"10.35652/igjps.2022.12027","DOIUrl":"https://doi.org/10.35652/igjps.2022.12027","url":null,"abstract":"Objective:Acinetobacter baumanniiis a Gram-negative opportunistic bacteria with carbapenemase-associated antibiotic resistance accounting for a majority of nosocomial infections globally. We sought to detectcarbapenemase producers among carbapenem-resistant A. baumannii(CRAB) clinical isolates using Blue-Carba Test(BCT).Methods: This study was an observational descriptive study. At first, A. baumanniiclinical isolates (142) were collected from January 2014 to September 2017and stored at the Microbiology Laboratoryof the Faculty of Medicine, Atma Jaya Hospital. Next step involved the identification of the carbapenem-resistant isolates using WHONET 5.3 software (https://whonet.org/software.html). Here, Imipenem and Meropenem served as markers. Finally, the identified carbapenem-resistant isolates were subjected to Blue-Carba Test. Results: Among 142 A. baumannii isolates, 51.4% (73/142) were identified as CRAB. Of these, 36 isolates were revived and all were found to be carbapenemase positive. Conclusion: Conclusively, a cent percent (36/36) prevalence of carbapenemase producers was observed in the CRAB group, which is an important clinical finding for antibiotic selection against A. baumannii infection.©2022iGlobal Research and PublishingFoundation. All rights reserved.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"133 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76223501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence, Pathogenesis and Identification of Clinical Risk Factors Associated with Dengue Virus (DENV)","authors":"Mohsina F.P, Faheem I.P, M. Mukim, Shahana Tabassum, Shoheb Tarkash, I. Shah, Abhinandan H. Patil","doi":"10.35652/igjps.2022.12023","DOIUrl":"https://doi.org/10.35652/igjps.2022.12023","url":null,"abstract":"Dengue, also called the break bone fever. Dengue disease is caused by dengue virus (DENV) having four categories that escalate by the bite of infected Aedes mosquito’s family are Flaviviridae. The infected person shows the signs and symptoms from mild asymptomatic changes with fever to severe deadly dengue hemorrhagicfever/dengue shock syndrome (DHF/DSS). Nearly 2.5-3 billion people stay in dengue-prone areas with more than 100 million new cases ruled out every year worldwide. Number of Dengue cases has increased tremendous ratio in recent years with sudden risk of the increase in the size of human population. A condition known as viremia (medical term: virus present in blood) occurs due to spread of DENV, which represents high level of viruses in bloodstream of patient. In response the immune system gets activated and produces antibodies against the dengue viral particles, which in turn activates the complement cascade which in combination of the antibodies and WBC get rid of the virus. The cytotoxic T cells (CD8+ T) produced by the body immune system, which identifies and destroy infected cells. Dengue spreads drastically, its virus regress the immunity of body. DENV reduces the bodies’ resistance and decreases the Platelets count and Hemoglobin. Fall in blood pressure and bleeding from Nose and Gums, Dehydration can occur. Small blood vessels are fragile, the fluid in the body leaks out, accumulate in the lungs. When there is bleeding, the fluid is accumulated in the stomach it can result to mortality or can be fatal. The DENV-3 infection cause Dengue Viral Hemorrhagicfever (VHFs)which is severe and fatal form of the disease. The main Dengue shock syndrome is the most severe form of Dengue Hemorrhagicfever. Dengue has presently become a complex issue according to pathophysiological, economic and ecologic. In the last 5 decades anumber of treatment strategies and plans to control dengue came out in India, but the scientific studies related to various problems of dengue disease have been a limited resource in the centerswhere treatment was carried out. The key note point to reduce the number of disease related morbidity and mortality has to be carried out by early identification and immediate commencement of proper treatment.©2022iGlobal Research and PublishingFoundation. All rights reserved.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84181577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Telecardiology in the Era of COVID-19: Slaying the Lernaen Hydra of Cardiovascular Disease with the Assistance of a Post-modern Iolaus","authors":"C. Tsagkaris, L. Matiashova, Andreas S. Papazoglou, Dimitrios V. Moysidis, A. Loudovikou, A. Alexiou, Mohammad Amjad Kamal","doi":"10.35652/igjps.2022.12010","DOIUrl":"https://doi.org/10.35652/igjps.2022.12010","url":null,"abstract":"The delivery of healthcare to patients with chronic non-communicable diseases has been challenging during the COVID-19 pandemic. Cardiovascular diseases constitute the leading causes of morbidity and mortality in the western world and beyond. Telecardiology services are essential for the continuity of medical care, the prevention,and early diagnosis of disease exacerbations. This is a dire need for both patients, who can experience long-term impairment and decrease in functional independence if left untreated, and healthcare systems, who cannot endure additional burden in times of crisis. The development and maintenance of effective remote care frameworks in this field is a multidisciplinary endeavor, where input and scholarly dialogue in the whole spectrum of applied sciences is valuable. In this context, the authors provide an overview of telecardiology applications, discuss its strengths and weaknesses and elaborate on strategies for safe and effective remote cardiovascular care during and beyond the COVID-19 pandemic.