Indo Global Journal of Pharmaceutical Sciences最新文献_第6页

Phytochemical Screening for Secondary Metabolites and Nutraceutical Value of Sesbania grandiflora (L) Pers leaf extract 大田菁叶提取物次生代谢产物的植物化学筛选及营养价值研究

Indo Global Journal of Pharmaceutical Sciences Pub Date : 2021-01-01 DOI: 10.35652/igjps.2021.111004

M. Apoorva, S. Pooja, G. Vidyasagar

引用次数: 3

Biosynthesis, Characterization and Biological Studies of Copper Nanoparticles from Methanolic Extract of Bulb of Zephyranthes citrina 西风球茎甲醇提取物纳米铜的合成、表征及生物学研究

Indo Global Journal of Pharmaceutical Sciences Pub Date : 2021-01-01 DOI: 10.35652/igjps.2021.112012

Prakash Jayavel, V. Subramaniam

{"title":"Biosynthesis, Characterization and Biological Studies of Copper Nanoparticles from Methanolic Extract of Bulb of Zephyranthes citrina","authors":"Prakash Jayavel, V. Subramaniam","doi":"10.35652/igjps.2021.112012","DOIUrl":"https://doi.org/10.35652/igjps.2021.112012","url":null,"abstract":"This work reports the biosynthesis, characterization and biological studies of copper oxide nanoparticles using a methanolic extract of bulb of Zephyranthes citrina. The synthesised copper oxide nanoparticles were characterized by using various spectral techniques. The functional, structural and morphological studies were confirmed by FT-IR, XRD and SEM respectively. The elemental composition was determined by EDAX analysis. The various spectral data confirms the formation of copper oxide nanoparticles and is found to be orthorhombic, 18-50 nm of size and spherical in shape. The synthesised copper oxide nanoparticles were investigated for antibacterial activity against gram positive (Staphylococcus aureus, Bacillus subtilis and Staphylococcus epidermidis), gram negative (Salmonella typhi, Escherichia coli and Klebseilla pneumoniae) and antifungal (Aspergillus niger, Candida albicans and Fusarium oxysporum) activities with different pathogens. The results revealed that copper oxide nanoparticles exhibit excellent inhibition efficiency against representative microorganisms. The outcome of the study could be useful for the development of value added products from indigenous medicinal plants. © 2020 iGlobal Research and Publishing Foundation. All rights reserved.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"81 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79139126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Effect of Solanum melongena Linn. Leaves Extracts on Clonidine Induced Catalepsy and Milk Induced Leukocytosis and Eosinophilia in Mice 龙葵的药效。叶提取物对可乐定致小鼠猝睡和乳致小鼠白细胞增多和嗜酸性粒细胞增多的影响

Indo Global Journal of Pharmaceutical Sciences Pub Date : 2021-01-01 DOI: 10.35652/igjps.2021.112005

Ramdas N. Kale, Ravindra Y. Patil

{"title":"Effect of Solanum melongena Linn. Leaves Extracts on Clonidine Induced Catalepsy and Milk Induced Leukocytosis and Eosinophilia in Mice","authors":"Ramdas N. Kale, Ravindra Y. Patil","doi":"10.35652/igjps.2021.112005","DOIUrl":"https://doi.org/10.35652/igjps.2021.112005","url":null,"abstract":"Objective: To study the Effect of Solanum melongena Linn. leaves extracts on Clonidine induced catalepsy and milk induced Leukocytosis and Eosinophilia in mice. Methods: Methanolic and chloroform extracts of Solanum melongena Linn. leaves were prepared. Preliminary phytochemical screening of the prepared extracts was carried out. Effects of prepared extracts were studied on Clonidine induced catalepsy and milk induced leukocytosis and eosinophila in mice. Results: Maximum duration of catalepsy was observed at 90 min after the clonidine administration. There was significant inhibition (p˂0.05) of clonidine induced catalepsy in the animals pretreated with chlorpheniramine maleate, methanol and chloroform extract of S. melongena. Administration of milk (4mg/kg) subcutaneous route exhibited significant increase in leucocyte and eosinophil count after 24 hrs of administration. Chloroform extract at the dose of 500mg/kg body weight showed significant inhibition (p˂0.05) of milk induced leukocytosis and eosinophilia. Conclusions: These results suggest that Solanum melongena leaves extract may have the potential therapeutic value in the treatment of allergic diseases. © 2020 iGlobal Research and Publishing Foundation. All rights reserved.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87443393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Treatment of AIDS: Development of Medicine by Innovation with Special Emphasis on Protease Inhibitors 艾滋病的治疗:以蛋白酶抑制剂为重点的创新医学发展

