Charota (Cassia tora) Gum: A Potential Element as Suspending Agent, An Investigation of Suitability forDevelopment of Paracetamol Suspension

Abstract

Background: Charota (Cassia tora)gum is well reported as an additivefor food product and generally recognized as safe” (GRAS). It is obtained from the seedof the herbaceousplantsof the Caesalpiniaceaefamily. The plant's seedcontainsgluco-mannose polysaccharides, which swell in water and form a colloidaldispersion with increasing viscosity.This property of the gum was exploredto use as a suspending agent for the preparation ofparacetamolsuspension. Result: In the present investigation, charota gum was extracted from the plant and used as a suspending agent in a range of 2-4% w/v in preparation of paracetamol suspension(5% w/v). The investigation has beenperformed comparedwith gum acacia, tragacanth,and gelatin at a similar range of 2-4% w/v.The parameters like sedimentation profile, rheological studies, redispersibility, pH, anddissolution rate were determinedtoevaluatesuspending abilityof Cassia toragum. Conclusion: A comparative datawith other gum reported a higher viscosity and lowest zeta potential for the suspension prepared with Charota gum. At different concentrations, itshowed better suspending ability and redispersibility compare, and it was stable throughout the storage period of 6 weeks. The study's dataconclude that charota gum produced flocculated suspension,redispersedintheleast no of shakespost sedimentation.©2022iGlobal Research and PublishingFoundation. All rights reserved.Cite this article as:Sarwa, K.K.; Vishwakarma, P.K.; Suryawanshi, V.K.; Uraon, D.;Sao, M.Charota (Cassia tora) Gum: A Potential Element as Suspending Agent, An Investigation of Suitability For Development of Paracetamol Suspension.Indo Global J. Pharm. Sci., 2022; 12:228-236.