©2022iGlobal Research and PublishingFoundation. All rights reserved","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80348111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation and Evaluation of Colon Targeted Drug Delivery System","authors":"Suruse Pravin, Godbole Mangesh, Bhamre Kumudini, Shivhare Umesh","doi":"10.35652/igjps.2022.12011","DOIUrl":"https://doi.org/10.35652/igjps.2022.12011","url":null,"abstract":"Purpose:The objective of the present study was to develop colon targeted drug delivery system of Metronidazole using guar gum as the carrier.Methods:Matrix tablets containing various proportions of guar gum were prepared by direct compression technique. Rapidly disintegrating Metronidazole core tablets were prepared and compression coated with guar gum and 20% of microcrystalline cellulose. The tablets were evaluated for hardness, thickness, drug uniformity and subjected to in vitro drug release studies under conditions mimicking mouth to colon transit. Results and Conclusions: The FTIR study indicates no possible interaction between Metronidazole and carriers. The tablets were found within the permissible limits for various physiological parameters. In vitro drug release studies in pH 6.8 phosphate buffer solution containing rat cecal contents have demonstrated the susceptibility of guar gum to the colonic bacterial enzyme action with consequent drug release. The pretreatment of rats orally with 1 ml of 2% w/v aqueous dispersion of guar gum for 7 d induced enzyme specifically acting on guar gum thereby increasing drug release. Dissolution studies were performed in 0.1N HCl for 2 h, in pH 7.4 buffer for 3 h and pH 6.8 up to 24 h. The cumulative percentage of drug release of Metronidazole after 24 h in pH 6.8 phosphatebuffers was found to be 98.51±0.02, 86.69±0.02, 84.55±0.04, 39.31±0.02, 24.60±0.02, 18.85±0.02 for formulation F1, F2, F3, F4, F5 and F6. It can be concluded that formulation F1 is considered a potential formulation for targeting the drug to the colon. The results showed that guar gum protects the drug from being release completely in the physiological environment of stomach and small intestine.©2022iGlobal Research and PublishingFoundation. All rights reserved.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80756044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Charota (Cassia tora) Gum: A Potential Element as Suspending Agent, An Investigation of Suitability forDevelopment of Paracetamol Suspension","authors":"K. Sarwa, P. Vishwakarma, V. Suryawanshi, Dhaneshwar Uraon, M. Sao","doi":"10.35652/igjps.2022.12029","DOIUrl":"https://doi.org/10.35652/igjps.2022.12029","url":null,"abstract":"Background: Charota (Cassia tora)gum is well reported as an additivefor food product and generally recognized as safe” (GRAS). It is obtained from the seedof the herbaceousplantsof the Caesalpiniaceaefamily. The plant's seedcontainsgluco-mannose polysaccharides, which swell in water and form a colloidaldispersion with increasing viscosity.This property of the gum was exploredto use as a suspending agent for the preparation ofparacetamolsuspension. Result: In the present investigation, charota gum was extracted from the plant and used as a suspending agent in a range of 2-4% w/v in preparation of paracetamol suspension(5% w/v). The investigation has beenperformed comparedwith gum acacia, tragacanth,and gelatin at a similar range of 2-4% w/v.The parameters like sedimentation profile, rheological studies, redispersibility, pH, anddissolution rate were determinedtoevaluatesuspending abilityof Cassia toragum. Conclusion: A comparative datawith other gum reported a higher viscosity and lowest zeta potential for the suspension prepared with Charota gum. At different concentrations, itshowed better suspending ability and redispersibility compare, and it was stable throughout the storage period of 6 weeks. The study's dataconclude that charota gum produced flocculated suspension,redispersedintheleast no of shakespost sedimentation.©2022iGlobal Research and PublishingFoundation. All rights reserved.Cite this article as:Sarwa, K.K.; Vishwakarma, P.K.; Suryawanshi, V.K.; Uraon, D.;Sao, M.Charota (Cassia tora) Gum: A Potential Element as Suspending Agent, An Investigation of Suitability For Development of Paracetamol Suspension.Indo Global J. Pharm. Sci., 2022; 12:228-236.