Indo Global Journal of Pharmaceutical Sciences Pub Date : 2021-01-01 DOI: 10.35652/igjps.2021.113004

Agnita Kundu

{"title":"Treatment of AIDS: Development of Medicine by Innovation with Special Emphasis on Protease Inhibitors","authors":"Agnita Kundu","doi":"10.35652/igjps.2021.113004","DOIUrl":"https://doi.org/10.35652/igjps.2021.113004","url":null,"abstract":":In the light of the recent events in the world concerning COVID-19 virus, it is important to review the challenges faced by the world by another pandemic, AIDS. The painstaking research by the scientists, the pharmaceutical companies, the medical professionals have led to this day when AIDS patients are living their whole life span. Though we do not have any vaccine for AIDS but by intelligent use of medication, we have been able to combat the disease to a large extent. HIV is a RNA virus, whose treatment is mainly done by finding the structure and function of the proteins that are vital to its life cycle. Designing a drug/inhibitor to make those proteins ineffective constitutes the next step. WHO has recognized AIDS as a pandemic almost 40 years back but the world is yet to find a cure or a vaccine. The current treatment method is called HAART, Highly Active Anti Retroviral Therapy, where different types of inhibitors,eg. Reverse Transcriptase inhibitors, Protease inhibitors; each arresting a different important protein are given in combination. The virus replicates very fast and forms mutations which render it ineffective to the inhibitors thus resistance to the inhibitors develop. Hence development of new types of inhibitors is crucial to the problem. There are certain similarities between AIDS and COVID-19, both in terms of the attacking virus and effective medication, which make it more important than ever that the research on HIV is revisited and knowledge we gain from it is used to battle the new pandemic. © 2020 iGlobal Research and Publishing Foundation. All rights reserved.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75993162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantitative Estimation and Comparative Analysis of Mineral Content of Syzygium jambos Fruit and Its Seed 杨梅果实及其种子矿物质含量的定量估算与比较分析

Indo Global Journal of Pharmaceutical Sciences Pub Date : 2021-01-01 DOI: 10.35652/igjps.2021.112010

S. Dutta, K. Khaled

{"title":"Quantitative Estimation and Comparative Analysis of Mineral Content of Syzygium jambos Fruit and Its Seed","authors":"S. Dutta, K. Khaled","doi":"10.35652/igjps.2021.112010","DOIUrl":"https://doi.org/10.35652/igjps.2021.112010","url":null,"abstract":"In recent times, medicinal plants are gaining popularity in human life as an alternative to drugs. The use of genus Syzygium, as a traditional medicine are practiced since ancient times. Syzygium jambos is one of them. It is generally found in South-East Asian countries. The fruit of this plant is commonly known as ‘Malabar plum’ / ‘Rose apple’ / ‘Plum rose’. In West Bengal (India) it is familiar as ‘Golapjam’. Purpose: The main objective of this study to the estimate mineral content like, Calcium, Phosphorus, Iron, Sodium, Potassium, Zinc, Selenium, Iodine, Copper, Manganese, Lead and Sulphur of Syzygium jambos fruit and its seed that has not been revealed yet. Method: Standard methods of AOAC have been used to quantify different mineral contents of samples. Result: The finding shows that Syzygium jambos fruit and its seed contain an adequate amount of essential macro and micro minerals. These are mostly abundant in Calcium, Phosphorus, Potassium and Copper content. Conclusion: So, it may be concluded that Syzygium jambos fruit and seed could be one of the good sources to meet the daily dietary requirements for an adult as well as it could keep diseases away. Finally, a comparative study has been done among the mineral content of Syzygium jambos fruit, seed with Jackfruit, Black plum, Watermelon and their respective edible seeds. © 2020 iGlobal Research and Publishing Foundation. All rights reserved.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79505808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

