应对新出现的SARS-CoV-2变体的加强剂

Ajay Kumar, Anupam Kumar, R. Banerjee, Nayan Das
{"title":"应对新出现的SARS-CoV-2变体的加强剂","authors":"Ajay Kumar, Anupam Kumar, R. Banerjee, Nayan Das","doi":"10.35652/igjps.2022.12028","DOIUrl":null,"url":null,"abstract":"A novel species of coronavirus has engulfed the entire world. Its severity and rate at which it transmits have left no country untouched. Massive replication has brought mutation in the genomic sequence of the virus. Due to this, many newer variants of SARS-COV-2 have come into play. Many therapies are available for covid 19, such as Remdesivir, Baricitinib, Molnupiravir, etc., but none are effective at preventing SARS-CoV-2 infection. Even most of the efficacious vaccines against the earlier variants are now inefficacious against, the newer variants. So, the people already vaccinated with the primary course of vaccination are at risk of reinfection and symptomatic COVID 19 illness.Furthermore, the initial immune response produced by these vaccines may have diminished with time, paving the pathway for discussion on the absolute need for time off and booster doses for vaccinated people. Some developed countries like the U.K and Israel favor the booster dose strategy, while some defy it, claiming it is necessary to vaccinate unvaccinated people first rather than giving vaccines multiple times. In this article, we have explained the necessity of booster doses in tackling newer variants. However, for the time being, devising a variant-specific vaccine seems promising to hiatus this transmission.©2022iGlobal Research and PublishingFoundation. All rights reserved.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Booster Dose for Tackling Emerging Variant of SARS-CoV-2\",\"authors\":\"Ajay Kumar, Anupam Kumar, R. Banerjee, Nayan Das\",\"doi\":\"10.35652/igjps.2022.12028\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A novel species of coronavirus has engulfed the entire world. Its severity and rate at which it transmits have left no country untouched. Massive replication has brought mutation in the genomic sequence of the virus. Due to this, many newer variants of SARS-COV-2 have come into play. Many therapies are available for covid 19, such as Remdesivir, Baricitinib, Molnupiravir, etc., but none are effective at preventing SARS-CoV-2 infection. Even most of the efficacious vaccines against the earlier variants are now inefficacious against, the newer variants. So, the people already vaccinated with the primary course of vaccination are at risk of reinfection and symptomatic COVID 19 illness.Furthermore, the initial immune response produced by these vaccines may have diminished with time, paving the pathway for discussion on the absolute need for time off and booster doses for vaccinated people. Some developed countries like the U.K and Israel favor the booster dose strategy, while some defy it, claiming it is necessary to vaccinate unvaccinated people first rather than giving vaccines multiple times. In this article, we have explained the necessity of booster doses in tackling newer variants. However, for the time being, devising a variant-specific vaccine seems promising to hiatus this transmission.©2022iGlobal Research and PublishingFoundation. All rights reserved.\",\"PeriodicalId\":13366,\"journal\":{\"name\":\"Indo Global Journal of Pharmaceutical Sciences\",\"volume\":\"1 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Indo Global Journal of Pharmaceutical Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.35652/igjps.2022.12028\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indo Global Journal of Pharmaceutical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.35652/igjps.2022.12028","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

一种新型冠状病毒席卷了整个世界。它的严重程度和传播速度使任何国家都无法幸免。大规模复制导致病毒基因组序列发生突变。正因为如此,许多新的SARS-COV-2变种开始发挥作用。针对covid - 19的治疗方法有很多,如Remdesivir、Baricitinib、Molnupiravir等,但没有一种能有效预防SARS-CoV-2感染。即使大多数对早期变种有效的疫苗现在对较新的变种无效。因此,已经接种过初级疫苗的人有再次感染和出现症状的COVID - 19疾病的风险。此外,这些疫苗产生的最初免疫反应可能会随着时间的推移而减弱,从而为讨论是否绝对需要休息和为接种疫苗的人增加剂量铺平了道路。英国、以色列等发达国家赞成加强接种,但也有人反对,认为有必要先给未接种疫苗的人接种疫苗,而不是多次接种疫苗。在这篇文章中,我们解释了加强剂量在处理新变种的必要性。然而,就目前而言,设计一种变异特异性疫苗似乎有望阻断这种传播。©2022全球研究与出版基金会。版权所有。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Booster Dose for Tackling Emerging Variant of SARS-CoV-2
A novel species of coronavirus has engulfed the entire world. Its severity and rate at which it transmits have left no country untouched. Massive replication has brought mutation in the genomic sequence of the virus. Due to this, many newer variants of SARS-COV-2 have come into play. Many therapies are available for covid 19, such as Remdesivir, Baricitinib, Molnupiravir, etc., but none are effective at preventing SARS-CoV-2 infection. Even most of the efficacious vaccines against the earlier variants are now inefficacious against, the newer variants. So, the people already vaccinated with the primary course of vaccination are at risk of reinfection and symptomatic COVID 19 illness.Furthermore, the initial immune response produced by these vaccines may have diminished with time, paving the pathway for discussion on the absolute need for time off and booster doses for vaccinated people. Some developed countries like the U.K and Israel favor the booster dose strategy, while some defy it, claiming it is necessary to vaccinate unvaccinated people first rather than giving vaccines multiple times. In this article, we have explained the necessity of booster doses in tackling newer variants. However, for the time being, devising a variant-specific vaccine seems promising to hiatus this transmission.©2022iGlobal Research and PublishingFoundation. All rights reserved.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信