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80637632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolation and Characterization of Principle Bioactive Compounds from Ulva fasciata","authors":"Ch. V. A. Sasikala, D. Geetharamani, Natarajan Swetha","doi":"10.35652/igjps.2022.12014","DOIUrl":"https://doi.org/10.35652/igjps.2022.12014","url":null,"abstract":"Microorganisms have developed new strategies to evade the action of antibiotics leading to multiple drug resistant bacterial strains, leading to an increasing demand in screening for new therapeutic drugs from natural product. Marine organisms are identified as a potential source of novel bioactive compounds. With this in view the study was undertaken to explore the principle bioactive compounds with antimicrobial activity from green seaweed Ulva fasciata.Seaweeds possess bioactive compounds and they have been found toexhibit biological activity against human pathogens. Extraction of the seaweed was carried out using ethanol. The extract was screened for antibacterial and antifungal activity against various bacterial and fungal human pathogens by disc diffusion assay. The bioactive compound present in seaweed was identified using Gas Chromatography and Mass Spectrometry.The ethanolic extract of U. fasciata showed wide range of activity against Gram negative bacterial and few fungal pathogens, while the extract was effective only against Enterococcus faecalisamong the Gram-positive organisms selected for the study. The ethanolic extract of U. fasiatawas subjected to antibacterial activity guided fractionation which led to the separation of the bioactive compound Cholest–5-en-3-ol.The result of present study revealed that the extracts of the seaweed showed potential antimicrobial activity against thetested pathogens. The presence of the bioactive compound makes the seaweed an effective drug of choice for treating various bacterial infections. Hence it is concluded Cholest-5-en-3-ol isolated from U. fasciatacan be used as a potential bioactive compound for therapeutic purpose.©2022iGlobal Research and PublishingFoundation. All rights reserved.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80409121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review on Computational Software Tools for Drug Design and Discovery","authors":"Jimish R. Patel, H. Joshi, Ujashkumar A. Shah, Jayvadan K. Patel","doi":"10.35652/igjps.2022.12006","DOIUrl":"https://doi.org/10.35652/igjps.2022.12006","url":null,"abstract":"In the current era of modern drug design & development via computer-aided drug design, the potential role of computational software tools is widely enlarged in use. Computer-based drug design is revolutionary in the new drug discovery process because these processes are fast, time, and cost-saving with more efficient pharmacological activity. Computer-Based drug design is mainly applied for the drug-design and gets many successes in new drug research. There is plenty of software available in drug design; however; still, many issues are rising during its use. To clarify these issues, an attempt has been provided here in this article about the information about worldwide used 189 computation tools along with citation of software tools, download links, computer operative system and application of tools for available software such as Molecular modeling, docking, proteins conformation, pharmacophore mapping, ADMET, Docking pose visualization, force field calculation, homology modeling, 3D structure generator, Computational Crystallography, protein Database, and calculation software. This vital information enlightens all the software right from old to a recent one. Review article important for choice and application of wide-reaching used Drug Design software.©2022iGlobal Research and PublishingFoundation. All rights reserved.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82050821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Virulent Disease Called Monkeypox: A Case Report ofCountries in Africa Where The Disease is Endemic","authors":"Michael P. Okoh, Kenneth C., Nwachukwu","doi":"10.35652/igjps.2022.12030","DOIUrl":"https://doi.org/10.35652/igjps.2022.12030","url":null,"abstract":"Cases of Monkeypox continue to rise and the World Health Organization (WHO), declared it a public health emergency of international concern (PHEIC). A virus called monkey pox causes the disease and it is zoonotic. The epidemiological surveillance from 1981-1986 in the Democratic Republic of Congo (DRC) a country in Africa were the disease is endemic, documented only 338 cases. Previously, 90% of the affected personswere children approximately 15 years of age at leastin the endemic countries in Africa. BeyondAfrica, 99% cases ofthe current outbreak were found in men and of those, 98% involved men who have sex with men implying it is being transmitted through sexual activities. Crowded living quarters, poor hygiene, discontinuation of the smallpox vaccination, amongst others wereimplicated in the human to human transmission. The symptoms of the disease includes, viremia with 1-2 days of fever and lymphadenopathy before lesions appear. Patients at this stage may be contagious. For treatments, there are no known clinically proventreatments for the disease. Polymerase chain reaction (PCR) amplification are used for specific diagnosisand smallpox vaccines are effective against the disease. Table 1 shows cases from Africa union member countries (AUMC), and Congo Republic, Cameroon and DRC, have a high cumulative frequency(CFR) of occurrence(43, 5.6 and 4.1%), respectively (see Fig 2). The vaccine is not readily available in these endemic countries thus, donors countries needs to collaborate with researchers and health officials to determine what these endemic countries in the global south requires towards enabling scale up in response to this disease. ©2022iGlobal Research and PublishingFoundation. All rights reserved.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"174 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79686719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}