FTIR Analysis and Phytoconstituents Screening of Aegle Marmelos L. Leaves in Various Extracts 蜜瓜叶不同提取物的FTIR分析及成分筛选

Indo Global Journal of Pharmaceutical Sciences Pub Date : 2021-01-01 DOI: 10.35652/igjps.2021.112001

T. Deokar, Sushama M. Pawar

{"title":"FTIR Analysis and Phytoconstituents Screening of Aegle Marmelos L. Leaves in Various Extracts","authors":"T. Deokar, Sushama M. Pawar","doi":"10.35652/igjps.2021.112001","DOIUrl":"https://doi.org/10.35652/igjps.2021.112001","url":null,"abstract":"Medicinal plants are used in traditional medicine to cure various ailments. They consist of a number of bioactive components like alkaloids, flavonoids, glycosides, steroids, tannins, phenolic compounds, etc. are used for the treatment of several diseases. Aegle marmelos L. is a spiritual, religious and important medicinal plant commonly called bael. Different parts of bael used in ethnomedicine are known to possess antioxidant, antidiarrheal, antibacterial, antidysenteric, anti-inflammatory, antipyretic, analgesic activities. The aim of the present investigation is to carry screening of phytochemical constituents and Fourier Transform Infrared spectroscopic analysis of various extracts of Aegle marmelos L. leaves. The preliminary screening of phytoconstituents was carried out by standard methods. In the Aegle marmelos L. leaves the presence of phytochemicals such as carbohydrates, proteins, amino acids, steroids, alkaloids, flavonoids, glycosides, saponins, tannins were present in aqueous, acetone, ethyl acetate, dichloromethane, ethanol, methanol and petroleum ether extract. Results of the FTIR spectra of leaves extracts revealed the presence of various functional groups like alkanes, aldehydes, amides, alcohols, esters, ethers, carboxylic acids, carbonyl group, aromatic compounds, etc. All these compounds pertain to the bioactive components and could be responsible for the medicinal properties of Aegle mermelos L. © 2020 iGlobal Research and Publishing Foundation. All","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"85 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91522678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Development and Validation of Double Divisor Ratio Spectra Derivative Method for Simultaneous Estimation of Telmisartan, Chlorthalidone and Cilnidipine in Tablet Dosage Form 双除数比光谱导数法同时测定片剂中替米沙坦、氯噻酮和西尼地平含量的建立与验证

Indo Global Journal of Pharmaceutical Sciences Pub Date : 2021-01-01 DOI: 10.35652/igjps.2021.111001

D. Patel, Pinkal Patel, Janki Patel

{"title":"Development and Validation of Double Divisor Ratio Spectra Derivative Method for Simultaneous Estimation of Telmisartan, Chlorthalidone and Cilnidipine in Tablet Dosage Form","authors":"D. Patel, Pinkal Patel, Janki Patel","doi":"10.35652/igjps.2021.111001","DOIUrl":"https://doi.org/10.35652/igjps.2021.111001","url":null,"abstract":": Aim: Development and Validation of Double Divisor Ratio Spectra Derivative Method for Simultaneous Estimation of Telmisartan, Chlorthalidone and Cilnidipine in Tablet Dosage Form. Method: A new method was developed for the simultaneous quantification of ternary mixtures by double divisor spectra method and validated as per International Conference on Harmonization [(ICH) Q2 (R1)] guideline. In double divisor spectra method absorption spectrum of ternary mixture divided by two of the three compounds in the mixture. Methanol used as solvent for this method. Calibration graphs were established in the range 10-50 μg/mL for Telmisartan, 7.5-17.5 μg/mL for Chlorthalidone and 5-25 μg/mL for Cilnidipine. Results: all the drugs exhibited good linearity over the reported concentration range with acceptable correlation coefficient. The method was validated according to ICH guideline parameters such as accuracy, repeatability, reproducibility showing acceptable percent relative standard deviation of less than 2. Conclusion: The proposed method demonstrated that the method is accurate, simple, precise, compounds not interference with each other and no any prior separation of compounds. © 2020 iGlobal Research and Publishing Foundation.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"89 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80365848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Antinociceptive activity shown by Aerva javanica flowering top extract and its mechanistic evaluation 土芹花顶提取物的抗伤活性及其机理评价

Indo Global Journal of Pharmaceutical Sciences Pub Date : 2021-01-01 DOI: 10.35652/igjps.2021.111005

S. K. Swarnkar, A. Khunteta, M. Gupta, P. Jain, S. Sharma, S. Paliwal

引用次数: 3

Development and Validation of Stability Indicating RP-HPLC Method For the Simultaneous Estimation of Glucosamine Sulphate, Methyl Sulfonyl Methane and Diacerein in Tablet Dosage Form 稳定性指示反相高效液相色谱法测定片剂剂型中硫酸氨基葡萄糖、甲磺酰基甲烷和二乙胺含量的建立与验证

Indo Global Journal of Pharmaceutical Sciences Pub Date : 2021-01-01 DOI: 10.35652/igjps.2021.112002

G. Rajitha, A. G. Susmita, K. Kranthi

{"title":"Development and Validation of Stability Indicating RP-HPLC Method For the Simultaneous Estimation of Glucosamine Sulphate, Methyl Sulfonyl Methane and Diacerein in Tablet Dosage Form","authors":"G. Rajitha, A. G. Susmita, K. Kranthi","doi":"10.35652/igjps.2021.112002","DOIUrl":"https://doi.org/10.35652/igjps.2021.112002","url":null,"abstract":": Purpose: The objective of the proposed method is to develop an economical, accurate, precise, sensitive, reproducible, selective and validated RP-HPLC for simultaneous estimation of Glucosamine sulphate (Glu), Methyl Sulfonyl Methane (MSM) and Diacerein (Dia) in combined dosage form. Method: Mobile phase containing water and acetonitrile in the ratio of 50:50v/v was pumped through the Zodiasil C 18 150×4.6mm,3.5µ column. The flow rate was 0.8ml/min and temperature was maintained at 30°C. The eluents were observed at a wavelength of 210nm using PDA detector. Results: The retention time of Glu, MSM, and Dia were found to be 2.323, 2.842 and 3.453 respectively. The percentage RSD of intraday precision were found to be 0.5 for Glu, 0.2 for MSM and 0.7 for Dia. The percentage RSD of interday precision was found to be 0.7 for Glu, 0.8 for MSM, and 0.9 for Dia. Percentage recovery was found to be 100.30% for Glu, 99.65% for MSM and 100.13% for and Dia. Conclusion: The developed method was simple, precise, accurate, linear, rapid, economical and degradation studies revealed that the method has the ability to separate degradation products in pharmaceutical dosage forms so it can be adopted in regular quality control test for the simultaneous estimation of Glu, MSM, and Dia in tablet dosage form. © 2020 Research and Publishing Foundation. All rights","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"67 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83417053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Syntheses, Characterization and Biochemical Behaviour of Tungsten Complex 钨配合物的合成、表征及生化行为

Indo Global Journal of Pharmaceutical Sciences Pub Date : 2021-01-01 DOI: 10.35652/igjps.2021.112009

V. K. Srivastava

引用次数: 0